医学博士，副主任医师，山东大学副教授，学术和专业型硕士研究生导师。

【临床医疗】从事临床工作17年，擅长强迫障碍、抑郁障碍、焦虑障碍、睡眠障碍等临床常见精神障碍的诊断和治疗。

【研究方向】抑郁障碍发病机制；应激、中枢与肠道菌群的交互影响；精神障碍的流行病学特征。主持和参与国家级及省部级科研课题10余项；在Molecular Psychiatry、Epidemiology and Psychiatric Sciences等杂志发表论文30余篇，其中SCI收录20余篇，2篇（Epidemiol Psychiatr Sci. 2021;30:e36；BMC Public Health. 2024;24(1):1639）入选ESI高被引；参编教材3部。

【近三年已发表论文】

(1) Liang W, Hou L, Wang W, et al. Alterations in miR-151a-3p of plasma-derived exosomes and associated multimodal neuroimaging patterns in major depressive disorder. Mol Psychiatry. Published online July 9, 2025. doi:10.1038/s41380-025-03102-0(中科院一区，共同通讯作者 IF 11.8)

(2) Huang SM, Cai BY, Liu L, et al. Structural characterization of the urea transporter bound to the orally bioavailable inhibitor E3. Acta Pharmacol Sin. Published online June 16, 2025. doi:10.1038/s41401-025-01595-7(中科院一区，共同第一作者 IF 8.6)

(3) Zhang Y, Wang W, Zhang X, et al. Neurotrophin-3 as a mediator in the link between PM2.5 exposure and psychiatric disorders: A Mendelian randomization study. Ecotoxicol Environ Saf. 2025;289:117658. doi:10.1016/j.ecoenv.2024. 117658 (中科院二区，TOP刊， 共同通讯作者 IF 6.3)

(4) Wang W, Wang Y, Shao K, et al. Global, regional, and national burden of bullying related mental disorders of adolescent from 1990 to 2019: A systematic analysis for the Global Burden of Disease Study 2019. Psychiatry Res. 2024;341:116154. doi:10.1016/j.psychres.2024.116154(中科院二区，最后位通讯作者 IF 5.3)

(5) Wang W, Wang Y, Wang F, et al. Notable dysthymia: evolving trends of major depressive disorders and dysthymia in China from 1990 to 2019, and projections until 2030. BMC Public Health. 2024;24(1):1585. Published 2024 Jun 13. doi:10.1186/s12889-024-18943-7 (中科院二区，TOP刊， 最后位通讯作者 IF 3.9)

(6) Zhang X, Yang L, Wang W, Yang L. Psychological distress, emotion regulation, neuroticism, and sexual relationship on patients with temporary ejaculation failure in vitro fertilization-embryo transfer treatment. Front Psychol. 2023;13:1090244. Published 2023 Jan 6. doi:10.3389/fpsyg.2022.1090244 (Q1 区，最后位通讯作者 IF 4.3)

(7) Li Z, Yang L, Chen H, et al. Global, regional and national burden of autism spectrum disorder from 1990 to 2019: results from the Global Burden of Disease Study 2019. Epidemiol Psychiatr Sci. 2022;31:e33. Published 2022 May 10. doi:10.1017/S2045796022000178 (中科院一区，TOP刊，共同第一作者 IF 8.1)

(8) Chen, Wanyu, Yang, Lejin, et al. Adolescent-Parent Career Congruence and Career Adaptability in High School Students: Learning Factors' Mediation. J Career Dev. 2025;08948453251323825.(参与作者)

(9) Zhang X, Liu G, Zhong YN, et al. Structural basis of ligand recognition and activation of the histamine receptor family. Nat Commun.2024;15(1):8296. Published 2024 Sep 27. doi:10.1038/s41467-024-52585-y(参与作者)

(10) Zhang T, Sun L, Yin X, Chen H, Yang L, Yang X. Burden of drug use disorders in the United States from 1990 to 2021 and its projection until 2035: results from the GBD study. BMC Public Health. 2024;24(1):1639. Published 2024 Jun 19. doi:10.1186/s12889-024-19142-0 (参与作者)

(11) Yang X, Yang L, Zhang T, Zhang H, Chen H, Zuo X. Causal atlas between inflammatory bowel disease and mental disorders: a bi-directional 2-sample Mendelian randomization study. Front Immunol. 2023;14:1267834. Published 2023 Oct 13. doi:10.3389/fimmu.2023.1267834(参与作者)

(12) Shang P, Rong N, Jiang JJ, et al. Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell. 2023;186(24):5347-5362.e24. doi:10.1016/j.cell.2023.10.014(参与作者)