- Modeling and Control of Colorectal Cancer
- 点击次数：
- 发表刊物：PLOS ONE
- 关键字：SCREENING STRATEGIES
- 摘要：Colorectal Cancer (CRC) is becoming a major threat to people's life in China. Screening methods adopted by many other countries as effective counter-cancer methods have not been explicitly explored for people there. Thus, we present a Markov model with detailed precancerous adenoma states and then evaluate various screening strategies in this paper. Different from current researches, our model considers the population's heterogeneous risk of developing adenomas and observation-based screening strategies. Furthermore, we also give a new cost-effectiveness metric. After calibrating, the model is simulated using the Monte Carlo method. Numerical results show that there are threshold values of compliance rates below which strategy with every ten-year colonoscopy becomes the most cost-effective method; otherwise, an observation-based screening strategy is the most cost-effective. We also find that strategy with single colonoscopy for adenoma-free individuals and every three-year colonoscopy for those with adenoma is recommended when the observation-based strategy is not considered. Our findings give an explicit and complete instruction in CRC screening protocol in average-risk Chinese.
- 全部作者：Wang Hao-Yu
- 通讯作者：Song Li-Peng
- 论文编号：e0161349
- 卷号：11
- 期号：8
- 是否译文：否
- 发表时间：2016-08-01
