教师简介

中共党员,教授,副主任医师,博士生导师,国家级青年人才,国家重点研发计划青年科学家项目首席,山东省青年人才,山东大学杰出中青年学者,妇儿与生殖健康研究院院长助理。师从于我国著名生殖医学专家陈子江院士,主要从事以肥胖和多囊卵巢综合征为代表女性重大生殖内分泌代谢性疾病的病因学及临床分型防治研究,致力于探索生殖与代谢的交互作用关系。近五年,累计发表/参与发表 SCI 论文 50余篇,以通讯作者在Cell Metabolism、Signal Transduction and Targeted Therapy、Nature Human Behaviour、Nature Communications、Journal of Pineal Research、Research、EMBO Reports、Science China-Life Sciences、Fertility and Sterility、Human Reproduction、BMC Medicine等杂志发表SCI论文30余篇,申请国家发明专利15件,授权5件,1件已完成转化。目前承担国家重点研发计划青年科学家项目1项、子课题2项,国家自然科学基金项目3项,山东省重点研发计划1项,山东省优秀青年基金项目1项,横向科研课题2项。获得中华医学会青年科技奖、山东省医学会青年科技奖等荣誉。兼任中国妇幼保健协会临床质谱精准应用与生殖健康专业委员会常务委员,中国毒理学会发育毒理与发育源性疾病防控专业委员会常务委员,中国健康管理协会妇幼健康管理分会理事,中国细胞生物学学会生殖细胞生物学分会委员,山东省医学会肥胖防治多学科联合委员会副主任委员,山东省医学会生殖医学分会委员,山东省研究型医院协会生殖医学研究分会委员,济南市科协创新智库专家,山东大学附属生殖医院学术委员会秘书,齐鲁医学院青年人才联盟副主席Exploration期刊青年学术顾问,iMeta、Fundamental Research(基金委主办期刊)、 Genomics, Proteomics & Bioinformatics(中科院主管)、Phenomics等期刊青年编委。


教育经历
  • 2012-9 — 2015-7
    上海交通大学
    妇产科学
    博士生
  • 2005-9 — 2012-7
    山东大学
    临床医学
    医学硕士学位
研究概况

生殖医学与智慧医疗

研究方向
论文成果

(1) Caloric restriction prevents inheritance of polycystic ovary syndrome through oocyte-mediated DNA methylation reprogramming.Cell metabolism.2025

(2) Population-level analyses identify host and environmental variables influencing the vaginal microbiome.Signal Transduction and Targeted Therapy.2025

(3) Maternal adiposity and perinatal and offspring outcomes: an umbrella review.Nature Human Behaviour.2024

(4) THADA inhibition in mice protects against type 2 diabetes mellitus by improving pancreatic β-cell function and preserving β-cell mass.Nature Communications.2023,14 (1)

(5) Three-dimensional genome structures of single mammalian sperm.Nature Communications.2025

(6) Bariatric Surgery Impact on Women with Polycystic Ovary Syndrome: A Prospective Cohort Study.Research.2025

(7) Unveiling lipoprotein subfractions signature in high-FNPO PCOS: implications for PCOM diagnosis and risk assessment using advanced machine learning models.BMC Medicine.2025

(8) DENND1A desensitizes granulosa cells to FSH by arresting intracellular FSHR transportation.Science China Life Science.2024

(9) Peripheral blood RNA modifications as a novel diagnostic signature for polycystic ovary syndrome..Science China Life Science.2025

(10) ZP2: the precision regulator of egg coat architecture during fertilization..Science China Life Science.2024

(11) Cellular atlases of ovarian microenvironment alterations by diet and genetically-induced obesity.Science China Life sciences.2024

(12) snRNA-seq of human ovaries reveals heat shock proteins are associated with obesity related cancer risk.Journal of Translational Medicine.2024

(13) CHK1 controls zygote pronuclear envelope breakdown by regulating F-actin through interacting with MICAL3.EMBO Reports.2024

(14) Deciphering the DNA methylome in women with PCOS diagnosed using the new international evidence-based guidelines.Human Reproduction.2023

(15) Novel WEE2 gene variants identified in patients with fertilization failure and female infertility.Fertility and Sterility.2019,111 (3):519

(16) The impact of sleep on in vitro fertilization embryo transfer outcomes: a prospective study.Fertility and Sterility.2023,119 (1):47

(17) Melatonin promotes human oocyte maturation and early embryo development by enhancing clathrin-mediated endocytosis.Journal of Pineal Research.2019

(18) No Association of Polycystic Ovary Syndrome with Pancreatic Cancer: A Mendelian Randomization Study.Phenomics.2024

(19) Deconvolution at the single-cell level reveals ovarian cell-type-specific transcriptomic changes in PCOS.Reproductive Biology and Endocrinology.2024

(20) Association between Pregestational Vaginal Dysbiosis and Incident Hypertensive Disorders of Pregnancy Risk: a Nested Case-Control Study.mSphere.2023

(21) Verification of a ZBTB16 variant in polycystic ovary syndrome patients.Reproductive BioMedicine Online.2020

(22) Effect of Maternal Body Mass Index on the Transcriptomic Network of Human First-Trimester Chorionic Villi.Reprodutive Sciences.2023

(23) PCOS-GWAS Susceptibility Variants in THADA, INSR, TOX3, and DENND1A Are Associated With Metabolic Syndrome or Insulin Resistance in Women With PCOS.Frontiers in Endocrinology.2020

(24) Multiomics Analysis Reveals Molecular Abnormalities in Granulosa Cells of Women With Polycystic Ovary Syndrome.Frontiers in Genetics.2021,12

(25) Growth Hormone Promotes in vitro Maturation of Human Oocytes.Frontiers in Endocrinology.2019

(26) Mitochondrial DNA variations and risk of incident gestational diabetes mellitus: a nested case-control study..Acta Diabetologica.2025

(27) Applications of Melatonin in Female Reproduction in the Context of Oxidative Stress.Oxidative Medicine and Cellular Longevity.2021,2021

(28) An integrated RNA-Seq and network study reveals that valproate inhibited progesterone production in human granulosa cells.Journal of steroid biochemistry and molecular biology.2021

(29) Role of Androgen Receptor for Reconsidering the "True" Polycystic Ovarian Morphology in PCOS.Scientific reports.2020,10 (1)

(30) Variants in the 5'-UTR of APELA gene in women with preeclampsia.Prenatal Diagnosis.2019,39 (4):308

(31) Serum asprosin level in different subtypes of polycystic ovary syndrome: a cross-sectional study.Revista Da Associacao Medica Brasileira.2021,67 (4):590

(32) 重大生殖疾病的分子机制研究.《生命科学》.2017

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