生殖细胞发生机制研究与药物研发 生殖医学与子代健康全国重点实验室山东大学附属生殖医院 刘洪彬，男，教授/博导，生殖医学与子代健康全国重点实验室（山东大学）PI。山东省泰山学者青年专家，山东大学齐鲁青年学者，山东大学未来青年学者。主要从事遗传与表观遗传因子在生殖细胞发生机制研究与药物研发。在Genome Biology、EMBO Journal、Science Advances、Protein & Cell、Nucleic Acids Research (x3）、Advanced Science（x2）、Science Bulletin、eLife（x2）等主流期刊发表高水平论文近30篇，获授权国家发明专利5项。主持国家自然科学基金面上项目2项、国家重点研发计划课题1项、山东省杰出青年基金1项、山东省重大科技创新工程1项、山东省自然科学基金面上项目1项等，参与国家重点研发计划3项（独立PI）、国家自然科学基金重大项目1项（独立PI）、横向课题3项。荣获全国妇幼健康科学技术奖一等奖、中华医学科技奖一等奖。山东大学附属生殖医院、生殖内分泌教育部重点实验室（山东大学）和香港中文大学-山东大学生殖遗传联合实验室课题组组长。担任中国生理学会生殖科学专业委员会委员、中国解剖学会医学发育生物学分会青年委员、山东省干细胞学会第一届干细胞技术与临床应用研究专业委员会委员。 研究方向利用基因敲除、条件性基因敲除、点突变和标签小鼠，研究生殖细胞减数分裂的分子机制，解析基因异常与不孕不育的关系，为临床诊疗提供理论支持。以临床问题为导向，依托山东大学生殖疾病资源库，结合高通量 、基因修饰小鼠模型等手段，系统解析遗传/表观遗传因子在配子发生异常中的作用，并探索其不孕不育疾病中的发病机理，为优生遗传提供分子标记。卵子/早期胚胎发育的调控机制。生殖及遗传疾病药物研发。研究生招聘报考院系：依托基础医学院（享受生殖医院待遇）报考专业方向：细胞生物学研究领域：生殖细胞发生异常与人类不孕不育招生名额：学术型硕士1名、学术型博士1名 博士后招聘常年招收博士后（每年2-3名）http://www.sduivf.sdu.edu.cn/info/1031/1508.htm博士后课题方向如下：（都已拿到小鼠模型，支持申请博后相关基金和人才）1.配子发生：包括减数分裂启动、DNA双链断裂与修复等2.雌雄配子减数分裂时期性染色体调控差异3.卵子成熟与胚胎激活4.非梗阻性无精症家系新的遗传病因解析（与多家临床医院合作）5.辅助生殖药物研发(已建立稳定筛选和动物模型)：包括促排卵、胚胎培养液、生精、男性勃起功能障碍、优生优育遗传诊断标记筛选。与香港中文大学和天津药物研究院有限公司(药物成药性评价与系统转化全国重点实验室)，签订“生殖及遗传疾病药物研发战略合作”，充分发挥双方优势，开发我国自主知识产权的生殖相关药物。优秀的博后，可以推荐到香港中文大学继续做博后（QS世界大学排名36），开展合作课题，年薪税后50万港币。 生殖医学与子代健康全国重点实验室链接：：http://www.sduivf.sdu.edu.cn/ 主持/参与项目1. 国家自然科学基金重大项目：减数分裂DNA双链断裂修复途径和修复中间产物解体方式的选择调控，2019.01-2023.122. 国家重点研发计划：生精微环境调控异常与精子发生障碍，2021.12-2024.113. 国家重点研发计划：减数分裂异常导致人类不孕不育的分子基础，2018.12-2021.124. 国家重点研发计划：改善卵母细胞成熟的临床策略及安全性评价，2017.07-2020.125. 国家自然科学基金面上项目：SENP3参与减数分裂调控及在男性不育中的机制研究，2021.01-2024.126. 国家自然科学基金面上项目：PCOS新易感基因HMGA2在颗粒细胞增殖中的作用和机制研究，2017.01-2021.127. 国家自然科学基金基础科学中心项目：卵子发生和胚胎发育的调控，2020.01-2024.12，参与8. 山东省重大创新工程项目：精子发生异常的致病基础与分子诊断研究，2022.01-2024.129. 山东省自然科学基金省杰青基金项目：配子发生异常与不孕不育，2022.01-2024.12 10.中国医学科学院-创新单元 <配子发生与辅助生殖子代健康>, 2020-2024,参与依托平台1. 生殖医学与子代健康全国重点实验室2. 生殖内分泌教育部重点实验室3. 国家辅助生殖与优生工程技术研究中心4. 山东大学“学科高峰计划”5. 山东省生殖医学重点实验室6. 山东省生殖健康临床医学研究中心7. 香港中文大学-山东大学生殖遗传联合实验室 社会兼职1. 中国动物学会生殖生物学分会-中国生理学会生殖科学专业委员2. 山东省医学会干细胞临床研究与应用分会委员3. 山东省干细胞学会干细胞技术与临床应用研究专业委员会委员 荣誉奖励/Honors & Awards1. 山东大学青年学者未来计划，2016年2. 山东大学齐鲁青年学者，2020年3. 山东省泰山学者青年专家，2020年4. 山东省杰出青年基金获得者，2021年5. 山东省研究生教育课程思政师范教学团队（3/8），2021年6. 中华医学科技奖青年科技奖（3/7），2021年7. 妇幼健康科学技术奖自然科学奖一等奖（6/15），2021年发表文章2024年Wang S, Cai Y, Li T, Wang Y, Bao Z, Wang R, Qin J, Wang Z, Liu Y, Liu Z, Chan WY, Chen X, Lu G*, Chen Z-J*, Huang T*, Liu H*. CWF19L2 is Essential for Male Fertility and Spermatogenesis by Regulating Alternative Splicing. Adv Sci (Weinh). 2024 Jun 18:e2403866. Liu Y, Li T, Shi M, Wan Y, Li H, Zhang M, Wang Z, Wang S, Lv Y, Lu G, Liu H*, Zhang H*, Huang T*. MORN2 regulates the morphology and energy metabolism of mitochondria and is required for male fertility in mice. J Transl Med. 2024 Mar 5;22(1):240. Wang Z, Li T, Liu D, Li M, Liu S, Yu X, Li H, Song H, Zhao W, Liu Z, Chen X, Lu G, Chen Z-J, Huang T*, Liu H*. The deubiquitinase cofactor UAF1 interacts with USP1 and plays an essential role in spermiogenesis. iScience. 2024 Mar 11;27(4):109456. Bao Z, Wang Y, Wang R, Dong F, Li T, Chan WY, Chen ZJ, Lu G*, Liu H*, Chen X*. Pathogenic TDRD12 variants cause defective piRNA pathway and male infertility in humans and mice. J Genet Genomics. 2024 Jul 1:S1673-8527(24)00156-5. doi: 10.1016/j.jgg.2024.06.014. Epub ahead of print. PMID: 38960314.Wang Jing, Yin Yingying, Yang Lei, Qin Junchao, Wang Zixiang, Qiu Chunhong, Gao Yuan, Lu Gang, Gao Fei, Chen Zi-jiang, Zhang Xiyu, Liu Hongbin*, Liu Zhaojian* (2024) TMC7 deficiency causes acrosome biogenesis defects and male infertility in mice. eLife 13:RP95888 https://doi.org/10.7554/eLife.95888. Li L, Mao R, Yuan S, Xie Q, Meng J, Gu Y, Tan S, Xu X, Gao C, Liu H, Ma C, Man SM, Meng X, Xu T, Qi X. NCF4 attenuates colorectal cancer progression by modulating inflammasome activation and immune surveillance. Nat Commun. 2024 Jun 17;15(1):5170. doi: 10.1038/s41467-024-49549-7. PMID: 38886341 Ran J, Guo G, Zhang S, Zhang Y, Zhang L, Li D, Wu S, Cong Y, Wang X, Xie S, Zhao H, Liu H, Ou G, Zhu X, Zhou J, Liu M. KIF11 UFMylation Maintains Photoreceptor Cilium Integrity and Retinal Homeostasis. Adv Sci (Weinh). 2024 Jul;11(25):e2400569. doi: 10.1002/advs.202400569. Epub 2024 Apr 26. 2023年 Wang Z#, Fang K, Wan Y, Yin Y, Li M, Xu K, Li T, Cao Y, Lv Y, Lu G, Liu H, Huang T*. TTC6-Mediated Stabilization of the Flagellum Annulus Ensures the Rapid and Directed Motion of Sperm. Cells. 2023 Aug 18;12(16):2091. [IF: 5.99]Wan Y#, Yang S#, Li T, Cai Y, Wu X, Zhang M, Muhammad T, Huang T, Lv Y, Chan WY, Lu G, Li J, Sha QQ*, Chen ZJ*, Liu H*. LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance. Nucleic Acids Res. 2023 Nov 27;51(21):11652-11667. [IF: 16.40] Liu C#, Wang Q#, Gu L#, Wang X#, Yin Y#, Huang T, Xiao S, Zhang S, Wang F, Zhou T, Xu G, Wang L, Dong F, Jiang J, Luo M, Li J, Zhang H, Chen Z-J, Ji W*, Ji B*, Liu H*, Li W*. CCDC176 stabilizes microtubule doublets 1 and 9 to ensure proper sperm movement. Current Biology. Available online 25 July 2023. 33,1-18. [IF: 11.00]Muhammad T#, Wan Y#, Lv Y, Li H, Naushad W, Chan W-Y, Lu G*, Chen Z-J*, Liu H*. Maternal Obesity: A potential disruptor of female fertility and current interventions to reduce associated risks. Obesity Reviews. 2023 Oct;24(10):e13603. [IF: 9.80]Wang M#, Kang J, Shen Z, Hu Y, Chen M, Cui X, Liu H*, Gao F*. CCDC189 is involved in sperm flagellum formation by interacting with CABCOCO1. National Science Review. nwad181, https://doi.org/10.1093/nsr/nwad181. Published:26 June 2023. [IF: 22.30]Huang T#, Wu X#, Wang S, Bao Z, Wan Y, Wang Z, Li M, Yu X, Lv Y, Liu Z, Chen X, Chan W-Y, Gao F, Lu G*, Chen Z-J*, Liu H*. SPIDR is Required for Homologous Recombination During Mammalian Meiosis. Nucleic Acids Research. 2023 May 8;51(8):3855-3868. [IF: 16.40]Xu K#, Su X#, Fang K#, Lv Y , Huang T, Li M, Wang Z , Yin Y, Muhammad T, Liu S, Chen X, Jiang J, Li J, Chan W-Y, Ma J, Lu G*, Chen Z-J*, Liu H*.The Slingshot phosphatase 2 is required for acrosome biogenesis during spermatogenesis in mice. eLife. 2023 Mar 21;12:e83129. [IF: 8.30]Qin J# , Huang T #, Wang Z # , Zhang X , Wang J, Dang Q, Cui D, Wang X, Zhai Y, Zhao L, Lu G, Shao C , Li S, Liu H*, Liu Z*. Bud31-mediated alternative splicing is required for spermatogonial stem cell self-renewal and differentiation . Cell Death and Differentiation. 2023 Jan;30(1):184-194. [IF: 13.30] Fucheng Dong, Xiuge Wang, Tao Huang, Yingying Yin, Sai Xiao, Yanjie Ma, Huafang Wei, Bingbing Wu, Ruidan Zhang, Liying Wang, Xuejiang Guo, Fei Gao, Chao Liu, Hongbin Liu*, Jianguo Zhao*, Wei Li*. CCDC178-mediated cytoskeleton assembly is required for spermiogenesis in mice,Genes & Diseases,2023,101132,ISSN 2352-3042, https://doi.org/10.1016/j.gendis.2023.101132.2022年1. Yuan S#, Huang T*#, Bao Z#, Wang S#, Wu X#, Liu J*, Liu H*, Chen Z-J*. The histone modification reader ZCWPW1 promotes double‑strand break repair by regulating cross‑talk of histone modifications and chromatin accessibility at meiotic hotspots. Genome Biology. 2022 Sep 6;23(1):187. [IF: 17.40]2. Lv Y# , Lu G# , Cai Y#, Su R# , Liang L, Wang X, Mu W, He X, Huang T, Ma J, Zhao Y, Chen Z-J*, Xue Y*, Liu H*, Chan W-Y*. RBM46 is essential for gametogenesis and functions in posttranscriptional roles affecting meiotic cohesin subunits. Protein & Cell. 2022 Sep 14;14(1):51-63. [IF: 16.70]3. Yin Y#, Mu W, Yu X, Wang Z, Xu K, Wu X, Cai Y, Zhang M, Lu G, Chan W-Y, Ma J, Huang T*, Liu H*. LRRC46 Accumulates at the Midpiece of Sperm Flagella and Is Essential for Spermiogenesis and Male Fertility in Mouse. International Journal of Molecular Sciences. 2022 Jul 31;23(15):8525. [IF: 6.20]4. Wan Y#, Muhammad T#, Huang T, Lv Y, Sha Q, Yang S, Lu G, Chan W-Y, Ma J, Liu H*. IGF2 reduces meiotic defects in oocytes from obese mice and improves embryonic developmental competency. Reproductive Biology and Endocrinology. 2022 Jul 14;20(1):101. [IF: 5.30] 5. Yu X#, Lu S, Yuan M, Ma G, Li X, Zhang T, Gao S, Wei D, Chen Z-J, Liu H*, Zhang H*. Does ICSI outcome in obstructive azoospermia differ according to the origin of retrieved spermatozoa or the cause of epididymal obstruction? A comparative study. International Urology and Nephrology. 2022 Dec;54(12):3087-3095. [IF: 2.20]2021年1. Liu C#, Liu H#, Zhang H#, Wang L#, Li M, Cai F, Wang X, Wang L, Zhang R,Yang S, Liu W, Liang Y, Wang L, Song X, Su S, Gao H, Jiang J, Li J, Luo M, Gao F, Chen Q, Li W*, Chen Z-J*. Paternal USP26 mutations raise Klinefelter Syndrome risk in the offspring of mice and humans. EMBO Journal. 2021 Jul 1;40(13):e106864. [IF: 14.16]2. Wu B#, Yu X#, Liu C, Wang L, Huang T, Lu G, Chen Z-J, Li W*, Liu H*. Essential role of CFAP53 in sperm flagellum biogenesis. Frontiers in Cell and Developmental Biology. 2021 May 28;9:676910. [IF: 6.58]3. Yu X#, Li M#, Cai F, Yang S, Liu H*, Zhang H*. A new TEX11 mutation causes azoospermia and testicular meiotic arrest. Asian Journal of Andrology. Sep-Oct 2021;23(5):510-515. [IF: 3.68]2020年1. Muhammad T#, Wan Y#, Sha Q, Wang J, Huang T, Cao Y, Li M, Yu X, Yin Y, Chan W-Y, Chen Z-J, You L*, Lu G*, Liu H*. IGF2 improves the developmental competency and meiotic structure of oocytes from aged mice. Aging-US. 2020 Dec 9;13(2):2118-2134. [IF: 6.38]2. Shang Y#, Huang T#, Liu H, Liu Y, Liang H, Yu X, Li M, Zhai B 2, Yang X, Wei Y, Wang G, Chen Z-J*, Wang S*, Zhang L*. MEIOK21: a new component of meiotic recombination bridges required for spermatogenesis. Nucleic Acids Research. 2020 Jul 9;48(12):6624-6639. [IF: 15.54]3. Huang T#, Yin Y#, Liu C, Li M, Yu X, Wang X, Zhang H, Muhammad T, Gao F, Li W, Chen Z-J*, Liu H*, Ma J*. Absence of Murine CFAP61 Causes Male Infertility due to Multiple Morphological Abnormalities of the Flagella. Science Bulletin. 2020 May 30;65(10);854-864. [IF: 14.20]4. Huang T#, Yuan S#, Gao L, Li M, Yu X, Zhang J, Yin Y, Liu C, Zhang C, Lu G, Li W, Liu J*, Chen Z-J*, Liu H*. The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double strand break repair. eLife. 2020 May 6;9. pii: e53459. [IF: 9.06]5. Muhammad T#, Li M#, Wang J, Huang T, Zhao S, Zhao H, Liu H*, Chen Z-J*. Roles of insulin-like growth factor II in regulating female reproductive physiology. Science China-Life Sciences. 2020 Jun;63(6);849-865. [IF: 7.10]2019年1. Li M#, Huang T#, Li M#, Zhang C#, Yu X, Yin Y, Liu C, Wang X, Feng H, Zhang T, Liu M, Han C, Lu G, Li W, Ma J, Chen Z-J, Liu H*, Liu K*.The histone modification reader ZCWPW1 is required for meiosis prophase I in male but not in female mice. Science Advances. 2019 Aug 14;5(8):eaax1101. [IF: 14.10]2. Liu H#, Huang T#, Li M#, Li M, Zhang C, Jiang J, Yu X, Yin Y, Zhang F, Lu G, Luo M, Zhang L, Li J, Liu K, Chen Z-J*. SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice. Nucleic Acids Research. 2019 Jun 20;47(11):5670-5683. [IF: 11.80]3. Liu H#, Muhammad T#, Guo Y#, Li M, Sha Q, Zhang C, Liu H, Zhao S, Zhao H, Zhang H, Du Y, Sun K, Liu K, Lu G, Guo X, Sha J, Fan H, Gao F, Chen Z-J*. RNA‐Binding Protein IGF2BP2/IMP2 is a Critical Maternal Activator in Early Zygotic Genome Activation. Advanced Science. 2019 May 24;6(15):1900295. [IF: 15.63]4. Wang S*#, Veller C#, Sun F, Ruiz-Herrera A, Shang Y, Liu H, Denise Zickler, Chen Z-J, Kleckner N*, Zhang L*. Per-Nucleus Crossover Covariation and Implications for Evolution. Cell. 2019 Apr 4;177(2):326-338.e16. [IF: 38.62]5. Li M#, Zhao H, Zhao S, Wei D, Zhao Y, Huang T, Muhammad T, Yan L, Gao F, Li L, Lu G, Chan W-Y, Leung P, Dunaif A, Liu H*, Chen Z-J*. The HMGA2-IMP2 Pathway Promotes Granulosa Cell Proliferation in Polycystic Ovary Syndrome. Journal Of Clinical Endocrinology & Metabolism. 2019 Apr 1;104(4):1049-1059. [IF: 5.88] 6. Liu M#, Sun A, Zhao S, Liu H, Ma S, Li M, Huai Y, Zhao H, Liu H*. Resveratrol improves in vitro maturation of oocytes in aged mice and humans. Fertility and Sterility. 2018 May;109(5):900-907. [IF: 5.19]