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个人信息Personal Information
教授 博士生导师 硕士生导师
任职 : Aging，Cancer，Cancer Genetics，Oncology Letters，General Physiology and Biophysics ，Experimental and Therapeutic Medicine，Food & Function, Psychosomatic Medicine Research(Section Editor), Current Pharmaceutical Biotechnology, 赣南医学院学报, 中国生物工程杂志，解剖科学进展
性别：男
毕业院校：清华大学
学历：研究生(博士)毕业
学位：博士生
在职信息：在职
所在单位：基础医学院
入职时间：2021-01-27
学科：遗传学
发育生物学
生物化学与分子生物学
办公地点：山东大学趵突泉校区电镜楼209
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研究领域
实验室将主要通过模式生物的正向（EMS诱变）以及反向遗传学方法（RNAi文库筛选与CRISPR/Cas9基因组靶向编辑），筛选与鉴定组织纤维化疾病和神经退行性疾病的关键调控分子。采用多维活体显微成像、 Chip-seq和酵母双杂交等技术，系统分析这些调控因子在生物体细胞外基质（extracellular matrix，ECM）重塑和神经细胞退化过程中的亚细胞定位和动态变化，明确其在体功能及其分子调控机制。结合线虫遗传学体系以及细胞与小鼠模型，验证调控因子的功能，揭示生物体细胞外基质重塑和神经细胞退化的分子调控网络。
- Nanxuan Luo, Yijie Xiao, 翟义乐, Jie Li, Lijie Lv, Houhua Yin, Fang Lin, Biwen Wan, Ke Zhang, Junchi Hu, Junyan Liu, Yongjun Dang, Yi He, Yahui Zhao, 张哲, Shenyou Nie and Haixin Yuan. Vitamin A and its analogues modulate MUFAs metabolism to improve ferroptosis and aging by direct targeting of ACSL3. Acta Pharmaceutica Sinica B, 2025.
- . Comparison of epidemiological characteristics and transmissibility of different strains of COVID-19 based on the incidence data of all local outbreaks in China as of March 1, 2022. Frontiers in Public Health, 10, 949594, 2022.
- 张哲*, Shuo Luo, Guilherme Oliveira Barbosa, Meirong Bai, Thomas B Kornberg and Dengke Ma*. The conserved transmembrane protein TMEM-39 coordinates with COPII to promote collagen secretion and regulate ER stress response. PLoS Genetics, 2021.
- 张哲, Meirong Bai, Guilherme Oliveira Barbosa, Yuehua Wei, Andrew Chen, Shuo Luo, Xin Wang, Bingying Wang, Tatsuya Tsukui, Hao Li, Dean Sheppard, Thomas B Kornberg and Dengke K Ma*. Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking. Science Advances, 2020.
- Pei Zhao#, 张哲#, Hongmei Ke, Yiren Yue and Ding Xue*. Oligonucleotide-based targeted gene editing in C. elegans via the CRISPR/Cas9 system. Cell research, 2014.
- Pei Zhao#, 张哲#, Xiaoying Lv, Xiang Zhao, Yuji Suehiro, Yinan Jiang, Xinquan Wang, Shohei Mitani, Haipeng Gong and Ding Xue*. One-step homozygosity in precise gene editing by an improved CRISPR/Cas9 system. Cell research, 2016.
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