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Education Background
  • 2003-09-01-2007-01-01
    中国海洋大学
    药理学
  • 2000-09-01-2003-06-30
    山东医学科学院
    药物化学
  • 1996-09-01-2000-07-30
    山东中医药大学
    Science of Chinese Pharmacology
  • 1993-09-01-1996-07-01
    栖霞第四中学
Work Experience
  • 2008-07 — Now
    山东大学医学院
Publication
Research direction
Papers

(1)许莹莹. VAR2HP recognizing heparin‐like epitopes in targeted therapy and diagnosis of tumors .Proteoglycan Research .2024 (2)

(2)马大鹏. cGAS suppresses hepatocellular carcinoma independent of its cGAMP synthase activity .Cell Death and Differentiation .2024 (1083):722

(3) Tumor-neutrophil cross talk orchestrates the tumor microenvironment to determine the bladder cancer progression .Proc Natl Acad Sci U. S. A. .2024 ,121 (20)

(4)马大鹏. cGAS suppresses hepatocellular carcinoma independent of its cGAMP synthase activity .Cell Death and Differentiation .2024 (1083)

(5)朱泽萌. 食品安全监管工作、落实情况与满意度的调查研究 .饮食保健 .2018

(6)孙偲瑜. Inhibiting Src-mediated PARP1 tyrosine phosphorylation confers synthetic lethality to PARP1 inhibition in HCC. .Cancer Letters .2022 (1)

(7) cGAS Mediates Inflammation by Polarizing Macrophages to M1 Phenotype via the mTORC1 Pathway .J Immunol .2023 (210)

(8)马小敏. The E3 ubiquitin ligase MG53 inhibits hepatocellular carcinoma by targeting RAC1 signaling. .ONCOGENESIS .2022 (1)

(9)林月轲. TRIM50 promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization. .EMBO Reports .2022 (11)

(10)马小敏. NOD1 inhibits proliferation and enhances response to chemotherapy via suppressing SRC-MAPK pathway in hepatocellular carcinoma .JOURNAL OF MOLECULAR MEDICINE-JMM .2020 ,98 (2):221

(11)荆卫强. Breast cancer cells promote CD169(+) macrophage-associated immunosuppression through JAK2-mediated PD-L1 upregulation on macrophages .《Inter Immunopharmacol》 .2020 ,78

(12)荆卫强. Krill Oil Perturbs Proliferation and Migration of Mouse Colon Cancer Cellsin vitroby Impeding Extracellular Signal-Regulated Protein Kinase Signaling Pathway .Lipids .2021

(13)马小敏. NOD2 inhibits tumorigenesis and increases chemosensitivity of hepatocellular carcinoma by targeting AMPK pathway .Cell Death & Disease .2020 ,11 (3)

(14)王文爽. Assembling custom side chains on proteoglycans to interrogate their function in living cells .NATURE COMMUNICATIONS .2020 ,11 (1)

(15)朱礼慧. The E3 ubiquitin ligase TRIM7 suppressed hepatocellular carcinoma progression by directly targeting Src protein .Cell Death and Differentiation .2020 ,27 (6):1819

(16)赵云雪. G-CSF shifts erythropoiesis from bone marrow into spleen in the setting of systemic inflammation .Life Science Alliance .2020 (1)

(17)马大鹏. Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response .科学前沿 .2021 ,7 (13)

(18)荆卫强. Breast cancer cells promote CD169 + macrophage-associated immunosuppression through JAK2-mediated PD-L1 upregulation on macrophages .INTERNATIONAL IMMUNOPHARMACOLOGY .2020 (78)

(19)Han Lihui. The E3 ubiquitin ligase TRIM7 suppressed hepatocellular carcinoma progression by directly targeting Src protein. .Cell Death and Differentiation .2020

(20)Han Lihui. NOD2 inhibits tumorigenesis and increases chemosensitivity of hepatocellular carcinoma by targeting AMPK pathway. .Cell Death & Disease .2020

(21)Han Lihui. NOD1 inhibits proliferation and enhances response to chemotherapy via suppressing SRC-MAPK pathway in hepatocellular carcinoma. .J Mol Med (Berl) .2020

(22)Han Lihui. TRIM50 suppressed hepatocarcinoma progression through directly targeting SNAIL for ubiquitous degradation. .Cell Death & Disease .2018

(23)邱驭旻. TRIM50 acts as a novel Src suppressor and inhibits ovarian cancer progression .BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH .2019 ,1866 (9):1412

(24)刘敏. Macrophages Support Splenic Erythropoiesis in 4T1 Tumor-Bearing Mice .PLoS ONE. .2015 ,10 (3):121921

(25)金星. In vitro and in vivo anticancer effects of singly protonated dehydronorcantharidin silver coordination polymer in CT-26 murine colon carcinoma model. .BIOORGANIC & MEDICINAL CHEMISTRY LETTERS .2015 ,25 (20):4477

(26)荆卫强. G-CSF mediates lung injury in mice with adenine-induced acute kidney injury .International Immunopharmacology .2018 ,63 :1

(27)荆卫强. Targeting macrophages for cancer therapy disrupts bone homeostasis and impairs bone marrow erythropoiesis in mice bearing Lewis lung carcinoma tumors .Cellular Immunology .2018 ,331 :168

(28)张岫美. Effects of oridonin nanosuspension on cell proliferation and apoptosis of human prostatic carcinoma PC-3 cell line .INTERNATIONAL JOURNAL OF NANOMEDICINE .2010 ,5 (0):735

(29)赵云雪. Macrophages Support Splenic Erythropoiesis in 4T1 Tumor-Bearing Mice .PLoS ONE. .2015 ,10 (3):e0121921

(30)赵云雪. In vitro and in vivo anticancer effects of singly protonated dehydronorcantharidin silver coordination polymer in CT-26 murine colon carcinoma model. .BIOORGANIC & MEDICINAL CHEMISTRY LETTERS .2015 ,25 (20):4477

(31)赵云雪. Singly protonated dehydronorcantharidin silver coordination polymer induces apoptosis of lung cancer cells via reactive oxygen species-mediated mitochondrial pathway .EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY .2014 ,86 :1

(32)赵云雪. 紫杉醇载药体系及其抗肿瘤活性和临床应用 .《生物物理学报》 .2012 ,28 (3):200

(33)赵云雪. Gold nanoparticles trigger apoptosis and necrosis in lung cancer cells with low intracellular glutathione .Journal of nanoparticle research .2013 ,15 (8):1

(34)孙霞. Hydroxysafflor Yellow A suppresses thrombin generation and inflammatoryresponses following focal cerebral ischemia–reperfusion in rats .BIOORGANIC & MEDICINAL CHEMISTRY LETTERS .2010 ,20 (14):4120

(35)张岫美. Effects of oridonin nanosuspension on cell proliferation and apoptosis of human prostatic carcinoma PC-3 cell line .INTERNATIONAL JOURNAL OF NANOMEDICINE .2010 ,5 (0):735

(36)孙霞. Hydroxysafflor Yellow A suppresses thrombin generation and inflammatoryresponses following focal cerebral ischemia–reperfusion in rats .BIOORGANIC & MEDICINAL CHEMISTRY LETTERS .2010 ,20 (14):4120

(37)荆卫强. G-CSF mediates lung injury in mice with adenine-induced acute kidney injury .International Immunopharmacology .2018 ,63 :1

(38)荆卫强. Targeting macrophages for cancer therapy disrupts bone homeostasis and impairs bone marrow erythropoiesis in mice bearing Lewis lung carcinoma tumors .Cellular Immunology .2018 ,331 :168

(39)张岫美. Effects of oridonin nanosuspension on cell proliferation and apoptosis of human prostatic carcinoma PC-3 cell line .INTERNATIONAL JOURNAL OF NANOMEDICINE .2010 ,5 (0):735

(40)孙霞. Hydroxysafflor Yellow A suppresses thrombin generation and inflammatoryresponses following focal cerebral ischemia–reperfusion in rats .BIOORGANIC & MEDICINAL CHEMISTRY LETTERS .2010 ,20 (14):4120

(41)赵云雪. Macrophages Support Splenic Erythropoiesis in 4T1 Tumor-Bearing Mice .PLoS ONE. .2015 ,10 (3):e0121921

(42)赵云雪. In vitro and in vivo anticancer effects of singly protonated dehydronorcantharidin silver coordination polymer in CT-26 murine colon carcinoma model. .BIOORGANIC & MEDICINAL CHEMISTRY LETTERS .2015 ,25 (20):4477

(43)赵云雪. Singly protonated dehydronorcantharidin silver coordination polymer induces apoptosis of lung cancer cells via reactive oxygen species-mediated mitochondrial pathway .EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY .2014 ,86 :1

(44)赵云雪. Gold nanoparticles trigger apoptosis and necrosis in lung cancer cells with low intracellular glutathione .Journal of nanoparticle research .2013 ,15 (8):1

(45)赵云雪. 紫杉醇载药体系及其抗肿瘤活性和临床应用 .《生物物理学报》 .2012 ,28 (3):200

Patents
Research Projects

1. 中性粒细胞外泌体靶向纳米颗粒抗乳腺癌活性研究, 2025-04-11-2028-04-11

2. 红景天苷防治高原反应研究与开发, 2023-01-17-2026-01-17

3. 基于高通量拉曼流式细胞分选仪对人外周血免疫细胞进行检测和分选的技术研发, 2022-09-26-2025-09-25

4. 组蛋白去乙酰化酶10对cGAS介导的抗病毒天然免疫反应的调控效应与分子机制, 2021-10-12-2025-12-31

5. 南极磷虾油-紫杉醇和多西紫杉醇纳米载药体系抗肿瘤活性及其机制研究, 2020-08-25-2022-12-31

6. 二甲硅油粉雾剂研究的药效学评价研究, 2019-09-12-2021-12-31

7. 岩白菜素代谢产物的分离鉴定及对GABA受体作用机制研究, 2011-07-01-2014-12-31

8. 新型AT1受体拮抗剂EXP-2528对AngⅡ诱导脑缺血-再灌注损伤中凝血酶表达的影, 2010-11-01-2013-11-01

9. 南极磷虾油肿瘤患者康复全营养配方食品的生物功能评价及配方工艺优化, 2018-11-20-2020-12-31

10. 基于卵巢癌微环境关键靶点,应用新型纳米材料进行微创高效肿瘤精准治疗的转化医学研究, 2017-01-01-2019-12-01

11. 基于c-Met抑制剂的肿瘤免疫微环境粒细胞靶向重塑效应及个性化治疗研究, 2017-01-01-2019-12-31

12. RGD靶向多肽-紫杉醇纳米粒子抗卵巢癌活性及其机制研究, 2016-09-01-2018-12-31

13. 壁虎小肽抑制血管生成活性及其作用机制研究, 2009-09-01-2011-12-31

14. 生长激素抑制素类似物Cv-1-119抑制血管生成活性及作用机制的研究, 2009-09-01-2011-09-30

15. 抑制细胞谷胱甘肽表达靶向金纳米粒子载药体系抗肿瘤活性及机制研究, 2012-01-01-2014-12-31

16. 多孔金纳米颗粒作为抗癌药阿霉素载体逆转肿瘤细胞耐药性的基础研究, 2010-11-01-2013-11-01

17. 生长激素抑制素(Somatostatin)类似物Cv-1-119的抗血管生成作用及其作用机, 2009-11-01-2011-11-30

Student Information
  • 熊高中  2025-10-15 Hits:[] Times
  • 金星  2025-10-15 Hits:[] Times
  • 刘雪梅  2025-10-15 Hits:[] Times
  • 曹洋  2025-10-15 Hits:[] Times
  • 李馨媛  2025-10-15 Hits:[] Times
  • 李秀秀  2025-10-15 Hits:[] Times
  • 毕玉璇  2025-10-15 Hits:[] Times
  • 郭欢欢  2025-10-15 Hits:[] Times
  • 郭兴  2025-10-15 Hits:[] Times
  • 李馨媛  2023-09-23 Hits:[] Times
  • 熊高中  2020-08-07 Hits:[] Times
  • 郭欢欢  2020-03-20 Hits:[] Times
  • 毕玉璇  2019-04-18 Hits:[] Times
  • 郭兴  2019-04-18 Hits:[] Times
  • 李秀秀  2019-04-18 Hits:[] Times
  • 金星  2019-04-17 Hits:[] Times
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