• 2009-09 — 2014-07
  山东大学
  妇产科学
  博士
• 2003-09 — 2009-07
  山东大学
  临床医学
  医学学士学位

• 2025-12 — 至今
   生殖内分泌教育部重点实验室 
  副主任
• 2025-01 — 至今
   教育教学办公室  山东大学妇儿与生殖健康研究院 
  主任
• 2025-01 — 至今
   山东大学附属生殖医院 
  副主任医师
• 2024-01 — 至今
   山东大学妇儿与生殖健康研究院 
  教授，博士生导师
• 2019-09 — 2023-12
   山东大学生殖医学研究中心 
  副教授，硕士生导师
• 2016-07 — 2019-08
   山东大学生殖医学研究中心 
  助理研究员
• 2014-02 — 2016-02
   美国国立卫生研究院(NIH) 
  博士后

• 2023-01 — 至今
  山东省免疫学会青年工作委员会 委员
• 2024-01 — 至今
  《Phenomics》 青年编委
• 2024-01 — 至今
  《生殖医学杂志》 编委
• 2024-01 — 至今
  山东省医学会妇产科学分会 委员
• 2023-01 — 至今
  中国免疫学会生殖免疫分会 委员
• 2024-01 — 至今
  中国遗传学会青年委员会 委员
• 2024-01 — 至今
  中国动物学会生殖生物学分会 委员
• 2019-11 — 至今
  山东免疫学会生殖免疫专业委员会委员

1. 女性生殖衰老调控机制及临床研究

2. 生殖障碍疾病免疫致病机制及干预研究

1.生殖障碍性疾病；生殖内分泌；生殖免疫；生殖衰老；卵巢衰老；母-胎免疫耐受

(1) Stress granule clearance mediated by V-ATPase-interacting protein NCOA7 mitigates ovarian aging.Nature Aging.2025

(2) CCR8+ decidual regulatory T cells maintain maternal-fetal immune tolerance during early pregnancy.Science Immunology.2025,10 (106):eado2463

(3) 董婷.Oxidative stress response protein delays ovarian aging by promoting stress granule clearance.Nature Aging.2025,5 (9):1667-1668

(4) NLRP14 modulates the activity of E3 ubiquitin ligases during the oocyte-to-embryo transition.Nat Commun.2026 (17):4986

(5) Calumenin prevents fibroblasts senescence and lung aging by promoting vimentin proteostasis.Proc Natl Acad Sci U S A.2026,123 (4):2426723123

(6) 胡孟春.Can ferroptosis be a target for reproductive health.TRENDS IN ENDOCRINOLOGY AND METABOLISM.2024 (na)

(7) NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance.Cell Reports.2023,42 (12)

(8) Treg deficiency-mediated TH1 response causes human premature ovarian insufficiency through apoptosis and steroidogenesis dysfunction of granulosa cells.CLINICAL AND TRANSLATIONAL MEDICINE.2021 (6)

(9) 刘薇.Increased NKG2A+CD8+ T-cell exhaustion in patients with adenomyosis.MUCOSAL IMMUNOLOGY.2023,16 (2):121

(10) 焦雪.Molecular Genetics of Premature Ovarian Insufficiency.TRENDS IN ENDOCRINOLOGY AND METABOLISM.2018,29 (11):795

(11) Cohort Profile: the Chinese Ovarian Aging Cohort (COACH).Phenomics.2026,0 (0):0

(12) ERAP2 as a potential marker for ovarian aging and spontaneous ovulation recovery in women with premature ovarian insufficiency.BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY.2025,0 (0):0

(13) Influence of COVID-19 on endocrine and metabolic profiles in women with pathological ovarian aging.JOURNAL OF OVARIAN RESEARCH.2025,18 (1):259

(14) 祝晨迪.New theca-cell marker insulin-like factor 3 is associated with premature ovarian insufficiency.Fertility and Sterility.2021 (2):455

(15) 李念娱.Two distinct resident macrophage populations coexist in the ovary.Frontiers in Immunology.2022 (13)

(16) 李竹青.Association between thyroid autoimmunity and the decline of ovarian reserve in euthyroid women.Reproductive BioMedicine Online.2022,45 (3):615

(17) The TH 22-mediated IL-22 deficiency associated with premature ovarian insufficiency.Am J Reprod Immunol.2023,89 (4)

(18) 李念娱.The impact of moderately high preconception thyrotropin levels on ovarian reserve among euthyroid infertile women undergoing assisted reproductive technology.Thyroid.2022,32 (7):841

(19) 孟婷婷.Ovarian Reserve and ART Outcomes in Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Patients With FOXL2 Mutations.Frontiers in Endocrinology.2022 (13):829153

(20) Ovarian Reserve Markers in Premature Ovarian Insufficiency: Within Different Clinical Stages and Different Etiologies.Frontiers in Endocrinology.2021 (601752)

(21) 刘雪莹.Growth hormone cotreatment for low-prognosis patients according to the POSEIDON criteria.Frontiers in Endocrinology.2021 (12):790160

(22) Autophagy Regulates Differentiation of Ovarian Granulosa Cells through Degradation of WT1.Autophagy.2022,18 (8):1864

(23) 刘培昊.Dysregulated cytokine profile associated with biochemical premature ovarian insufficiency.AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY.2020,84 (4)

(24) 柯晗昵.Impact of Thyroid Autoimmunity on Ovarian Reserve, Pregnancy Outcomes, and Offspring Health in Euthyroid Women Following In Vitro Fertilization/Intracytoplasmic Sperm Injection.Thyroid.2020,30 (4):588

(25) Gao, Jing.Identification of patients with primary ovarian insufficiency caused by autoimmunity.Reproductive BioMedicine Online.2017,35 (4):475

(26) 焦雪.Premature Ovarian Insufficiency: Phenotypic Characterization Within Different Etiologies.JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM.2017,102 (7):2281

(27) Zhang, Dunfang.D-mannose induces regulatory T cells and suppresses immunopathology.nature medicine.2017,23 (9):1036

(28) Guo, Ting.Mutations in MSH5 in primary ovarian insufficiency.Human Molecular Genetics.2017,26 (8):1452

(29) 焦雪.Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.Nat Commun.2015

(30) 焦雪.Genetics of primary ovarian insufficiency: new developments and opportunities.Hum Reprod Update.2015

(31) 焦雪.CSB-PGBD3 Mutations Cause Premature Ovarian Failure.PLoS Genet.2015

(32) 焦雪.Transcription factor SOHLH1 potentially associated with primary ovarian insufficiency.fertil steril.2015

(33) 秦莹莹.Novel variants in the SOHLH2 gene are implicated in human premature ovarian failure.fertil steril.2014 (4):1104

(34) 焦雪.Novel NR5A1 missense mutation in premature ovarian failure: detection in han chinese indicates causation in different ethnic groups.Plos one.2013 (9)

(35) Cytogenetic analysis of 531 Chinese women with premature ovarian failure.Hum Reprod.2012 (7)

(36) 朱瑞敏.新时代医学类研究生招生工作路径探索.教育教学论坛.2024 (19)

(37) 李念娱.性腺组织驻留巨噬细胞的研究进展.中华生殖与避孕杂志.2022,42 (4):419

1. 一种利用琼脂糖-海藻酸钙复合水凝胶微腔进行次级卵泡三维培养的方法

2. 一种卵巢功能衰退女性的妊娠预测模型及其应用

3. 检测ERAP2的试剂在制备预测POI预后情况的产品中的应用

4. 早发性卵巢功能不全相关致病基因及其应用

1. 女性生育力受损主要不良因素及关键生物靶标鉴定, 2024-12-01-2027-11-30

2. 母胎耐受关键细胞分子在流产防治及干细胞移植中的应用, 2022-11-03-2027-11-30

3. 生殖发育与子代健康, 2023-01-01-2025-12-31

4. 蜕膜CCR8+Treg细胞在母-胎免疫耐受维持及早期妊娠丢失中的作用及机制研究, 2023-08-24-2027-12-31

5. （包干项目）卵巢功能不全, 2022-11-01-2025-12-30

6. 母源效应基因NLRP14在人类早期胚胎停滞中的作用及致病机制研究, 2021-10-12-2025-12-31

7. 卵巢病变对卵母细胞发育和成熟的影响, 2018-12-01-2021-12-31

8. 卵巢驻留NK细胞特性及在早发性卵巢功能不全发病中的作用, 2019-08-16-2023-12-31

9. 性腺器质性病变的机制, 2016-07-01-2021-06-30

10. IL-17/IL-17Rs信号通路在原发性卵巢功能不全中的作用及其机制研究, 2016-11-18-2019-06-30

11. Th17/Treg失衡在原发性卵巢功能不全发生中的作用及其机制研究, 2016-08-17-2019-12-31

1. 山东省医学会青年科技奖

2. 妇幼健康科学技术奖

3. 山东医学科技奖

1. 第二届中国医学教育题库命题创新大赛

2. 中国国际大学生创新大赛（2025）山东赛区金奖/山东省大学生创新大赛（2025）金奖 指导教师

3. 中国国际大学生创新大赛（2025）银奖 指导教师

4. 山东省第十届高等教育省级教学成果奖（研究生）

5. 山东省研究生创新成果奖 指导教师

1.朱寒冰

2.卢悦双

3.司品欣

4.孟姝彤

5.王心璐

6.朱寒冰

7.王常静

8.王常静

9.朱寒冰

10.司品欣

11.卢悦双

1.齐鲁医学院   妇产科学   2025  

2.齐鲁医学院   妇产科学   2025  

1. 生殖内分泌学 第二版

2. 临床诱导排卵与卵巢刺激

3. 中华妇产科学 第四版

4. Genetics of Primary Ovarian Insufficiency