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个人信息Personal Information
教授 博士生导师 硕士生导师
任职 : Aging，Cancer，Cancer Genetics，Oncology Letters，General Physiology and Biophysics ，Experimental and Therapeutic Medicine，Food & Function, Psychosomatic Medicine Research(Section Editor), 赣南医学院学报, 中国生物工程杂志
性别：男
毕业院校：清华大学
学历：研究生(博士)毕业
学位：博士
在职信息：在职
所在单位：基础医学院
入职时间：2021-01-27
学科：遗传学
发育生物学
生物化学与分子生物学
办公地点：山东大学趵突泉校区电镜楼209
联系方式：zhezhang@sdu.edu.cn 课题组常年招聘助理教授，博士后；并欢迎博士生，硕士生，本科生报考和实习。
Oxidative stress impairs cell death by repressing the nuclease activity of mitochondrial endonuclease G
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发表刊物：Cell reports
摘要：Endonuclease G (EndoG) is a mitochondrial protein that is released from mitochondria and relocated into the nucleus to promote chromosomal DNA fragmentation during apoptosis. Here, we show that oxidative stress causes cell-death defects in C. elegans through an EndoG-mediated cell-death pathway. In response to high reactive oxygen species (ROS) levels, homodimeric CPS-6-the C. elegans homolog of EndoG-is dissociated into monomers with diminished nuclease activity. Conversely, the nuclease activity of CPS-6 is enhanced, and its dimeric structure is stabilized by its interaction with the worm AIF homolog, WAH-1, which shifts to disulfide cross-linked dimers under high ROS levels. CPS-6 thus acts as a ROS sensor to regulate the life and death of cells. Modulation of the EndoG dimer conformation could present an avenue for prevention and treatment of diseases resulting from oxidative stress.
全部作者：Riley Skeen-Gaar,Wei-Zen Yang,Pei Zhao,张哲,Xiao Ge,Shohei Mitani
第一作者：Jason LJ Lin#,Akihisa Nakagawa#
论文类型：期刊论文
通讯作者：Ding Xue*,Hanna S Yuan*
论文编号：8
是否译文：否
发表时间：2016-07-01
收录刊物：SCI