• 1988-09-01-1993-07-01
  青岛医学院
  检验
• 1995-09-01-1998-07-01
  山东省医科院
  Immunology
• 2001-09-01-2004-06-01
  山东大学
  Immunology

• 2000-07 — Now
  山东大学
• 2013-10 — 2014-10
  美国威斯康星大学麦迪逊校区
• 2006-06 — 2006-12
  美国加州大学尔湾分校
• 1998-07 — 2000-07
  山东医科大学
• 1993-07 — 1995-07
  单县中心医院

1. 肿瘤免疫

(1) PDCD4 triggers α-synuclein accumulation and motor deficits via co-suppressing TFE3 and TFEB translation in a model of Parkinson's disease .NPJ PARKINSONS DISEASE .2024 ,1 (10)

(2)陈诺. Brain Short-Chain Fatty Acids Induce ACSS2 to Ameliorate Depressive-Like Behavior via PPARγ-TPH2 Axis .Research .2024 ,7 (27)

(3) TIPE2 inhibits the migration and invasion of endometrial cells by targeting β-catenin to reverse epithelial-mesenchymal transition .HUMAN REPRODUCTION .2020 ,35 (6):1377-1390

(4)石永玉. Identification and analysis of tumour-associated antigens in hepatocellular carcinoma .Br J Cancer .2005 ,92 (5):929

(5)张利宁. Human tumor necrosis factor (TNF)-alpha-induced protein 8-like 2 suppresses hepatocellular carcinoma metastasis through inhibiting Rac1 .Mol Cancer .2013 ,12 (1)

(6)张利宁. Tumor suppressor gene PDCD4 negatively regulates autophagy by inhibiting the expression of autophagy-related gene ATG5 .Autophagy .2013 ,9 (5):743

(7)张利宁. Effect of Non-cell Corynebacterium Parvum on Differentiation and Maturation of Bone Marrow-derived Dendritic Cells .Immunol Invest .2012

(8)张利宁. The unique expression profile of human TIPE2 suggests new functions beyond its role in immune regulation .mol immunol. .2011 ,48 (9-10):1209

(9)张利宁. Programmed cell death 4 enhances chemosensitivity of ovarian cancer cells by activating death receptor pathway in vitro and in vivo .Cancer Sci. .2010 ,101 (10):2163

(10) TIPE2 inhibits the migration and invasion of epithelial ovarian cancer cells by targeting Smad2 to reverse TGF-β1-induced EMT .The FASEB Journal .2024 (2024;38:e70045)

(11) IL-37d enhances COP1-mediated C/EBPβ degradation to suppress spontaneous neutrophil migration and tumor progression .Cell Reports .2024 ,43 (2)

(12) PDCD4 triggers α-synuclein accumulation and motor deficits via co-suppressing TFE3 and TFEB translation in a model of Parkinson’s disease .NPJ PARKINSONS DISEASE .2024 ,10 (1)

(13)郭亚新. D-arabinose acts as antidepressant by activating the ACSS2-PPARγ/TFEB axis and CRTC1 transcription .Pharmacological Research .2024 ,202

(14) ACSS2 controls PPARγ activity homeostasis to potentiate adipose-tissue plasticity .Cell Death and Differentiation .2024

(15)陈诺. IL-37d suppresses Rheb-mTORC1 axis independently of TCS2 to alleviate alcoholic liver disease .Communications Biology .2024 ,7 (1)

(16)陈诺. Brain Short-Chain Fatty Acids Induce ACSS2 to Ameliorate Depressive-Like Behavior via PPARγ-TPH2 Axis .Research .2024 ,7

(17)赵明. D-mannose acts as a V-ATPase inhibitor to suppress inflammatory cytokines generation and bacterial killing in macrophage .Molecular Immunology .2023 ,162 :84-94

(18)宋兴国. Tumor suppressor gene PDCD4 negatively regulates autophagy by inhibiting the expression of autophagy-related gene ATG5 .Autophagy .2013 ,9 (5):743-755

(19)刘素侠. 靶向于端粒酶调控区反义RNA腺病毒载体的构建 .《山东大学学报》（医学版） .2005 ,43 (8):667

(20) IL-37 isoform D acts as an inhibitor of soluble ST2 to boost type 2 immune homeostasis in white adipose tissue .CELL DEATH DISCOVERY .2022 ,8 (1):163

(21)王新宇. A20 interacts with mTORC2 to inhibit the mTORC2/Akt/Rac1 signaling axis in hepatocellular carcinoma cells .CANCER GENE THERAPY .2023 (3)

(22)李文. TNFAIP8L2/TIPE2 impairs autolysosome reformation via modulating the RAC1-MTORC1 axis .Autophagy .2021 (17(6):1410-1425)

(23)陈晓彤. Programmed cell death 4 modulates lysosomal function by inhibiting TFEB translation .Cell Death and Differentiation .2021 (28(4):1237-1250)

(24)石永玉. Identification and analysis of tumour-associated antigens in hepatocellular carcinoma .British Journal of Cancer .2003 ,92 (5):929-934

(25)石永玉. Screening and analysis of hepatocellular carcinoma-associated antigens and their encoding genes .《Chinese Science Bulltin》 .2003 ,48 (20):2192-2195

(26)Wang, Xianteng. Activated macrophages down-regulate expression of E-cadherin in hepatocellular carcinoma cells via NF-kappa B/Slug pathway .tumor biology .2014 ,35 (9):8893-8901

(27) Ubiquitin C-terminal hydrolase L1 promotes expression of programmed cell death-ligand 1 in non-small-cell lung cancer cells .CANCER SCIENCE .2020 ,111 (9):3174-3183

(28)王皓. CD68+HLA-DR+ M1-like macrophages promote motility of HCC cells via NF-κB/FAK pathway .Cancer letters .2014 ,345 (1):91-99

(29)石永玉. Synergy of anti-CD40, CpG and MPL in activation of mouse macrophages .Molecular Immunology .2015 ,66 (2):208-215

(30)于化云. TRIM27 regulates the expression of PDCD4 by the ubiquitin？proteasome pathway in ovarian and endometrial cancer cells .Ocology Report .2022 ,48 (1)

(31)石永玉. The dual roles of A20 in cancer .Cancer letters .2021 (511)

(32)石永玉. Ubiquitin C-terminal hydrolase L1 promotes expression of programmed cell death-ligand 1 in non-small-cell lung cancer cells. .CANCER SCIENCE .2020 ,111 (9)

(33)宗兆运. M1 Macrophages Induce PD-L1 Expression in Hepatocellular Carcinoma Cells Through IL-1β Signaling .Frontiers in Immunology .2019

(34)石永玉. Regulatory mechanisms of PD-L1 expression in cancer cells .《CANCER IMMUNOLOGY IMMUNOTHERAPY》 .2018 ,67 (10):1481

(35)邹佳欢. MYC inhibition increases PD-L1 expression induced by IFN-gamma in hepatocellular carcinoma cells .Molecular Immunology .2018 ,101 :203

(36)李亚雯. Exosomes derived from Toxoplasma gondii stimulate an inflammatory response through JNK signaling pathway .Nanomedicine .2018 ,13 (10):1157

(37)李娜. Cross-talk between TNF-alpha and IFN-gamma signaling in induction of B7-H1 expression in hepatocellular carcinoma cells .《CANCER IMMUNOLOGY IMMUNOTHERAPY》 .2018 ,67 (2):271

(38)石永玉. 肿瘤相关巨噬细胞对肝癌细胞c-Met 分子表达的影响 .《山东大学学报》（医学版） .2016

(39)石永玉. A20 inhibits the motility of HCC cells induced by TNF-α .ONCOTARGET .2016 ,7 (12):14742

(40)石永玉. Synergy of anti-CD40, CpG and MPL in activation of mouse macrophages. .mol immunol. .2015 ,66 (2):208

(41)石永玉. Activated macrophages down-regulate expression of E-cadherin in hepatocellular carcinoma cells via NF-κB/Slug pathway .Tumor Biol. .2014 ,35 (9):8893

(42)石永玉. CD68(+)HLA-DR(+) M1-like macrophages promote motility of HCC cells via NF-κB/FAK pathway .Cancer Lett. .2014 ,345 (1):91

(43)石永玉. 肿瘤相关巨噬细胞在肝癌上皮细胞间质转型中的作用 .《山东大学学报》（医学版） .2014 ,52 (4):8

(44)石永玉. CD68(+)HLA-DR(+) M1-like macrophages promote motility of HCC cells via NF-κB/FAK pathway .Cancer Lett. .2014 ,345 (1):91

(45)石永玉. Down-regulation of a20 mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus .J Clin immunol .2012 ,32 (6):1287

(46)石永玉. Expression of TNFAIP3 mRNA in peripheral blood mononuclear cells negatively correlates with disease severity in psoriasis vulgaris .Clin Vaccine Immunol .2012 ,19 (12):1938

(47)石永玉. 免疫负调控基因Ａ２０在肝癌中的表达及其真核表达载体的构建 .山东大学学报(医学版) .2012 ,50 (12):19

(48)张利宁. PDCD5 promotes cisplatin-induced apoptosis of glioma cells via activating mitochondrial apoptotic pathway .Cancer Biol Ther .2012

(49)石永玉. Upregulation of B7-H1 expression is associated with macrophage infiltration in hepatocellular carcinomas .Cancer Immunol Immunother .2012 ,61 (6):101

(50)石永玉. 人TIPE2基因启动子的鉴定及其表达调控区域的研究 .《山东大学学报》（医学版） .2011 ,49 (7):39

(51)石永玉. Down-regulation of TIPE2 mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus .Clin Immunol .2009 ,133 (3):422

(52)石永玉. CD70在肝癌中的表达及其对淋巴细胞增殖抑制作用的研究 .山东大学学报医学版 .2008 ,46 (1):27

1. CCR6过表达和PDCD4表达沉默的CAR-M细胞治疗消化系统肿瘤的机制研究, 2022-09-07-2026-12-31

2. 肝癌细胞对炎症微环境促其免疫逃逸的记忆的研究, 2019-08-16-2023-12-31

3. 生物多糖激活的巨噬细胞抗肿瘤作用的研究, 2017-01-01-2018-12-31

4. A20 抑制肝癌细胞迁移的分子机制的研究, 2016-08-17-2020-12-31

5. 肿瘤相关巨噬细胞诱导肝癌细胞高表达免疫抑制分子B7-H1及其增强体机制的研究, 2013-08-15-2017-12-31

6. TIPE2抑制肿瘤相关炎症的实验研究, 2009-12-01-2012-12-31

7. TIPE2基因抵抗肝癌相关性炎症促肝癌效应的作用及其机制的研究, 2011-01-01-2013-12-31