• 2021-03 — 至今
   山东大学 
  副教授
• 2019-10 — 2020-10
   德国马尔堡大学 
  客座研究员
• 2016-10 — 2019-09
   德国哥廷根大学医学中心 
  博士后/助教
• 2013-06 — 2013-09
   瑞士苏黎世大学 
  访问博士生

• BMC Pregnancy Childb编委
• Scientific Reports编委
• 国家自然科学基金项目函评专家
• 北京市自然科学基金项目函评专家
• 教育部全国研究生教育评估监测专家
• 山东省医学会医学科管分会学组委员
• 山东省医学会健康传播分会学组委员
• 山东省青年科学家协会会员
• 山东省高层次人才发展促进会会员

1.早期胚胎发育的代谢调控规律

2.围植入期胚胎细胞谱系分化调控机制

3.胚胎发育异常与生殖障碍

(1) Maternal LDHB Safeguards Redox Balance and Developmental Competence During Preimplantation Embryo Cleavage.FASEB Journal.2026 (40)

(2) Crosstalk between H3K4me3 and oxidative stress is a potential target for the improvement of ART-derived embryos..Nat Commun.2025 (1)

(3) 时永香.童第周核质互作理论虚拟仿真实验课程及其智能体的创建.生物学杂志.2025 (9)

(4) Astaxanthin promotes in vitro maturation of mouse oocytes by regulating mitochondrial functions and protein homeostasis？.BIOLOGY OF REPRODUCTION Journal.2025

(5) The asymmetric expression of HSPA2 in blastomeres governs the first embryonic cell-fate decision.Elife.2025,13

(6) 史明泽.SHMT2 is essential for mammalian preimplantation embryonic development through de novo biosynthesis of nucleotide metabolites.MOLECULAR THERAPY-NUCLEIC ACIDS.2025,36 (2)

(7) 张传鑫.2-bromoacetamide exposure impairs oocyte maturation in mice and humans primarily via disrupting the cytoskeleton.Ecotoxicology and Environmental Safety.2024,272

(8) 陈晓蕾.Calcium ionophore improves embryonic development and pregnancy outcomes in patients with previous developmental problems in ICSI cycles.BMC PREGNANCY AND CHILDBIRTH.2022,22 (1)

(9) 吴克良.Proteomic analysis implicates that postovulatory aging leads to aberrant geneexpression, biosynthesis, RNA metabolism and cell cycle in mouse oocytes.JOURNAL OF OVARIAN RESEARCH.2022 (112)

(10) 宋劲竹.Functional substitution of zona pellucida with modified sodium hyaluronate gel in human embryos.JOURNAL OF ASSISTED REPRODUCTION AND GENETICS.2022

(11) Zou, Zhuoning.Translatome and transcriptome co-profiling reveals a role of TPRXs in human zygotic genome activation..Science.2022 :eabo7923

(12) 刘博洋.Temporal Gradients Controlling Embryonic Cell Cycle.BIOLOGY-BASEL.2021,10 (6)

(13) 刘博洋.Fluorescence Fluctuation Analysis Reveals PpV Dependent Cdc25 Protein Dynamics in Living Embryos.PLOS Genetics.2020,16 (4)

(14) 刘博洋.A Link between Deoxyribonucleotide Metabolites and Embryonic Cell-Cycle Control.Current Biology.2019,29 (7)

(15) 刘博洋.The Role of dNTP Metabolites in Control of the Embryonic Cell Cycle.Cell Cycle.2019,18 (21)

(16) 刘博洋.Multiple Functions of the Essential Gene PpV in Drosophila Early Development.G3-Genes Genomes Genetics.2019,9 (11)

(17) 刘博洋.Link of Zygotic Genome Activation and Cell Cycle Control.Meth Mol Biol.2017,1605

1. 基于微流控技术的体外人类胚胎培养体系建立, 2022-09-30-2024-12-31

2. （包干项目）哺乳动物胚胎早期发育的代谢调控, 2022-03-30-2025-03-31

3. 类器官研究、人类胚胎研究、 基因编辑动物研究的伦理规则, 2022-08-18-2023-05-15

4. 人类胚胎着床过程中的细胞分化机制研究-2024-11-30

5. 丝氨酸羟甲基转移酶在哺乳动物胚胎母源-合子过渡过程中的调控机制研究-2024-12-31

6. 哺乳动物胚胎早期发育的代谢调控-2025-03-31

7. SHMT2代谢酶在小鼠早期胚胎发育中的代谢调控机制研究-2024-12-31

1.迟超鑫

2.张译文

3.邓田田

1.基础医学院   基础医学   2025