团队聚焦肿瘤免疫微环境重塑及相关细胞调控，系统研究HBV、代谢等环境因素诱发肝脏炎症及其恶性转化的分子机制及干预策略，阐明了免疫调控分子Tim-3和ZHX2等在介导HBV感染、代谢性肝病和肝癌等疾病进程中的作用机制。

在学术带头人国家杰青马春红教授的带领下，近三年来在Sci Transl Med、J Exp Med、Nat Commun、J Hepatol、Hepatology、J Am Chem Soc、Signal Transduct Target Ther,、Cell Mol Immunol, Cell Death Differ、Adv Sci、Cell Rep等杂志发表1区高水平SCI论文20余篇。

团队导师现有教授5名，副教授2名，每年硕士研究生名额10个左右，博士研究生名额4-5个，欢迎有志于从事肿瘤免疫以及肝脏相关疾病研究的优秀学生加入！

近三年代表性成果

1.    Ma S^#, Wu Q^#, Wu W^#, Tian Y, Zhang J, Chen C, Sheng X, Zhao F, Ding L, Wang T, Zhao L, Xie Y, Wang Y, Yue X, Wu Z, Wei J, Zhang K, Liang X, Gao L, Wang H, Wang G*, Li C*, Ma C*. Urolithin A hijacks ERK1/2-ULK1 cascade to improve CD8⁺ T cell fitness for antitumor immunity. Adv Sci. 2024 Mar 6:e2310065 .(IF=16.7)

2.    Ding L, Sun Y, Liang Y, Zhang J, Fu Z, Ren C, Li P, Liu W, Xiao R, Wang H, Zhang Z, Yue X, Li C, Wu Z, Feng Y, Liang X, Ma C, Gao L. Beta-Cell Tipe1 Orchestrates Insulin Secretion and Cell Proliferation by Promoting Gαs/cAMP Signaling via USP5. Adv Sci (Weinh). 2024 Feb 28:e2304940. (IF=16.7)

3.    Xiao R^#, Tian Y^#, Zhang J, Li N, Qi M, Liu L, Wang J, Li Z, Zhang J, Zhao F, Wang T, Tan S, Li C, Wu Z, Yu M, Jiang X, Zhan P, Gao L, Han B*, Liu X*, Liang X*, Ma C*. Increased Siglec-9/Siglec-9L interactions on NK cells predict poor HCC prognosis and present a targetable checkpoint for immunotherapy. J Hepatol. 2024 Feb 7:S0168-8278(24)00106-5. (IF=26.2)

4.    Ma S^#, Tian Y^#, Peng J^#, Chen C, Peng X, Zhao F, Li Z, Li M, Zhao F, Sheng X, Zong R, Li Y, Zhang J, Yu M, Zhu Q, Tian X, Li Y, Neckenig MR, Liu H, Zhan P, Yue X, Wu Z, Gao L, Liang X, Liu X*, Li C*, Ma C*. Identification of a small-molecule Tim-3 inhibitor to potentiate T cell-mediated antitumor immunotherapy in preclinical mouse models. Sci Transl Med. 2023 Nov 15;15(722):eadg6752. (IF=19.0)

国际期刊Trends in Molecular Medicine (IF = 14.5)为该论文配发热点推荐（spotlight）文章“TIM-3 inhibitors: a promising strategy for tumor immunotherapy”。

5.    Zhang Y, Fan Y, Hu H, Zhang X, Wang Z, Wu Z, Wang L, Yu X, Song X, Xiang P, Zhang X, Wang T, Tan S, Li C, Gao L, Liang X, Li S, Li N, Yue X*, Ma C*. ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury. Nat Commun. 2023 Nov 18;14(1):7527. (IF=17)

6.    Tan S^#, Wang Z^#, Li N, Guo X, Zhang Y, Ma H, Peng X, Zhao Y, Li C, Gao L, Li T, Liang X*, Ma C*. Transcription factor Zhx2 is a checkpoint that programs macrophage polarization and antitumor response. Cell Death Differ. 2023 Sep;30(9):2104-2119. (IF=13.3)

7.    Tian P, Yang W, Guo X, Wang T, Tan S, Sun R, Xiao R, Wang Y, Jiao D, Xu Y, Wei Y, Wu Z, Li C, Gao L, Ma C*, Liang X*. Early life gut microbiota sustains liver-resident natural killer cells maturation via the butyrate-IL-18 axis. Nat Commun. 2023 Mar 27;14(1):1710. (IF=17)

8.    Qin L, Song Y, Zhang F, Wang R, Zhou L, Jin S, Chen C, Li C, Wang M, Jiang B, Sun G, Ma C, Gong Y*, Li P*. CRL4B complex-mediated H2AK119 monoubiquitination restrains Th1 and Th2 cell differentiation. Cell Death Differ. 2023 Jun;30(6):1488-1502. (IF=13.3)

9.    Kong Y, Wu M, Wan X, Sun M, Zhang Y, Wu Z, Li C, Liang X, Gao L, Ma C, Yue X*. Lipophagy-mediated cholesterol synthesis inhibition is required for the survival of hepatocellular carcinoma under glutamine deprivation. Redox Biol. 2023 Jul;63:102732. (IF=11.9)

10. Guo X, Tan S, Wang T, Sun R, Li S, Tian P, Li M, Wang Y, Zhang Y, Yan Y, Dong Z, Yan L, Yue X, Wu Z, Li C, Yamagata K, Gao L, Ma C, Li T*, Liang X*. NAD+ salvage governs mitochondrial metabolism, invigorating natural killer cell antitumor immunity. Hepatology. 2023 Aug 1;78(2):468-485. (IF=15.3)

11. Wu Z, Lei X, Wang X, Zhang Z, Li Y, Gao L, Liang X, Wang P, Wang J, Ma C. Peptide targeting the interaction of S protein cysteine-rich domain with Ezrin restricts pan-coronavirus infection. Signal Transduct Target Ther. 2023 Jan 18;8(1):19. (IF=37.2)

12. Wang Y, Wang Y, Ding L, Ren X, Wang B, Wang L, Zhao S, Yue X, Wu Z, Li C, Liang X, Ma C, Gao L*. Tim-4 reprograms cholesterol metabolism to suppress antiviral innate immunity by disturbing the Insig1-SCAP interaction in macrophages. Cell Rep. 2022 Nov 29;41(9):111738. (IF= 9.9)

13. Wang L^#, Zhang G^#, Sun Y, Wu Z, Ren C, Zhang Z, Peng X, Zhang Y, Zhao Y, Li C, Gao L, Liang X, Sun H, Cui J*, Ma C*. Enhanced Delivery of TLR7/8 Agonists by Metal-Organic Frameworks for Hepatitis B Virus Cure. ACS Appl Mater Interfaces. 2022 Oct 19;14(41):46176-46187. (IF=9.6)

14. Ding Y^#, Chen C^#, Ma S, Sheng X, Zhao F, Peng J, Dong H, Ma C*, Li C*. Intrinsic PD-L1 promotes antitumor activity of CD8+ cytotoxic T lymphocytes via in cis interaction with CD80. Cancer Commun (Lond). 2022 Aug;42(8):784-788. (IF=14.4)

15. Sun Y, Teng Y, Wang L, Zhang Z, Chen C, Wang Y, Zhang X, Xiang P, Song X, Lu J, Li N, Gao L, Liang X, Xia Y, Wu Z, Ma C. LINC01431 Promotes Histone H4R3 Methylation to Impede HBV Covalently Closed Circular DNA Transcription by Stabilizing PRMT1. Adv Sci (Weinh). 2022 May;9(16):e2103135. (IF=15.1)

16. Cheng Y^#, Bai F^#, Ren X^#, Sun R, Guo X, Liu W, Wang B, Yang Y, Zhang X, Xu Y, Li C, Yang X, Gao L, Ma C, Li X*, Liang X*. Phosphoinositide-Binding Protein TIPE1 Promotes Alternative Activation of Macrophages and Tumor Progression via PIP3/Akt/TGFβ Axis. Cancer Res. 2022 Apr 15;82(8):1603-1616. (IF=13)

17. Liu L, Bai F, Song H, Xiao R, Wang Y, Yang H, Ren X, Li S, Gao L, Ma C, Yang X, Liang X. Upregulation of TIPE1 in tubular epithelial cell aggravates diabetic nephropathy by disrupting PHB2 mediated mitophagy. Redox Biol. 2022 Apr;50:102260. (IF=11.4)

18. Yang X, Li M, Qin X, Tan S, Du L, Ma C, Li M. Photophosphatidylserine Guides Natural Killer Cell Photoimmunotherapy via Tim-3. J Am Chem Soc. 2022 Mar 9;144(9):3863-3874. (IF=15.0)

19. Wang T, Zhang J, Li N, Li M, Ma S, Tan S, Guo X, Wang Z, Wu Z, Gao L, Ma C, Liang X. Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development. Mol Ther. 2022 Mar 2;30(3):1135-1148. (IF=12.4)

20. Zhao S, Wang C, Lu P, Lou Y, Liu H, Wang T, Yang S, Bao Z, Han L, Liang X, Ma C, Gao L. Switch receptor T3/28 improves long-term persistence and antitumor efficacy of CAR-T cells. J Immunother Cancer. 2021 Nov;9(12):e003176. (IF=10.9)

21. Wang T, Ma C. The hepatic macrophage pool in NASH. Cell Mol Immunol. 2021 Aug;18(8):2059-2060. (IF=17.7)

22. Wang L, Sun Y, Song X, Wang Z, Zhang Y, Zhao Y, Peng X, Zhang X, Li C, Gao C, Li N, Gao L, Liang X, Wu Z*, Ma C*. Hepatitis B virus evades immune recognition via RNA adenosine deaminase ADAR1-mediated viral RNA editing in hepatocytes. Cell Mol Immunol. 2021 Aug;18(8):1871-1882. (IF=17.7)

23. Tan S, Guo X, Li M, Wang T, Wang Z, Li C, Wu Z, Li N, Gao L, Liang X, Ma C*. Transcription factor Zhx2 restricts NK cell maturation and suppresses their antitumor immunity. J Exp Med. 2021 Sep 6; 218(9):e20210009. (IF=16.4)

24. Chen C, Peng J, Ma S, Ding Y, Huang T, Zhao S, Gao L, Liang X, Li C*, Ma C*. Ribosomal protein S26 serves as a checkpoint of T-cell survival and homeostasis in a p53-dependent manner. Cell Mol Immunol. 2021 Jul;18(7):1844-1846. (IF=17.7)

25. Wu Z, Zhang Z, Wang X, Zhang J, Ren C, Li Y, Gao L, Liang X, Wang P, Ma C. Palmitoylation of SARS-CoV-2 S protein is essential for viral infectivity. Signal Transduct Target Ther. 2021 Jun 11;6(1):231.(IF=39.3)

26. Wang Y, Gao L. Monocyte-derived KCs (MoKCs) contribute to the KC pool in NASH. Cell Mol Immunol. 2021 Mar;18(3):518-519. (IF=17.7)