个人简介
吴贯召，山东省泰山学者青年专家，山东大学齐鲁青年学者，博士生导师。2018-2021年在Texas Tech University从事博士后研究。从事罕见病药物分子研发、手性高分子与生物医药应用、线粒体疾病发病机制与药物开发方向的研究。本课题组长期招聘医学、化学、分子生物学等方向博士后、神经病学方向的博士和硕士研究生。
发表论文：
1. Guanzhao Wu#, Yangxue Liu#, Zhen Yang#, Tao Jiang, Nandakumar Katakam, Hossein Rouh, Liulei Ma, Yao Tang, Sultan Ahmed, Anis U. Rahman, Hongen Huang, Daniel Unruh, and Guigen Li*. Enantioselective assembly of multi-layer 3D chirality. National Science Review, 2020, 7, 588-599.
2. Guanzhao Wu#, Yangxue Liu#, Zhen Yang#, Nandakumar Katakam, Hossein Rouh, Sultan Ahmed, Daniel Unruh, Kazimierz Surowiec, and Guigen Li*. Multilayer 3D chirality and its synthetic assembly. Research, 2019, 6717104.
3. Guanzhao Wu#, Yangxue Liu#, Zhen Yang#, Liulei Ma, Yao Tang, Xianliang Zhao, Hossein Rouh, Qixuan Zheng, Peng Zhou, Jia Yin Wang, Farhan Siddique, Sai Zhang, Shengzhou Jin, Daniel Unruh, Adelia J. A. Aquino*, Hans Lischka*, Kristin M. Hutchins*, and Guigen Li*. Triple-Columned and Multiple-Layered 3D Polymers: Design, Synthesis, Aggregation-Induced Emission (AIE), and Computational Study. Research, 2021, 3565791.
4. Guanzhao Wu#, Yangxue Liu#, Hossein Rouh#, Liulei Ma, Yao Tang, Sai Zhang, Peng Zhou, Jia-Ying Wang, Shengzhou Jin, Daniel Unruh, Kazimierz Surowiec, Yanzhang Ma, and Guigen Li*. Asymmetric Catalysis to Multi-Layer 3D Chirality. Chemistry-A European Journal, 2021, 27, 8013-8020.
5. Yangxue Liu#, Guanzhao Wu#, Zhen Yang, Hossein Rouh, Nandakumar Katakam, Sultan Ahmed, Daniel Unruh, Zhonghua Cui*, Hans Lischka*, and Guigen Li*. Multi-layer 3D chirality: new synthesis, AIE and computational studies. Science China Chemistry, 2020, 63, 692-698.
6. Zheyi Wang, Liying Meng, Xinxin Liu, Lingzi Zhang, Zongjiang Yu*, Guanzhao Wu*. Recent progress toward developing axial chirality bioactive compounds. European Journal of Medicinal Chemistry, 2022, 114700.
7. Guanzhao Wu*. Recent advances in helical polyacetylene derivatives used as coated chiral stationary phases for enantioseparation. Polymer Chemistry, 2022, 13, 3036-3047.
8. Xinxin Liu, Liying Meng, Zheyi Wang, Zongjiang Yu, Chen Zhang, Limin Liu, Zen Coen*, Zhongjun Yang*, Guanzhao Wu*. Novel construction of multifunctional photo-responsive and nucleic acid-triggered doxorubicin-releasing liposomes for cancer therapy, European Journal of Medicinal Chemistry, 2023, 250, 115207.
9. Chen Zhang, Guanzhao Wu*. Recent advances in fluorescent probes for ATP imaging, Talanta, 2024, 126622.
10. Zheyi Wang, Yize Sun, Zetai Bai, Mei Li, Deyuan Kong, Guanzhao Wu*. Mitochondria‐Related Genome‐Wide Mendelian Randomization Identifies Putatively Causal Genes for Neurodegenerative Diseases. Movement Disorders, 2025, 40, 693-703.
11. Xiangyi Kong, Penghui Wei, Liying Meng, Zongjiang Yu, Xuemeng Liu, Mei Li, Yanan Zou, Jianjun Li*, Guanzhao Wu*. Discovery of a potential anti-ischemic stroke agent by suppressing ferroptosis through the ATF3/SLC7A11/GPX4 pathway, European Journal of Medicinal Chemistry, 2026, 296, 117873.
12. Mei Li, Deyuan Kong, Qingguo Ren, Zhuopeng Li, Zheyi Wang, Zetai Bai, Liying Meng, Xuemeng Liu, Zhongjun Yang*, Guanzhao Wu*.A mitochondria-targeted idebenone derivative W1a mitigates cerebral ischemia-reperfusion injury by preserving mitochondrial integrity and suppressing neuroinflammation, Bioorganic Chemistry, 2026, 168, 109356.
13. Longfei Wang, Fei Wang, Xingjun Wang, Xiangning Chen, Chengwei Li, Kaiyue Shan, Haipeng Zhou, Guanzhao Wu*, Zhipeng Xu*, Xiangyi Kong*, Penghui Wei*. The lung-brain axis: elucidating the mechanisms of pulmonary-driven neurological disorders, Journal of Neuroinflammation, 2026, 23, 115.
14. Hongwei Li, Huiying Zhuang, Dianxi Zhang, Tingting Qiu, Lu Liu, Ziyi Sunyang, Yuqiang Han, Rilei Yu, Guanzhao Wu*, Ruijuan Yin*, Tao Jiang*. Discovery of Imidazo[2,1-b][1,3,4]thiadiazole-Based MNK Inhibitors with Anti-inflammatory Efficacy via Dual Suppression of eIF4E Phosphorylation and NF-κB Signaling, Journal of Medicinal Chemistry, 2026, 69, 9713-9731.
15. Teng Pan, Xiao Li, Ying Zhou, Na Wang, Xue Song, Zixuan Zhang, Tao Jiang, Zhuo Huang, Wei Wang, Guanzhao Wu*, Yukun Jiang*, Rilei Yu*. Design, Synthesis, and Structure-Activity Relationship Study of μ-Conotoxin KIIIA toward Nav1.4, Journal of Medicinal Chemistry, 2026, 69, 7856-7868.
科研项目：
国家自然科学基金青年项目，主持
山东省泰山学者青年专家项目，主持
山东大学齐鲁青年学者基金，主持
山东省自然科学基金面上项目，主持