李新林,助理研究员(讲师),甘肃陇南人,博士毕业于中国科学院大学(中国科学院分子植物科学卓越创新中心,原中国科学院上海生命科学研究院)
联系方式(Email):xinlinli@sdu.edu.cn;
ORCID ID:https://orcid.org/my-orcid?orcid=0000-0002-6094-0577
地址:山东省济南市历下区文化西路44号山东大学齐鲁医学院(药学院)
1.特殊生境微生物来源的活性天然产物挖掘与化学生物学研究
2.天然产物的生物合成与合成生物学开发
(1) Xin-Lin Li, Yanlei Sun, Ying Yin, Shuai Zhan, Chengshu Wang*.A bacterial-like Pictet-Spenglerase drives the evolution of fungi to produce β-carboline glycosides together with separate genes.Proceedings of the National Academy of Sciences of the United States of America.2023,120 :e2303327120.
(2) Xin-Lin Li#, Yu-Xing Xu#, Yuan Li, Rui Zhang, Tian-Yuan Hu, Ping Su, Man Zhou, Ting Tang, Ying Zeng, Yan-Long Yang*, Wei Gao*.Rapid discovery and functional characterization of diterpene synthases from basidiomycete fungi by genome mining.Fungal Genetics and Biology.2019,128 :36-42.
(3) Yuan Li, Xin-Lin Li, Chang-Jiang-Sheng Lai, Rui-Shan Wang, Li-Ping Kang, Ting Ma, Zhen-Hua Zhao, Wei Gao*, Lu-Qi Huang*.Functional characterization of three flavonoid glycosyltransferases from Andrographis paniculata.Royal Society Open Science.2019,6 :190150.
(4) Yanlei Sun#, Bo Chen#, Xin-Lin Li, Ying Yin, Chengshu Wang*.Orchestrated biosynthesis of the secondary metabolite cocktails enables the producing fungus to combat diverse bacteria.mBio.2022,13 :e0180022.
(5) Tianyuan Hu, Jiawei Zhou, Yuru Tong, Ping Su, Xin-Lin Li, Yuan Liu, Nan Liu, Xiaoyi Wu, Yifeng Zhang, Jiadian Wang, Linhui Gao, Lichan Tu, Yun Lu, Zhouqian Jiang, Yongjin J Zhou, Wei Gao*, Luqi Huang*.Engineering chimeric diterpene synthases and isoprenoid biosynthetic pathways enables high-level production of miltiradiene in yeast.Metabolic Engineering.2020,60 :87-96.
(6) Yuan Li, Hui-Xin Lin, Jian Wang, Jian Yang, Chang-Jiang-Sheng Lai, Xing Wang, Bao-Wei Ma, Jin-Fu Tang, Yong Li, Xin-Lin Li, Juan Guo, Wei Gao*, Lu-Qi Huang*.Glucosyltransferase capable of catalyzing the last step in Neoandrographolide biosynthesis.Organic Letters.2018,20 :5999-6002.
1. 山东省自然科学基金青年项目,主持,2025.01 - 2027.12
2. 国家自然科学基金青年项目(30万),主持,2025.01 - 2027.12