听觉神经生物学
1. 听觉转导与耳聋发生
2. 毛细胞静纤毛发育与维持
1. 姚雪波. Esrp1 and Esrp2 Regulate the Stability of tmc1/2a mRNAs in Zebrafish Sensory Hair Cells. Journal of Neuroscience, 45, 2025.
2. 闫科吉. EVL is not essential for cuticular plate and stereocilia development in mouse auditory hair cells. FEBS LETTERS, 2025.
3. . Mechano-electrical transduction components TMC1-CIB2 undergo a Ca2+-induced conformational change linked to hearing loss. Developmental Cell, 2025.
4. Keji Yan , Haoqing Zhang , Chengli Qu , Yuehui Xi , Ze-Guang Han and Zhigang Xu. BAIAP2L1 and BAIAP2L2 differently regulate hair cell stereocilia morphology. FASEB J, 38, e23860, 2024.
5. Nana Li , Shuang Liu , Dange Zhao , Haibo Du , Yuehui Xi , Xiaoxi Wei , Qingling Liu , Ulrich Müller , Qing Lu , Wei Xiong and Zhigang Xu. Disruption of Cdh23 exon 68 splicing leads to progressive hearing loss in mice by affecting tip-link stability. Proc Natl Acad Sci U S A, 121, e2309656121, 2024.
6. Ying Guan , Hai-Bo Du , Zhao Yang , Yu-Zhu Wang , Rui Ren , Wen-Wen Liu , Chao Zhang , Jia-Hai Zhang , Wen-Tao An , Na-Na Li , Xiao-Xue Zeng , Jie Li , Yi-Xiao Sun , Yan-Fei Wang , Fan Yang , Jun Yang , Wei Xiong , Xiao Yu , Ren-Jie Chai , Xiao-Ming Tu , Jin-Peng Sun and Zhi-Gang Xu. Deafness-associated ADGRV1 mutation impairs USH2A stability through improper phosphorylation of WHRN and WDSUB1 recruitment. Advanced Science, 10, e2205993, 2023.
7. Xiaoying Wang , Shuang Liu , Qi Cheng , Chengli Qu , Rui Ren , Haibo Du , Nana Li , Keji Yan , Yanfei Wang , Wei Xiong and Zhigang Xu. CIB2 and CIB3 regulate stereocilia maintenance and mechanoelectrical transduction in mouse vestibular hair cells. Journal of Neuroscience, 43, 3219-3231, 2023.
8. Rui Ren , Haiyue Xing , Xiaoying Wang , Haibo Du , Yanfei Wang and Zhigang Xu. Loss of TMCC2 activates endoplasm reticulum stress and causes auditory hair cell death. Human Molecular Genetics, 32, 1622-1633, 2023.
9. Huang Wang , Haibo Du , Rui Ren , Tingting Du , Lin Lin , Zhe Feng , Dange Zhao , Xiaoxi Wei , Xiaoyan Zhai , Hongyang Wang , Tingting Dong , Jin-Peng Sun , Hao Wu , Zhigang Xu and Qing Lu. Temporal and spatial assembly of inner ear hair cell ankle link condensate through phase separation. Nature Communications, 14, 1657, 2023.
10. Xiaoyan Zhai , Haibo Du , Yuxin Shen , Xiujuan Zhang , Zhengjun Chen , Yanfei Wang and Zhigang Xu. FCHSD2 is required for stereocilia maintenance in mouse cochlear hair cells. Journal of Cell Science, 135, jcs259912, 2022.
11. Haibo Du , Linzhi Zou , Rui Ren , Nana Li , Jie Li , Yanfei Wang , Jinpeng Sun , Jun Yang , Wei Xiong and Zhigang Xu. Lack of PDZD7 long isoform disrupts ankle-link complex and causes hearing loss in mice. FASEB Journal, 34, 1136, 2020.
12. Xiao-Ning Cheng , Ming Shao , Ji-Tong Li , Yan-Fei Wang , Jing Qi , Zhi-Gang Xu and De-Li Shi. Leucine repeat adaptor protein 1 interacts with Dishevelled to regulate gastrulation cell movements in zebrafish. Nature Communications, 8, 1353, 2017.
13. Qiao-Xia Hu , Jun-Hong Dong , Hai-Bo Du , Dao-Lai Zhang , Hong-Ze Ren , Ming-Liang Ma , Yuan Cai , Tong-Chao Zhao , Xiao-Lei Yin , Xiao Yu , Tian Xue , Zhi-Gang Xu and Jin-Peng Sun. Constitutive Gαi coupling activity of very large G protein-coupled receptor 1 (VLGR1) and its regulation by PDZD7 protein. Journal of Biological Chemistry, 289, 24215-24225, 2014.
1. 神经生物学
2. 细胞生物学
3. 神经生物学
4. 细胞生物学
5. 细胞生物学
6. 细胞生物学
7. 神经生物学
8. 神经生物学
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1. Hair bundles - Development, maintenance, and function
2. Mechanotransduction of the hair cell
