听觉神经生物学
1. 听觉转导与耳聋发生
2. 毛细胞静纤毛发育与维持
1. 孙春娇 , 赵静霜 , 李娜娜 , 姚雪波 , 王燕飞 , Chul Hoon Kim , Jinwoong Bok , Anthony W. Peng and 徐志刚. Alternative splicing of the Rbm24 gene is essential for cochlear hair cell stereocilia integrity and hearing function in mice. Proc Natl Acad Sci U S A ., 123, e2531564123, 2026.
2. 宗文 , 闫科吉 , 邢海月 , 张浩晴 , 张雯 , 高瑞 , 彭晓娜 , 李唐亮 , 汪兆琦 and 徐志刚. Nucleolin is essential for hair cell stereocilia maintenance and auditory function in mice. J Cell Sci, 139, jcs264793, 2026.
3. Xuebo Yao , Yan Zhang , Xiaying Hong , Yanyi Xing and Zhigang Xu. Esrp1 and Esrp2 regulate the stability of tmc1/2a mRNAs in zebrafish Sensory Hair Cells. Journal of Neuroscience, 45, e0837242025, 2025.
4. Shaoxuan Wu , Lin Lin , Qiaoyu Hu , Xuebo Yao , Hongyang Wang , Shang Liu , Qingling Liu , Yuehui Xi , Yuzhe Lin , Jianqiao Gong , Ruixing Hu , Wei Zhan , Yi Luo , Guang He , Zhijun Liu , Wei Xiong , Qiuju Wang , Zhigang Xu , Fang Bai and Qing Lu. Mechano-electrical transduction components TMC1-CIB2 undergo a Ca2+-induced conformational change linked to hearing loss. Developmental Cell, 60, 1586-1600, 2025.
5. Nana Li , Shuang Liu , Dange Zhao , Haibo Du , Yuehui Xi , Xiaoxi Wei , Qingling Liu , Ulrich Müller , Qing Lu , Wei Xiong and Zhigang Xu. Disruption of Cdh23 exon 68 splicing leads to progressive hearing loss in mice by affecting tip-link stability. Proc Natl Acad Sci U S A, 121, e2309656121, 2024.
6. Ying Guan , Hai-Bo Du , Zhao Yang , Yu-Zhu Wang , Rui Ren , Wen-Wen Liu , Chao Zhang , Jia-Hai Zhang , Wen-Tao An , Na-Na Li , Xiao-Xue Zeng , Jie Li , Yi-Xiao Sun , Yan-Fei Wang , Fan Yang , Jun Yang , Wei Xiong , Xiao Yu , Ren-Jie Chai , Xiao-Ming Tu , Jin-Peng Sun and Zhi-Gang Xu. Deafness-associated ADGRV1 mutation impairs USH2A stability through improper phosphorylation of WHRN and WDSUB1 recruitment. Advanced Science, 10, e2205993, 2023.
7. Xiaoying Wang , Shuang Liu , Qi Cheng , Chengli Qu , Rui Ren , Haibo Du , Nana Li , Keji Yan , Yanfei Wang , Wei Xiong and Zhigang Xu. CIB2 and CIB3 regulate stereocilia maintenance and mechanoelectrical transduction in mouse vestibular hair cells. Journal of Neuroscience, 43, 3219-3231, 2023.
8. Rui Ren , Haiyue Xing , Xiaoying Wang , Haibo Du , Yanfei Wang and Zhigang Xu. Loss of TMCC2 activates endoplasm reticulum stress and causes auditory hair cell death. Human Molecular Genetics, 32, 1622-1633, 2023.
9. Huang Wang , Haibo Du , Rui Ren , Tingting Du , Lin Lin , Zhe Feng , Dange Zhao , Xiaoxi Wei , Xiaoyan Zhai , Hongyang Wang , Tingting Dong , Jin-Peng Sun , Hao Wu , Zhigang Xu and Qing Lu. Temporal and spatial assembly of inner ear hair cell ankle link condensate through phase separation. Nature Communications, 14, 1657, 2023.
10. Xiaoyan Zhai , Haibo Du , Yuxin Shen , Xiujuan Zhang , Zhengjun Chen , Yanfei Wang and Zhigang Xu. FCHSD2 is required for stereocilia maintenance in mouse cochlear hair cells. Journal of Cell Science, 135, jcs259912, 2022.
1.硕士研究生招生，2025，发育生物学；生物与医药，生命科学学院
2.博士研究生招生，2025，发育生物学；生物与医药，生命科学学院
1. Hair bundles - Development, maintenance, and function
2. Mechanotransduction of the hair cell
