教师简介

汪昭,男,199611月出生于安徽芜湖,中国共产党党员,医学博士,博士后,山东大学副研究员,中国生物工程学会终身会员。主要从事新型高效抗耐药性的抗病毒药物的研发,运用基于靶标的药物设计理念,构建高质量抗病毒靶标化合物库,经过活性筛选、结构生物学研究与成药性评价发现具有临床价值的候选药物。近五年以第一作者/通讯作者身份发表SCI论文10篇以及中文核心期刊1篇,并作为主要作者参与发表SCI论文20余篇。相关成果连续发表于医学/药物化学领域一区Top期刊J. Med. Chem. 2023(第一作者)、Acta Pharm. Sin. B 2024(第一作者)、J. Med. Virol. 2024a(第一作者)、J. Med. Virol. 2024b(通讯作者)、J. Med. Chem. 2022(第一作者)、J. Med. Chem. 2021(第一作者)、Eur. J. Med. Chem. 2020(第一作者),其中两篇J. Med. Chem.和一篇Bioorg. Med. Chem.论文入选当期封面文章,一篇J. Med. Virol.论文获得期刊主编推荐。相关科研进展被山东大学中英文官网、药学院官网和X-MOL学术网站报道。此外,作为项目负责人主持国自然青年基金江苏省青年基金山东省青年基金中国博士后面上基金等项目5项,参编中文专著《基于靶标的抗艾滋病药物研究》,受邀担任国际病毒学/化学SCI期刊VirusesFront. Chem.Appl. Sci.客座编辑、以及Curr. Med. Chem.Curr. Top. Med. Chem.Lett. Drug Des. Discov.SCI期刊的特邀审稿人,荣获USERN Prize 2024青年科学家提名奖、中国山东博士后创新创业大赛铜奖、全国新医科与生物医药博士后海河学术交流活动优秀论文一等奖、全国新医药技术创新博士后青年科技人才论坛创新论文、全国宝钢教育奖、山东省优秀毕业生等多个省部级奖项。

教育经历
  • 2013-9 — 2017-6
    山东大学
    药学
    理学学士学位
  • 2017-9 — 2022-6
    山东大学
    药物化学
    医学博士学位
工作经历
  • 2022-07 — 2024-11
     山东大学 
    博士后
学术兼职
  • 2024-10 — 至今
    国际化学SCI期刊Frontiers in Chemistry客座编辑
  • 2024-5 — 2024-11
    国际综合性SCI期刊Applied Sciences客座编辑
  • 2023-3 — 2023-9
    国际病毒学SCI期刊Viruses客座编辑
研究概况

近年来主要从事新型高效抗耐药性抗病毒药物的研发,运用基于靶标的药物设计理念,构建高质量抗病毒靶标化合物库,经过活性筛选、结构生物学研究与成药性评价发现具有临床价值的候选药物。

研究方向
论文成果

(1) Escaping from flatland: multiparameter optimization leads to the discovery of novel tetrahydropyrido[4,3-d]pyrimidine derivatives as human immunodeficiency virus-1 non-nucleoside reverse transcriptase inhibitors with superior antiviral activities against non-nucleoside reverse transcriptase inhibitor-resistant variants and favorable drug-like profiles.Journal of Medicinal Chemistry.2023,66 (13):8643-8665

(2) Structure-based design and optimization lead to the identification of novel dihydrothiopyrano[3,2-d]pyrimidine derivatives as potent HIV-1 inhibitors against drug-resistant variants.Acta Pharmaceutica Sinica B.2024,14 (3):1257-1282

(3) Contemporary medicinal chemistry strategies for the discovery and development of novel HIV-1 non-nucleoside reverse transcriptase inhibitors.Journal of Medicinal Chemistry.2022,65 (5):3729-3757

(4) Discovery of novel dihydrothiopyrano[4,3-d]pyrimidine derivatives as potent HIV-1 NNRTIs with significantly reduced hERG inhibitory activity and improved resistance profiles.Journal of Medicinal Chemistry.2021,64 (18):13658-13675

(5) Structure-based design, synthesis, and biological characterization of indolylarylsulfone derivatives as novel human immunodeficiency virus type 1 inhibitors with potent antiviral activities and favorable drug-like profiles.Journal of Medical Virology.2024,96 (8):e29830

(6) Targeting dual tolerant regions of binding pocket: Discovery of novel morpholine-substituted diarylpyrimidines as potent HIV-1 NNRTIs with significantly improved water solubility.European Journal of Medicinal Chemistry.2020,206 :112811

(7) Structure-based design of diarylpyrimidines and triarylpyrimidines as potent HIV-1 NNRTIs with improved metabolic stability and drug resistance profiles.Journal of Medical Virology.2024,96 (3):e29502

(8) Design, synthesis and biological evaluation of novel acetamide-substituted doravirine and its prodrugs as potent HIV-1 NNRTIs.Bioorganic & Medicinal Chemistry.2019,27 (3):447-456

(9) Design and synthesis of Fsp3-enriched spirocyclic-substituted diarylpyrimidine derivatives as novel HIV-1 NNRTIs.Chemical Biology & Drug Design.2024,103 (3):e14510

(10) Design, synthesis, and antiviral evaluation of novel hydrazone-substituted thiophene[3,2-d]pyrimidine derivatives as potent human immunodeficiency virus-1 inhibitors.Chemical Biology & Drug Design.2018,92 (6):2009-2021

(11) 以蛋白质-蛋白质相互作用为靶点的HIV抑制剂的研究进展.药学学报.2019,54 (4):620-628

版权所有   ©山东大学 地址:中国山东省济南市山大南路27号 邮编:250100 
查号台:(86)-0531-88395114
值班电话:(86)-0531-88364731 建设维护:山东大学信息化工作办公室