Cui-jie Kang    Professor and PhD director       cjkang@sdu.edu.cn

I graduated from Shandong University with a PhD degree in zoology. Then, and then stayed in the university to teach as a lecturer, associate professor and professor.From 2010.11 to 2011.11, i worked as visiting scholar in University of Missouri, USA, and 2007.03-2007.08,  worked asvisiting scholar in Yonsei University School of Medicine, South Korea. I am also worked as the secretary of Shandong Zoological Society,executive director and the editorial board member of journal of biology. The laboratory has been recruiting master, doctoral and postdoctoral personnel for a long time, the treatment is favourable, welcome to contact.

Research Direction 

1. signal transduction pathway and molecular mechanism of animal innate immunity 

2. application development of animal immunity-related active substances

3.  innate immunity effector gene function research

 Chairing projects (2011-present)    

1. National Natural Science Foundation of China (NSFC): Mechanism and Functional Conservativeness Analysis of Ubiquitinated ECSIT-Mediated Very Early Gene Transcription of WSSV, 2024.01-2027.12, in progress, presided over

2. Natural Science Foundation of Shandong Province (NSF-SD): Functional Identification and Mechanism Analysis of an alarmin Protein in Shrimp in Antiviral Immunity. 2023.01-2025.12, under research, presided over

3. Sub-theme of National Key R&D Programme: Functional identification and regulatory mechanism investigation of key genes for disease resistance in Penaeus japonicus, 2018.12-2022.12, completed, presided over.

4. National Natural Science Foundation of China (NSFC): molecular mechanism of 2-Cys peroxiredoxin in shrimp antiviral immune response, 2016.01-2019.12, completed, presided.

5. National Natural Science Foundation of China (NSFC): Role and Functional Analysis of ECSIT and Syntenin Genes in Innate Immunity and Developmental Signalling Pathways of Shrimp , 2013.01-2016.12, completed, presided over.

6. National Natural Science Foundation of China (NSFC) Youth Project: Expression and Functional Analysis of Shrimp Immunity-Related Genes in the Reproductive System, 2009.01-2011.12, completed and chaired.

7. Independent Innovation Fund of Shandong University: Functions and Applications of Immunity-related Active Substances from Marine Biological Sources, 2012.01-2014.12, completed, chairperson.

 8.  Shandong Outstanding Young and Middle-aged Incentive Fund: Cloning and Functional Study of Immunity-related Genes in the Reproductive System of Shrimp, 2009.01-2011.12, completed, chairperson. 

Representative publications   （2013—today）    Corresponding author*

1. Ran XQ, Gao L, Yan M, Kang CJ*. Peroxiredoxin 4 Interacts With Domeless and Participates in Antibacterial Immune Response Through the JAK/STAT Pathway. Front Immunol. 2022 May 26;13:907183.

2. Ding D, Sun XJ, Yan M, Chen Q, Gao L, Kang CJ*.The ECSIT Mediated Toll3-Dorsal-ALFs Pathway Inhibits Bacterial Amplification in Kuruma Shrimp. Front Immunol. 2022 Jan 31;13:807326.

3. Guo NN, Sun XJ, Xie YK, Yang GW, Kang CJ*. Cloning and functional characterization of thioredoxin gene from kuruma shrimp Marsupenaeus japonicus. Fish Shellfish Immunol. 2019 Mar;86:429-435.  

4.  Liu ZQ, Liu Y, Gu Y, Gao LL, Li A, Liu DW*, Kang CJ*, Pang QX*, Wang XQ, Han Q, Yu HR. Met-enkephalin inhibits ROS production through Wnt/β-catenin signaling in the ZF4 cells of zebrash. Fish Shellfish Immunol. 2019 May;88432-88440

5. Xia WL, Kang LH, Liu CB, Kang CJ*. Death associated protein 1 (DAP 1)positively regulates virus replication and apoptosis of hemocytes in shrimp Marsupenaeus japonicus. Fish Shellfish Immunol. 2017Apr;63:304-313.  

6：Xie YK, Ding D, Wang HM, Kang CJ*. A homologue gene of β-catenin participatesin the development of shrimps and immune response to bacteria and viruses. Fish Shellfish Immunol. 2015 Nov;47(1):147-156.

7：Liu Q, Chen XW, Che CJ, Ding D, Kang CJ*. Syntenin is involved in the bacteria clearance response of kuruma shrimp (Marsupenaeus japonicus). Fish Shellfish Immunol. 2015 Jun;44(2):453-461.

8：Shi XZ¹, Kang CJ¹, Wang SJ, Zhong X, Beerntsen BT, Yu XQ. Functions of Armigeres subalbatus C-type lectins in innate immunity. Insect Biochem Mol Biol. 2014 Sep;52:102-114.

9：Ding D, Chen XW, Kang LH, Jiang HS, Kang CJ*. Role of evolutionarily conserved signaling intermediate in Toll pathways (ECSIT) in the antibacterial immunity of Marsupenaeus japonicus. Dev Comp Immunol. 2014 Oct;46(2): 246-254.

10：Chen XW, Kang LH, Ding D, Liu Q, Wang JX, Kang CJ*. Characterization of a 2-Cys peroxiredoxin IV in Marsupenaeus japonicus (kuruma shrimp) and its role in the anti-viral immunity. Fish Shellfish Immunol. 2013 Dec;35(6):1848-1857.

Patents

1. TLK protein and its application in breeding antiviral strains of shrimps and crabs, 2021 Patent No.: ZL201811584949.5

2. A shrimp protein with antiviral activity and its application, 2015 Patent No.: ZL201310376612.6

3. Application of small peptide A with bacteriostatic and anticancer effects, 2011 Patent No.: ZL200910018759.1

4. Application of small peptide B with antibacterial and anticancer effects, 2011 Patent No.: ZL200910018758.7

5. Application of small peptide C with antibacterial and anticancer effects, 2011 Patent No.: ZL200910018757.2

6. Application of small peptide D with antibacterial and anticancer effects and its application, 2011 Patent No.: ZL201310376612.

Award

1. Wang Jinxing, Zhao Xiaofan, Kang Cuijie. Mechanism of innate immune defence against bacteria and viruses in shrimp. 2011. Outstanding Achievement Award for Scientific Research in Colleges and Universities under the Ministry of Education  (Natural Science Award, First Prize).