At present, my research mainly focuses on the interdisciplinary applications of microfluidic technology, such as tumor organoid chips, pathogenic microbial detection, single-cell spatial omics, and the development and application of biomimetic polymer materials.

• University of Toronto
  Chemistry
• Zhejiang University
  Chemistry
• China University of Petroleum (East China)
  Applied Chemistry

• Department of Mechanical & Industrial EngineeringUniversity of Toronto
  Postdoctoral Fellow

1. Organ and organoid on a chip

2. Microfluidic systems for pathogenic microorganism detection

3. Single-cell sequencing and spatial transcriptomics

(1)刘梦绮,王一鹤. A Microfluidic 3D-Tumor-Spheroid Model for the Evaluation of Targeted Therapies from Angiogenesis-Related Cytokines at the Single Spheroid Level .Advanced Healthcare Materials .2024 (2402321)

(2)王一鹤. Recent methods of droplet microfluidics and their applications in spheroids and organoids .Lab on a Chip .2023 (23):1080

(3)Yihe Wang. Prediction of DNA Integrity from Morphological Parameters Using a Single‐Sperm DNA Fragmentation Index Assay .Advanced Science .2019 ,6 :1900712

(4)Yihe Wang. Two-dimensional arrays of cell-laden polymer hydrogel modules .Biomicrofluidics .2016 ,10 :014110

(5)Yihe Wang. Exploring a direct injection method for microfluidic generation of polymer microgels .Lab on a Chip .2013 ,13 (13):2547-2553

(6)Yihe Wang. Excess Molar Volumes of 1,3-Diethyl Propanedioate with Methanol, Ethanol, Propan-1-ol, Propan-2-ol, Butan-2-ol, 2-Methyl-propan-1-ol, and Pentan-1-ol at T = (288.15, 298.15, 313.15, and 328.15) K .J. Chem. Eng. Data .2010 ,55 (9):4029–4032

(7)Yihe Wang. Excess molar enthalpies of diethyl malonate+ (1-butanol, 2-methyl-1-propanol, 1-pentanol, n-heptane, and ethyl acetate) at T= (288.2, 298.2, 313.2, 328.2, 338.2, and 348.2 K) and p = 101.3 kPa .Fluid Phase Equilibria .2010 ,291 (1):8-12

(8)Yihe Wang. Excess Molar Enthalpies of Diethyl Malonate + (Methanol, + Ethanol, + 1-Propanol, and + 2-Propanol) at T = (288.2, 298.2, 313.2, and 328.2) K and p = 101.3 kPa .J. Chem. Eng. Data .2009 ,55 (1):381–384

(9)Mohammad Simchi. High-throughput sperm DNA analysis at the single-cell and population levels .Analyst .2023 ,148 :3748-3757

(10)褚玉金. Rapid and High-Throughput SARS-CoV-2 RNA Detection without RNA Extraction and Amplification by Using a Microfluidic Biochip .chemistry-a European journal .2022 ,28 (18):e202104054

(11)宋方腾. Multi-Phenotypic Exosome Secretion Profiling Microfluidic Platform for Exploring Single-Cell Heterogeneity .Small Methods .2022 ( 2200717)

(12)王超. High-Throughput, Living Single-Cell, Multiple Secreted Biomarker Profiling Using Microfluidic Chip and Machine Learning for Tumor Cell Classification .Advanced Healthcare Materials .2022 ,11 (13)

(13)Jiaoyan Qiu. Lys-AuNPs@MoS2 Nanocomposite Self-Assembled Microfluidic Immunoassay Biochip for Ultrasensitive Detection of Multiplex Biomarkers for Cardiovascular Diseases .Analytical Chemistry .2022 ,94 (11):4720-4728

(14)Elisabeth Prince. Microfluidic arrays of breast tumor spheroids for drug screening and personalized cancer therapies .Advanced Healthcare Materials .2021 ,11 (1):2101085

(15)Jae Bem You. Machine learning for sperm selection .Nat Rev Urol .2021 ,18 (7):387-403

(16)Mohammad Simchi. Selection of high-quality sperm with thousands of parallel channels .Lab on a Chip .2021 ,21 (12):2464-2475

(17)Jason Riordon. Two-Dimensional Planar Swimming Selects for High DNA Integrity Sperm .Lab on a Chip .2019 ,19 (13):2161-2167

(18)Christopher McCallum. Deep learning-based selection of human sperm with high DNA integrity .Commun Biol. .2019 ,3 (2):250

1. Research on tumor drug resistance mechanism based on microfluidic biomimetic three-dimensional multicellular tumor chip and machine learning., 2020/09/18-2023/12/31

2. Research on high-throughput low-cost detection chips and systems for tumor and cerebrovascular disease markers-1, 2021/05/01-2024/06/30

3. Sensor microfluidic chip for real-time analysis of single-cell exosomes, 2021/10/12-2025/12/31

4. 小型自动化病原微生物建库仪开发及产业化, 2022/05/11-2025/05/10

5. 山东大学青年学者未来计划