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个人信息Personal Information
教授 博士生导师 硕士生导师
任职 : Aging，Cancer，Cancer Genetics，Oncology Letters，General Physiology and Biophysics ，Experimental and Therapeutic Medicine，Food & Function, Psychosomatic Medicine Research(Section Editor), 赣南医学院学报, 中国生物工程杂志
性别：男
毕业院校：清华大学
学历：研究生(博士)毕业
学位：博士生
在职信息：在职
所在单位：基础医学院
入职时间：2021-01-27
学科：遗传学
发育生物学
生物化学与分子生物学
办公地点：山东大学趵突泉校区电镜楼209
联系方式：zhezhang@sdu.edu.cn 课题组常年招聘助理教授，博士后；并欢迎博士生，硕士生，本科生报考和实习。
VHL-1 inactivation and mitochondrial antioxidants rescue C. elegans dopaminergic neurodegeneration
点击次数：
发表刊物：Protein & cell
摘要：Mitochondrial complex I is important for cellular ATP production by transporting electrons and generating proton gradient across the mitochondrial inner membrane (Hirst, 2013). It is also a major cellular locus where electron leakage to oxygen produces superoxide, an ROS (reactive oxygen species), particularly under oxidative stress conditions. Dysfunctional complex I contributes to the most common oxidative phosphorylation disorder in humans, with many identified genetic mutations in complex I subunits causing a variety of human disorders including Leigh syndrome, encephalomyopathy, cardiomyopathy, parkinsonism and hereditary optic neuropathy (Hirst, 2013; Guo et al., 2017). In addition, complex I is the major target of many parkinsonismcausing neurotoxins including rotenone and MPTP.
全部作者：张哲
第一作者：Shuo Luo#,Song Chen#
论文类型：期刊论文
通讯作者：Dengke Ma*
论文编号：6
是否译文：否
发表时间：2019-08-01
收录刊物：SCI