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2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies
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Affiliation of Author(s):药学院
Journal:《Journal of Medicinal Chemistry》
First Author:康东伟
Document Code:B6CD2C31617A48FAABE36D596B435BCD
Volume:64
Issue:7
Page Number:4239
Translation or Not:no
Date of Publication:2021-04-08
Pre One:Exploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives as potent HIV-1 NNRTIs
Next One:Design, synthesis, and evaluation of "dual-site"-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase
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