Title : Design, synthesis, and antiviral evaluation of novel hydrazone-substituted thiophene[3,2-d]pyrimidine derivatives as potent human immunodeficiency virus-1 inhibitors
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Affiliation of Author(s):药学院
Title of Paper:Design, synthesis, and antiviral evaluation of novel hydrazone-substituted thiophene[3,2-d]pyrimidine derivatives as potent human immunodeficiency virus-1 inhibitors
Journal:Chemical Biology & Drug Design
All the Authors:zhanpeng,liuxinyong
First Author:汪昭
Indexed by:Unit Twenty Basic Research
Document Code:2BBCC8DD65164DBC84E6EE9F3BF50435
Volume:92
Issue:6
Page Number:2009
Translation or Not:no
Date of Publication:2018-12-01
Pre One : Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles
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