孙龚萍,教授、博士生导师、山东省泰山学者青年专家、山东大学齐鲁青年学者,主要从事器官的稳态维持与再生的分子机制研究,相关研究成果发表在Nature Communications、Cell Death and Differentiation、Cell Reports、Journal of Cell Biology、Elife、Science Signaling等国际知名期刊。
器官发育与再生过程中的生长调控
细胞重生在肿瘤中的作用及调控机制
1. 器官稳态维持与再生
2. 肿瘤复发与转移
1. 姜威. GABA transporter 1 is a promising drug target for CUL4B mutation-associated epilepsy. ACTA PHARMACOLOGICA SINICA, 2025.
2. 曹志远. Sublethal executioner caspase activation in hepatocytes promotes liver regeneration through the JAK/STAT3 pathway. PLOS BIOLOGY, 23, 2025.
3. 刘凯旋. CUL4B protects kidneys from acute injury by restraining p53/PAI-1 signaling. Cell Death & Disease, 15, 2024.
4. 于瑞祺. Cullin 4B-RING E3 ligase negatively regulates the immunosuppressive capacity of mesenchymal stem cells by suppressing iNOS. Cell Death and Differentiation, 2024.
5. 马燕燕. CUL4B mutations impair human cortical neurogenesis through PP2A-dependent inhibition of AKT and ERK. Cell Death & Disease, 15, 2024.
6. 孙龚萍. Death and survival from executioner caspase activation. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2024.
7. 姜威. The X-linked intellectual disability gene CUL4B is critical for memory and synaptic function. Acta Neuropathologica Communications, 2024.
8. Yanyan Ma , Xiaolin Liu , Min Zhou , Wenjie Sun , Baichun Jiang , Qiao Liu , Molin Wang , Yongxin Zou , Qiji Liu , Yaoqin Gong and Gongping Sun. CUL4B mutations impair human cortical neurogenesis through PP2A-dependent inhibition of AKT and ERK. Cell Death & Disease, 2024,15(2):121,
9. Gongping Sun. Death and survival from executioner caspase activation. Seminars in Cell & Developmental Biology, 2024, 156:66-73,
10. Ru Wang , Yuxing Wang , Xiaohe Liu , Menghao Liu , Lili Sun , Xiaohua Pan , Huili Hu , Baichun Jiang , Yongxin Zou , Qiao Liu , Yaoqin Gong , Molin Wang and Gongping Sun. Anastasis enhances metastasis and chemoresistance of colorectal cancer cells through upregulating cIAP2/NFkB signaling. Cell Death & Disease, 2023, 14(6):388,
11. Yuxing Wang , Ru Wang , Xiaohe Liu , Menghao Liu , Lili Sun , Xiaohua Pan , Huili Hu , Baichun Jiang , Yongxin Zou , Qiao Liu , Yaoqin Gong , Molin Wang and Gongping Sun. Chemotherapy-induced executioner caspase activation increases breast cancer malignancy through epigenetic de-repression of CDH12. Oncogenesis, 2023, 12(1):34,
12. Yu Song , Shiqi Jin , Gongping Sun and Yaoqin Gong. Cullin 4B-RING E3 ligase complex in immune cell differentiation and function. Cellular & Molecular Immunology, 2023, 20(10): 1254-1256,
13. Shiqi Jin , Yu Song , Li Zhou , Wei Jiang , Liping Qin , Yufeng Wang , Ruiqi Yu , Yuting Liu , Yujie Diao , Fan Zhang , Kaixuan Liu , Peishan Li , Huili Hu , Baichun Jiang , Wei Tang , Fan Yi , Yaoqin Gong , Guangyi Liu and Gongping Sun. Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis. Cell Reports, 2023, 42(6): 112550,
14. Lili Sun , Chen Yao , Xiaojiao Li , Yuxing Wang , Ru Wang , Molin Wang , Qiao Liu , Denise J. Montell , Changshun Shao , Yaoqin Gong and Gongping Sun. Anastasis confers ovarian cancer cells increased malignancy through elevated p38 MAPK activation. Cell Death & Differentiation, 2023, 30(3): 809-824,
15. Yanyan Ma , Zhendong Wang , Xiaolin Liu , Wenjie Sun , Yaoqin Gong , Guangyi Liu and Gongping Sun. Generation and characterization of an integration-free iPSC line SDUBMSi006-A from a patient with Alport syndrome caused by COL4A3 gene mutations. Stem Cell Research, 2021, 52:102237,
16. Gongping Sun , Xun Austin Ding , Yewubdar Argaw , Xiaoran Guo and Denise J. Montell. Akt1 and dCIZ1 promote cell survival from apoptotic caspase activation during regeneration and oncogenic overgrowth. Nature Communications, 2020, 11(1): 5726,
17. Gongping Sun and Denise J. Montell. Q&A: Cellular near death experience-what is anastasis?. BMC Biology, 2017, 15 (1):92,
18. Gongping Sun , Elmer Guzman , Varuzhan Balasanyan , Christopher M. Conner , Kirsten Wong , Hongjun Robin Zhou , Kenneth S. Kosik and Denise J. Montell. A molecular signature for anastasis, recovery from the brink of apoptotic cell death. Journal of Cell Biology, 2017, 216 (10): 3355-3368,
19. Xun Austin Ding , Gongping Sun , Yewubdar G. Argaw , Jessica O. Wong , Sreesankar Easwaran and Denise J. Montell. CasExpress reveals widespread and diverse patterns of cells survival of caspase-3 activation during development in vivo. Elife, 2016, 5:e10936,
20. Gongping Sun and Kenneth D. Irvine. Control of growth during regeneration. Current Topics in Developmental Biology, 2014, 108: 95-120,
21. Gongping Sun and Kenneth D. Irvine. Ajuba family proteins link JNK to Hippo signaling. Science Signaling, 2013, 6 (292): ra81,
22. Gongping Sun and Kenneth D. Irvine. Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors. Developmental Biology, 2011, 350(1): 139-151,
23. Yuanyuan Yu , Gongping Sun , Guangyi Liu , Yingshuo Wang , Zhengping Shao , Zhimin Chen and Jun Yang. Effects of Mycoplasma pneumoniae infection on sphingolipid metabolism in human lung carcinoma A549 cells. Microbial Pathogenesis, 2008, 46 (2): 63-72,
24. Gongping Sun , Xuefeng Xu , Yingshuo Wang , Xiaoyun Shen , Zhimin Chen and Jun Yang. Mycoplasma pneumoniae infection induces reactive oxygen species and DNA damage in human lung carcinoma A549 cells. Infection and Immunity, 2008, 76 (10): 4405-4413,
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刘巧
1.孙丽丽
2.姚晨
3.金士琦
4.李晓娇
5.王宇星
6.曹志远
7.王翠平
8.李恩红
9.程浩然
10.苏元林
11.周丽
12.刘凯旋
13.刘秀秀
14.左慕秋
15.李盈慷
16.张园园
17.周建媛
18.郝晓宇
19.丁慧媛
20.郝晓宇
21.刘凯旋
22.张园园
23.周丽
24.苏元林
25.李晓娇
26.周建媛
27.郝晓宇
28.刘秀秀
29.曹志远
30.王翠平
31.李恩红