贾木天，教授，医学博士，博士生导师，国家优青，国家重点研发计划青年科学家项目首席，山东省泰山学者青年专家，山东大学齐鲁青年学者。贾木天致力于“固有免疫激活与调控”研究领域，重点研究感染等应激条件下免疫细胞代谢重塑及蛋白翻译后修饰变化对固有免疫激活与调控的影响，从而揭示病理状态下机体维持免疫稳态的机制。阐明了免疫细胞内氧化还原和代谢稳态在固有免疫激活中的重要作用，并发现了多种蛋白质修饰途径调控固有免疫反应的关键因子及机制，为感染性及炎性疾病的防治提供了科学依据。相关工作以第一作者或通讯作者（含共同）发表于Nature Immunology、Nature Communications、PLoS Pathogens、Science Advances和Cell Reports等杂志。
代表性论文:
1. Mutian Jia#, Danhui Qin, Chunyuan Zhao, Li Chai, Zhongxia Yu, Wenwen Wang, Li Tong, Lin Lv, Yuanyuan Wang, Jan Rehwinkel, Jinming Yu, Wei Zhao*. Redox homeostasis maintained by GPX4 facilitates STING activation，Nature Immunology，2020 Jul;21(7):727-735.
2. Mutian Jia#, Li Chai#, Jie Wang, Mengge Wang, Danhui Qin, Hui Song, Yue Fu, Chunyuan Zhao, Chengjiang Gao, Jihui Jia, Wei Zhao*. S-nitrosothiol homeostasis maintained by ADH5 facilitates STING-dependent host defense against pathogens, Nature Communications, 2024 Feb 26;15(1):1750.
3. Mutian Jia#, Yuanyuan Wang#, Jie Wang, Danhui Qin, Mengge Wang, Li Chai, Yue Fu, Chunyuan Zhao, Chengjiang Gao, Jihui Jia,Wei Zhao*. Myristic acid as a checkpoint to regulate STING-dependent autophagy and interferon responses by promoting N-myristoylation, Nature Communications, 2023, 14(1)
4. Lin Lv, Li Chai, Jie Wang, Mengge Wang, Danhui Qin, Hui Song, Yue Fu, Chunyuan Zhao, Jihui Jia, Wei Zhao*, Mutian Jia*. Selenoprotein K enhances STING oligomerization to facilitate antiviral response. PloS Pathogens. 2023 Apr 6;19(4):e1011314. 10.1371/journal.ppat.1011314.
5. Wenwen Wang#, Mutian Jia#, Chunyuan Zhao#, Zhongxia Yu, Hui Song, Ying Qin, Wei Zhao*. RNF39 mediates K48-linked ubiquitination of DDX3X and inhibits RLR-dependent antiviral immunity, Science Advances, 2021 Mar 5;7(10).
6. Zhongxia Yu#, Lijuan Wang, Jing Zhao, Hui Song, Chunyuan Zhao, Wei Zhao*, Mutian Jia*. TOB1 attenuates IRF3-directed antiviral responses by recruiting HDAC8 to specifically suppress IFN-β expression. Communications Biology, 2022 Sep 9;5(1):943.
7. Chunyuan Zhao#, Mutian Jia #, Hui Song, Zhongxia Yu, Wenwen Wang, Qi Li, Lining Zhang, Wei Zhao*, Xuetao Cao*. The E3 Ubiquitin Ligase TRIM40 Attenuates Antiviral Immune Responses by Targeting MDA5 and RIG-I，Cell Reports，2017 Nov 7;21(6):1613-1623.
