【个人信息】
徐晓文，男，副教授，硕士生导师。2014年1月于中国科学院长春应用化学研究所电分析化学国家重点实验室获得理学博士学位（导师：杨秀荣院士）。2013年12月至2015年4月在美国佛罗里达国际大学化学与生物化学系从事博士后研究。2015年6月至今在山东大学化学与化工学院分析化学专业从事教学科研工作。
【联系方式】
地址：山东省济南市山大南路27号
山东大学中心校区生命北楼404室
E-mail: xuxw@sdu.edu.cn
电话：0531-88363916
【教学课程】
化学分析，仪器分析，仪器分析实验 （本科生）
现代光电分析测量技术 （研究生）
【研究内容】
研究内容主要为设计DNA化学传感方法，用于生物标志物分析检测。发表SCI 收录论文60余篇，参与编写美国化学会出版的专著1 篇章。作为第一/通讯作者在《分析化学》、Analytical Chemistry、Chemical Science、Chemical Engineering Journal、Small、Chemical Communications和Biosensors and Bioelectronics等刊物发表系列研究论文，论文单篇最高被引用200余次；作为第一发明人授权国家发明专利5项。作为完成人之一获得省自然科学一等奖等科技奖励。
在生化检测试剂研制、生物分析方法设计、可视化检测试纸构建等方面具有较丰富的经验，欢迎有相关技术需求的企业或单位邮件联系洽谈。
【招生计划】
欢迎对分析化学感兴趣的同学以推免生或统考生等方式加入攻读硕士学位。
欢迎对分析化学感兴趣的本科生加入进行毕业设计或创新实验。
【主要论文】
31. Hongzheng Zheng‡, Xuesi Li‡, Xiuqian Liu, Xiaowen Xu*, Controlling the depth of hybridization chain reaction by extended dangling ends and its analytical applications. Analytical Chemistry, 2024, 96, 17054-17058. (‡: Co-first author)
30. Juanjuan Song, Chuhao Zhang, Siting Fu, Xiaowen Xu*, Visualized lateral flow assay for logic determination of co-existing viral RNA fragments. Biosensors and Bioelectronics, 2024, 261, 116519.
29. Yuanmeng Zhang, Muyang Lin, Jingkang Yao, Xiaowen Xu*, A DNA tetrahedron dimer for dual membrane protein logic recognition and interaction inhibition. Chemical Communications, 2024, 60, 3721-3724.
28. Le Liu, Ruixue Zhang, Jingkang Yao, Xiaowen Xu*, Design of a folding DNA triangular prism for cell analysis and regulation. Chemical Engineering Journal, 2023, 474, 145951.
27. Juanjuan Song, Liangwen Zhang, Luhao Zeng, Xiaowen Xu*, Visualized lateral flow assay for dual viral RNA fragments detection. Analytical Chemistry, 2023, 95, 11187-11192.
26. Jingwen Ge, Juanjuan Song, Xiaowen Xu*, Colorimetric detection of viral RNA fragments based on an integrated logic-operated three-dimensional DNA walker. Biosensors and Bioelectronics, 2022, 217, 114714.
25. Wantong Zhang, Juanjuan Song, Hongzheng Zheng, Xiaowen Xu*, Colorimetric detection of RNA fragments based on associated toehold-mediated reaction and gold nanoparticles. Chemical Communications, 2022, 58, 8666-8669.
24. Ruixue Zhang, Ruiyuan Zhang, Chunyan Zhao, Xiaowen Xu*, A DNA tetrahedron docking assembly for imaging telomerase activity in cancerous cells. Analytica Chimica Acta, 2022, 1193, 339395.
23. Ruixue Zhang, Wenjing Chen, Wei Jiang, Xiaowen Xu*, Construction of telomerase activity test strip and visual determination of cancerous cells. Chinese Journal of Analytical Chemistry, 2021, 49, 702-709 (Cover).
22. Ruiyuan Zhang, Ruixue Zhang, Wei Jiang, Xiaowen Xu*, A multicolor DNA tetrahedron nanoprobe for analyzing human telomerase in living cells. Chemical Communications, 2021, 57, 2188-2191.
21. Hong Zhang, Xiaowen Xu*, Wei Jiang*, An interparticle relatively motional DNA walker and its sensing application. Chemical Science, 2020, 11, 7415-7423.
20. Dafeng Jiang, Chao Huang, Lijun Shao, Xiaolin Wang, Yanni Jiao, Wei Li, Jindong Chen*, Xiaowen Xu*, Magneto-controlled aptasensor for simultaneous detection of ochratoxin A and fumonisin B1 using inductively coupled plasma mass spectrometry with multiple metal nanoparticles as element labels. Analytica Chimica Acta, 2020, 1127, 182-189.
19. Han Pang, Xiaowen Xu*, Wei Jiang*, A track-regenerated DNA walker: Construction and its derived sensing application. Sensors and Actuators B: Chemical, 2020, 314, 128053.
18. Xiaowen Xu, Pingping Zhang, Ruiyuan Zhang, Nan Zhang*, Wei Jiang*, A DNA walker powered by endogenous enzymes for imaging uracil-DNA glycosylase activity in living cells. Chemical Communications, 2019, 55, 6026-6029.
17. Xiaowen Xu, Lei Wang, Wanling Cui, Wei Jiang*, Multiple sealed primers-mediated rolling circle amplification strategy for sensitive and specific detection of DNA methyltransferase activity. Talanta, 2019, 194, 282-288.
16. Xiaowen Xu, Lei Wang, Kan Li, Qihong Huang, Wei Jiang*, A smart DNA tweezer for detection of human telomerase activity. Analytical Chemistry, 2018, 90, 3521-3530.
15. Xiaowen Xu, Lei Wang, Wanling Cui, Wei Jiang*, An integrated and restructive probe mediated strand displacement amplification strategy for sensitive and specific DNA methyltransferase activity detection. Sensors and Actuators B: Chemical, 2018, 266, 124-130.
14. Xiaowen Xu, Lei Wang, Desong Zhu, Yan Wang*, Wei Jiang*, Protein binding protection in combination with DNA masking for sensitive and reliable transcription factor detection. Talanta, 2018, 186, 293-298.
13. Rui Wang, Lei Wang, Xiaowen Xu*, Wei Jiang*, An enzyme-free and label-free fluorescence biosensor for microRNA detection based on cascade amplification of DNAzyme-powered three-dimensional DNA walker and hybridization chain reaction. Sensors and Actuators B: Chemical, 2018, 268, 287-292.
12. Pingping Zhang, Lei Wang, Haiyan Zhao, Xiaowen Xu*, Wei Jiang*, Self-primer and self-template recycle rolling circle amplification strategy for sensitive detection of uracil-DNA glycosylase activity, Analytica Chimica Acta, 2018, 1001, 119-124.
11. Wenjing Chen, Lei Wang, Rong He, Xiaowen Xu*, Wei Jiang*, Convertible DNA ends-based silver nanoprobes for colorimetric detection human telomerase activity. Talanta, 2018, 178, 458-463.
10. Xiaowen Xu, Lei Wang, Yushu Wu, Wei Jiang*, Uracil removal-inhibited ligase reaction in combination with catalytic hairpin assembly for the sensitive and specific detection of uracil-DNA glycosylase activity. Analyst, 2017, 142, 4655-4660.
9. Xiaowen Xu, Haiping Wei, Wei Jiang*, A target triggered proximity combination-based fluorescence sensing strategy for adenosine detection. Analyst, 2017, 142, 2247-2252.
8. Haixiang Yu‡, Xiaowen Xu‡, Pingping Liang, Kang Yong Loh, Bhargav Guntupalli, Daniel Roncancio, Yi Xiao*, A broadly applicable assay for rapidly and accurately quantifying DNA surface coverage on diverse particles. Bioconjugate Chemistry, 2017, 28, 933-943. (‡: Co-first author)
7. Kan Li, Lei Wang, Xiaowen Xu*, Wei Jiang*, Label-free molecular beacons-based cascade amplification DNA machine for sensitive detection of telomerase activity. Talanta, 2017, 167, 645-650.
6. Xiaowen Xu, Lei Wang, Yongqi Huang, Wushuang Gao, Kan Li, Wei Jiang*, Model-guided interface probe arrangement for sensitive protein detection. Analytical Chemistry, 2016, 88, 9885-9889.
5. Xiaowen Xu, Xiurong Yang*, Reversion of DNA strand displacement with functional nucleic acids as toeholds. Chemical Communications, 2014, 50, 805-807.
4. Xiaowen Xu, Xiurong Yang*, Facile colorimetric detection of glucose based on an organic Fenton reaction. Analytical Methods, 2011, 3, 1056-1059 (Inside cover).
3. Xiaowen Xu, Jia Zhang, Fan Yang, Xiurong Yang*, Colorimetric logic gates for small molecules using split/integrated aptamers and unmodified gold nanoparticles. Chemical Communications, 2011, 47, 9435-9437.
2. Xiaowen Xu, Juan Wang, Fan Yang, Kui Jiao*, Xiurong Yang*, Label-free colorimetric detection of small molecules utilizing DNA oligonucleotides and silver nanoparticles. Small, 2009, 5, 2669-2672.
1. Xiaowen Xu, Juan Wang, Kui Jiao*, Xiurong Yang*, Colorimetric detection of mercury ion (Hg2+) based on DNA oligonucleotides and unmodified gold nanoparticles sensing system with a tunable detection range. Biosensors and Bioelectronics, 2009, 24, 3153-3158.
【授权专利】
5. 徐晓文，葛婧雯，一种用于SARS-CoV-2检测的DNA步行器及其制备方法，ZL 202210617332.9。
4. 徐晓文，张琬童，一种基于杂交链式反应的SARS-CoV-2检测体系及检测方法， ZL 202210512078.6。
3. 徐晓文，张瑞雪，用于细胞分析和调控的折叠DNA三棱柱探针及其制备方法，ZL 202210242396.5。
2. 徐晓文，张芮源，一种靶向肿瘤的端粒酶检测系统、端粒酶检测方法及试剂盒，ZL 202110551808.9。
1. 徐晓文，张芮源，一种顺序点亮多色DNA四面体纳米探针SLMN及其制备方法和应用，ZL 202110023886.1。
