教授
博士生导师
硕士生导师
性别：女
毕业院校：武汉大学
学历：研究生(博士后)
学位：医学博士学位
在职信息：在职
所在单位：基础医学院
入职时间：2001-07-01
联系方式：15562619322
访问量：
最后更新时间：..
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[1]
.
Soluble Tim-3 serves as a tumor prognostic marker and therapeutic target for CD8 + T cell exhaustion and anti-PD-1 resistance.
CELL REPORTS MEDICINE,
5,
2024.
-
[2]
.
Urolithin A Hijacks ERK1/2-ULK1 Cascade to Improve CD8+ T Cell Fitness for Antitumor Immunity.
Advanced Science,
2024.
-
[3]
武专昌.
Peptide targeting the interaction of S protein cysteine-rich domain with Ezrin restricts pan-coronavirus infection.
SIGNAL TRANSDUCTION AND TARGETED THERAPY,
8,
2023.
-
[4]
.
Identification of a small-molecule Tim-3 inhibitor to potentiate T cell-mediated antitumor immunotherapy in preclinical mouse models.
SCIENCE TRANSLATIONAL MEDICINE,
15,
2023.
-
[5]
张言坤.
ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury.
NATURE COMMUNICATIONS,
14,
2023.
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[6]
孔亮.
Monocarboxylate transporter 1 promotes classical microglial activation and pro-inflammatory effect via 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3.
16,
2019.
-
[7]
.
Frontline Science: Tim-3-mediated dysfunctional engulfment of apoptotic cells in SLE.
JOURNAL OF LEUKOCYTE BIOLOGY,
102,
1313,
2017.
-
[8]
.
CUL4B facilitates HBV replication by promoting HBx stabilization.
CANCER BIOLOGY & MEDICINE,
2021.
-
[9]
张晓东.
TIPE1 promotes liver regeneration by enhancing ROS-FoxO1 axis mediated autophagy..
FEBS JOURNAL,
2022.
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[10]
丁璐.
Zhx2 maintains islet β-cell mass and function by transcriptionally regulating Pax6.
iScience,
26,
106871,
2023.
-
[11]
王樱淳.
Depletion and reconstitution of macrophages in mice with vesicular stomatitis virus infection.
STAR Protocols,
2023.
-
[12]
.
Tim-4 maintains adipose tissue homeostasis by orchestrating M2 macrophage polarization via NF-κB pathway..
Immunology,
168,
49-62,
2022.
-
[13]
王玉珍.
TIM-4 orchestrates mitochondrial homeostasis to promote lung cancer progression via ANXA2/PI3K/AKT/OPA1 axis.
Cell Death & Disease,
14,
2023.
-
[14]
焦德雁.
Lipid accumulation-mediated histone hypoacetylation drives persistent NK cell dysfunction in anti-tumor immunity.
Cell Reports,
42,
2023.
-
[15]
田盼盼.
Early life gut microbiota sustains liver-resident natural killer cells maturation via the butyrate-IL-18 axis..
NATURE COMMUNICATIONS,
2023.
-
[16]
王樱淳.
Tim-4 reprograms cholesterol metabolism to suppress antiviral innate immunity by disturbing the Insig1-SCAP interaction in macrophages.
cell reports,
2022.
-
[17]
孙杨.
LINC01431 Promotes Histone H4R3 Methylation to Impede HBV Covalently Closed Circular DNA Transcription by Stabilizing PRMT1.
Advanced Science,
9,
e2103135,
2022.
-
[18]
岳学田.
SREBF2-STARD4 axis confers sorafenib resistance in HCC by regulating mitochondrial cholesterol homeostasis..
CANCER SCIENCE,
2022.
-
[19]
谭思雨.
Transcription factor Zhx2 restricts NK cell maturation and suppresses their antitumor immunity.
Journal of Experimental Medicine,
218,
2021.
-
[20]
王体潇.
Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development.
MOLECULAR THERAPY,
2022.
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