研究内容：

  工程生物学团队聚焦于非粮生物质的高效降解利用、单细胞油脂/蛋白的规模化生产、生物基醇/酸/酯的绿色制造；以细胞工厂深度代谢定制、智能化装备及算法、生物-化工融合工艺为特色；针对生物制造瓶颈重点打造秸秆糖平台、天玑自动化平台、占微过程优化平台，服务于粮食安全/能源安全/环境安全的国家重大需求。

组织架构：

  团队负责人崔球教授，团队下设3个支撑小组（分析组、天玑组、占微组）以及3个业务小组（糖前组、糖化组、糖后组）

代表性成果：

1.千吨级秸秆连续糖化装备及生产线

2.千吨级单细胞油脂、蛋白生产线

3.全栈自研合成生物学并行自动流水线

4.细胞代谢分析装备及过程优化算法

5.木质纤维素融合酶系糖化新工艺

技术转移转化:

1.高效基因转化仪，青岛百奥新创生物技术有限公司

2. 微生物油脂高效生产技术，杭州合碳创物科技有限公司

代表性学术论文:

1.Huan Liu^#*, Wei Gao^#, Tianlun Cui, Sen Wang, Xiaojin Song, Zhuojun Wang, Huidan Zhang, Shiming Li, Yong-Liang Yu, Qiu Cui*(2024) A high-throughput platform enables in situ screening of fatty acid-producing strains using laser ablation electrospray ionization mass spectrometry and a Python package. Talanta 268:125234. [PMID: 37839326] [Full text (Publisher website)]

2. Fei Xiao, Tai-Ping Zhou, Sheng Dong, Tong Li, Cai-Hong Yun, Yinggang Feng, Qiu Cui, Kui Hong, Binju Wang*, Wenli Li* （2024）  Molecular basis for the P450-catalyzed sp3 C‒N glycosidic bond formation in staurosporine biosynthesis. ACS Catalysis, 14, 14274–14284.  

3.Sheng Dong,  Jinsong Xuan, Yingang Feng, Qiu Cui (2024) Deciphering the stereo-specific catalytic mechanisms of cis-epoxysuccinate hydrolases producing L(+)-tartaric acid. Journal of Biological Chemistry 300(2)：105635-105641.

4.Yilan Wang, Yuedong Zhang, Qiu Cui, Yingang Feng, Jinsong Xuan (2024) Composition of Lignocellulose Hydrolysate in Different Biorefinery Strategies: Nutrients and Inhibitors Molecules 29(10)：2275-2301.

5.Chao Chen; Hongwu Yang; ShengDong; Cai You; Sarah Moraïs; EdwardA.Bayer; Ya-Jun Liu; Jinsong Xuan; Qiu Cui; Itzhak Mizrahi; Yingang Feng (2024) Acellulosomal double-dockerin module from Clostridium thermocellum shows distinct structural and cohesin-binding features. Protein Science. 33:e4937.

6. Min Xiao; Ya-Jun Liu; Edward A. Bayer; Akihiko Kosugi; Qiu Cui; Yingang Feng (2024) Cellulosomal hemicellulases: Indispensable players for ensuring effective lignocellulose bioconversion. Green Carbon 2(2)：57-69.

7. Sheng Dong; Chao Chen; Jie Li; Ya‐Jun Liu; Edward A. Bayer; Raphael Lamed; Itzhak Mizrahi; Qiu Cui; Yingang Feng (2024) Unique Fn3‐like biosensor in σI/anti‐σI factors for regulatory expression of major cellulosomal scaffoldins in Pseudobacteroides cellulosolvens. Protein Science, 33(11).