On the afternoon of September 25, Professor Chengpeng Fan from the Basic Medical School of Wuhan University was invited by Professor Dalei Wu of the State Key Laboratory of Microbial Technology at Shandong University to participate in the “Microcosmic Exploration for Scientific Insight—Graduate Student Specialized Course” and deliver an academic lecture titled “Addressing Challenges in Structural Resolution: Perspectives and Approaches. ” The lecture, chaired by Professor Dalei Wu, attracted over 100 faculty members and students.

Focusing on methodologies in structural biology, the report provided an in-depth exploration of the field. Professor Chengpeng Fan comprehensively elaborated on the fundamental principles of protein crystallization and technical approaches for protein structure resolution, enhancing attendees' understanding of the mechanisms involved. He further introduced advanced techniques such as phase acquisition through X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy, highlighting cutting-edge developments in the discipline.

Following a concise overview of protein tertiary structure classification, Professor Fan drew from his extensive research experience to dissect over twenty complex case studies. Through vivid explanations and practical examples, he illustrated common challenges in scientific research and shared strategic solutions. Additionally, he synthesized current bottlenecks in structural resolution, sparking critical reflection among attendees and offering valuable insights for their future investigations.

The lecture not only strengthened participants' systematic grasp of principles ranging from protein crystal cultivation to structural determination but also imparted profound research wisdom drawn from Professor Fan's expertise, laying a robust foundation for their academic pursuits.

During the Q&A session, students engaged in active discussions with Professor Fan, who addressed their questions regarding structural resolution and research methodologies, fostering intellectual inspiration. This event not only deepened the academic community's understanding of protein structure analysis but also proposed innovative directions for advancements in related fields.

Text: Xiaoyu Chen, Xufeng Gao

Photo: Na Li