Title:Professor
Supervisor of Doctorate Candidates
Supervisor of Master's Candidates
I am a bioinformatics researcher dedicated to addressing two fundamental challenges in the field: protein structure prediction and functional annotation, with the goal of advancing their applications in complex biological systems.
Protein structure prediction
Co-developed the mTM-align algorithm for multi-template structural alignment and established its widely used online server (adopted by researchers in over 50 countries).
Contributed to cutting-edge deep learning-based methods, including MapPred and trRosetta (trRosetta ranked among top performers in recent CASP competitions).
Extended the trRosetta framework to RNA structure prediction, creating trRosettaRNA, which outperformed other deep learning methods in CASP15 and RNA-Puzzles experiments.
Protein function prediction
Developed pioneering tools (DisoRDPbind, CLIP) for identifying functional motifs in intrinsically disordered proteins (IDPs), demonstrating superior accuracy in predicting biomolecule-binding regions.
Designed sequence-based binding site predictors (NucBind, CoABind) and enhanced databases (COACH-D, Q-BioLip) to support protein-ligand interaction studies.
Future Directions
Deciphering the dynamic structure and functional mechanisms of IDPs.
Advancing computational strategies for protein directed evolution.
Academic Contributions
Published 40+ SCI-indexed papers in leading journals including PNAS, Nature Communications, Nature Protocols, Advanced Science, and Nucleic Acids Research (total citations >3,000; one paper cited 800+ times).
Principal Investigator of 4 national grants, including the NSFC Excellent Young Scholars Program and sub-projects of China's National Key R&D Program.
University of Alberta, Canada  Software Engineering and Intelligent Systems  Postgraduate (Doctoral)  Doctoral Degree in Philosophy
Xiangtan University  Applied Mathematics  Postgraduate (Master's Degree)  Master
Hengyang Normal University  Applied Mathematics  University student  Bachelor
Shandong University Research Center for Mathematics and Interdisciplinary Sciences (Frontiers Science Center for Nonlinear Expectations) Professor
Tianjin University The Center for Applied Mathematics Associated professor
University of Washington, Seattle, USA Biochemistry Visitor
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