毕明君，山东大学高等医学研究院，研究员、博士生导师、入选国家级海外引才计划，泰山学者青年专家, 山东省海外优青, 山东大学“齐鲁青年学者”。

长期致力于基因表达的表观遗传学调控研究。主要研究聚焦在解析癌症（乳腺癌和胆管癌等）耐药和转移进程中的表观遗传学调控分子机制。相关工作以第一作者或通讯作者（含共同）身份发表于Nature Cell Biology、Molecular Cell、eLife等国际著名专业期刊，参与编写专著《动物克隆与基因组编辑》，参与美国NIH U54, R01和Susan G. Komen等研究项目，目前主持国自然面上和省自然面上等多个课题项目。已被Theranostics, Cancer Letters, Nucleic Acids Research, eLife, Drug Resistance Updates等多个杂志邀请担任审稿人。2012年获Monsanto Scholarship Award奖。目前担任山东省卫生健康委员会医药卫生铁代谢临床研究重点实验室学术委员会委员和山东省“校园青年引才大使”。

本课题组以表观遗传学，基因组学和肿瘤生物学为基础，以癌症细胞和小鼠为模型，同时利用生物化学、分子生物学、蛋白质组学（BioID/TurboID）、高通量测序（RNA-seq/ATAC-seq/GRO-seq/ChIP-seq/CUT&RUN/CUT&Tag）、生物信息学和CRISPR基因编辑等多学科前沿技术，采用干湿实验结合的方式，研究人类重大疾病（尤其是乳腺癌和胆管癌耐药性和转移）的表观基因组调控机制以及寻找新的药物治疗靶点。

真诚欢迎以探索为乐的有志青年能够加入团队，攻读硕士、博士学位；同时欢迎对本实验室研究方向感兴趣的本科生前来进行科研训练。本实验室长期招聘博士后与科研助理。

近三年发表论文

1. Chi Zhang, Xianfu Yi, Mengfan Hou, Qingyang Li, Xueying Li, Lu Lu, Enlin Qi, Mingxin Wu, Lin Qi, Huan Jian, Zhangyang Qi, Yigang Lv, Xiaohong Kong, Mingjun Bi^#, Shiqing Feng^#, Hengxing Zhou^#. The landscape of m1A modification and its posttranscriptional regulatory functions in primary neurons. eLife, 2023 12: e85324.

2. Mingjun Bi*, Zhao Zhang*, Yi-Zhou Jiang, Pengya Xue, Hu Wang, Zhao Lai, Xiaoyong Fu, Carmine De Angelis, Yue Gong, Zhen Gao, Jianhua Ruan, Victor X. Jin, Elisabetta Marangoni, Elodie Montaudon, Christopher K. Glass, Wei Li, Tim Hui-Ming Huang, Zhi-Min Shao, Rachel Schiff, Lizhen Chen, and Zhijie Liu. Enhancer reprogramming driven by high-order assemblies of transcription factors promotes phenotypic plasticity and breast cancer endocrine resistance. Nat. Cell Biol. 2020 22(6):701-715. **Featured as a “News and Views” in Nature Cell Biology: Wu X, Vakoc C. A pliable ERα cistrome evades therapy. Nat. Cell Biol. 2020 Jun; 22(6): 619-620.［Selected for Faculty Opinions (F1000Prime) and was rated "Very Good".］

3. Chi Zhu*, Li Li*, Zhao Zhang*, Mingjun Bi*, Hu Wang, Wenyue Su, Karen Hernandez, Pingping Liu, Junqiang Chen, Mingqiu Chen, Tim Hui-Ming Huang, Lizhen Chen, Zhijie Liu. A non-canonical role of YAP/TEAD is required for activation of estrogen-regulated enhancers in breast cancer. Mol. Cell 2019 75(4):791-806. **Highlighted with a Commentary article in J. Mol. Cell. Biol.

4. Joo-Hyung Lee, Ruoyu Wang, Feng Xiong, Joanna Krakowiak, Zian Liao, Phuoc T. Nguyen, Elena V. Moroz-Omori, Jiaofang Shao, Xiaoyu Zhu, Michael J. Bolt, Haoli Wu, Pankaj K. Singh, Mingjun Bi, Caleb J. Shi, Naadir Jamal, Guojie Li, Ragini Mistry, Sung Yun Jung, Kuang-Lei Tsai, Josephine C. Ferreron, Fabio Stossi, Amedeo Caflisch, Zhijie Liu, Michael A. Mancini, Wenbo Li. Enhancer RNA m6A methylation facilitates transcription condensates formation and gene activation. Mol. Cell 2021 81(16):3368-3385.

5. Mei Yang, Ji-Hoon Lee, Zhao Zhang, Richard De La Rosa, Mingjun Bi, Yuliang Tan, Yiji Liao, Juyeong Hong, Baowen Du, Yanming Wu, Jessica Scheirer, Tao Hong, Wei Li, Teng Fei, Chen-Lin Hsieh, Zhijie Liu, Wenbo Li, Michael G. Rosenfeld, and Kexin Xu. Enhancer RNAs mediate estrogen-induced decommissioning of selective enhancers by recruiting ERα and its cofactor. Cell Rep. 2020 Jun 23; 31(12):107803.

6. Zhao Zhang, Wei Yu, Dan Tang, Yufan Zhou, Mingjun Bi, Hu Wang, Yan Zheng, Mingqiu Chen, Li Li, Xinping Xu, Wei Zhang, Huimin Tao, Victor X. Jin, Zhijie Liu, and Lizhen Chen. Epigenomics-based identification of estrogen-regulated long noncoding RNAs in ER+ breast cancer. RNA Biol. 2020 Nov; 17(11):1590-1602.

毕明君-山东大学高等医学研究院

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