Runping Fang
Professor
Based on research experience, my interests are, 1. Investigating the mechanisms of tumor progression; 2. Identifying biomarkers and druggable targets in cancer; 3. Translating bench-side science into early diagnostics and therapeutics that could benefit patients. More+
Scientific Research
Working-Papers
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Epigenetic regulation of glioblastoma;
Molecular mechanisms of breast cancer metastasis;
Discovery of biomarkers and druggable targets in glioblastoma and breast carcinoma.
Paper Publications
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Runping Fang, Lihong Ye and Hui Shi. Understanding the roles of N6-methyladenosine writers, readers and erasers in breast cancer. Neoplasia, 23, 551-560, 2021.
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Runping Fang, Xin Chen, Sicong Zhang, Hui Shi, Youqiong Ye, Hailing Shi, Zhongyu Zou, Peng Li, Qing Guo, Li Ma, Chuan He and Suyun Huang. EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma. Nature Communications, 12, 177, 2021.
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Runping Fang, Feifei Xu, Hui Shi, Yue Wu, Can Cao, Hang Li, Ke Ye, Yingyi Zhang, Qian Liu, Shuqin Zhang, Weiying Zhang and Lihong Ye. LAMTOR5 raises abnormal initiation of O-glycosylation in breast cancer metastasis via modulating GALNT1 activity. Oncogene, 39, 2290-2304, 2020.
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Yaohui Chen, Runping Fang, Chen Yue, Guoqiang Chang, Peng Li, Qing Guo, Jing Wang, Aidong Zhou, Sicong Zhang, Gregory N. Fuller, Xiaobing Shi and Suyun Huang. Wnt-Induced Stabilization of KDM4C Is Required for Wnt/beta-Catenin Target Gene Expression and Glioblastoma Tumorigenesis. Cancer Research, 80, 1049-1063, 2020.
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Yue Wang, Runping Fang, Ming Cui, Weiying Zhang, Xiao Bai, Huawei Wang, Bowen Liu, Xiaodong Zhang and Lihong Ye. The oncoprotein HBXIP up-regulates YAP through activation of transcription factor c-Myb to promote growth of liver cancer. Cancer Letters, 385, 234-242, 2017.
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Leilei Li, Runping Fang, Bowen Liu, Hui Shi, Yue Wang, Weiying Zhang, Xiaodong Zhang and Lihong Ye. Deacetylation of tumor-suppressor MST1 in Hippo pathway induces its degradation through HBXIP-elevated HDAC6 in promotion of breast cancer growth. Oncogene, 35, 4048-57, 2016.
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Runping Fang, Qingxin Cui, Jixue Sun, Xixi Duan, Xiaoyao Ma, Weiya Wang, Binfeng Cheng, Yang Liu, Yuanyuan Hou and Gang Bai. PDK1/Akt/PDE4D axis identified as a target for asthma remedy synergistic with beta2 AR agonists by a natural agent arctigenin. Allergy, 70, 1622-32, 2015.
Published Books
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Research Projects
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（包干项目）蛋白G3BP1与PKR通过结合YTH家族蛋白调控m6A修饰促进胶质母细胞瘤进展的分子机制, 2024-01-01-2026-12-31
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（包干项目）m6A识别蛋白YTHDF2调控胶质母细胞瘤应激适应的分子机制, 2023-08-24-2026-12-31
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（包干项目）RNA修饰促癌新机制与化学干预, 2023-01-01-2025-12-31
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Research and innovation project for doctoral students of Nankai University, key project, 2016-01-01-2016-12-31
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Qilu Young Scholars of Shandong University, 2021-12-09-2026-12-08
Research Team
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