从事RNA病毒研究，主要研究领域为分子病毒学与传染病流行病学，研究内容包括病毒的生物学特性、传播和流行规律、蛋白质结构与功能、病毒-宿主相互作用的分子机制等，重点对RNA病毒蛋白结构与功能、蜱媒病毒的传播与流行特点进行持续研究。

作为课题负责人主持国家重点研发计划、国家自然科学基金、及其他省部级课题共10余项；获省部级科技奖励2项。近五年以第一/通讯作者发表学术论文100余篇，获国家发明专利3项，软著3项。参编规划教材10部，获教学奖励10余项，培养病毒学领域博、硕士研究生40余名，获评2025年度齐鲁医学优秀教师。

兼任中华医学会医学病毒学分会常委、中华预防医学会卫生检验专业委员会常委、中华预防医学会消毒分会常委、《INFECTIOUS MEDICINE》编委等。

近几年主持的主要科研项目情况

1)   “十四五”国家重点研发计划，复杂生物危害现场的消杀处置关键技术与装备研究。课题负责人。80万元。

2)   “十三五”国家重点研发计划，“公共安全风险防控与应急技术装备”重点专项。课题负责人。430万元。

3)    国家自然科学基金面上项目，肠道病毒71型3D聚合酶及非编码区中神经毒力位点的精确定位及相互作用研究。课题负责人。70万元。

4)   山东省自然科学基金面上项目：山东省新型布尼亚病毒遗传变异与分子进化机制研究。课题负责人。10万元。

5)   山东省重点研发计划，手足口病防控关键技术研究。课题负责人。15万元。

6)   山东省自然科学基金面上项目，肠道病毒71型诱导细胞自噬的分子机制。 课题负责人。15万元。

代表性研究成果 

(1) Sun XF#, Zhao L#, Wen HL#, Luo, LM, Yu, XJ.; Anaplasma species in China, Lancet Infectious Diseases, 2015, 15(11): 1263-1264.     (期刊论文)

(2) Li-Zhu Fang^#; Li Zhao^#; Hong-Ling Wen^#; Zhen-Tang Zhang; Jian-Wei Liu; Shu-Ting He; Zai-Feng Xue; Dong-Qiang Ma; Xiao-Shuang Zhang; Yan Zhang; Xue-jie Yu^*; Reservoir Host Expansion of Hantavirus, China, Emerging Infectious Diseases, 2015, 21(1): 170-171.     (期刊论文)

(3) Wen, Hong-ling^#; Si, Lu-ying^#; Yuan, Xiao-jing; Hao, Shu-bin; Gao, Feng; Chu, Fu-lu; Sun, Cheng-xi; Wang, Zhi-yu^*; Complete genome sequencing and analysis of six enterovirus 71 strains with different clinical phenotypes, Virology Journal, 2013, 10: 1-11.     (期刊论文)

(4) Hong-ling Wen^#; Li Zhao^#; Shenyong Zhai; Yuanyuan Chi; Feng Cui; Duxu Wang; Ling Wang; Zhiyu Wang; Qian Wang; Shoufeng Zhang; Yan Liu; Hao Yu; Xue-jie Yu^*; Severe Fever with Thrombocytopenia Syndrome, Shandong Province, China, 2011, Emerging Infectious Diseases, 2014, 20(1): 1-5.     (期刊论文)

(5) Sun, Le-le^#; Wang, Jia-Kun^#; Cui, Xiao-qing; Hao, Shu-Bin; Li, Jing; Zhao, Li; Yuan, Xiao-jing; Wen, Hong-ling^*; Yu, Xue-jie; Wang, Zhi-Yu; Association of viral replication capacity with the pathogenicity of enterovirus 71, Virus Research, 2014, 189: 1-7.     (期刊论文)

(6) Jian-Wei Liu^#; Hong-Ling Wen^#; Li-Zhu Fang; Zhen-Tang Zhang; Shu-Ting He; Zai-Feng Xue; Dong-Qiang Ma; Xiao-Shuang Zhang; Tao Wang; Hao Yu; Yan Zhang; Li Zhao; Xue-jie Yu.^*; Prevalence of SFTSV among Asian House Shrews and Rodents, China, January–August 2013, Emerging Infectious Diseases, 2014, 20(12): 2126-2128.     (期刊论文)

(7) Ma, Ying-wei^#; Hao, Shu-bin^#; Sun, Le-le; Li, Jing; Qiao, Qiao; Gao, Feng; Zhao, Li; Yu, Xue-jie; Wang, Zhi-yu; Wen, Hong-ling^*; Construction and characterization of infectious cDNA clones of enterovirus 71 (EV71), Virologica Sinica, 2015, 30(4): 305-308.     (期刊论文)

(8) Zhuang, Zhi-Chao; Kou, Zeng-Qiang; Bai, Yong-Juan; Cong, Xiang; Wang, Li-Hong; Li, Chun; Zhao, Li; Yu, Xue-Jie; Wang, Zhi-Yu; Wen, Hong-Ling^*; Epidemiological Research on Hand, Foot, and Mouth Disease in Mainland China, Viruses-Basel, 2015, 7(12): 6400-6411.     (期刊论文)

(9) Li Jing; Gao Feng; Hao Shu Bin; Cheng Dong; Zhang Wen Qiang; Lin Bin; Zhao Li; Yu Xue Jie; Wang Zhi Yu; Wen Hong Ling^*; Contribution of 3CD Region to the Virulence of Enterovirus 71, Biomedical and Environmental Sciences, 2017, 30(10): 767-771.     (期刊论文)

(10) Li Chun; Qiao Qiao; Hao Shu Bin; Dong Zhen; Zhao Li; Ji Jing; Wang Zhi Yu; Wen Hong Ling^*; Nonstructural protein 2A modulates replication and virulence of enterovirus 71, Virus Research, 2018, 244: 262-269.     (期刊论文)

(11) Dong, Zhen; Liu, Zi Wei; Chen, Rui; Wen, Xiao Jing; Ji, Jing; Zheng, Xue Xing; Zhao, Li; Wang, Zhi Yu; Wen, Hong Ling^*; The untranslated regions of EV-A71 contribute to its pathogenicity and virulence, Virus Research, 2019, 263: 55-63.     (期刊论文)

(12) Chen, Rui; Kou, Zengqiang; Xu, Liuchen; Cao, Jie; Liu, Ziwei; Wen, Xiaojing; Wang, Zhiyu; Wen, Hongling^*; Analysis of epidemiological characteristics of four natural-focal diseases in Shandong Province, China in 2009-2017: A descriptive analysis, PLos One, 2019, 14(8): e0221677.     (期刊论文)

(13) Liu, Zi-Wei; Zhuang, Zhi-Chao; Chen, Rui; Wang, Xiao-Rui; Zhang, Hai-Lu; Li, Shu-Han; Wang, Zhi-Yu; Wen, Hong-Ling^*; Enterovirus 71 VP1 Protein Regulates Viral Replication in SH-SY5Y Cells via the mTOR Autophagy Signaling Pathway, Viruses-Basel, 2020, 12(1): 11.     (期刊论文)

(14) Rui, Chen; Zeng-qiang, Kou; Xiao-rui, Wang; Shu-han, Li; Hai-lu, Zhang; Zi-wei, Liu; Dong, Cheng; Zhi-yu, Wang; Xue-Jie, Yu; Hong-ling, Wen^*; Severe fever with thrombocytopenia syndrome virus infection during pregnancy in C57/BL6 mice causes fetal damage, PLoS Neglected Tropical Diseases, 2020, 14(7): e0008453.     (期刊论文)

(15) Wang, Xiaorui; Zhao, Jin; Li, Xi; Li, Hanping; Zhang, Yu; Liu, Yongjian; Chen, Lin; Zheng, Chenli; Jia, Lei; Han, Jingwan; Li, Tianyi; Wang, Xiaolin; Li, Jingyun; Wen, Hongling^*; Li, Lin^*; Identification of a novel HIV-1 second-generation Circulating Recombinant Form CRF109_0107 in China, Journal of Infection, 2020, 81(5): 842-846.     (期刊论文)

(16) Yao, Mingxiao; Jiang, Fachun; Zhang, Yuwei; Li, Yan; Pang, Bo; Liang, Hao; Kou, Zengqiang; Jiang, Xiaolin; Wen, Hongling; Xu, Yifei^*; SARS-CoV-2 Variant of Concern 202 012/01 (B.1.1.7) in a traveller from the UK to China, Journal of Travel Medicine, 2021, 28(4): taab032.     (期刊论文)

(17) Wang, Xiaorui; Zhang, Yu; Liu, Yongjian; Li, Hanping; Jia, Lei; Han, Jingwan; Li, Tianyi; Wang, Xiaolin; Li, Jingyun; Wen, Hongling^*; Li, Lin^*; Phylogenetic Analysis of Sequences in the HIV Database Revealed Multiple Potential Circulating Recombinant Forms in China, AIDS Research and Human Retroviruses, 2021, 37(9): 694-705.     (期刊论文)

(18) Wen, Xiaojing; Zhang, Li; Zhao, Shan; Liu, Qiang; Guan, Wenyi; Wu, Jiajing; Zhang, Qiwei^*; Wen, Hongling^*; Huang, Weijin^*; High-Throughput Screening and Identification of Human Adenovirus Type 5 Inhibitors, Frontiers in Cellular and Infection Microbiology, 2021, 11: 767578.     (期刊论文)

(19) Wang, Yao; Song, Zexuan; Wei, Xuemin; Yuan, Haowen; Xu, Xiaoying; Liang, Hao; Wen, Hongling^*; Clinical laboratory parameters and fatality of Severe fever with thrombocytopenia syndrome patients: A systematic review and meta-analysis, PLoS Neglected Tropical Diseases, 2022, 16(6): e0010489.     (期刊论文)

(20) Han, Hecheng; Xu, Xiaoying; Kan, Haopeng; Tang, Yunxiang; Liu, Chang; Wen, Hongling^*; Wu, Lili; Jiang, Yanyan^*; Wang, Zhou; Liu, Jiurong; Wang, Fenglong^*; Synergistic photodynamic/photothermal bacterial inactivation over heterogeneous quaternized chitosan/silver/cobalt phosphide nanocomposites, Journal of Colloid and Interface Science, 2022, 616: 304-315.     (期刊论文)

(21) Wang, Yao; Song, Zexuan; Xu, Xiaoying; Wei, Xuemin; Yuan, Haowen; Liang, Hao; Wen, Hongling^*; Clinical symptoms associated with fatality of severe fever with thrombocytopenia syndrome: A systematic review and meta-analysis, Acta Tropica, 2022, 232: 106481.     (期刊论文)

(22) Chen, Rui; Li, Qiang; Chen, Hongmei; Yang, Hongguang; Wei, Xuemin; Chen, Mengting; Wen, Hongling^*; Severe fever with thrombocytopenia syndrome virus replicates in brain tissues and damages neurons in newborn mice, BMC Microbiology, 2022, 22(1): 204.     (期刊论文)

(23) Wang, Yao; Pang, Bo; Ma, Wei; Kou, Zengqiang^*; Wen, Hongling^*; Analysis of the spatial-temporal components driving transmission of the severe fever with thrombocytopenia syndrome in Shandong Province, China, 2016-2018, Transboundary and Emerging Diseases, 2022, 69(6): 3761-3770.     (期刊论文)

(24) Wang, Yao; Pang, Bo; Ma, Wei; Kou, Zengqiang^*; Wen, Hongling^*; Spatiotemporal analysis of severe fever with thrombocytopenia syndrome in Shandong Province, China, 2014-2018, BMC Public Health, 2022, 22(1): 1998.     (期刊论文)

(25) Wei, Xuemin; Li, Shuhan; Lu, Yan; Qiu, Ling; Xu, Nannan; Guo, Xianhu; Chen, Mengting; Liang, Hao; Cheng, Dong; Zhao, Li; Hao, Shubin; Kou, Zengqiang; Wen, Hongling^*; Severe fever with thrombocytopenia syndrome virus aerosol infection in C57/BL6 mice, Virology, 2023, 581: 58-62.     (期刊论文)

(26) Wang, Yao; Pang, Bo; Wang, Zequn; Tian, Xueying; Xu, Xiaoying; Chong, Xiaowen; Liang, Hao; Ma, Wei; Kou, Zengqiang^*; Wen, Hongling^*; Genomic diversity and evolution analysis of severe fever with thrombocytopenia syndrome in East Asia from 2010 to 2022, Frontiers in Microbiology, 2023, 14: 1233693.     (期刊论文)

(27) Wang, Yao; Duan, Qing; Pang, Bo; Tian, Xueying; Ma, Jing; Ma, Wei; Kou, Zengqiang^*; Wen, Hongling^*; Assessing the Relationship between Climate Variables and Hemorrhagic Fever with Renal Syndrome Transmission in Eastern China: A Multi-Cities Time Series Study, Transboundary and Emerging Diseases, 2023, 2023: 5572334.     (期刊论文)

(28) Duan, Qing; Wang, Yao; Jiang, Xiaolin; Ding, Shujun; Zhang, Yuwei; Yao, Mingxiao; Pang, Bo; Tian, Xueying; Ma, Wei; Kou, Zengqiang^*; Wen, Hongling^*; Spatial-temporal drivers and incidence heterogeneity of hemorrhagic fever with renal syndrome transmission in Shandong Province, China, 2016-2022, BMC Public Health, 2024, 24(1): 1032.     (期刊论文)

(29) Xu, Xiaoying; Ma, Shao; Liu, Ziwei; Yuan, Haowen; Wang, Yao; Chen, Mengting; Du, Mengyu; Kan, Haopeng; Wang, Zequn; Chong, Xiaowen; Wen, Hongling^*; EV71 5'UTR interacts with 3D protein affecting replication through the AKT-mTOR pathway, Virology Journal, 2024, 21(1): 114.     (期刊论文)

(30) Wang, Yao; Tian, Xueying; Pang, Bo; Ma, Wei; Kou, Zengqiang; Wen, Hongling^*; Long-term effects of meteorological factors on severe fever with thrombocytopenia syndrome incidence in eastern China from 2014 to 2020: An ecological time-series study, PLoS Neglected Tropical Diseases, 2024, 18(6): e0012266.     (期刊论文)

(31) Wang, Xiaorui; Zhu, Bo; Li, Hanping; Han, Jingwan; Wang, Xiaolin; Jia, Lei; Zhang, Bohan; Li, Jingyun; Wang, Linding; Liu, Yongjian^*; Wen, Hongling^*; Li, Lin^*; The origin and transmission of HIV-1 CRF80_0107 among two major first-tier cities in China, BMC Infectious Diseases, 2025, 25(1): 104.     (期刊论文)

(32) Yu, Miao; Wang, Xiaorui; Jia, Lei; Han, Jingwan; Li, Hanping; Wang, Xiaolin; Zhang, Bohan; Li, Jingyun; Liu, Yongjian^*; Wen, Hongling^*; Li, Lin^*; Sequence Notes: Identification of Two New CRF01_AE/CRF07_BC Recombinants in Men Who Have Sex with Men Populations in Beijing, China, AIDS Research and Human Retroviruses, 2025.     (期刊论文)

(33) Wang, Xiaorui; Zhu, Bo; Li, Hanping; Han, Jingwan; Wang, Xiaolin; Jia, Lei; Zhang, Bohan; Li, Jingyun; Liu, Yongjian^*; Wen, Hongling^*; Li, Lin^*; Identification of a Novel HIV-1 Second-Generation Circulating Recombinant Form (CRF117_0107) in China, AIDS Research and Human Retroviruses, 2025, 41(4): 211-215.     (期刊论文)

(34) Wang, Yao; Pang, Bo; Tian, Xueying; Kou, Zengqiang^*; Wen, Hongling^*; Epidemiology and Demographic Trends of Severe Fever With Thrombocytopenia Syndrome in Shandong Province From 2015 to 2022: A Comprehensive Analysis, Journal of Medical Virology, 2025, 97(3): e70316.     (期刊论文)

(35) Sheng R, Cheng T, Wang Y, Wen H^*. Molecular evolution and geographic migration of severe fever with thrombocytopenia syndrome virus in Asia. PLoS Pathogens. 2025，21(3):e1012970   (期刊论文)