孙允东
教授
所属院部: 齐鲁医学院
访问次数:
基本信息
  • 教师拼音名称:
    sunyundong
  • 入职时间:
    2006-07-16
  • 所在单位:
    基础医学院
  • 职务:
    教授
  • 学历:
    研究生(博士后)
  • 办公地点:
    基础医学院6号楼
  • 性别:
  • 联系方式:
    328366628
  • 学位:
    博士生
  • 在职信息:
    在职
  • 毕业院校:
    山东大学
  • 博士生导师
  • 硕士生导师
教师简介

、 基本情况:

孙允东,男,山东大学病原微生物教授,博士生导师,1977年5月出生,2011年美国密歇根大学访问学者。《current microbiology》, 《biomed research international》与《molecular biology reports》杂志审稿人,国家自然基金委函审专家。山东省微生物与免疫学会会员。   

QQ:328366628

研究方向:幽门螺杆菌耐药机制;消化道菌群与健康

二、 科研成果

(一) 承担课题

1、 SpoT(ppGpp)调控幽门螺杆菌适应抗生素压力分子机制研究(81471991),国家自然基金面上项目,72万,2015-2018。

2、 压力加重幽门螺杆菌胃炎分子机制研究(81671978),国家自然基金面上项目,70万,2017-2020。

3、 幽门螺杆菌SpoT基因适应INF-γ表达调控机制研究(81071313),国家自然基金面上项目,32万,2011-2013。

4、 SpoT调控幽门螺旋杆菌氧应激严谨应答分子机制研究(30800037),国家自然基金青年基金,20万,2009-2011。

5、 σ54调控幽门螺杆菌平台期氧损伤分子机制研究(中国博士后特别资助),10万,2010-2011。

(二) 发表论文(*:通讯作者)

1、Sun Y, Zhang M, Chen CC, Gillilland M 3rd, Sun X, El-Zaatari M, Huffnagle GB, Young VB, Zhang J, Hong SC, Chang YM, Gumucio DL, Owyang C, Kao JY*. Stress-induced corticotropin-releasing hormone-mediated NLRP6 inflammasome inhibition and transmissible enteritis in mice. Gastroenterology. 144(7):1478-87, 1487.e1-8; 2013 Jun.(消化类杂志排名第一,IF=18.18)


2、Li, Y., Li, W., Wang, X., Ding, C., Liu, J., Li, Y., Li, W., & Sun, Y*. (2020). High-Salt Diet-Induced Gastritis in C57BL/6 Mice is Associated with Microbial Dysbiosis and Alleviated by a Buckwheat Diet. Molecular nutrition & food research64(8), e1900965. https://doi.org/10.1002/mnfr.201900965


3、Han, Y., Li, Y., Hu, Z., Wang, X., Liu, J., Ren, X., Yu, Y., Li, Y., Li, W., & Sun, Y*. (2020). Hydrogen sulfide-mediated resistance against water avoidance stress-induced gastritis by maintenance of gastric microbial homeostasis. MicrobiologyOpen9(1), e00951. https://doi.org/10.1002/mbo3.951


4、Cai, Y., Wang, C., Chen, Z., Xu, Z., Li, H., Li, W., & Sun, Y*. (2020). Transporters HP0939, HP0497, and HP0471 participate in intrinsic multidrug resistance and biofilm formation in Helicobacter pylori by enhancing drug efflux. Helicobacter, e12715. Advance online publication. https://doi.org/10.1111/hel.12715



5、Ge, X., Cai, Y., Chen, Z., Gao, S., Geng, X., Li, Y., Li, Y., Jia, J., & Sun, Y*(2018). Bifunctional Enzyme SpoT Is Involved in Biofilm Formation of Helicobacter pylori with Multidrug Resistance by Upregulating Efflux Pump Hp1174 (gluP). Antimicrobial agents and chemotherapy62(11), e00957-18. https://doi.org/10.1128/AAC.00957-18


6、Geng, X., Li, W., Chen, Z., Gao, S., Hong, W., Ge, X., Hou, G., Hu, Z., Zhou, Y., Zeng, B., Li, W., Jia, J., & Sun, Y*. (2017). The Bifunctional Enzyme SpoT Is Involved in the Clarithromycin Tolerance of Helicobacter pylori by Upregulating the Transporters HP0939, HP1017, HP0497, and HP0471. Antimicrobial agents and chemotherapy61(5), e02011-16. https://doi.org/10.1128/AAC.02011-16


7、Zhekai Hu, Yu Zhang, Zhiyu Li, Yuedi Yu, Wenyan Kang, Yingnan Han, Xiwen Geng, Shaohua Ge*, Yundong Sun*.Effect of Helicobacter pylori infection on chronic periodontitis by the change of microecology and inflammation.Oncotarget.2016 August 20.doi: 10.18632 /oncotarget.9573.


8、Yuqun Shan, Xingxiao Lu, Yingnan Han, Xinpeng Li, Xiao Wang, Chunhong Shao,Lixiang Wang, Zhifang Liu, Wei Tang, Yundong Sun*and Jihui Jia. Helicobacter pylori Outer Membrane Protein 18 (Hp1125) Is Involved in Persistent Colonization by Evading Interferon-γ Signaling. Biomed Res Int. 2015;2015:571280. doi: 10.1155/2015/571280. Epub 2015 Apr 6

9、Sun Y#*, Liu S#, Li W, Shan Y, Li X, Lu X, Li Y, Guo Q, Zhou Y, Jia J*. Proteomic analysis of the function of sigma factor σ54 in Helicobacter pylori survival with nutrition deficiency stress in vitro. PLoS One. 8(8):e72920;2013 Aug 28. doi: 10.1371


10、Sun Y, Li X, Li W, Zhao M, Wang L, Liu S, Zeng J, Liu Z, Jia J*. Proteomic analysis of the function of SpoT in Helicobacter pylori anti-oxidative stress in vitro and colonization in vivo. J Cell Biochem.113(11):3393-402; 2012 Nov.


11、Sun YD, Fu LD, Jia YP, Du XJ, Wang Q, Wang YH, Zhao XF, Yu XQ, Wang JX. A hepatopancreas-specific C-type lectin from the Chinese shrimp Fenneropenaeus chinensis exhibits antimicrobial activity. Mol Immunol. 2008 Jan;45(2):348-61. Epub 2007 Aug 6.


12、Sun YD, Zhao XF, Kang CJ, Wang JX. Molecular cloning and characterization of Fc-TSP from the Chinese shrimp Fennerpenaeus chinensis. Mol Immunol. 2006 Mar;43(8):1202-10. Epub 2005 Aug 18


三、教学成果


1、医学微生物学山东省精品课程骨干成员。

2、2014年山东大学中青年教师讲课比赛优秀奖。

3、作为医学微生物系中青年教学骨干教师参加山东大学教学与促进发展中心举办的教学能力提升研修班。

4、山东省微课比赛三等奖

5、全国医学类微课比赛鼓励奖

四、其它工作


1、指导口腔学院校长奖学金获得者马驷骎大学生创新实验

2、指导口腔学院本本科生胡哲凯等大学生创新实验,并在《oncotarget》发表文章

3、指导研究生蔡玉莹获得国家级奖学金

4、指导医学院六年制本科生崔岳被宾夕法尼亚大学录取为全额奖学金博士生

5、指导口腔学院本科生李淑彤,荣兴等获得国家级大学生创新项目

 


教育经历
  • 2003-9 — 2006-6
    山东大学
    动物学
    博士生
  • 2000-9 — 2003-6
    山东农业大学
    动物遗传育种与繁育
    农学硕士学位
  • 1996-9 — 2000-6
    山东农业大学
    畜牧类
    学士
  • 1992-9 — 1996-7
    桓台一中
工作经历
  • 2006-07-至今
    山东大学医学院
科研成果
论文

1.  . Lnc-PLCB1 is stabilized by METTL14 induced m6A modification and inhibits Helicobacter pylori mediated gastric cancer by destabilizing DDX21.  Cancer letters,  588,  2024. 

2.  . Antibiotic-induced ROS-mediated Fur allosterism contributes to Helicobacter pylori resistance by inhibiting arsR activation of mutS and mutY..  Antimicrob Agents Chemother,  2024. 

3.  赵一璨. Aloe-emodin destroys the biofilm of Helicobacter pylori by targeting the outer membrane protein 6.  Microbiological Research ,  2024. 

4.  . Effects of alcohol on the symptoms of gouty arthritis and taxonomic structure of gut microbiota in C57BL/6 mice.  FRONTIERS IN MICROBIOLOGY,  14,  2023. 

5.  孙薏丰. 2016—2021年山东省11个地区摩根摩根菌的抗生素耐药变迁.  .《山东大学学报(医学版)》,  2022. 

6.  . The Quinone-Derived Small Molecule M5N32 Is an Effective Anti-Helicobacter pylori Agent Both In Vivo and In Vitro.  JOURNAL OF INFECTIOUS DISEASES,  2022. 

7.  李汶娟. CircMAN1A2 is upregulated by Helicobacter pylori and promotes development of gastric cancer.  Cell Death Dis.,  13,  2022. 

8.  李淑彤. Helicobacter pylori infection is correlated with the incidence of erosive oral lichen planus and the alteration of the oral microbiome composition..  BMC Microbiol,  2021. 

9.  王立祥. FoxM1 is Overexpressed in Helicobacter pylori-Induced Gastric Carcinogenesis and Is Negatively Regulate by miR-370.  Molecular cancer research,  2013. 

10.  李亚. High-Salt Diet-Induced Gastritis in C57BL/6 Mice is Associated with Microbial Dysbiosis and Alleviated by a Buckwheat Diet.  Mol Nutr Food Res ,  64,  2020. 

11.  蔡玉莹. Transporters HP0939, HP0497, and HP0471 participate in intrinsic multidrug resistance and biofilm formation inHelicobacter pyloriby enhancing drug efflux.  25,  2020. 

12.  赵一璨. SpoT-Mediated NapA Upregulation Promotes Oxidative Stress-Induced Helicobacter pylori Biofilm Formation and Confers Multidrug Resistance.  Antimicrobial Agents and Chemotherapy,  65,  2021. 

13.  李淑彤. Helicobacter pylori infection is correlated with the incidence of erosive oral lichen planus and the alteration of the oral microbiome composition.  BMC MICROBIOLOGY,  21,  2021. 

14.  李焕杰 , 李汶娟  and 孙允东. Transporters HP0939, HP0497, and HP0471 participate in intrinsic multidrug resistance and biofilm formation in Helicobacter pylori by enhancing drug efflux.  Helicobacter ,  2020. 

15.  李岩. Fractional order dynamics for clarithromycin against helicobacter pylori.  2017. 

16.  李岩. Identification of Fractional-order Dynamics for Helicobacter Pylori Bacteria in Antibiotic Environment.  ICIAM2015,  2015. 

17.  王晓 , 李岩 , 李汶娟  and 孙允东. High-Salt Diet-Induced Gastritis in C57BL/6 Mice Is Associated With Microbial Dysbiosis and Alleviated by a Buckwheat Diet.  Mol Nutr Food Res ,  2020. 

18.  韩凤娟. JMJD2B is required for Helicobacter pylori-induced gastric carcinogenesis via regulating COX-2 expression.  ONCOTARGET,  7,  38626, 2016. 

19.  葛潇冉. Bifunctional Enzyme SpoT Is Involved in Biofilm Formation of Helicobacter pylori with Multidrug Resistance by Upregulating Efflux Pump Hp1174 (gluP).  Antimicrobial Agents and Chemotherapy,  62,  2018. 

20.  韩英男. Hydrogen sulfide-mediated resistance against water avoidance stress-induced gastritis by maintenance of gastric microbial homeostasis.  MicrobiologyOpen,  9,  2020. 

21.  李汶娟 , 孙允东 , 贾继辉  and 贾文笑. Long noncoding RNA THAP9-AS1 is induced by Helicobacter pylori and promotes cell growth and migration of gastric cancer.  OncoTargets and Therapy,  6653, 2019. 

22.  李汶娟 , 孙允东 , 刘志方 , 贾继辉 , 马芳 Downregulation of eukaryotic translation initiation factor 3b inhibited proliferation and metastasis of gastric cancer.  Cell Death Dis,  10,  623, 2019. 

23.  刘志方 , 徐霞 , 李汶娟 , 孙允东 , 曾季平 , 于晗  and 贾继辉. Helicobacter pylori CagA inhibits the expression of Runx3 via Src/MEK/ERK and p38 MAPK pathways in gastric epithelial cell.  J cellular biochemistry,  113,  1080, 2012. 

24.  刘志方 , 徐霞 , 李汶娟 , 于晗 , 孙允东 , 曾季平  and 贾继辉. RUNX3 inhibits survivin expression and induces cell apoptosis in gastric cancer.  European Journal of Cell Biology,  93,  118, 2014. 

25.  贾继辉 , 刘志方 , 李汶娟 , 孙允东 , 于晗 , 周亚滨 , 曾季平  and 赵大鹏. Helicobacter pylori CagA upregulation of CIP2A is dependent on the Src and MEK/ERK pathways.  J med microbiology,  59,  259, 2010. 

26.  葛少华  and 孙允东. Effect of Helicobacter pylori infection on chronic periodontitis by the change of microecology and inflammation..  ONCOTARGET,  2016. 

27.  李岩  and 孙允东. Proteomic Analysis of the Function of Sigma Factor σ54 in Helicobacter pylori Survival with Nutrition Deficiency Stress In Vitro.  Plos one,  2013. 

28.  孙允东 , 贾继辉 , 于晗 , 周亚滨 Changes of proteome components of Helicobacter pylori biofilms induced by serum starvation..  Mol Med Rep,  2013. 

29.  孙允东 , 周亚滨 , 贾继辉 , 李汶娟 , 于晗 , 刘志方 , 曾季平 The antibacterial mode of action of allitridi for its potential use as a therapeutic agent against Helicobacter pylori infection..  FEMS Microbiol Lett.,  0,  183, 2010. 

30.  贾继辉 , 孙允东 , 于晗 , 李汶娟  and 曾季平. Upregulation of progranulin by Helicobacter pylori in human gastric epithelial cells via p38MAPK and MEK1/2 signaling pathway: role in epithelial cell proliferation and migration..  FEMS Immunol Med Microbiol,  0,  82, 2011. 

31.  王金星 , 孙允东  and 赵小凡. A single whey acidic protein domain (SWD)-containing peptide from fleshy prawn with antimicrobial and proteinase inhibitory activities.  AQUACULTURE,  284,  246, 2008. 

32.  王金星 , 孙允东  and 赵小凡. A hepatopancreas-specific C-type lectin from the Chinese shrimp Fenneropenaeus chinensis exhibits antimicrobial activity.  Molecular Immunology,  45,  348, 2008. 

33.  王金星 , 孙允东 , 赵小凡  and 康翠洁. Molecular cloning and characterization of Fc-TSP from the Chinese shrimp Fenneropenaeus chinensis..  Molecular Immunology,  43,  1201, 2006. 

34.  李汶娟 , 贾继辉 , 孙允东 , 侯桂华 , 周亚滨  and 耿熙炆. The Bifunctional Enzyme SpoT Is Involved in the Clarithromycin Tolerance of Helicobacter pylori by Upregulating the Transporters HP0939, HP1017, HP0497, and HP0471.  Antimicrobial Agents and Chemotherapy,  61,  2017. 

35.  孙允东 , 刘世利 , 贾继辉 , 王立祥 , 于晗 , 刘志方 , 曾季平 MicroRNA-212 inhibits proliferation of gastric cancer by directly repressing retinoblastoma binding protein 2..  J Cell Biochem.,  114,  2666, 2013. 

36.  贾继辉 , 李汶娟 , 于晗 , 曾季平 , 周亚滨 , 孙允东 , 刘世利 Helicobacter pylori promotes epithelial–mesenchymal transition in gastriccancer by downregulating PDCD4.  Plos one,  2014. 

37.  周亚滨 , 胡晓燕 , 吴伟芳 , 孙允东 , 曹倩 , 肖颖 , 闫世坤  and 冯凡. 干酪乳酸杆菌代谢物对白假丝酵母菌生物被膜的体外抑菌效果及分子机制.  《山东大学学报》(医学版),  55,  74, 2017. 

38.  孙允东 , 葛少华  and 康文燕. Metformin Inhibits Porphyromonas gingivalis Lipopolysaccharide-Influenced Inflammatory Response in Human Gingival Fibroblasts via Regulating Activating Transcription Factor-3 Expression.  journal of periodontology,  88,  2017. 

39.  孙允东  and 葛少华. Effect of Helicobacter pylori infection on chronic periodontitis by the change of microecology and inflammation.  ONCOTARGET,  vol.7,  66700, 2016. 

40.  李汶娟 , 贾继辉 , 孙允东 , 刘志方  and 于晗. JMJD2B is required for Helicobacter pylori-induced gastric carcinogenesis via regulating COX-2 expression.  ONCOTARGET,  7,  38626, 2016. 

41.  李汶娟 , 孙允东 , 曾季平 , 于晗 , 贾继辉 , 徐霞  and 刘志方. Helicobacter pylori CagA inhibits the expression of Runx3 via Src/MEK/ERK and p38 MAPK pathways in gastric epithelial cell.  J cellular biochemistry,  113,  1080, 2012. 

42.  孙允东 , 刘志方 , 唐伟 , 贾继辉 , 王晓  and 王立祥. Helicobacter pylori Outer Membrane Protein 18 (Hp1125) Is Involved in Persistent Colonization by Evading Interferon- γ Signaling..  biomed res int,  2015. 

43.  孙允东  and 葛少华. Effect of Helicobacter pylori infection on chronic periodontitis by the change of microecology and inflammation..  ONCOTARGET,  2016. 

44.  贾继辉 , 李汶娟 , 刘世利 , 于晗 , 曾季平  and 孙允东. Mutual amplification of HNF4α and IL-1R1 composes an inflammatory circuit in Helicobacter pylori associated gastric carcinogenesis.  ONCOTARGET,  7,  11349, 2016. 

45.  贾继辉 , 曾季平 , 徐霞 , 李汶娟 , 于晗 , 孙允东  and 刘志方. RUNX3 inhibits survivin expression and induces cell apoptosis ingastric cancer.  European Journal of Cell Biology,  93,  118, 2014. 

46.  孙允东  and 李岩. Proteomic Analysis of the Function of Sigma Factor σ54 in Helicobacter pylori Survival with Nutrition Deficiency Stress In Vitro.  Plos one,  2013. 

47.  孙允东  and 贾继辉. Changes of proteome components of Helicobacter pylori biofilms induced by serum starvation..  Mol Med Rep,  2013. 

48.  孙允东  and 孙霞. Stress-Induced Corticotropin-Releasing Hormone-Mediated NLRP6 Inflammasome Inhibition and Transmissible Enteritis in Mice.  Gastroenterology,  2013. 

49.  孙允东 , 周亚滨 , 李岩  and 贾继辉. Proteomic Analysis of the Function of Sigma Factor σ(54) in Helicobacter pylori Survival with Nutrition Deficiency Stress In Vitro..  Plos one,  2013. 

50.  刘志方 , 李汶娟 , 孙允东 , 贾继辉 , 曾季平 , 于晗 , 刘世利 , 王立祥 FoxM1 is Overexpressed in Helicobacter pylori-Induced Gastric Carcinogenesis and Is Negatively Regulated by miR-370.  Mol Cancer Res.,  11,  834, 2013. 

51.  王金星 , 孙允东  and 赵小凡. Two Cysteine proteinases respond to bacterial and WSSV challenge in Chinese white shrimp Fenneropenaeus chinensis..  Fish Shellfish Immunol,  29,  551, 2010. 

52.  李汶娟 , 于晗 , 刘志方 , 曾季平 , 孙允东  and 贾继辉. The antibacterial mode of action of allitridi for its potential use as a therapeutic agent against Helicobacter pylori infection..  FEMS Microbiol Lett.,  0,  183, 2010. 

53.  于晗 , 李汶娟 , 曾季平 , 孙允东  and 贾继辉. Upregulation of progranulin by Helicobacter pylori in human gastric epithelial cells via p38MAPK and MEK1/2 signaling pathway: role in epithelial cell proliferation and migration..  FEMS Immunol Med Microbiol,  0,  82, 2011. 

54.  曾季平 , 李汶娟 , 孙允东 , 于晗 , 周亚滨 , 贾继辉  and 刘志方. Helicobacter pylori CagA upregulation of CIP2A is dependent on the Src and MEK/ERK pathways.  J med microbiology,  59,  259, 2010. 

55.  赵小凡 , 孙允东  and 王金星. A single whey acidic protein domain (SWD)-containing peptide from fleshy prawn with antimicrobial and proteinase inhibitory activities.  AQUACULTURE,  284,  246, 2008. 

56.  孙允东 , 赵小凡  and 王金星. A hepatopancreas-specific C-type lectin from the Chinese shrimp Fenneropenaeus chinensis exhibits antimicrobial activity.  Molecular Immunology,  45,  348, 2008. 

57.  肖颖 , 孙允东 , 周亚滨 , 胡晓燕 , 曹倩 , 曾贝妮 In vitro and in vivo effects of suloctidil on growth and biofilm formation of the opportunistic fungus Candida albicans.  ONCOTARGET,  8,  69972, 2017. 

58.  李汶娟 , 贾继辉 , 孙允东 , 刘志方 , 于晗  and 张瑾瑾. MiRNA-491-5p inhibits cell proliferation, invasion and migration via targeting JMJD2B and serves as a potential biomarker in gastric cancer.  American journal of translational research,  10,  525, 2018. 

59.  孙允东 , 赵小凡 , 康翠洁  and 王金星. Molecular cloning and characterization of Fc-TSP from the Chinese shrimp Fenneropenaeus chinensis..  Molecular Immunology,  43,  1201, 2006. 

60.  王立祥 , 于晗 , 刘志方 , 曾季平  and 贾继辉. MicroRNA-212 inhibits proliferation of gastric cancer by directly repressing retinoblastoma binding protein 2..  J Cell Biochem.,  114,  2666, 2013. 

61.  孙允东  and 葛少华. Effect of Helicobacter pylori infection on chronic periodontitis by the change of microecology and inflammation..  ONCOTARGET,  2016. 

62.  孙允东  and 李岩. Proteomic Analysis of the Function of Sigma Factor σ54 in Helicobacter pylori Survival with Nutrition Deficiency Stress In Vitro.  Plos one,  2013. 

63.  孙允东  and 贾继辉. Changes of proteome components of Helicobacter pylori biofilms induced by serum starvation..  Mol Med Rep,  2013. 

64.  孙允东 , 赵小凡  and 王金星. Two Cysteine proteinases respond to bacterial and WSSV challenge in Chinese white shrimp Fenneropenaeus chinensis..  Fish Shellfish Immunol,  29,  551, 2010. 

65.  李汶娟 , 于晗 , 刘志方 , 曾季平 , 孙允东  and 贾继辉. The antibacterial mode of action of allitridi for its potential use as a therapeutic agent against Helicobacter pylori infection..  FEMS Microbiol Lett.,  0,  183, 2010. 

66.  于晗 , 李汶娟 , 曾季平 , 孙允东  and 贾继辉. Upregulation of progranulin by Helicobacter pylori in human gastric epithelial cells via p38MAPK and MEK1/2 signaling pathway: role in epithelial cell proliferation and migration..  FEMS Immunol Med Microbiol,  0,  82, 2011. 

67.  赵小凡 , 孙允东  and 王金星. A single whey acidic protein domain (SWD)-containing peptide from fleshy prawn with antimicrobial and proteinase inhibitory activities.  AQUACULTURE,  284,  246, 2008. 

68.  孙允东  and 葛少华. Effect of Helicobacter pylori infection on chronic periodontitis by the change of microecology and inflammation..  ONCOTARGET,  2016. 

69.  孙允东  and 贾继辉. The antibacterial mode of action of allitridi for its potential use as a therapeutic agent against Helicobacter pylori infection..  FEMS Microbiol Lett.,  0,  183, 2010. 

70.  刘世利 , 于晗 , 曾季平 , 孙允东 , 李汶娟  and 贾继辉. Mutual amplification of HNF4α and IL-1R1 composes an inflammatory circuit in Helicobacter pylori associated gastric carcinogenesis.  ONCOTARGET,  7,  11349, 2016. 

71.  王立祥 , 曾季平 , 于晗 , 刘世利 , 刘志方 , 孙允东 , 李汶娟  and 贾继辉. FoxM1 is Overexpressed in Helicobacter pylori-Induced Gastric Carcinogenesis and Is Negatively Regulated by miR-370.  Mol Cancer Res.,  11,  834, 2013. 

72.  徐霞 , 李汶娟 , 于晗 , 孙允东 , 曾季平 , 贾继辉  and 刘志方. RUNX3 inhibits survivin expression and induces cell apoptosis ingastric cancer.  European Journal of Cell Biology,  93,  118, 2014. 

73.  贾继辉. MicroRNA-212 inhibits proliferation of gastric cancer by directly repressing retinoblastoma binding protein 2..  J Cell Biochem.,  114,  2666, 2013. 

74.  贾继辉 , 李汶娟 , 孙允东 , 刘志方 , 于晗  and 张瑾瑾. MiRNA-491-5p inhibits cell proliferation, invasion and migration via targeting JMJD2B and serves as a potential biomarker in gastric cancer.  American journal of translational research,  10,  525, 2018. 

75.  于晗. Helicobacter pylori promotes epithelial–mesenchymal transition in gastriccancer by downregulating PDCD4.  Plos one,  2014. 

76.  孙允东  and 贾继辉. Changes of proteome components of Helicobacter pylori biofilms induced by serum starvation..  Mol Med Rep,  2013. 

77.  于晗 , 李汶娟 , 曾季平 , 孙允东  and 贾继辉. Upregulation of progranulin by Helicobacter pylori in human gastric epithelial cells via p38MAPK and MEK1/2 signaling pathway: role in epithelial cell proliferation and migration..  FEMS Immunol Med Microbiol,  0,  82, 2011. 

78.  周亚滨 , 胡晓燕 , 吴伟芳 , 孙允东 , 曹倩 , 肖颖 , 闫世坤  and 冯凡. 干酪乳酸杆菌代谢物对白假丝酵母菌生物被膜的体外抑菌效果及分子机制.  《山东大学学报》(医学版),  55,  74, 2017. 

79.  孙允东 , 葛少华  and 康文燕. Metformin Inhibits Porphyromonas gingivalis Lipopolysaccharide-Influenced Inflammatory Response in Human Gingival Fibroblasts via Regulating Activating Transcription Factor-3 Expression.  journal of periodontology,  88,  2017. 

80.  李汶娟 , 孙允东 , 曾季平 , 于晗 , 徐霞 , 贾继辉  and 刘志方. Helicobacter pylori CagA inhibits the expression of Runx3 via Src/MEK/ERK and p38 MAPK pathways in gastric epithelial cell.  J cellular biochemistry,  113,  1080, 2012. 

81.  贾继辉 , 李汶娟 , 孙允东 , 于晗 , 周亚滨 , 曾季平  and 刘志方. Helicobacter pylori CagA upregulation of CIP2A is dependent on the Src and MEK/ERK pathways.  J med microbiology,  59,  259, 2010. 

82.  赵小凡 , 孙允东  and 王金星. A single whey acidic protein domain (SWD)-containing peptide from fleshy prawn with antimicrobial and proteinase inhibitory activities.  AQUACULTURE,  284,  246, 2008. 

83.  孙允东 , 刘志方 , 于晗 , 贾继辉  and 李汶娟. JMJD2B is required for Helicobacter pylori-induced gastric carcinogenesis via regulating COX-2 expression.  ONCOTARGET,  7,  38626, 2016. 

84.  孙允东 , 赵小凡  and 王金星. Two Cysteine proteinases respond to bacterial and WSSV challenge in Chinese white shrimp Fenneropenaeus chinensis..  Fish Shellfish Immunol,  29,  551, 2010. 

85.  孙允东 , 赵小凡  and 王金星. A hepatopancreas-specific C-type lectin from the Chinese shrimp Fenneropenaeus chinensis exhibits antimicrobial activity.  Molecular Immunology,  45,  348, 2008. 

86.  孙允东  and 李岩. Proteomic Analysis of the Function of Sigma Factor σ54 in Helicobacter pylori Survival with Nutrition Deficiency Stress In Vitro.  Plos one,  2013. 

87.  孙允东 , 赵小凡 , 康翠洁  and 王金星. Molecular cloning and characterization of Fc-TSP from the Chinese shrimp Fenneropenaeus chinensis..  Molecular Immunology,  43,  1201, 2006. 

88.  葛少华  and 孙允东. Effect of Helicobacter pylori infection on chronic periodontitis by the change of microecology and inflammation.  ONCOTARGET,  vol.7,  66700, 2016. 

89.  王晓 , 王立祥 , 刘志方 , 唐伟 , 贾继辉  and 孙允东. Helicobacter pylori Outer Membrane Protein 18 (Hp1125) Is Involved in Persistent Colonization by Evading Interferon- γ Signaling..  biomed res int,  2015. 

90.  孙霞  and 孙允东. Stress-Induced Corticotropin-Releasing Hormone-Mediated NLRP6 Inflammasome Inhibition and Transmissible Enteritis in Mice.  Gastroenterology,  2013. 

91.  贾继辉 , 李岩 , 周亚滨  and 孙允东. Proteomic Analysis of the Function of Sigma Factor σ(54) in Helicobacter pylori Survival with Nutrition Deficiency Stress In Vitro..  Plos one,  2013. 

92.  李汶娟 , 贾继辉 , 孙允东 , 侯桂华 , 周亚滨  and 耿熙炆. The Bifunctional Enzyme SpoT Is Involved in the Clarithromycin Tolerance of Helicobacter pylori by Upregulating the Transporters HP0939, HP1017, HP0497, and HP0471.  Antimicrobial Agents and Chemotherapy,  61,  2017. 

93.  胡晓燕 , 曹倩  and 曾贝妮. In vitro and in vivo effects of suloctidil on growth and biofilm formation of the opportunistic fungus Candida albicans.  ONCOTARGET,  8,  69972, 2017. 

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