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    刘磊

    • 教授 博士生导师 硕士生导师
    • 性别:男
    • 毕业院校:匹兹堡大学
    • 学历:博士研究生毕业
    • 学位:博士
    • 在职信息:在职
    • 所在单位:化学与化工学院
    • 入职时间: 2012-06-04
    • 办公地点:中心校区老数学楼113
    • 联系方式:0531-88363010
    • 电子邮箱:

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    个人简介:

    刘磊,男,1981年11月生,教授、博士生导师

    入选国家优青、教育部新世纪优秀人才、山东省杰青、山东大学齐鲁青年学者


    研究方向:课题组长期从事有机合成和药物化学研究,主要研究兴趣为不对称催化与合成、活性天然产物的全合成、抗肿瘤活性分子的发现。


    联系电话:0531-88363010

    邮箱:leiliu@sdu.edu.cn

    地址:山东省济南市历城区山大南路27号山东大学老数学楼113

    课题组主页:http://leiliugroup.com


    学习及工作经历】

    教育经历:

    2006.08-2011.03         美国匹兹堡大学  博士   导师:Paul E. Floreancig 教授

    2003.09-2006.06         兰州大学        硕士   导师:王锐 院士

    1999.09-2003.06         兰州大学        学士   导师:王锐 院士


    工作经历:

    2012.06-至今            山东大学        教授、博士生导师

    2011.03-2012.04         美国哈佛大学    博士后  导师:Yoshito Kishi 教授


    【主讲课程】

    《有机化学》(本科生)



    【研究领域和兴趣】

    (1)不对称催化与合成:基于氧化反应的不对称合成策略研究

    (2)活性天然产物的全合成及构效关系研究

    (3)药物化学:具有生物活性的小分子试剂的设计和发现研究


    【科研项目】

    在研项目

    国家优秀青年基金           2018-2021   负责人

    霍英东青年教师基金         2016-2019   负责人

    国家自然科学基金面上项目   2015-2018   负责人

    广西师大国重室开放基金     2016-2018   负责人


    结题项目

    山东省“杰出青年基金”     2015-2017   负责人

    深圳市科技计划项目         2015-2017   负责人

    山东大学交叉学科培育基金   2015-2017   负责人

    教育部“新世纪优秀人才”   2014-2016   负责人

    “齐鲁青年学者”启动经费   2012-2016   负责人

    国家自然科学基金青年项目   2013-2015   负责人

    山东省优秀中青年科学家科研奖励基金  2013-2015   负责人


    人才计划和获奖情况

    国家基金委优秀青年基金(2017)

    霍英东教育基金奖励(2016)

    Thieme Chemistry Journal Award (2016)

    山东省自然科学基金“杰出青年基金”(2014)

    教育部“新世纪优秀人才”(2013

    “齐鲁青年学者”(2012

    国家优秀自费留学生奖学金(中国驻纽约总领事馆)(2010)

    中国科学院奖学金(2005



    【主要论著】

    山东大学独立研究工作

    2019年

    38. Catalytic enantioselective oxidative coupling of saturated ethers with carboxylic acid derivatives. Wang, G.; Xin, X.; Wang, Z.; Lu, G.; Ma, Y.; Liu, L.* Nature Commun. 10.1038/s41467-019-08473-x.


    2018年

    37. Three-component oxyarylation of alkenes enables access to C3-substituted dihydrobenzofurans. Feng, G.; Sun, S.; Liu, G.; Long, H.; Liu, L.* Org. Lett. 201820, 7522. (Top 20 most downloaded article for Nov 2018)

    36. Metal-free three-component oxyalkynylation of alkenes. Li, Y.; Lu, R.; Sun, S.; Liu, L.Org. Lett. 201820, 6836.

    35. Catalytic asymmetric cross-dehydrogenative coupling of 2H-chromenes and aldehydes. Pan, X.; Liu, X.; Sun, S.; Meng, Z.; Liu, L.Chin. J. Chem. 201836, 1187. (Dedicated to Professor Xiyan Lu on the occasion of his 90th birthday)

    34. Iron(II)-catalyzed site-selective functionalization of unactivated C-H bonds guided by alkoxyl radical. Guan, H.; Sun, S.; Mao, Y.; Chen, L.; Lu, R.; Huang, J.; Liu, L.* Angew. Chem. Int. Ed. 2018, 57, 11413.

    33. Copper-catalyzed oxidative cross-dehydrogenative coupling of 2H-chromenes and terminal alkynes. Yang, F.; Li, Y.; Floreancig, P. E.*; Li, X.*; Liu, L.Org. Biomol. Chem. 201816, 5144.

    32. 饱和开链醚的氧化碳氢炔基化研究. Guan, H.; Chen, L.; Liu, L.Acta Chimica Sinica 201876, 440(invited contribution)

    31. Redox deracemization of 1,3,4,9-tetrahydropyrano[3,4-b]indoles. Lu, R.; Li, Y.; Zhao, J.; Li, J.; Wang, S.; Liu, L.* Chem. Commun. 2018, 54, 4445.

    30. Direct Oxidative C-H Alkynylation of N-Carbamoyl Tetrahydroisoquinolines and Dihydroisoquinolines. Chen, L.; Sun, C.; Feng, G.; Cao, M.; Zhao, S.; Yan, J.; Wan, R.*; Liu, L.* Org. Biomol. Chem. 2018, 16, 2792.

    29.  A novel tetrahydroisoquinoline (THIQ) analogue induces mitochondria-dependent Apoptosis. Sun, X.; Liu, M.; Gao, L.; Mao, Y.; Zhao, D.; Zhang, J.; Liu, L.Eur. J. Med. Chem. 2018150, 719.

    28. Efficient Access to Chiral Benzo[c]chromenes via Asymmetric Transfer Hydrogenation of Ketals. Li, Y.; Wan, M.; Sun, S.; Fu, Z.; Huang, H.; Liu, L.Org. Chem. Front. 2018, 5, 1280.


    2017年

    27. Oxidative C-H functionalization of N-carbamoyl 1,2-Dihydroquinolines. Liu, Z.; Chen, L.; Li, J.; Liu, K.; Zhao, J.; Xu, M.; Feng, L.; Wan, R.; Li, W.; Liu, L.* Org. Biomol. Chem. 2017, 15, 7600.

    26. Regio- and Diastereoselective Cross-Dehydrogenative Coupling of Tetrahydropyridines with 1,3-Dicarbonyl Compounds. Long, H.; Wang, G.; Lu, R.; Xu, M.; Zhang, K.; Qi, S.; He, Y.; Bu, Y.; Liu, L.* Org. Lett. 201719, 2146.

    25. Organocatalytic Redox Deracemization of Cyclic Benzylic Ethers Enabled by An "Acetal Pool" Strategy. Wan, M.; Shu, S.; Li, Y.; Liu, L.* Angew. Chem. Int. Ed. 2017, 56, 5116.


    2016年

    24. Wang, G.; Mao, Y.; Liu, L.Diastereoselectively Complementary C-H Functionalization Enables Access to Structurally and Stereochemically Diverse 2,6-Substituted Piperidines. Org. Lett. 2016,18, 6476.

    23. Wang, G.; Sun, S.; Mao, Y.; Xie, Z.; Liu, L.* Chromium (II) Catalyzed Enantioselective Arylation of Ketones. Beilstein. J. Org. Chem. 2016, 12, 2771. (Invited by Professor Tehshik P Yoon for Thematic Series "Strategies in Asymmetric Synthesis")

    22. Sun, Y.; Wang, G.; Chen, J.; Liu, C.; Cai, M.; Zhu, R.*; Huang, H.*; Li, W.*; Liu, L.A Practical Oxidative C-H Functionalization of N-Carbamoyl Tetrahydro-beta-Carbolines with Diverse Potassium Trifluoroborates. Org. Biomol. Chem. 201614, 9431.

    21. Xie, Z.; Zan, X.; Sun, S.; Pan, X.; Liu, L.* Organocatalytic Enantioselective Cross-Dehydrogenative Coupling of N-Carbamoyl Cyclic Amines with Aldehydes. Org. Lett. 201618, 3944.  

    20. Xie, Z.; Liu, X.; Liu, L.* Copper-Catalyzed Aerobic Enantioselective Cross-Dehydrogenative Coupling of N-Aryl Glycine Esters with Terminal Alkynes. Org. Lett. 2016, 18, 2982. (Highlight by Synfacts)

    19. Sun, S.; Liu, L.* Catalytic Enantioselective Alkynylation of Tetrahydroisoquinoline-Based N-Acyl Hemiaminals. Synthesis 201648, 2627 (Invited for specific topic "Asymmetric Synthesis" by Erick Carreira)

    18. Xie, Z.; Jia, J.; Liu, X.; Liu, L.* Copper(II) Triflate-Catalyzed Aerobic Oxidative C-H Functionalization of Glycine Derivatives with Olefins and Organoboranes. Adv. Synth. Catal. 2016358, 919.  

    17. Liu, G.; Qian, J.; Hua, J.; Cai, F.; Li, X.; Liu, L.* An Economical Synthesis of Substituted Quinoline-2-Carboxylates through the Potassium Persulfate-Mediated Cross-Dehydrogenative Coupling of N-Aryl Glycine Derivatives with Olefins. Org. Biomol. Chem. 201614, 1147.


    2015年

    16. Chen.J.; Wan, M.; Hua, J.; Sun, Y.; Lv, Z.; Li, W.*; Liu, L.* TBHP/TFA Mediated Oxidative Cross-Dehydrogenative Coupling of N-Heterocycles with Aldehydes. Org. Biomol. Chem. 201513, 11561. (Highlight by Synfacts)

    15. Wan, M.; Lou,H.; Liu, L.* C1-Benzyl and benzoyl isoquinoline synthesis throughdirect oxidative cross-dehydrogenative coupling with methyl arenes. Chem. Commun. 201551, 13953. (Highlight by Synfacts)  

    14. Sun, S.; Mao,Y.; Lou, H.; Liu, L.* Copper(II)/amine synergisticallycatalyzed enantioselective alkylation of cyclic N-acyl hemiaminals withaldehydes. Chem. Commun. 201551, 10691.

    13. Liu, X.; Sun,S.; Meng, Z.; Lou, H.; Liu, L.* Organocatalytic asymmetricC-H vinylation and arylation of N-acyl tetrahydroisoquinolines. Org. Lett. 201517, 2396. (Top 20 most downloaded article for May2015)

    12. Li, F.; Meng,Z.; Hua, J.; Li, W.; Lou, H.; Liu, L.* Indium-catalyzedoxidative cross-dehydrogenative coupling of chromenes with 1,3-dicarbonyls andaryl rings. Org. Biomol. Chem201513, 5710.

    11. Sun, S.; Li,C.; Floreancig, P. E.; Lou, H.; Liu, L.* Highly enantioselectivecatalytic cross-dehydrogenative coupling of N-carbamoyl tetrahydro isoquino-lines and terminal alkynes. Org. Lett. 201517, 1684.(Highlight by Synfacts)

    10. Liu, X.;Meng, Z.; Li, C.; Lou, H.; Liu, L.* OrganocatalyticEnantioselective Oxidative C-H Alkenylation and Arylation of N-CarbamoylTetrahydropyridines and Tetrahydro-β-Carbolines. Angew. Chem. Int. Ed. 201554,6012. (Highlight by Synfacts)


    2014年

    9. Chen, W.;Xie, Z.; Zheng, H.; Lou, H.*; Liu, L.* Structurally Diverseα-Substituted Benzopyran Synthesis through A Practical Metal-Free C(sp3)-HFunctionalization. Org. Lett. 201416, 5988.

    8. Sun, S.; Yang,J.; Li, F.; Lv, Z.; Li, W.*; Lou, H.*; Liu, L.* Seven- and Eight-MemberedHeterocyclic Biaryl Synthesis through A Metal-Free Oxidative Coupling Reaction.Tetrahedron Lett. 201455, 6899.

    7. Wan, M.; Meng,Z.; Lou, H.; Liu, L.* Practical and Highly Selective C-H Functionalizationof Structurally Diverse Ethers. Angew. Chem. Int. Ed. 201453,13845. (Selected as “hot paper” by Angew Chem)

    6. Yang, J.; Sun, S.; Zeng, Z.; Zheng, H.; Lou, H.; Liu, L.* Aneconomic and Environmentally Friendly Oxidative Biaryl Coupling Promoted byActivated MnO2Org. Biomol. Chem. 201412,7774.

    5. Pan, X. H.;Hu, Q. W.; Chen, W. F.; Liu, X. G.; Sun, B.; Huang, Z. L.; Zeng, Z. Y.; Wang,L. G.; Zhao, D.; Ji, M.; Liu, L.*; Lou, H.* Copper(II) CatalyzedCross-Dehydrogenative Coupling of Cyclic Benzylic Ethers with Simple Carbonyl Compoundsby Na2S2O8Tetrahedron 201470,3447.

    4. Chen, W. F.;Zheng, H. B.; Pan, X. H.; Xie, Z. Y.; Zan, X.; Sun, B.; Liu, L.*;Lou, H.* A Metal-Free Cross-Dehydrogenative Coupling of N-Carbamoyl Tetrahydroispquinolineby Sodium Persulfate. Tetrahedron Lett. 201455, 2879.

    3. Xie, Z. Y.; Liu,L.*; Chen, W. F.; Zheng, H. B.; Xu, Q. Q.; Yuan, H. Q.; Lou, H.* PracticalMetal-Free C(sp3)-H Functionalization: Construction of Structurally Diverse a-SubstitutedN-Benzyl and N-Allyl Carbamates. Angew. Chem. Int. Ed. 201453,3904. (Highlight by Chinese J Org Chem)

    2. Meng, Z. L.; Sun, S. T.; Yuan, H. Q.; Lou, H. X.*; Liu, L.Catalytic Enantioselective Oxidative Cross-Coupling of Benzylic Ethers withAldehydes. Angew. Chem. Int. Ed. 201453, 543. (selectedas “Hot Paper” by AngewChem/Highlightby Synfact2014341)


    2013年

    1. Liu, X. G.; Sun, B.; Xie, Z. Y.; Qin, X. J.; Liu, L.*; Lou, H. X.* Manganese dioxide-Methanesulfonic Acid Promoted Direct DehydrogenativeAlkylation of sp3 C–H Bonds Adjacent to A Heteroatom. J. Org. Chem. 201378, 3104.


    哈佛大学博士后研究工作(2011-2012)

    13. Liu, L.;Henderson, J. A.; Yamamoto, A.; Brémond, P.; Kishi, Y. Synthesis of alcoholsfrom m-Fluorophenylsulfones and Dialkylboranes: Application to theC14-C35 Building Block of E7389. Org. Lett. 201214,2262. 


    匹兹堡大学攻读博士期间工作2006-2011
    12. Liu,L.; Floreancig, P. E. Stereoselective Synthesis of Tertiary Ethersthrough Geometrical Control of Highly Substituted Oxocarbenium Ions. Angew. Chem. Int. Ed. 201049, 5894. (Highlighted in SynFacts2010, 1152 and Synstory 2010, A101)

    11. Liu, L.; Floreancig, P. E. Structurally and Stereochemically Diverse TetrahydropyranSynthesis through Oxidative Carbon–Hydrogen Bond Activation. Angew. Chem. Int. Ed. 201049, 3069. (Selected as “Hot Paper” in Angew.Chem. Int. Ed.)

    10. Liu, L.; Floreancig, P. E. Stereoselective Heterocycles Synthesis through OxidativeCarbon–Hydrogen Bond Activation. Curr. Opin. Drug. Discov. Devel. 2010,13, 733.

    9. Liu, L.;Floreancig, P. E. DDQ-Catalyzed Reactions Employing MnO2 as A StoichiometricOxidant. Org. Lett. 201012, 4686.

    8. Liu, L.;Floreancig, P. E. Cyclization Reactions through DDQ-Mediated Vinyl OxazolidinoneOxidation. Org. Lett. 200911, 3152. (Highlightedin SynFacts 2009, 998)

    7. Tu, W.; Liu,L.; Floreancig, P. E. Diastereoselective Tetrahydropyrone Synthesis throughTransition-Metal-Free Oxidative Carbon–Hydrogen Bond Activation. Angew. Chem. Int. Ed. 200847, 4184.


    兰州大学攻读硕士期间工作(2003-2006

    6. Liu, L.;Wang, R.; Kang, Y.-F.; Cai, H.-Q.; Chen, C. Highly Enantioselective Addition of Phenylacetylene to Ketones Catalyzed by Bis(hydroxycamphorsulfonamide)-copper(II) Complex. Synlett. 20068, 1245.

    5. Liu, L.;Wang, R.; Kang, Y.-F.; Chen, C.; Xu, Z.-Q.; Zhou, Y.-F.; Ni, M.; Cai, H.-Q.;Gong, M.-Z. Highly Enantioselective Phenylacetylene Addition to Aromatic KetonesCatalyzed by Cinchona Alkaloid-Aluminum Complexes. J. Org. Chem. 2005,70, 1084.

    4. Liu, L.;Kang, Y.-F.; Wang, R.; Zhou, Y.-F.; Chen, C.; Ni, M.; Gong, M.-Z. EnantioselectiveAlkynylation of Aromatic Ketones Promoted by (S)-Phenylalanine-derived β-Amino Alcohol. Tetrahedron: Asymmetry 200415, 3757.

    3. Kang, Y.-F.; Liu,L.; Wang, R.; Zhou, Y.-F.; Yan, W.-J. Enantioselective Alkynylation ofAromatic Ketones Catalyzed by New Chiral Oxazolidine Ligands. Adv. Synth.Catal. 2005347, 243.

    2. Kang, Y.-F.; Liu,L.; Wang, R.; Yan, W.-J.; Zhou, Y.-F. The Use of Bifunctional CatalystSystems in the Asymmetric Addition of Alkynylzinc to Aldehydes. Tetrahedron:Asymmetry 200415, 3155.

    1. Kang, Y.-F.; Liu,L.; Wang, R.; Ni, M.; Han, Z.-J. Enantioselective Addition of Diethylzincto Aromatic Aldehydes Catalyzed by New Chiral Oxazolidine Ligand. Synth.Commun. 200535, 1819.


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