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Education Background
  • 2004-09-01-2010-06-30
    山东大学
    病原生物学
  • 1999-09-01-2004-06-30
    山东大学
    Clinical Medicine
Work Experience
  • 2010-07 — Now
    山东大学医学院
Publication
Research direction

1. 致瘤病毒及免疫调控

Papers

(1)张魏芳. The human papillomavirus type 58 E7 oncoprotein modulates cell cycle regulatory proteins and abrogates cell cycle checkpoints .Virology .2010 ,391 (1):139

(2)李琦曌. Astaxanthin Inhibits STING Carbonylation and Enhances Antiviral Responses .J Immunol .2024 ,212 (7)

(3) A Therapeutic DNA Vaccine Targeting HPV16 E7 in Combination with Anti-PD-1/PD-L1 Enhanced Tumor Regression and Cytotoxic Immune Responses .INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES .2023 ,24 (20)

(4)田永昊. SIRT2 promotes the viability, invasion and metastasis of osteosarcoma cells by inhibiting the degradation of Snail .Cell Death & Disease .2022 ,13 (11):935

(5)张魏芳. A postulated role of p130 in telomere maintenance by human papillomavirus oncoprotein E7 .Medical Hypotheses .2012 ,79 (2):178

(6)黄玉洁. Rab31 promotes the invasion and metastasis of cervical cancer cells by inhibiting MAPK6 degradation .International Journal of Biological Sciences .2022 ,18 (1):112

(7)侯晓艳. Phosphorylation of RCC1 on Serine 11 Facilitates G1/S Transition in HPV E7-Expressing Cells .BIOMOLECULES .2021 ,11 (7)

(8)黄玉洁. Rab12 Promotes Radioresistance of HPV-Positive Cervical Cancer Cells by Increasing G2/M Arrest .FRONTIERS IN ONCOLOGY .2021 ,11

(9)张文浩. 人乳头瘤病毒早期癌蛋白E6/E7稳定表达细胞系的构建及其对Rab12表达的影响 .山东大学学报(医学版) .2018 (12)

(10)田永昊. CIP2A facilitates the G1/S cell cycle transition via B-Myb in human papillomavirus 16 oncoprotein E6-expressing cells .Journal of Cellular and Molecular Medicine .2018 ,22 (9):4150

(11)乔立君. Regulator of chromatin condensation 1 abrogates the G1 cell cycle checkpoint via Cdk1 in human papillomavirus E7-expressing epithelium and cervical cancer cells .Cell Death & Disease .2018 ,9

(12)王晓. CIP2A is associated with multidrug resistance in cervical adenocarcinoma by a P-glycoprotein pathway .tumor biology .2016 ,37 (2):2673

(13)张魏芳. miR-17对人包皮成纤维细胞衰老的影响 .《山东大学学报》（医学版） .2015

(14)张魏芳. Role of Cdk1 in the p53-independent abrogation of the postmitotic checkpoint by human papillomavirus E6 .Journalof Virology .2015

(15)张魏芳. Cancerous inhibitor of protein phosphatase 2A contributes to human papillomavirus oncoprotein E7-induced cell proliferation via E2F1 .ONCOTARGET .2015

(16)王晓. CIP2A is associated with multidrug resistance in cervical adenocarcinoma by a P-glycoprotein pathway .tumor biology .2016 ,37 (2):2673

(17)田永昊. CIP2A facilitates the G1/S cell cycle transition via B-Myb in human papillomavirus 16 oncoprotein E6-expressing cells .Journal of Cellular and Molecular Medicine .2018 ,22 (9):4150

(18)乔立君. Regulator of chromatin condensation 1 abrogates the G1 cell cycle checkpoint via Cdk1 in human papillomavirus E7-expressing epithelium and cervical cancer cells .Cell Death & Disease .2018 ,9

(19)张文浩. 人乳头瘤病毒早期癌蛋白E6/E7稳定表达细胞系的构建及其对Rab12表达的影响 .山东大学学报(医学版) .2018 (12)

(20)张魏芳. miR-17对人包皮成纤维细胞衰老的影响 .《山东大学学报》（医学版） .2015

(21)张魏芳. Role of Cdk1 in the p53-independent abrogation of the postmitotic checkpoint by human papillomavirus E6 .Journalof Virology .2015

(22)张魏芳. Cancerous inhibitor of protein phosphatase 2A contributes to human papillomavirus oncoprotein E7-induced cell proliferation via E2F1 .ONCOTARGET .2015

Research Projects

1. 人乳头瘤病毒转化蛋白E7通过SIRT7调控减数分裂重组蛋白Mre11促进DSB修复的机制研究, 2024-08-23-2028-12-31

2. （包干项目）组蛋白去乙酰化酶SIRT7促进DNA双链断裂修复介导宫颈癌化疗耐药的机制研究, 2024-01-01-2026-12-30

3. HPV癌蛋白E6及E7通过靶向STING的稳定性及转运抑制cGAS-STING信号通路的机制研究, 2021-10-12-2025-12-31

4. HPV癌蛋白E6及E7通过靶向STING的稳定性及转运抑制cGAS-STING信号通路的机制研究, 2021-08-18-2025-12-31

5. “HPV E7-NCAPH”反馈环路的形成及其促进宫颈癌发生发展 的机制研究, 2020-12-12-2023-12-31

6. 人乳头瘤病毒变异与宫颈癌发病年轻化关系的研究, 2009-01-01-2011-12-31

7. 肿瘤微环境信号分子PGRN调控宫颈癌肿瘤生长与代谢的研究, 2012-08-17-2016-12-31

8. 宫颈癌中“HPV E7-CIP2A-自噬”反馈环路的形成机制, 2016-10-29-2019-06-30

9. 细胞分裂周期蛋白Cdc6在HPV癌蛋白E7表达细胞中的功能与调控, 2014-08-15-2018-12-31

10. 人乳头瘤病毒E6蛋白通过非p53依赖方式逃避细胞周期检验点的机制研究, 2015-07-01-2017-12-31

11. 人乳头瘤病毒HPV E6基因调控G1检验点的新机制, 2015-08-17-2019-12-31

12. 58型HPV E7蛋白激活端粒替代延长机制的研究, 2011-07-01-2014-12-31

13. MiR-17在HPV58E7致细胞永生化中的作用研究, 2012-01-01-2012-12-31

14. HPV16E6蛋白诱导多倍体细胞形成及其机制研究, 2012-01-01-2014-12-31

Student Information
  • 程也萍  2023-09-23 Hits:[] Times
  • 李雪雯  2023-09-23 Hits:[] Times
  • 吴硕硕  2023-09-23 Hits:[] Times
  • 高志潇  2023-09-23 Hits:[] Times
  • 侯晓艳  2020-08-07 Hits:[] Times
  • 韩学超  2020-03-20 Hits:[] Times
  • 刘瑞娟  2019-04-18 Hits:[] Times
  • 黄玉洁  2019-04-18 Hits:[] Times
  • 郑静怡  2019-04-18 Hits:[] Times
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