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Biography

王官锋，教授，博士生和硕士生导师，玉米抗病遗传育种团队课题组长

邮箱：gfwang@sdu.edu.cn

个‍人简介

王官锋，山东大学“齐鲁青年学者”特聘教授，杰出中青年学者，博士生导师。博士毕业于中科院遗传发育所，先后在美国马里兰大学巴尔的摩郡分校和北卡罗来纳州立大学从事博士后研究。主持国家自然科学基金面上项目、国际（地区）合作交流项目和十四五国家重点研发计划等多项国家级课题，主要研究方向为玉米抗病基因的挖掘和抗病分子机理研究。以通讯作者或第一作者在Molecular Plant, The Plant Cell, Trends in Plant Science, Plant Biotechnology Journal, PLoS Pathogens, Cell Reports, The Plant Journal, Plant Physiology 等国际著名期刊发表论文二十多篇。担任中国生物工程学会农业分会委员，中国植物病理学位青年委员会委员，中国植物保护学会青年委员会委员，山东省植物生理与分子生物学会常务理事，山东省植物病理学会常务理事；国际著名植物病理杂志Molecular Plant-Microbe Interactions编委 (Associate editor)。

招生招聘

博士、硕士研究生

学术型：细胞生物学、植物学

专业型：生物与医药

博士后科研人员：常年招聘，欢迎具有农学、植物病理学、遗传学、植物学、生物化学、生物信息学、分子生物学和细胞生物学等相关方向的博士随时联系，待遇优渥。

研究方向

1）玉米抗病基因的挖掘和分子机理解析：

以玉米为主要研究材料，综合运用遗传学、生物化学、分子生物学和生物信息学等方法，针对玉米主要病害（如大斑病、小斑病、灰斑病、南方锈病、青枯病/茎腐病和穗腐病等）开展抗病信号通路中重要基因的发掘和功能分析，为玉米的遗传育种提供基因资源和理论依据。

2）NLR 类免疫受体蛋白的调控机理研究：

利用玉米中一个能引起类病斑超敏感防卫反应的NLR突变体 Rp1-D21 为工具，挖掘新的NLR调控因子，并揭示其在NLR介导超敏感防卫反应和玉米抗病中的分子机制。

3）病原真菌与玉米的互作机理研究：

（1）玉米南方锈病效应因子与玉米互作的分子机理研究；

（2）玉米普通锈病效应因子与玉米互作的分子机理研究；

（3）针对引起青枯病和穗腐病的拟轮枝镰孢菌中效应因子与玉米互作的分子机理研究。

4）玉米广谱抗病新种质创制

通过基因编辑、分子标记辅助育种等现代农业方法和技术，创制对玉米多种病害产生广谱抗性且不影响产量的优异新种质。

发表论文 (*通讯作者； #共同第一作者)

代表性论文

>Chang-Xiao Tang, Shi-Jun Ma, Qi-Dong Ge, Yang Sun, Tong-Tong Liu, Man Yang, Zi-Xuan Kang, Yu-Chen Dai, Xuan Zhang, Xueman Liu, Yanyong Cao, Guan-Feng Wang*. 2026. The F-box protein ZmFBK1 facilitates autophagy-mediated degradation of maize NLR protein Rp1-D21 to suppress the hypersensitive response. Molecular Plant S1674-2052(26)00001-8. doi: 10.1016/j.molp.2026.01.001.

>Yang Sun, Shijun Ma, Xiangguo Liu, Guan-Feng Wang*. 2023. The maize ZmVPS23-like protein relocates the nucleotide-binding leucine-rich repeat protein Rp1-D21 to endosomes and suppresses the defense response. The Plant Cell 35: 2369-2390.

>Ya-Jie Li^#, Jin-Ming Gu^#, Shijun Ma^#, Yang Xu, Mengjie Liu, Chuang Zhang, Xiangguo Liu, Guan-Feng Wang*. 2023. Genome editing of the susceptibility gene ZmNANMT confers multiple disease resistance without agronomic penalty in maize. Plant Biotechnology Journal 21:1525-1527.

>Xudong Li, Cong Liu, Jinge Du, Yuqing Sun, Ruibo Hu, Shuqing Liu, Qiyu Xu, Xiaoli He, Chang-Xiao Tang, Ran Xu, Yunhai Li, Zheng Qing Fu, Guan-Feng Wang*, Shengjun Li*. 2025. DEAD-box protein SMA1 activates immunity likely through the formation of nuclear condensates with EDS1 in Arabidopsis. Cell Reports 44:115895.

>Yang Sun, Yu-Xiu Zhu, Peter J. Balint-Kurti, Guan-Feng Wang*. 2020. Fine-tuning immunity: players and regulators for plant NLRs. Trends in Plant Science 25: 695-713.

>Qing-Ling Luan^#, Yu-Xiu Zhu^#, Shijun Ma, Yang Sun, Xiao-Ying Liu, Mengjie Liu, Peter J. Balint-Kurti, Guan-Feng Wang*. 2021. Maize metacaspases modulate the defense response mediated by the NLR protein Rp1-D21 likely by affecting its subcellular localization. The Plant Journal 105:151-166.

其它通讯或第一作者论文

>Mengjie Liu, Ya-Jie Li, Yu-Xiu Zhu, Yang Sun, Guan-Feng Wang*. 2021. Maize nicotinate N-methyltransferase interacts with the NLR protein Rp1-D21 and modulates the hypersensitive response. Molecular Plant Pathology 22:564-579.

>Chunxia Ge^#, Yi-Ge Wang^#, Shouping Lu, Xiangyu Zhao, Bing-kai Hou, Peter Balint-Kurti, Guan-Feng Wang*. 2021. Multi-omics analyses reveal the regulatory network and the function of ZmUGTs in maize defense response. Frontiers in Plant Science, 12: 738261.

>Yu-Xiu Zhu, Chunxia Ge, Shijun Ma, Xiao-Ying Liu, Mengjie Liu, Yang Sun, Guan-Feng Wang*. 2020. Maize ZmFNSI homologs interact with an NLR protein to modulate hypersensitive response. International Journal of Molecular Sciences 21: 2529.

>Chunxia Ge, Chaoxiao Tang, Yu-Xiu Zhu, Guan-Feng Wang*. 2021. Genome-wide identification of the maize 2OGD superfamily genes and their response to Fusarium verticillioides and Fusarium graminearum. Gene 764: 145078.

>Shijun Ma, Hong Shi, Guan-Feng Wang*. 2021. The potential roles of different metacaspases in maize defense response. Plant Signaling & Behavior 16: e1906574

> Guan-Feng Wang*, Peter Balint-Kurti. 2016. Maize homologs of CCoAOMT and HCT, two key enzymes in lignin biosynthesis, form complexes with the NLR Rp1 protein to modulate the defense response. Plant Physiology 171: 2166-2177.

> Guan-Feng Wang*, Jiabing Ji, Farid EI-Kasmi, Jeffery L. Dangl, Guri Johal, Peter Balint-Kurti*. 2015. Molecular and functional analyses of a maize autoactive NB-LRR protein identify precise structural requirements for activity. PLoS Pathogens 11: e1004674.

> Guan-Feng Wang*, Yijian He, Renee Strauch, Bode A Olukolu, Dahlia Nielsen, Xu Li, Peter Balint-Kurti*. 2015. Maize homologs of hydroxycinnamoyltransferase, a key enzyme in lignin biosynthesis, bind the nucleotide binding leucine-rich repeat Rp1 proteins to modulate the defense response. Plant Physiology 169: 2230-2243.

> Bode A Olukolu^#, Guan-Feng Wang^#, Vijay Vontimitta^#, Bala P Venkata, Sandeep Marla, Jiabing Ji, Emma Gachomo, Kevin Chu, Adisu Negeri, Jacqueline Benson, Rebecca Nelson, Peter Bradbury, Dahlia Nielsen, James B Holland, Peter J Balint-Kurti*, Gurmukh Johal. 2014. A genome-wide association study of the maize hypersensitive defense response identifies genes that cluster in related pathways. PLoS Genetics 10: e1004562.

> Guan-Feng Wang*, Peter Balint-Kurti*. 2015. Cytoplasmic and nuclear localizations are important for the hypersensitive response conferred by maize autoactive Rp1-D21 protein. Molecular Plant-Microbe Interactions 28: 1023-1031.

> Guan-Feng Wang*, Renchun Fan, Xianping Wang, Daowen Wang*, Xiangqi Zhang*. 2015. TaSGT1 and TaRAR1 associate with TaHsp90 to function in bread wheat (Triticum aestivum L.) seedling growth and stripe rust resistance. Plant Molecular Biology 87: 577-589.

> Guan-Feng Wang, Savanna Seabolt, Safae Hamdoun, Ng Gina, Jin Park, Hua Lu*. 2011. Multiple roles of WIN3 in regulating disease resistance, cell death, and flowering time in Arabidopsis. Plant Physiology 156:1508-1519.

> Guan-Feng Wang^#, Xuening Wei^#, Renchun Fan, Huanbin Zhou, Xianping Wang, Chunmei Yu, Lingli Dong, Zhenning Dong, Xiaojie Wang, Zhensheng Kang, Hongqing Ling, Qian-Hua Shen, Daowen Wang*, Xiangqi Zhang*. 2011. Molecular analysis of common wheat genes encoding three types of cytosolic heat shock protein (Hsp90): functional involvement of cytosolic Hsp90s in the control of wheat seedling growth and disease resistance. New Phytologist 191: 418-431.

> Adisu Negeri^#, Guan-Feng Wang^#, Larissa Benavente, Cromwell M. Kibiti, Vijay Chaikam, Guri Johal, Peter Balint-Kurti. 2013. Characterization of temperature and light effects on the defense response phenotypes associated with the maize Rp1-D21 gene. BMC Plant Biology 13:106.

参与发表论文

> Li Q*, Lai J*, Chen J, Li L, Song W, Xin B, Zhao H, Xiao Y*, Tian F*, Li G, Liang Y, Liu L, Tan B, Wang B, Wu Y*, Yang X*, Di H, Ma Z, Song R, Zhan J, Zhang X, Qin F*, Chen Y, Dai M, Jiang C, Shi Y, Wang Y, Wu Q, Yang S, Yuan L, Zhang M, Zhao H, Xu M*, Chen J, Ding J, Duan C, Gao X, Gou M, Lai Z, Li P, Wang GF, Weng J, Wu J, Wu L, Yang Q, Zhang Y, Zhao H, Zhou Y, Wan X*, An X, Huang W, Jin W, Wu S, Wang H*, Chen H, Tang J, Zhang Z, Xie C*, Chen S, Liu C, Qi X, Wang H, Wang X, Yan J, Yan J*. 2025. Decades' progress and prospects on maize functional genomics and molecular breeding. Science China Life Sciences. 68(12):3509-3574.

> Ren RC, Kong LG, Zheng GM, Zhao YJ, Jiang X, Wu JW, Liu C, Chu J, Ding XH, Zhang XS, Wang GF, Zhao XY. 2024. Maize requires arogenate dehydratase 2 for resistance to Ustilago maydis and plant development. Plant Physiology 195(2):1642-1659.

> Jinghua Zhang^#, Xingmeng Jia^#, Guan-Feng Wang, Shijun Ma, Shunxi Wang, Qin Yang, Xueyan Chen, Yuqian Zhang, Yajing Lyu, Xiaoxu Wang, Jiawei Shi, Yangtao Zhao, Yanhui Chen, Liuji Wu*. 2022. Ascorbate peroxidase 1 confers resistance to southern corn leaf blight in maize. Journal of Integrative Plant Biology 64(6):1196-1211.

> Xu-Xu Huang , Yong Wang , Ji-Shan Lin , Lu Chen , Yan-Jie Li, Qian Liu , Guan-Feng Wang, Fang Xu, Lijing Liu, Bing-Kai Hou. 2021. The novel pathogen-responsive glycosyltransferase UGT73C7 mediates the redirection of phenylpropanoid metabolism and promotes SNC1-dependent Arabidopsis immunity. The Plant Journal 107(1):149-165.

> Saet-Byul Kim, Lisa Van den Broeck, Shailesh Karre, Hoseong Choi, Shawn A Christensen, Guan-Feng Wang, Yeonhwa Jo, Won Kyong Cho, Peter Balint-Kurti. 2021. Analysis of the transcriptomic, metabolomic, and gene regulatory responses to Puccinia sorghi in maize. Molecular Plant Pathology 22:465-479.

> Hua Lu*, Chong Zhang, Ute Albrecht, Rena Shimizu, Guanfeng Wang, Kim D. Bowman. 2013. Overexpression of a citrus NDR1 ortholog increases disease resistance in Arabidopsis. Frontiers in Plant Science 4:157.

> Chunmei Yu, Yiwen Li, Bin Li, Lifang Hao, Jing Chen, Weiqiang Qian, Shiming Li, Guanfeng Wang, Shiwei Bai, Hua Ye, Huanju Qin, Qianhua Shen, Liangbiao Chen, Aimin Zhang, Daowen Wang*. 2010. Molecular analysis of phosphomannomutase (PMM) genes reveals a unique PMM duplication event in diverse Triticeae species and the main PMM isozymes in bread wheat tissues. BMC Plant Biology 10: 214.