|
个人信息Personal Information
教授 博士生导师 硕士生导师
任职 : Aging，Cancer，Cancer Genetics，Oncology Letters，General Physiology and Biophysics ，Experimental and Therapeutic Medicine，Food & Function, Psychosomatic Medicine Research(Section Editor), Current Pharmaceutical Biotechnology, 中国生物工程杂志，解剖科学进展
性别：男
毕业院校：清华大学
学历：研究生(博士)毕业
学位：博士生
在职信息：在职
所在单位：基础医学院
入职时间：2021-01-27
学科：遗传学
发育生物学
生物化学与分子生物学
办公地点：山东大学趵突泉校区电镜楼209
联系方式：
扫描关注
研究领域
课题组致力于研究细胞稳态、代谢失衡与衰老相关疾病的分子机制。我们重点关注溶酶体与内质网等细胞器的功能障碍、脂质及维生素等关键代谢通路在驱动生物体衰老、生殖能力衰退和细胞死亡过程中的作用，并以此为基础开发代谢干预的新型治疗与长寿策略。
通过多维活体显微成像、高精度脂质组学/代谢组学分析、免疫荧光/共聚焦显微技术、生物化学分析和质谱鉴定等技术，系统分析相关调控因子在生物体衰老、生殖细胞退化和铁死亡等过程中的亚细胞定位、动态相互作用和代谢重编程，明确其在体功能及其分子调控机制。
结合动物疾病模型，验证调控因子的功能和保守性。推动蛋白质功能解析与制备，最终揭示溶酶体-代谢-衰老的分子调控网络，并开发靶向代谢的干预策略。
- Yile Zhai, Tiantian Wang, Jiangxue Han, Mengxiao Wu, Meixi Gong, Wenfei Li and 张哲. Lysosomal control of proteostasis and reproductive capacity by conserved LMD-3 protein in C. elegans. Science Advances, 2025.
- Nanxuan Luo, Yijie Xiao, 翟义乐, Jie Li, Lijie Lv, Houhua Yin, Fang Lin, Biwen Wan, Ke Zhang, Junchi Hu, Junyan Liu, Yongjun Dang, Yi He, Yahui Zhao, 张哲, Shenyou Nie and Haixin Yuan. Vitamin A and its analogues modulate MUFAs metabolism to improve ferroptosis and aging by direct targeting of ACSL3. Acta Pharmaceutica Sinica B, 2025.
- . Comparison of epidemiological characteristics and transmissibility of different strains of COVID-19 based on the incidence data of all local outbreaks in China as of March 1, 2022. Frontiers in Public Health, 10, 949594, 2022.
- 张哲*, Shuo Luo, Guilherme Oliveira Barbosa, Meirong Bai, Thomas B Kornberg and Dengke Ma*. The conserved transmembrane protein TMEM-39 coordinates with COPII to promote collagen secretion and regulate ER stress response. PLoS Genetics, 2021.
- 张哲, Meirong Bai, Guilherme Oliveira Barbosa, Yuehua Wei, Andrew Chen, Shuo Luo, Xin Wang, Bingying Wang, Tatsuya Tsukui, Hao Li, Dean Sheppard, Thomas B Kornberg and Dengke K Ma*. Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking. Science Advances, 2020.
- Pei Zhao#, 张哲#, Hongmei Ke, Yiren Yue and Ding Xue*. Oligonucleotide-based targeted gene editing in C. elegans via the CRISPR/Cas9 system. Cell research, 2014.
- 暂无内容
- 暂无内容
- 暂无内容