• 2005/09/01-2011/06/30
  Shandong University, China
  Microbiology
• 2010/01/10-2011/01/09
  Max Planck Institute for Terrestrial Microbiology
  Microbiology
• 2001/09/01-2005/06/30
  Shandong University, China
  Biology

• 2019-03 — 2024-07
  School of Life SciencesShandong University, China
  Professor
• 2017-05 — 2019-03
  MRC Protein Phosphorylation and Ubiquitylation Unit, UK
  Senior Research Associate
• 2011-09 — 2017-05
  The Centre for Gene Regulation and ExpressionUniversity of Dundee, UK
  Research Associate

1. The mechanism of maintaining genomic stability in oocytes and early embryos

(1)Yang Y. COSA-1 mediated pro-crossover complex formation promotes meiotic crossing over in C. elegans .Nucleic Acids Research .2024

(2)Arome Solomon Odiba. SMC-5/6 complex subunit NSE-1 plays a crucial role in meiosis and DNA repair in Caenorhabditis elegans .DNA repair .2024

(3)Xia Y,Sonneville R,Jenkyn-Bedford M. DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in Caenorhabditis elegans .Science .2023 (6664)

(4)Arome Solomon Odiba. Caenorhabditis elegans NSE3 homolog (MAGE-1) is involved in genome stability and acts in inter-sister recombination during meiosis .Genetics .2023

(5) The Last Chance Saloon .Frontiers in Cell and Developmental Biology .2021 ,9

(6)Hong Y. The conserved LEM-3/Ankle1 nuclease is involved in meiotic recombination and chromosome segregation in Caenorhabditis elegans .PLOS Genetics .2018 ,14 (6)

(7)Hong Y. LEM-3 is a midbody- tethered DNA nuclease that resolves chromatin bridges during late mitosis .Nature Communications .2018 ,9 (728)

(8)Bettina Meier,Nadezda V Volkova. Mutational signatures of DNA mismatch repair deficiency in C. elegans and human cancers .Genome Research .2018

(9)Hong Y. The SMC-5/6 complex and the HIM-6 (BLM) helicase synergistically promote meiotic recombination intermediate processing and chromosome maturation during C. elegans meiosis .PLOS Genetics .2016

(10)Adam Shlien. Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers .Nature Genetics .2015

1. Mechanism of metazoan replisome in the establishment of meiotic sister chromatid cohesion, 2024/08/26-2028/12/31

2. Mechanism and functional analysis of replication-coupled histone processing by a metazoan replisome, 2024/01/01-2026/12/31

3. Biochemical and in vivo functional characterization of LEM-3 nuclease, 2019/08/16-2022/12/31