Title : Design, synthesis and pharmacological evaluation of N-(5-chloro-2,4-dihydroxybenzoyl)-(R)-N-arylmethyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxamides as potent Hsp90 inhibitors

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Affiliation of Author(s):药学院

Title of Paper:Design, synthesis and pharmacological evaluation of N-(5-chloro-2,4-dihydroxybenzoyl)-(R)-N-arylmethyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxamides as potent Hsp90 inhibitors

Journal:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Key Words:Apoptosis;CETSA;Hsp90 inhibitors;IKK;Molecular dynamics simulation

First Author:梁传鹏

Document Code:1395248010526461954

Volume:143

Page Number:85-96

Number of Words:8

Translation or Not:no

Date of Publication:2018-01-01