赵伟教授
山东大学特聘教授，博士生导师；病原生物学系主任；国家杰出青年科学基金获得者；国家优秀青年科学基金获得者；牛顿高级学者，山东省杰出青年基金获得者；山东大学首批齐鲁(仲英)青年学者。从事固有免疫激活及调控机制研究，相关成果以通讯作者发表于Nat. Immunol.(2020)、Immunity.(2023)、J.Exp.Med.(2017, 2012)、J.Clin Invest.(2023)、Nat. Commun.(2024, 2023, 2021, 2020,2016, 2014)、Sci. Adv.(2021)、PNAS(2016)、Cell.Rep.(2024, 2017)等杂志。 More+
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研究方向：固有免疫激活及调控机制研究
聚焦固有免疫激活及调控的分子机制，以病毒感染及肿瘤为模型，揭示细胞内环境、代谢及组织微环境等在固有免疫活化中的作用及机制，阐明病毒及肿瘤的免疫逃逸机制，为相关疾病治疗提供理论依据。
- 赵春媛 and 马云瑾. Polyamine metabolism controls B-to-Z DNA transition to orchestrate DNA sensor cGAS activity. IMMUNITY, 2023.
- 贾木天. Redox homeostasis maintained by GPX4 facilitates STING activation. Nature Immunology, 2020.
- 秦颖. Posttranslational ISGylation of NLRP3 by HERC enzymes facilitates inflammasome activation in models of inflammation. Journal of Clinical Investigation, 2023.
- 贾木天. Myristic acid as a checkpoint to regulate STING-dependent autophagy and interferon responses by promoting N-myristoylation. Nature Communications, 2023.
- 秦颖. TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation. Nature Communications, 2021.
- 王雯雯. RNF39 mediates K48-linked ubiquitination of DDX3X and inhibits RLR-dependent antiviral immunity. Science Advances, 2021.
- 宋慧. UAF1 deubiquitinase complexes facilitate NLRP3 inflammasome activation by promoting NLRP3 expression. Nature Communications, 2020.
- 余仲夏. USP1-UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviral responses. Journal of Experimental Medicine, 2017.
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