李双喜，博士/硕士生导师。山东大学齐鲁青年学者，山东省优青（海外），山东省泰山学者青年专家。2013年11月，华东师范大学生命医学研究所/德克萨斯大学西南医学中心，联合培养博士；2014年7月至2016年11月，德克萨斯大学西南医学中心，博士后；2016年12至2021年2月，斯坦福大学医学院，博士后/基础生命科学研究科学家；2021年4月至今，山东大学生命科学学院。

研究方向: 果蝇发育和疾病(神经退行性疾病、肿瘤)中的RNA翻译及其调控   

发表论文:

1) IRE1/Xbp1 promotes the clearance of poly(GR) dipeptide repeats in amyotrophic lateral sclerosis. Yu Li, Dongyue Liu, Shuangxi Li*.  J Biol Chem. 2025 Nov;301(11):110764.

2) RACK1 and IRE1 participate in the translational quality control of amyloid precursor protein in Drosophila models of Alzheimer’s disease. Yu Li, Dongyue Liu, Xuejing Zhang, Suman Rimal, Bingwei Lu, Shuangxi Li*. J Biol Chem. 2024 Feb 2:105719    

3) The mTORC2/AKT/VCP axis is associated with quality control of the stalled translation of poly(GR) dipeptide repeats in C9-ALS/FTD. Yu Li^#, Ji Geng^#, Suman Rimal, Haochuan Wang, Xiangguo Liu, Bingwei Lu*, Shuangxi Li*. J Biol Chem. 2023 Feb 8;102995  

4) Stalled translation by mitochondrial stress upregulates a CNOT4-ZNF598 ribosomal quality control pathway important for tissue homeostasis. Ji Geng^#, Shuangxi Li^#, Yu Li, Zhihao Wu, Sunil Bhurtel, Suman Rimal, Danish Khan, Rani Ohja, Onn Brandman, Bingwei Lu. Nat Commun. 2024 Feb 22;15(1):1637  

5) TDP-43 Mediates Autophagic Degradation of Yki by Stabilizing Ref(2)P in Drosophila. Dongyue Liu, Yufang Xu, Haochuan Wang, Shuai Huang, Shuangxi Li*. FASEB J. 2026 Feb 28;40(4):e71572.

6) Outstretched wing is controlled by intestinal enteroblasts-derived unpaired 2 cytokine signaling in Drosophila. Yu Li, Dongyue Liu, Shengliang Zhang, Jinglan Zhou, Shuangxi Li*. FASEB J. 2024 Dec 15;38(23):e7022 

7) The IRE1/Xbp1 axis restores ER and tissue homeostasis perturbed by excess Notch in Drosophila. Yu Li^#, Dongyue Liu^#, Haochuan Wang, Xuejing Zhang, Bingwei Lu, Shuangxi Li*. Dev Biol. 2024 Mar:507:11-19   

8) Quality control mechanisms targeting translationally stalled and C-terminally extended poly(GR) associated with ALS/FTD. Shuangxi Li, Zhihao Wu, Ishaq Tantray, Yu Li, Songjie Chen, Jason Dong, Steven Glynn, Hannes Vogel, Michael Snyder, and Bingwei Lu. Proc Natl Acad Sci. 2020 Sep 21; 202005506

9) Altered MICOS Morphology and Mitochondrial Ion Homeostasis Contribute to Poly(GR) Toxicity Associated with C9-ALS/FTD. Shuangxi Li^#, Zhihao Wu^#, Yu Li, Ishaq Tantray, Diego De Stefani, Andrea Mattarei, Fen-Biao Gao, Hannes Vogel, and Bingwei Lu. Cell Rep. 2020 Aug 4; 32(5):107989

10) Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer's disease. Suman Rimal^#, Yu Li^#, Rasika Vartak^#, Ji Geng, Ishaq Tantray, Shuangxi Li, Sungun Huh, Hannes Vogel, Charles Glabe, Lea T Grinberg, Salvatore Spina, William W Seeley, Su Guo, Bingwei Lu. Acta Neuropathol Commun. 2021 Oct 18;9(1):169.

11) Protein products of nonstop mRNA disrupt nucleolar homeostasis. Zoe H Davis, Laura Mediani, Francesco Antoniani, Jonathan Vinet, Shuangxi Li, Simon Alberti, Bingwei Lu, Alex S Holehouse, Serena Carra, Onn Brandman. Cell Stress Chaperones. 2021 Feb 22.

12) Gilgamesh (Gish)/CK1γ regulates tissue homeostasis and aging in adult Drosophila midgut.Shuangxi Li^#, Aiguo Tian^#, Shuang Li^#, Yuhong Han, Bing Wang, Jin Jiang. J Cell Biol. 2020 Apr 6; 219 (4).

13) Regulation of Smo phosphorylation and high-level Hh signaling activity by a plasma membrane associated kinase. Shuangxi Li^#, Shuang Li^#, Yuhong Han, Chao Tong, Bing Wang, Yongbin Chen, Jin Jiang. PLoS Biol. 2016 Jun 9;14(6)

14) Overlapping functions of the MAP4K family kinases Hppy and Msn in Hippo signaling. Shuangxi Li^#, Yong Suk Cho^#,Tao Yue, Y Tony Ip, Jin Jiang. Cell Discov. 2015 Nov 24;1:15038

15) Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K. Yong Suk Cho, Jian Zhu, Shuangxi Li, Bing Wang, Yuhong Han, Jin Jiang. Nat Commun. 2018 Apr 25;9(1):1657

16) Regulation of Smoothened Ubiquitylation and Cell Surface Expression Through a Cul4-DDB1-Gβ E3 Ubiquitin Ligase Complex. Shuang Li, Yong Suk Cho, Bing Wang, Shuangxi Li, Jin Jiang. J Cell Sci. 2018 Aug 1;131(15)

17) Hedgehog reciprocally controls trafficking of Smo and Ptc through the Smurf family of E3 ubiquitin ligases. Shuang Li, Shuangxi Li, Bing Wang, Jin Jiang. Sci Signal. 2018 Feb 6;11(516).

18) Regulation of Smoothened Trafficking and Hedgehog Signaling by the SUMO Pathway. Guoqiang Ma, Shuang Li, Yuhong Han, Shuangxi Li, Tao Yue, Bing Wang, Jin Jiang. Dev Cell. 2016 Nov 21;39(4):438-451.

19) Injury-stimulated Hedgehog signaling promotes regenerative proliferation of Drosophila intestinal stem cells. Aiguo Tian, Qing Shi, Alice Jiang, Shuangxi Li, Bing Wang, and Jin Jiang. J Cell Biol. 2015 Mar 16;208(6):807-19

20) The conserved misshapen-warts-Yorkie pathway acts in enteroblasts to regulate intestinal stem cells in Drosophila. Qi Li, Shuangxi Li, Sebastian Mana-Capelli, Rachel J. Roth Flach, Laura V. Danai, Alla Amcheslavsky, Yingchao Nie, Satoshi Kaneko, Xiaohao Yao, Xiaochu Chen, Jennifer L. Cotton, Junhao Mao, Dannel McCollum, Jin Jiang, Michael P. Czech, Lan Xu and Y. Tony Ip. Dev Cell. 2014 Nov 10;31(3):291-304

21) Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator. Qing Shi, Shuang Li, Shuangxi Li, Alice Jiang, Yongbin Chen, Jin Jiang. Proc Natl Acad Sci. 2014 Dec 30;111(52):E5651-60 

22) Regulation of c-Myc protein stability by proteasome activator REGgamma. Shuangxi Li^#, Cong Jiang^#, Jingjing Pan, Xinbo Wang, Jiali Jin, Linlin Zhao, Weijuan Pan, Guanghong Liao, Xin Cai, Xiaotao Li, Jianru Xiao, Jin Jiang, Ping Wang. Cell Death Differ. 2015 Jun;22(6):1000-11

23) The 11S Proteasome Subunit PSME3 Is a Positive Feedforward Regulator of NF-κB and Important for Host Defense Against Bacterial Pathogens. Jinxia Sun, Yi Luan, Dong Xiang, Xiao Tan, Hui Chen, Qi Deng, Jiaojiao Zhang, Minghui Chen, Hongjun Huang, Weichao Wang, Tingting Niu, Wenjie Li, Hu Peng, Shuangxi Li, Lei Li, Wenwen Tang, Xiaotao Li, Dianqing Wu, Ping Wang. Cell Rep. 2016 Feb 2;14(4):737-749.

24) The Fbw7/human CDC4 Tumor Suppressor Targets Proliferative Factor KLF5 for Ubiquitination and Degradation Through Multiple Phosphodegron Motifs. Ning Liu, Hui Li, Shuangxi Li, Mingyue Shen, Ning Xiao, Yunfei Chen, Yan Wang, Weichao Wang, Rui Wang, Qian Wang, Jianhua Sun, Ping Wang. J Biol Chem. 2010 Jun 11;285(24):18858-67.