Education Background
  • 2006-08-2011-03
    美国匹兹堡大学
    化学类其他专业
  • 2003-09-2006-06
    兰州大学
    生物科学类其他专业
  • 1999-09-2003-06
    兰州大学
    生物技术
  • 1996-09-1999-06
    淄博第五中学
Work Experience
  • 2018-04 — Now
    山东大学化学与化工学院
  • 2015-09 — Now
    山东大学化学与化工学院
Social Affiliations
  • 山东省青年创新人才协会理事
  • 中国青年科技工作者协会委员
Publication
Research direction
Papers

(1) Cytochrome P450-Catalyzed Tetrahydrofuran Formation via Dual Pathways in Avermectin Biosynthesis .ACS Catalysis .2025 ,15 (4)

(2)关弘浩. Methane Monooxygenase Mimic Asymmetric Oxidation: Self-Assembling μ-Hydroxo, Carboxylate-Bridged Diiron(III)-Catalyzed Enantioselective Dehydrogenation .J. Am. Chem. Soc. .2022 (144)

(3) Site- and Enantiodifferentiating C(sp3)–H Oxidation Enables Asymmetric Access to Structurally and Stereochemically Diverse Saturated Cyclic Ethers .J. Am. Chem. Soc. .2020 (142)

(4)曹敏. Site- and Enantioselective Manganese-Catalyzed Benzylic C–H Azidation of Indolines .J. Am. Chem. Soc. .2022 (144)

(5) Catalytic Enantioselective Hydroxylation of Tertiary Propargylic C(sp3)-H Bonds in Acyclic Systems: a Kinetic Resolution Study .Journal of the American Chemical Society .2024 ,146 (27)

(6)李松. Late-Stage Chemo- and Enantioselective Oxidation of Indoles to C3-Monosubstituted Oxindoles .Journal of the American Chemical Society .2023 ,145 (49):27120-27130

(7)王岗. Catalytic Asymmetric Oxidation of Amines to Hydroxylamines .J. AM. CHEM. SOC. .2023 ,145 (40):22276

(8)Du, Tianxing. Copper-Catalyzed [3 + 2 + 1] Cycloaddition of Alkenes with Benzoquinones and Dicarbonyl Compounds via Tandem Oxidative Dicarbofunctionalization/Cyclization Sequence .Chinese Journal of Chemistry .2022 ,40 (14):1681-1686

(9)秦静. Design, synthesis and biological evaluation of novel 1,3,4,9-tetrahydropyrano[3,4-b]indoles as potential treatment of triple negative breast cancer by suppressing PI3K/AKT/mTOR pathway .Bioorg Med Chem. .2021 ,55 :116594

(10) Redox deracemization of β,γ-alkynyl α-amino esters .Chemical Science .2020 ,11 (17):4444-4449

(11)王东琳. 叔丁醇钠催化的δ-腈基-δ-芳基-双取代的对亚甲基苯醌和二芳基氧磷的磷氢化反应研究 .Chinese journal of organic chemistry .2021 ,41 (08):3192-3203

(12)叶鹏博. Nickel(II)-catalyzed asymmetric alkylation of acyclic oxocarbenium ions with carboxylic acid derivatives .CHINESE CHEMICAL LETTERS Journal .2021 ,32 (3):1237

(13) Site- and Enantiodifferentiating C(sp3)?H Oxidation Enables Asymmetric Access to Structurally and Stereochemically Diverse Saturated Cyclic Ethers .Journal of the American Chemical Society .2020 (45)

(14)秦静. Design, synthesis and biological evaluation of novel 1,3,4,9-tetrahydropyrano[3,4-b]indoles as potential treatment of triple negative breast cancer by suppressing PI3K/AKT/mTOR pathway .BIOORGANIC & MEDICINAL CHEMISTRY Journal .2022 ,55

(15)杜天星. Copper-Catalyzed [3?+?2?+?1] Cycloaddition of Alkenes with Benzoquinones and Dicarbonyl Compounds via Tandem Oxidative Dicarbofunctionalization/Cyclization Sequence .Chinese Journal of Chemistry .2022 (14)

(16)马银刚. Redox deracemization of diarylmethyl alkynes .Organic Chemistry Frontiers .2020 (7)

(17)谢智宇. Copper-Catalyzed Aerobic Enantioselective Cross-Dehydrogenative Coupling of N-Aryl Glycine Esters with Terminal Alkynes .ORGANIC LETTERS .2016 (12)

(18)刘希功. Construction of Vicinal Quaternary Carbon Stereocenters Through Diastereo- and Enantioselective Oxidative 1,6-Conjugate Addition .Angewandte Chemie International Edition .2021 (34):18499

(19)潘馨慧. Catalytic Asymmetric Cross-Dehydrogenative Coupling of 2H-Chromenes and Aldehydes .CHINESE JOURNAL OF CHEMISTRY Journal .2018 (12)

(20)周李凯. Enantioselective Transfer Hydrogenation of Oxocarbenium Ions Enables Asymmetric Access to alpha-Substituted 1,3-Dihydroisoben-zofurans .SYNTHESIS-STUTTGART .2022 ,54 (02):421

(21)刘希功. Construction of Vicinal Quaternary Carbon Stereocenters Through Diastereo- and Enantioselective Oxidative 1,6-Conjugate Addition .ANGEWANDTE CHEMIE-INTERNATIONAL EDITION .2021 ,60 (34):18499

(22)王岗. Kinetic resolution of indolines by asymmetric hydroxylamine formation .NATURE COMMUNICATIONS .2021 ,12 (1)

(23)关弘浩. Methane Monooxygenase Mimic Asymmetric Oxidation: Self-Assembling mu-Hydroxo, Carboxylate-Bridged Diiron(III)-CatalyzedEnantioselective Dehydrogenation br .Journal of the American Chemical Society .2022 ,144 (13):5976

(24)孙书涛. Site- and Enantiodifferentiating C(sp(3))-H Oxidation Enables Asymmetric Access to Structurally and Stereochemically Diverse Saturated Cyclic Ethers .Journal of the American Chemical Society .2020 ,142 (45):19346

(25)陈笑寒. Redox deracemization of alpha-substituted 1,3-dihydroisobenzofurans .CHINESE CHEMICAL LETTERS Journal .2021 ,32 (7):2305

(26)秦静. Rational design and synthesis of 6-aryl-6H-benzo[c]chromenes as non-steroidal progesterone receptor antagonists for use against cancers .BIOORGANIC & MEDICINAL CHEMISTRY Journal .2021 ,32

(27)朱亚胜. Enantioselective Construction of Single and Vicinal All-Carbon Quaternary Stereocenters through Ion-Pair-Catalyzed 1,6-Conjugate Addition .ORGANIC LETTERS .2021 ,23 (18):7248

(28)王泽华. Direct oxidative C(sp(3))-H cyanation of secondary benzylic ethers .CHINESE CHEMICAL LETTERS Journal .2019 ,30 (6):1241

(29)朱亚胜. Enantioselective Construction of Single and Vicinal All-Carbon Quaternary Stereocenters through Ion-Pair-Catalyzed 1,6-Conjugate Addition .ORGANIC LETTERS .2021 ,23 (18):7248

(30)王泽华. Synthesis of Chiral Triarylmethanes Bearing All-Carbon Quaternary Stereocenters: Catalytic Asymmetric Oxidative Cross-Coupling of 2,2-Diarylacetonitriles and (Hetero)arenes .ANGEWANDTE CHEMIE-INTERNATIONAL EDITION .2020 ,59 (8):3053

(31)孙书涛. Oxidative Kinetic Resolution of Cyclic Benzylic Ethers .ANGEWANDTE CHEMIE-INTERNATIONAL EDITION .2021 ,60 (1):176

(32)路然. Iron-Catalyzed Aerobic Dehydrogenative Kinetic Resolution of Cyclic Secondary Amines .Journal of the American Chemical Society .2019 ,141 (15):6318

(33)马银刚. Synthesis of Unsymmetric Triarylmethanes Bearing CF3-Substituted All-Carbon Quaternary Stereocenters: 1,6-Arylation of delta-Trifluo-romethyl Substitutedpara-Quinone Methides .SYNLETT Journal .2020 ,31 (16):1619

(34)马银刚. Redox deracemization of diarylmethyl alkynes .Organic Chemistry Frontier .2020 ,7 (17):2526

(35)孙奕. A practical oxidative C–H functionalization of N-carbamoyl tetrahydro-β-carbolines with diverse potassium trifluoroborates .Organic & Biomolecular Chemistry .2016

(36)谢智宇. Copper(II) Triflate-Catalyzed Aerobic Oxidative C-H Functionalization of Glycine Derivatives with Olefins and Organoboranes .Advanced Synthesis & Catalysis .2016

(37)孙霞. A novel tetrahydroisoquinoline (THIQ) analogue induces mitochondria-dependent apoptosis .EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY .2018 ,150 :719

(38)刘磊. A practical oxidative C–H functionalization of N-carbamoyl tetrahydro-β-carbolines with diverse potassium trifluoroborates .Organic & Biomolecular Chemistry .2016

(39)刘磊. An economical synthesis of substituted quinoline-2-carboxylates through the potassium persulfate-mediated cross-dehydrogenative coupling of N-aryl glycine derivatives with olefins .Organic & Biomolecular Chemistry .2015

(40)刘磊. Catalytic Enantioselective Oxidative Cross-Coupling of Benzylic Ethers with Aldehydes .Angew. Chem. Int. Ed. .2014

(41)刘磊. Practical and Highly Selective C–H Functionalization of Structurally Diverse Ethers .Angew. Chem. Int. Ed. .2014

(42)刘磊. Copper(II)/amine synergistically catalyzed enantioselective alkylation of cyclic N-acyl hemiaminals with aldehydes .CHEMICAL COMMUNICATIONS .2015

(43)刘磊. Practical and Highly Selective C-H Functionalization of Structurally Diverse Ethers .Angew. Chem. Int. Ed. .2014

(44)刘磊. Diastereoselectively Complementary C–H Functionalization Enables Access to Structurally and Stereochemically Diverse 2,6-Substituted Piperidines .ORGANIC LETTERS .2016

(45)刘磊. Structurally Diverse α?Substituted Benzopyran Synthesis through a Practical Metal-Free C(sp3)?H Functionalization .ORGANIC LETTERS .2014

(46)刘磊. Chromium(II)-catalyzed enantioselective arylation of ketones .Beilstein Journal of Organic Chemistry .2016

(47)刘磊. Organocatalytic Enantioselective Cross-Dehydrogenative Coupling of N-Carbamoyl Cyclic Amines with Aldehydes .ORGANIC LETTERS .2016

(48)刘磊. Copper-Catalyzed Aerobic Enantioselective Cross-Dehydrogenative Coupling of N?Aryl Glycine Esters with Terminal Alkynes .ORGANIC LETTERS .2016

(49)刘磊. Manganese Dioxide–Methanesulfonic Acid Promoted Direct Dehydrogenative Alkylation of sp3 C–H Bonds Adjacent to a Heteroatom .The journal of Organic Chemistry .2013

(50)刘磊. Indium-catalyzed oxidative cross-dehydrogenative coupling of chromenes with 1,3-dicarbonyls and aryl rings .Organic & Biomolecular Chemistry .2015

(51)刘磊. TBHP/TFA Mediated Oxidative Cross-Dehydrogenative Coupling of N-Heterocycles with Aldehydes .Organic & Biomolecular Chemistry .2015

(52)刘磊. Structurally Diverse α-Substituted Benzopyran Synthesis through A Practical Metal-Free C(sp3)-H Functionalization .ORGANIC LETTERS .2014

(53)刘磊. Copper(II) Triflate-Catalyzed Aerobic Oxidative C-H Functionalization of Glycine Derivatives with Olefins and Organoboranes .Advanced Synthesis & Catalysis .2016

(54)刘磊. C1-Benzyl and Benzoyl Isoquinoline Synthesis through Direct Oxidative Cross-Dehydrogenative Coupling with Methyl Arenes .CHEMICAL COMMUNICATIONS .2015

(55)刘磊. Highly Enantioselective Catalytic Cross-Dehydrogenative Coupling of N-Carbamoyl Tetrahydroisoquinolines and Terminal Alkynes .ORGANIC LETTERS .2015

(56)刘磊. Practical Metal-Free C(sp3)-H Functionalization: Construction of Structurally Diverse a-Substituted N-Benzyl and N-Allyl Carbamates .Angew. Chem. Int. Ed. .2014

(57)刘磊. Catalytic Enantioselective Oxidative Cross-Coupling of Benzylic Ethers with Aldehydes .Angew. Chem. Int. Ed. .2014

(58)刘磊. Organocatalytic Enantioselective Oxidative C-H Alkenylation and Arylation of N-Carbamoyl Tetrahydropyridines and Tetrahydro-bcarbolines .Angew. Chem. Int. Ed. .2015

(59)刘磊. Organocatalytic Asymmetric C-H Vinylation and Arylation of N-Acyl Tetrahydroisoquinolines .ORGANIC LETTERS .2015

(60)刘磊. Cyclization Reactions through DDQ-Mediated Vinyl Oxazolidinone Oxidation .ORGANIC LETTERS .2009

(61)刘磊. Copper(II) catalyzed cross-dehydrogenative coupling of cyclic benzylic ethers with simple carbonyl compounds by Na2S2O8 .Tetrahedron .2014

(62)刘磊. An economical and environmentally friendly oxidative biaryl coupling promoted by activated MnO2 .Organic & Biomolecular Chemistry .2014

(63)刘磊. Seven- and eight-membered heterocyclic biaryl synthesis through a metal-free oxidative coupling reaction .Tetrahedron Letters .2014

(64)刘磊. Practical Metal-Free C(sp3)-H Functionalization: Construction of Structurally Diverse alpha-Substituted N-Benzyl and N-Allyl Carbamates .Angew. Chem. Int. Ed. .2014

(65)刘磊. A Metal-Free Cross-Dehydrogenative Coupling of N-carbamoyl Tetrahydroisoquinoline by Sodium Persulfate .Tetrahedron Letters .2014

(66)刘磊. Highly Enantioselective Addition of Phenylacetylene to Ketones Catalyzed by Bis(hydroxycamphorsulfonamide)–Copper(II) Complex .synlett .2006

(67)刘磊. Highly Enantioselective Phenylacetylene Addition to Aromatic Ketones Catalyzed by Cinchona Alkaloid-Aluminum Complexes .journal of organic chemistry .2005

(68)刘磊. Enantioselective Alkynylation of Aromatic Ketones Promoted by (S)-Phenylalanine-derived β-Amino Alcohol .Tetrahedron Asymmetry .2004

(69)刘磊. Catalytic Enantioselective Alkynylation of Tetrahydroisoquinoline-Based N-Acyl Hemiaminals .SYNTHESIS .2016

(70)曹敏. Cross-dehydrogenative coupling of secondary benzylic ethers with indoles and pyrroles .Tetrahedron Letters .2019 ,60 (15):1075

(71)曹敏. Cross-dehydrogenative coupling of secondary benzylic ethers with indoles and pyrroles .Tetrahedron Letters .2019 ,60 (15):1075

(72)孙霞. A novel tetrahydroisoquinoline (THIQ) analogue induces mitochondria-dependent apoptosis .EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY .2018 ,150 :719

(73)刘磊. Manganese Dioxide–Methanesulfonic Acid Promoted Direct Dehydrogenative Alkylation of sp3 C–H Bonds Adjacent to a Heteroatom .The journal of Organic Chemistry .2013

(74)刘磊. Indium-catalyzed oxidative cross-dehydrogenative coupling of chromenes with 1,3-dicarbonyls and aryl rings .Organic & Biomolecular Chemistry .2015

(75)刘磊. TBHP/TFA Mediated Oxidative Cross-Dehydrogenative Coupling of N-Heterocycles with Aldehydes .Organic & Biomolecular Chemistry .2015

(76)刘磊. Diastereoselectively Complementary C–H Functionalization Enables Access to Structurally and Stereochemically Diverse 2,6-Substituted Piperidines .ORGANIC LETTERS .2016

(77)刘磊. Chromium(II)-catalyzed enantioselective arylation of ketones .Beilstein Journal of Organic Chemistry .2016

(78)刘磊. A practical oxidative C–H functionalization of N-carbamoyl tetrahydro-β-carbolines with diverse potassium trifluoroborates .Organic & Biomolecular Chemistry .2016

(79)刘磊. Organocatalytic Enantioselective Cross-Dehydrogenative Coupling of N-Carbamoyl Cyclic Amines with Aldehydes .ORGANIC LETTERS .2016

(80)刘磊. Copper-Catalyzed Aerobic Enantioselective Cross-Dehydrogenative Coupling of N?Aryl Glycine Esters with Terminal Alkynes .ORGANIC LETTERS .2016

(81)刘磊. Catalytic Enantioselective Alkynylation of Tetrahydroisoquinoline-Based N-Acyl Hemiaminals .SYNTHESIS .2016

(82)刘磊. An economical synthesis of substituted quinoline-2-carboxylates through the potassium persulfate-mediated cross-dehydrogenative coupling of N-aryl glycine derivatives with olefins .Organic & Biomolecular Chemistry .2015

(83)刘磊. Structurally Diverse α-Substituted Benzopyran Synthesis through A Practical Metal-Free C(sp3)-H Functionalization .ORGANIC LETTERS .2014

(84)刘磊. Copper(II) Triflate-Catalyzed Aerobic Oxidative C-H Functionalization of Glycine Derivatives with Olefins and Organoboranes .Advanced Synthesis & Catalysis .2016

(85)刘磊. C1-Benzyl and Benzoyl Isoquinoline Synthesis through Direct Oxidative Cross-Dehydrogenative Coupling with Methyl Arenes .CHEMICAL COMMUNICATIONS .2015

(86)刘磊. Copper(II)/amine synergistically catalyzed enantioselective alkylation of cyclic N-acyl hemiaminals with aldehydes .CHEMICAL COMMUNICATIONS .2015

(87)刘磊. Highly Enantioselective Catalytic Cross-Dehydrogenative Coupling of N-Carbamoyl Tetrahydroisoquinolines and Terminal Alkynes .ORGANIC LETTERS .2015

(88)刘磊. Organocatalytic Asymmetric C-H Vinylation and Arylation of N-Acyl Tetrahydroisoquinolines .ORGANIC LETTERS .2015

(89)刘磊. Practical Metal-Free C(sp3)- H Functionalization: Construction of Structurally Diverse a-Substituted N-Benzyl and N-Allyl Carbamates .Angew. Chem. Int. Ed. .2014

(90)刘磊. Catalytic Enantioselective Oxidative Cross-Coupling of Benzylic Ethers with Aldehydes .Angew. Chem. Int. Ed. .2014

(91)刘磊. Practical and Highly Selective C -H Functionalization of Structurally Diverse Ethers .Angew. Chem. Int. Ed. .2014

(92)刘磊. Organocatalytic Enantioselective Oxidative C-H Alkenylation and Arylation of N-Carbamoyl Tetrahydropyridines and Tetrahydro-bcarbolines .Angew. Chem. Int. Ed. .2015

(93)刘磊. Practical Metal-Free C(sp3)-H Functionalization: Construction of Structurally Diverse alpha-Substituted N-Benzyl and N-Allyl Carbamates .Angew. Chem. Int. Ed. .2014

(94)刘磊. A Metal-Free Cross-Dehydrogenative Coupling of N-carbamoyl Tetrahydroisoquinoline by Sodium Persulfate .Tetrahedron Letters .2014

(95)刘磊. Copper(II) catalyzed cross-dehydrogenative coupling of cyclic benzylic ethers with simple carbonyl compounds by Na2S2O8 .Tetrahedron .2014

(96)刘磊. An economical and environmentally friendly oxidative biaryl coupling promoted by activated MnO2 .Organic & Biomolecular Chemistry .2014

(97)刘磊. Practical and Highly Selective C–H Functionalization of Structurally Diverse Ethers .Angew. Chem. Int. Ed. .2014

(98)刘磊. Seven- and eight-membered heterocyclic biaryl synthesis through a metal-free oxidative coupling reaction .Tetrahedron Letters .2014

(99)刘磊. Structurally Diverse α?Substituted Benzopyran Synthesis through a Practical Metal-Free C(sp3)?H Functionalization .ORGANIC LETTERS .2014

(100)刘磊. Highly Enantioselective Addition of Phenylacetylene to Ketones Catalyzed by Bis(hydroxycamphorsulfonamide)–Copper(II) Complex .synlett .2006

(101)刘磊. Highly Enantioselective Phenylacetylene Addition to Aromatic Ketones Catalyzed by Cinchona Alkaloid-Aluminum Complexes .journal of organic chemistry .2005

(102)刘磊. Enantioselective Alkynylation of Aromatic Ketones Promoted by (S)-Phenylalanine-derived β-Amino Alcohol .Tetrahedron Asymmetry .2004

(103)刘磊. Cyclization Reactions through DDQ-Mediated Vinyl Oxazolidinone Oxidation .ORGANIC LETTERS .2009

Research Projects

1. 催化的电子自旋调控, 2024-12-01-2029-11-30

2. (包干项目)仿生不对称催化氧化, 2024-08-23-2029-12-31

3. 手性有机叠氮标准品的合成, 2023-12-14-2024-12-31

4. 系列糖类高级衍生物的制备和在生物医药领域的应用, 2023-12-04-2024-12-31

5. 抗肿瘤药物芦可替尼手性合成工艺研发, 2021-10-10-2026-10-09

6. (包干项目)新型1,3,4,9-四氢吡喃[3,4-b]_吲哚类化合物基于PI3K/AKT/mTOR信号通路抗三阴性乳腺癌的作用及机制, 2021-12-23-2024-12-31

7. H045 项目片段 2 委托工艺开发(L), 2022-03-25-2027-03-24

8. 手性[N4]铁催化不对称脱氢反应, 2021-12-20-2024-09-30

9. 氮、磷、硅等杂原子手性中心的不对称氧化构筑, 2021-12-03-2024-12-31

10. 烯烃的不对称环氧化, 2021-10-01-2026-10-01

11. 吲哚啉的不对称氧化, 2021-03-08-2025-03-07

12. 硫醚的不对称氧化, 2020-12-04-2023-12-31

13. 醚和胺的氧化动力学拆分和循环去外消旋化研究, 2019-08-16-2023-12-31

14. 脱羧18F化反应研究及应用, 2019-01-01-2020-12-31

15. 氢醌氧化技术, 2018-04-20-2018-04-20

16. 不对称合成, 2017-08-17-2020-12-31

17. 抗真菌和抗病毒天然产物(+)-deoxyrenolicin的不对称全合成和构效关系研究, 2016-03-09-2019-03-31

18. 有机合成, 2014-12-10-2017-12-31

19. 催化不对称碳-氢官能团化研究, 2014-08-15-2018-12-31

20. 基于烯基醚γ位碳-氢键的氧化活化构建2,6-顺-二取代四氢吡喃的研究, 2013-10-01-2015-12-31

21. 自噬相关基因beclin-1在先天性颅面畸形发生中的作用, 2012-07-01-2014-12-31

22. 通过碳-氢活化立体选择性的合成2,6-反-二取代四氢吡喃结构及其在天然产物(-, 2012-08-17-2015-12-31

Honors & Awards
Teaching Achievement
Student Information
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  • 徐子浩  2023-09-23 Hits:[] Times
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  • 关弘浩  2019-04-18 Hits:[] Times
  • 王东琳  2019-04-18 Hits:[] Times
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  • 王岗  2019-04-18 Hits:[] Times
  • 叶鹏博  2019-04-18 Hits:[] Times
  • 辛晓东  2019-04-18 Hits:[] Times
  • 曹敏  2019-04-18 Hits:[] Times
  • 王泽华  2019-04-18 Hits:[] Times
  • 关弘浩  2019-04-18 Hits:[] Times
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  • 毛颖  2019-04-17 Hits:[] Times
  • 李成坤  2019-04-17 Hits:[] Times
  • 王岗  2019-04-17 Hits:[] Times
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