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所属单位：
山东大学海洋学院
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论文名称：
Micro(nano)plastics in marine medaka: Entry pathways and cardiotoxicity with triphenyltin
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教研室：
山东大学海洋学院
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发表刊物：
Environmental Pollution
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刊物所在地：
荷兰
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关键字：
Micro(nano)plastics；Triphenyltin；Marine medaka；Entry pathway；Cardiotoxicity
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摘要：
The simultaneous presence of micro(nano)plastics (MNPs) and pollutants represents a prevalent environmental challenge that necessitates understanding their combined impact on toxicity. This study examined the distribution of 5 μm (PS-MP5) and 50 nm (PS-NP50) polystyrene plastic particles during the early developmental stages of marine medaka (Oryzias melastigma) and assessed their combined toxicity with triphenyltin (TPT). Results showed that 2 mg/L PS-MP5 and PS-NP50 could adhere to the embryo surface. PS-NP50 can passively enter the larvae and accumulate predominantly in the intestine and head, while PS-MP5 cannot. Nonetheless, both types can be actively ingested by the larvae and distributed in the intestine. 2 mg/L PS-MNPs enhance the acute toxicity of TPT. Interestingly, high concentrations of PS-NP50 (20 mg/L) diminish the acute toxicity of TPT due to their sedimentation properties and interactions with TPT. 200 μg/L PS-MNPs and 200 ng/L TPT affect complement and coagulation cascade pathways and cardiac development of medaka larvae. PS-MNPs exacerbate TPT-induced cardiotoxicity, with PS-NP50 exhibiting stronger effects than PS-MP5, which may be related to the higher adsorption capacity of NPs to TPT and their ability to enter the embryos before hatching. This study elucidates the distribution of MNPs during the early developmental stages of marine medaka and their effects on TPT toxicity, offering a theoretical foundation for the ecological risk assessment of MNPs.
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第一作者：
Ling Liu
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通讯作者：
Zhi-Hua Li
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全部作者：
Ling-Ming Kong,Ping Li,Cheng-Zhuang Chen,Jin-Xin Wang,Ruo-Lan Jia,Ren-Yan Du
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论文类型：
研究论文
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论文编号：
123079
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文献类型：
期刊论文
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卷号：
342
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ISSN号：
0269-7491
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是否译文：
否
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发表时间：
2024-02
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发布时间：
2025-04-09
