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所属单位：Shandong Provincial Hospital Affiliated to Shandong University

教研室：中医教研室

发表刊物：Int J Clin Exp Pathol

刊物所在地：欧洲

项目来源：山东省重点研发计划.项目编号2016GSF201018

关键字：Ulcerative colitis, p-glycoprotein, multidrug resistance gene, intestinal mucosa barrier

摘要：Aims: Efflux transporters such as P-glycoprotein (Pgp; MDR1/ABCB1) protect the enterocytes from potentially toxic substances. The aim of this study was to evaluate Pgp expression in inflamed mucosa of patients with active Ulcerative Colitis (UC), and to compare the results of Pgp expression with healthy subjects. We also explored the relationship between Pgp expression and the pathogenesis of UC in this study. Methods: Pgp expression was determined with real-time PCR (SYBR GREEN), immunohistochemistry (IHC-SP method) and Western blot in inflamed mucosa of newly diagnosed (n = 102) patients wi

论文类型：应用研究

学科门类：医学

一级学科：临床医学

文献类型：S

卷号：10(4）

期号：2017;10(4)

页面范围：:4552-4558

ISSN号：1936-2625

是否译文：否

发表时间：2017-04-15

收录刊物：SCI