王海龙

个人信息Personal Information

教授 博士生导师 硕士生导师

性别:男

毕业院校:湖南师范大学

学历:研究生(博士)毕业

学位:博士

在职信息:在职

所在单位:微生物技术国家重点实验室、研究院

入职时间:2013-06-03

学科:微生物学

联系方式:wanghailong@sdu.edu.cn


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1.    Yu, G. #; Duan, Q.; Cui, T.; Jiang, C.; Li, X.; Li, Y.; Fu, J.; Zhang, Y.;Wang, H.* & Luan, J.*, Development of a bacterial gene transcription activating strategy based on transcriptional activator positive feedback, Journal of Advanced Research, 2023, Dec 18:S2090-1232(23)00400-9.并列通讯作者co-corresponding authorIF=11.4综合性一区Top期刊

2.    Li, X. #; Guo, R.; Luan, J.; Fu, J.; Zhang, Y. & Wang, H.*, Improving spinosad production by tuning expressions of the forosamine methyltransferase and the forosaminyl transferase to reduce undesired less active byproducts in the heterologous host Streptomyces albus J1074, Microbial Cell Factories, 2023, 22(1), 15.独立通讯作者corresponding authorIF=6.3生物工程与应用微生物一区

3.    李雨桐Li, Y. #崔天琦Cui, T.; 张海林Zhang, H.; 于广乐Yu, G.; 栾霁Luan, J.*&王海龙Wang, H.*肿瘤靶向细菌Escherichia coli Nissle 1917在癌症治疗中的研究进展Research progress of tumor-targeting bacteria Escherichia coli Nissle 1917 in cancer treatment中国生物工程杂志China Biotechnology2023, 43(6): 54-68.并列通讯作者co-corresponding authorin Chinese

4.   姜婵娟Jiang, C. #崔天琦Cui, T.; 孙洪娈Sun, H.; 焦念志Jiao, N.; 符军Fu, J.; 张友明Zhang, Y.*; 王海龙Wang, H.*ExoCET-BAC策略高效抓取和组装高AT含量基因组大片段Efficient capture and assembly of AT-rich genomic fragments using ExoCET-BAC strategy合成生物学Synthetic Biology2022, 3(1): 238-251.末位并列通讯作者co-corresponding author, in Chinese

5.    Jiang, T. #,*; Yang, X. #; Li, G.; Zhao, X.; Sun, T.; Muller, R.; Wang, H.*; Li, M.* & Zhang, Y.*, Bacteria-based live vehicle for in vivo bioluminescence imaging, Analytical Chemistry, 2021, 93(47), 15687-15695.并列通讯作者co-corresponding authorIF=7.0化学一区Top期刊

6.    Tang, Y. #; Zhang, C.; Cui, T.; Lei, P.; Guo, Z. *; Wang, H.*& Liu, Q.*, The discovery of actinospene, a new polyene macrolide with broad activity against plant fungal pathogens and pathogenic yeasts, Molecules, 2021, 26(22).并列通讯作者co-corresponding authorIF=4.9

7.     Song, C.#; Luan, J.#; Li, R.; Jiang, C.; Hou, Y.; Cui, Q.; Cui, T.; Tan, L.; Ma, Z.; Tang, Y. J.; Stewart, A. F.; Fu, J.; Zhang, Y. & Wang, H.*, RedEx: a method for seamless DNA insertion and deletion in large multimodular polyketide synthase gene clusters, Nucleic Acids Research, 2020, 48(22), e130.独立通讯作者corresponding authorIF=16.4生化与分子生物学一区Top期刊

8.     Jiang, C. #; Zhou, H; Sun, H; He, R; Song, C; Cui, T; Luan, J; Fu, J; Zhang, Y; Jiao, N; Wang, H.*, Establishing an efficient salinomycin biosynthetic pathway in three heterologous Streptomyces hosts by constructing a 106-kb multioperon artificial gene cluster, Biotechnology & Bioengineering, 2021, 118: 4668-4677.独立通讯作者corresponding authorIF=4.0

9.    Abbasi, M. N. #; Fu, J.; Bian, X.; Wang, H.*; Zhang, Y.* & Li, A.*, Recombineering for genetic engineering of natural product biosynthetic pathways, Trends in Biotechnology, 2020, 38(7), 715-728.并列通讯作者co-corresponding authorIF=18.1生物工程与应用微生物一区Top期刊

10.    Song, C. #; Luan, J.#; Cui, Q.; Duan, Q.; Li, Z.; Gao, Y.; Li, R.; Li, A.; Shen, Y.; Li, Y.; Stewart, A. F.; Zhang, Y.*; Fu, J.* & Wang, H.*, Enhanced heterologous spinosad production from a 79-kb synthetic multi-operon assembly, ACS Synthetic Biology, 2019, 8(1), 137-147.末位并列通讯作者co-corresponding authorIF=4.8

11.    Wang, H. #; Li, Z.; Jia, R.; Yin, J.; Li, A.; Xia, L.; Yin, Y.; Muller, R.; Fu, J.*; Stewart, A. F.* & Zhang, Y.*, ExoCET: exonuclease in vitro assembly combined with RecET recombination for highly efficient direct DNA cloning from complex genomes, Nucleic Acids Research, 2018, 46(5), e28.独立一作first authorIF=16.4生化与分子生物学一区Top期刊

12.    Wang, H. #; Li, Z.#; Jia, R.; Hou, Y.; Yin, J.; Bian, X.; Li, A.; Muller, R.; Stewart, A. F.*; Fu, J.* & Zhang, Y.*, RecET direct cloning and Redαβ recombineering of biosynthetic gene clusters, large operons or single genes for heterologous expression, Nature Protocols, 2016, 11(7), 1175-1190.首位并列一作co-first authorIF= 16.9生化研究方法一区Top期刊

13.    Wang, H. #; Bian, X.; Xia, L.; Ding, X.; Müller, R.; Zhang, Y.*; Fu, J.* & Stewart, A. F.*, Improved seamless mutagenesis by recombineering using ccdB for counterselection, Nucleic Acids Research, 2014, 42(5), e37.独立一作first authorIF=16.4生化与分子生物学一区Top期刊

14.    Jing, X. #; Cui, Q. #; Li, X.; Yin, J.; Ravichandran, V.; Pan, D.; Fu, J.; Tu, Q.; Wang, H.*; Bian, X.* & Zhang, Y.*, Engineering Pseudomonas protegens Pf-5 to improve its antifungal activity and nitrogen fixation, Microbial Biotechnology, 2020, 13(1), 118-133.并列通讯作者co-corresponding authorIF=6.4

15.    Luan, J. #; Li, Z. #Wang, H.*; Fu, J. & Zhang, Y., In vitro assay revealed mismatches between guide RNA and target DNA can enhance Cas9 nuclease activity, Current Chinese Science, 2020, 1(1), 69-72.独立通讯作者corresponding author

16.    Zhang, Y. #; Liu, R. #; Tian, K. #; Wang, Z. #; Yang, X.; Gao, D.; Zhang, Y.; Fu, J.*; Wang, H.* & Zhao, J.*, Fiber2 and hexon genes are closely associated with the virulence of the emerging and highly pathogenic fowl adenovirus 4, Emerging Microbes & Infections, 2018, 7(1), 199.并列通讯作者co-corresponding authorIF=9.9传染病学一区Top期刊

17.    Wang, H. #; Yao, T.; Cai, M.; Xiao, X.; Ding, X. & Xia, L.*, A genome walking strategy for the identification of nucleotide sequences adjacent to known regions, Biotechnology Letters, 2013, 35(2), 279-284.独立一作first author

18.     Yu, G. #; Li, X.; Duan, Q.; Fu, J.; Zhang, Y.; Wang, H. & Luan J.*, Systematic identification of endogenous strong constitutive promoters from the diazotrophic rhizosphere bacterium Pseudomonas stutzeri DSM4166 to improve its nitrogenase activity. Microbial Cell Factories, 2023, 22(1): 91.

19.    Rostovskaya, M. #; Fu, J.; Obst, M.; Baer, I.; Weidlich, S.; Wang, H.; Smith, A. J. H.; Anastassiadis, K.* & Stewart, A. F.*, Transposon-mediated BAC transgenesis in human ES cells, Nucleic Acids Research, 2012, 40(19), e150.

20.    Zhang, W. #; Fu, J. #; Liu, J.; Wang, H.; Schiwon, M.; Janz, S.; Schaffarczyk, L.; von der Goltz, L.; Ehrke-Schulz, E.; Domer, J.; Solanki, M.; Boehme, P.; Bergmann, T.; Lieber, A.; Lauber, C.; Dahl, A.; Petzold, A.; Zhang, Y.*; Stewart, A. F.* & Ehrhardt, A.*, An engineered virus library as a resource for the spectrum-wide exploration of virus and vector diversity, Cell Reports, 2017, 19(8), 1698-1709.

21.    Zhang, W. #; Fu, J.; Liu, J.; Wang, H.; Schulz, E.; Solanki, M.; Boehme, P.; Gebbing, M.; Bergmann, T.; Doerner, J.; Stewart, A. F. & Ehrhardt, A.*, High-throughput cloning and tagging of an engineered adenovirus-library empowers vector diversity for broad applications, Molecular Therapy, 2015, 23, S21.

22.    Bian, X. #; Tang, B. #; Yu, Y.; Tu, Q.; Gross, F.; Wang, H.; Li, A.; Fu, J.; Shen, Y.; Li, Y.; Stewart, A. F.; Zhao, G.; Ding, X.*; Muller, R.* & Zhang, Y.*, Heterologous production and yield improvement of epothilones in Burkholderiales strain DSM 7029, ACS Chemical Biology, 2017, 12(7), 1805-1812.

23.    Yin, J. #Wang, H.; Li, R.; Ravichandran, V.; Bian, X.; Li, A.; Tu, Q.; Stewart, A.F.; Fu, J.* & Zhang, Y.*, A practical guide to recombineering in Photorhabdus and XenorhabdusCurrent Topics in Microbiology and Immunology, 2017.

24.    Ravichandran, V. #; Zhong, L.; Wang, H.; Yu, G.; Zhang, Y.* & Li, A.*, Virtual screening and biomolecular interactions of CviR-based quorum sensing inhibitors against chromobacterium violaceum, Frontiers in Cellular and Infection Microbiology, 2018, 8, 292.

25.    Liu, Q. #; Shen, Q. 1; Bian, X.; Chen, H.; Fu, J.; Wang, H.; Lei, P.; Guo, Z.; Chen, W.*; Li, D.* & Zhang, Y.*, Simple and rapid direct cloning and heterologous expression of natural product biosynthetic gene cluster in Bacillus subtilis via Red/ET recombineering, Scientific Reports, 2016, 6, 34623.

26.    Jiang, B. #; Zhang, R.; Feng, D.; Wang, F.; Liu, K.; Jiang, Y.; Niu, K.; Yuan, Q.; Wang, M.; Wang, H.; Zhang, Y. & Fang, X.*, A Tet-on and Cre-loxP based genetic engineering system for convenient recycling of selection markers in Penicillium oxalicumFrontiers in Microbiology, 2016, 7, 485.

27.    Zhu, L. #; Yue, X.; Han, K.; Li, Z.; Zheng, L.; Yi, X.; Wang, H.; Zhang, Y. & Li, Y.*, Allopatric integrations selectively change host transcriptomes, leading to varied expression efficiencies of exotic genes in Myxococcus xanthusMicrobial Cell Factories, 2015, 14, 105.

28.    Bian, X. #; Huang, F.; Wang, H.; Klefisch, T.; Muller, R.* & Zhang, Y.*, Heterologous production of glidobactins/luminmycins in Escherichia coli Nissle containing the glidobactin biosynthetic gene cluster from Burkholderia DSM7029, Chembiochem, 2014, 15(15), 2221-2224.

29.    Yu, F. #; Jing, X.; Li, X.; Wang, H.; Chen, H.; Zhong, L.; Yin, J.; Pan, D.; Yin, Y.; Fu, J.; Xia, L.; Bian, X.; Tu, Q. & Zhang, Y., Recombineering Pseudomonas protegens CHA0: An innovative approach that improves nitrogen fixation with impressive bactericidal potency, Microbiology Research, 2019, 218, 58-65.

30.    Fu, J.#; Bian, X.#; Hu, S.; Wang, H.; Huang, F.; Seibert, P. M.; Plaza, A.; Xia, L.; Müller, R.*; Stewart, A. F.* & Zhang, Y.*, Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting, Nature Biotechnology, 2012, 30(5), 440-446.