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所属单位：Shandong Provincial Hospital Affiliated to Shandong University

教研室：中医教研室

发表刊物：Oncotarget

刊物所在地：瑞士

项目来源：山东省重点研发计划.项目编号2016GSF201018

关键字：APC hypermethylation early diagnosis colorectal cancer

摘要：Adenomatous polyposis coli (APC) promoter hypermethylation has been frequently observed in colorectal cancer (CRC). The association between APC promoter methylation and clinicopathological significance in CRC is under investigation. We performed a meta-analysis to quantitatively evaluate the significance of APC methylation in CRC. The study included a total of 24 articles and 2025 CRC patients. The frequency of APC promoter hypermethylation was significantly higher in colorectal adenoma than in normal colorectal tissue, OR was 5.76, 95% CI, 2.45-13.56; p<0.0001, I2=0%. APC promoter more freque

论文类型：应用研究

学科门类：医学

一级学科：临床医学

文献类型：S

卷号：No. 28

期号：2017, Vol. 8, (No. 28)

页面范围：46468-46479

ISSN号：1949-2553

是否译文：否

发表时间：2017-05-02

收录刊物：SCI