1.  发表论文清单

1) Guomeng Sha, Wenhui Bi, Lili Zhang, Tong Chen, Xin Li, Guanjun Chen, Lushan Wang*.Dynamics and removal mechanisms of antibiotic and antibiotic resistance genes during the fermentation process of spectinomycin mycelial dregs: An integrated meta-omics study. Journal of Hazardous Materials 421:126822 (2022) DOI:10.1016/j.jhazmat.2021.126822

2) Lanzeng Zhang, Xue Li, Xiyue Zhang, Yingjie Li* and Lushan Wang. Bacterial alginate metabolism: an important pathway for bioconversion of brown algae.  Biotechnol Biofuels 14:158 (2021) DOI:10.1186/s13068-021-02007-8

   3) Yuxuan Song, Xiuyun Wu, Yue Zhao, Xukai Jiang* & Lushan Wang :Comparative molecular dynamics simulations identify a salt-sensitive loop           responsible for the halotolerant activity of GH5 cellulases. Journal of Biomolecular Structure and Dynamics (2021)        DOI:10.1080/07391102.2021.1930167 

4) Shu Zhang, Sha Zhao, Weihao Shang, Zijuan Yan, Xiuyun Wu*, Yingjie Li, Guanjun Chen, Xinli Liu and Lushan Wang. Synergistic mechanism of GH11 xylanases with diferent action modes from Aspergillus niger An76. Biotechnol Biofuels 14:118 (2021) doi:10.1186/s13068-021-01967-1  

5）Yuhong Lai, Weiguang Li, Xiuyun Wu and Lushan Wang*. A highly efficient protein degradation system in Bacillus sp. CN2: a functional-degradomics study. Appl Microbiol Biotechnol (2021). https://doi.org/10.1007/s00253-020-11083-z

6) Xiuyun Wu, Shu Zhang, Qun Zhang, Yue Zhao, Guanjun Chen, Weihua Guo and Lushan Wang*. The contribution of specific subsites to catalytic activities in active site architecture of GH11 xylanase. Appl Microbiol Biotechnol 104: 8735-8745 (2020) doi: 10.1007/s00253-020-10865-9.

7) Zelu Shi, Chao Han, Xiujun Zhang, Li Tian and Lushan Wang*. Novel synergistic mechanism for lignocellulose degradation by a thermophilic filamentous fungus and a thermophilic actinobacterium based on functional proteomics. Frontiers in Microbiology-Microbiotechnology 11: 872 (2020) doi: 10.3389/fmicb.2020.00872.

8) Xin Li, Chao Han, Weiguang Li, Guanjun Chen and Lushan Wang*. Insights into the cellulose degradation mechanism of the thermophilic fungus Chaetomium thermophilum based on integrated functional omics. Biotechnol Biofuels 13, 143 (2020) doi: 10.1186/s13068-020-01783-z

9) 沙国萌，陈冠军，陈彤，王禄山*．抗生素耐药性的研究进展与控制策略．微生物学通报. 2020 doi: 10.13344/j.microbiol.china.200668

10) 张舒，赵越，陈冠军，余俊红，吴秀芸*，王禄山．生物质多糖的高效降解与降解酶(系)的精确定制．生物化学与生物物理进展 2020 doi: 11.2161.Q.20200811.1612.002

11) 吴秀芸, 戴琳, 张舒, 尚伟昊, 余俊红, 黄小平, 王禄山*. 高效木聚糖降解酶系定制的新进展与挑战. 微生物学通报 47(7): 2278−2289 (2020) doi: 10.13344/j.microbiol.china.200316

12) Xiuyun Wu, Qun Zhang, Lanzeng Zhang, Shijia Liu, Guanjun Chen, Huaiqiang Zhang and Lushan Wang*. (2020) Insights Into the Role of Exposed Surface Charged Residues in the Alkali-Tolerance of GH11 Xylanase. Front Microbiol 11:872. doi: 10.3389/fmicb.2020.00872

13)Lili Zhang, Lijuan Li, Guomeng Sha, Chongxuan Liu, Zhiheng Wang, Lushan Wang*.  Aerobic composting as an effective cow manure management strategy for reducing the dissemination of antibiotic resistance genes: An integrated meta-omics study. Journal of Hazardous Materials 386: 121895 (2020) doi: 10.1016/j.jhazmat.2019.121895

14) Xiaomeng Sun, Yingjie Li, Zhennan Tian, Yuanchao Qian, Huaiqiang Zhang* & Lushan Wang*. A novel thermostable chitinolytic machinery of Streptomyces sp. F-3 consisting of chitinases with different action modes. Biotechnol Biofuels 12, 136 (2019) doi:10.1186/s13068-019-1472-1

15) Bo Gao, Yue Zhao, Yang Li, Juntao Liu, Lushan Wang, Guojun Li,* and Zhengchang Su*. Prediction of Driver Modules via Balancing Exclusive Coverages of Mutations in Cancer Samples. Adv. Sci. 2019, 6, 1801384

16) Yanmei Yang, Yang Liu, Lulu Ning, Lushan Wang* Yuguang Mu,* and Weifeng Li*, Binding Process and Free Energy Characteristics of Cellulose Chain into the Catalytic Domain of Cellobiohydrolase TrCel7A. J. Phys. Chem. B 2019, 123, 8853-8860. 

17) Zelu Shi, Weili Gong, Lili Zhang, Lin Dai, Guanjun Chen, Lushan Wang*. Integrated Functional-Omics Analysis of Thermomyces lanuginosus Reveals its Potential for Simultaneous Production of Xylanase and Substituted Xylooligosaccharides. Appl Biochem Biotechnol (2019) 187: 1515. https://doi.org/10.1007/s12010-018-2873-5

18) 张群,吴秀芸,蒋绪恺, 赵越, 王禄山*. 大数据时代杂合酶的设计及其新趋势[J]. 生物工程学报, 2018, 34(7):1033-1045.

19) Lili Zhang, Lijuan Li, Xiaoguang Pan, Zelu Shi, Xihong Feng, Bin Gong, Jian Li, Lushan Wang*.Enhanced growth and activities of the dominant functional microbiota of chicken manure composts in the presence of maize straw. Front. Microbiol. | doi: 10.3389/fmicb.2018.01131

20) Kundi Zhang, Wen Li, Yefei Wang, Yanlin Zheng, Fangcheng Tan, Xiaoqing Ma, Lishan Yao, Edwad A. Bayer, Lushan Wang*, Fu-Li Li*.Processive Degradation of Crystalline Cellulose by a Multimodular Endoglucanase via a Wirewalking Mode . Biomacromolecules, 19 (5), 1686–1696, 2018

21) Dongyu Wang, Lili Zhang, Haiyue Zou, and Lushan Wang*.Secretome profiling reveals temperature-dependent growth of Aspergillus fumigatus. Sci China Life Sci, 61（5）: 578–592,2018

22) 吴秀芸,刘淑萍,赵越,陈冠军,王禄山*.快速展示糖苷水解酶活性架构单点突变导致结合力变化的电泳技术. 生物化学与生物物理进展, 45(5): 560~566,2018

23) Weili Gong, Lin Dai, Huaiqiang Zhang, Lili Zhang, Lushan Wang*. A Highly Efficient Xylan-Utilization System in Aspergillus niger An76: A Functional-Proteomics Study.  Front. Microbiol. 9:430.2018

24) Lin Liu, Weili Gong, Xiaomeng Sun, Guanjun Chen, Lushan Wang*,Extracellular Enzyme Composition and Functional Characteristics of Aspergillus niger An-76 Induced by Food Processing Byproducts and Based on Integrated Functional Omics, J. Agric. Food Chem. 66, 1285−1295, 2018

25) Xiuyun Wu, Zhennan Tian, Xukai Jiang, Qun Zhang, Lushan Wang*. Enhancement in catalytic activity of Aspergillus niger XynB by selective site-directed mutagenesis of active site amino acids. Appl Microbiol Biotechnol, 102:249–260, 2018

26) 潘晓光,张丽丽,张怀强,王禄山*. 基于整合宏组学技术认识腐生生境功能微生物区系.微生物学通报; 44(9): 2231−2238, 2017

27) Xukai Jiang, Yuying Wang, Limei Xu, Guanjun Chen*, and Lushan Wang*. Substrate binding interferes with active site conformational dynamics in endoglucanase Cel5A from Thermobifida fusca. Biochem Biophys Res Commun. 491(1):236-240. 2017

28) Xukai Jiang, Wen Li, Guanjun Chen, and Lushan Wang*，Dynamic Perturbation of the Active Site Determines Reversible Thermal Inactivation in Glycoside Hydrolase Family 12. J. Chem. Inf. Model., 57: 288−297,2017

2. 著作/译著：

  1).张丽丽，秦玉琪译，王禄山校 真菌基因组学，化学工业出版社. 40万字, 2019

2). 王禄山，耿存亮，段晓云 等译 生物燃料的计算模拟，化学工业出版社. 40.4万字, 2012

3). 王禄山，张正 等译，纤维素降解的超分子机器——纤维小体，化学工业出版社. 40.2万字，2011

 4). 王禄山，张正 等译，生物质抗降解屏障——解构植物细胞壁产生物能，化学工业出版社. 65.4万字，2010

     5). 王禄山，高培基，生物信息学应用技术，化学工业出版社. 37.5万字，2008。

 

3. 参编著作：

1). 曲音波，木质纤维素降解酶与生物炼制，北京：化学工业出版社，44.7万字，2011。参编部分：第1章 木质纤维素生物降解转化技术的意义与展望，第3章 降解纤维素的微生物及酶系，第4章 纤维素酶类糖苷水解酶及其降解机理

2).“10000个科学难题”生物学编委会，10000个科学难题，北京：科学出版社，2010。参编部分：木质纤维素资源高效生物转化的难点与问题在哪里？

3). 李越中 等，基因组研究与生物信息学，济南：山东大学出版社，2001。参编部分：因特网，数据库在线分析，生物信息学软件。

 

4．奖励：

1) 王禄山；2013年度山东大学课堂教学质量优秀教师；山东大学，2014-04

2）陈冠军，张可炜，季明杰，王禄山。山东省精品课程立项：生物化学（2012BK178），山东省教育厅, 2012

3）王禄山。糖苷水解酶酸碱催化机制的理论探索，山东省人民政府学位委员会，山东省优秀学士学位论文指导教师，2012

 4）饶子和，王禄山。鸟类支气管炎病毒IBV非结构蛋白nsp2的表达纯化、结晶、结构与功能初探，山东省人民政府学位委员会，山东 省优秀学士学位论文指导教师，2010

 5）王禄山，高培基。纤维素酶CBHI连续催化机制的分子模拟研究，山东省人民政府学位委员会，山东省优秀学士学位论文指导教师，2009

 6) 李越中，王禄山，张治国，高培基，黎志凤。生物信息学课程体系的建设，山东大学，校级教学成果二等奖, 2008

 

5．专利：

1）王禄山，陈冠军，高培基，李亭亭。一种微米级均一纤维素粉末及其制备方法与应用， 2011.5.4，中国，ZL 2007100114797.8。

2) 王禄山，吴秀芸，刘诗佳，田震楠，张群，张怀强。一种木聚糖酶AnXynB的突变基因AnXynB_1及其应用，2019.0712，中国，ZL 201610498183.3。

3）王禄山，刘诗佳，吴秀芸，张怀强。一种木聚糖酶TlXynA的突变基因TlXynA_1及其应用，2019.0712，中国，ZL 201610498168.9。

4）王禄山，刘诗佳，吴秀芸，张怀强。一种木聚糖酶TlXynA的突变基因TlXynA_2及其应用，2019.0712，中国，ZL 201610498150.9。

5）王禄山，刘诗佳，吴秀芸，张怀强。一种木聚糖酶TlXynA的突变基因TlXynA_3及其应用，2019.0712，中国，ZL 201610497299.5。

      6）王禄山，吴秀芸，戴琳，陈冠军，高培基。一种降解小麦阿拉伯木聚糖的复合酶系及其应用，2020.1030,  中国，ZL                               201910589068.0。

      7）王禄山，孙晓萌，赵越，张怀强，吴秀芸。一种突变的几丁质酶及其应用，2021.0305, 中国，ZL  201911050815.X。