教师简介

【个人信息】

徐晓文,男,副教授,硕士生导师。2014年1月于中国科学院长春应用化学研究所电分析化学国家重点实验室获得理学博士学位(导师:杨秀荣院士)。2013年12月至2015年4月在美国佛罗里达国际大学化学与生物化学系从事博士后研究。2015年6月至今在山东大学化学与化工学院从事教学科研工作。


【联系方式】

地址:山东省济南市山大南路27号

           山东大学中心校区生命北楼404室

E-mail: xuxw@sdu.edu.cn

电话:0531-88363916


【教学课程】

分析化学,仪器分析实验 (本科生)

现代光电分析测量技术 (研究生)


研究内容】

研究内容主要集中在基于DNA寡聚核酸的生物传感与分析。以第一或通讯作者在Analytical Chemistry、Chemical Science、Small和Chemical Communications等国际刊物发表研究论文20余篇,论文引用1100余次,h-index为20;参与编写美国化学会出版的专著一篇章。作为研究骨干获2018年度吉林省自然科学一等奖。


招生计划】

欢迎对分析化学感兴趣的同学以推免生或统考生等方式加入攻读硕士学位。

欢迎对分析化学感兴趣的本科生加入进行毕业设计或创新实验。


【主要论文】

22. Ruiyuan Zhang, Ruixue Zhang, Wei Jiang, Xiaowen Xu*, A multicolor DNA tetrahedron nanoprobe for analyzing human telomerase in living cells. Chemical Communications, 2021, 57, 2188-2191.

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21. Hong Zhang, Xiaowen Xu*, Wei Jiang*, An interparticle relatively motional DNA walker and its sensing application. Chemical Science, 2020, 11, 7415-7423.

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20. Dafeng Jiang, Chao Huang, Lijun Shao, Xiaolin Wang, Yanni Jiao, Wei Li, Jindong Chen*, Xiaowen Xu*, Magneto-controlled aptasensor for simultaneous detection of ochratoxin A and fumonisin B1 using inductively coupled plasma mass spectrometry with multiple metal nanoparticles as element labels. Analytica Chimica Acta, 2020, 1127, 182-189.

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19. Han Pang, Xiaowen Xu*, Wei Jiang*, A track-regenerated DNA walker: Construction and its derived sensing application. Sensors and Actuators B: Chemical, 2020, 314, 128053.

Sensors B-2020-PangHan.jpg


18. Xiaowen Xu, Pingping Zhang, Ruiyuan Zhang, Nan Zhang*, Wei Jiang*, A DNA walker powered by endogenous enzymes for imaging uracil-DNA glycosylase activity in living cells. Chemical Communications, 2019, 55, 6026-6029.

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17. Xiaowen Xu, Lei Wang, Wanling Cui, Wei Jiang*, Multiple sealed primers-mediated rolling circle amplification strategy for sensitive and specific detection of DNA methyltransferase activity. Talanta, 2019, 194, 282-288.

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16. Xiaowen Xu, Lei Wang, Kan Li, Qihong Huang, Wei Jiang*, A smart DNA tweezer for detection of human telomerase activity. Analytical Chemistry, 2018, 90, 3521-3530.

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15. Xiaowen Xu, Lei Wang, Wanling Cui, Wei Jiang*, An integrated and restructive probe mediated strand displacement amplification strategy for sensitive and specific DNA methyltransferase activity detection. Sensors and Actuators B: Chemical, 2018, 266, 124-130.

Sensors B-DM-2018.jpg


14. Xiaowen Xu, Lei Wang, Desong Zhu, Yan Wang*, Wei Jiang*, Protein binding protection in combination with DNA masking for sensitive and reliable transcription factor detection. Talanta, 2018, 186, 293-298.

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13. Rui Wang, Lei Wang, Xiaowen Xu*, Wei Jiang*, An enzyme-free and label-free fluorescence biosensor for microRNA detection based on cascade amplification of DNAzyme-powered three-dimensional DNA walker and hybridization chain reaction. Sensors and Actuators B: Chemical, 2018, 268, 287-292.

Rui Wang-2018=Sensors B.jpg


12. Pingping Zhang, Lei Wang, Haiyan Zhao, Xiaowen Xu*, Wei Jiang*, Self-primer and self-template recycle rolling circle amplification strategy for sensitive detection of uracil-DNA glycosylase activity, Analytica Chimica Acta, 2018, 1001, 119-124.

ACA-2018-Pingping Zhang.jpg


11. Wenjing Chen, Lei Wang, Rong He, Xiaowen Xu*, Wei Jiang*, Convertible DNA ends-based silver nanoprobes for colorimetric detection human telomerase activity. Talanta, 2018, 178, 458-463.

Talanta-2018-AgNP.jpg


10. Xiaowen Xu, Lei Wang, Yushu Wu, Wei Jiang*, Uracil removal-inhibited ligase reaction in combination with catalytic hairpin assembly for the sensitive and specific detection of uracil-DNA glycosylase activity. Analyst, 2017, 142, 4655-4660.

Analyst-2017-UDG.jpg


9. Xiaowen Xu, Haiping Wei, Wei Jiang*, A target triggered proximity combination-based fluorescence sensing strategy for adenosine detection. Analyst, 2017, 142, 2247-2252.

Analyst 2017.jpg


8. Haixiang Yu(#), Xiaowen Xu(#), Pingping Liang, Kang Yong Loh, Bhargav Guntupalli, Daniel Roncancio, Yi Xiao*, A broadly applicable assay for rapidly and accurately quantifying DNA surface coverage on diverse particles. Bioconjugate Chemistry, 2017, 28, 933-943. (#: Co-first author)

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7. Kan Li, Lei Wang, Xiaowen Xu*, Wei Jiang*, Label-free molecular beacons-based cascade amplification DNA machine for sensitive detection of telomerase activity. Talanta, 2017, 167, 645-650.

Talanta-LiKan-2017.jpg


6. Xiaowen Xu, Lei Wang, Yongqi Huang, Wushuang Gao, Kan Li, Wei Jiang*, Model-guided interface probe arrangement for sensitive protein detection. Analytical Chemistry, 2016, 88, 9885-9889.

AC-2016.jpg


5. Xiaowen Xu, Xiurong Yang*, Reversion of DNA strand displacement with functional nucleic acids as toeholds. Chemical Communications, 2014, 50, 805-807.

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4. Xiaowen Xu, Xiurong Yang*, Facile colorimetric detection of glucose based on an organic Fenton reaction. Analytical Methods (Inside cover), 2011, 3, 1056-1059.

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3. Xiaowen Xu, Jia Zhang, Fan Yang, Xiurong Yang*, Colorimetric logic gates for small molecules using split/integrated aptamers and unmodified gold nanoparticles. Chemical Communications, 2011, 47, 9435-9437.

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2. Xiaowen Xu, Juan Wang, Fan Yang, Kui Jiao*, Xiurong Yang*, Label-free colorimetric detection of small molecules utilizing DNA oligonucleotides and silver nanoparticles. Small, 2009, 5, 2669-2672.

Small-2019.jpg


1. Xiaowen Xu, Juan Wang, Kui Jiao*, Xiurong Yang*, Colorimetric detection of mercury ion (Hg2+) based on DNA oligonucleotides and unmodified gold nanoparticles sensing system with a tunable detection range. Biosensors and Bioelectronics, 2009, 24, 3153-3158.

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【科研项目】

7. 电分析化学国家重点实验室开放课题基金 2020 – 2021   负责人

6. 山东大学青年学者未来计划资助               2018 – 2023    负责人

5. 国家自然科学基金青年基金                      2018 – 2020    负责人

4. 山东省自然科学基金博士基金                  2017 – 2019    负责人

3. 山东省博士后创新项目专项资金              2017 – 2019    负责人

2. 中国博士后科学基金面上资助                  2016 – 2018    负责人

1. 山东大学基本科研业务费                         2015 – 2017    负责人










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