刘磊
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刘磊，男，1981年11月生，教授、博士生导师，学院副院长
入选国家优青、泰山学者特聘专家、教育部新世纪优秀人才、山东省杰青、山东大学齐鲁青年学者
学术任职：任 中国化学会有机化学学科委员会委员（2022-）、 Chin. Chem. Lett.编委（2021-）、《有机化学》青年编委（2019-）
研究方向：仿生不对称氧化、复杂分子不对称合成、抗菌金属药物化学生物学
邮箱：leiliu@sdu.edu.cn
地址：山东省济南市历城区山大南路27号山东大学老数学楼113
课题组英文主页：http://leiliugroup.com
课题组长期招聘有机合成、金属有机化学、化学生物学、药物化学、理论计算化学专业的博士后
招聘启示见：https://www.chem.sdu.edu.cn/info/1285/17324.htm
简历
2012.06- 山东大学 教授、博士生导师
2011.03-2012.04 哈佛大学 博士后 导师：Yoshito Kishi 教授
2006.08-2011.03 匹兹堡大学 博士 导师：Paul Floreancig 教授
2003.09-2006.06 兰州大学 硕士 导师：王锐 院士
1999.09-2003.06 兰州大学 本科
主要研究方向
课题组聚焦不对称氧化新反应的发展，瞄准氧化反应的化学和对映选择性调控关键科学问题，根据底物与金属配位能力的不同，利用仿生学原理，开发了锰、铁和钛三类大位阻手性丰产金属催化剂，对一系列难与金属催化剂形成有效相互作用的底物开展不对称氧化研究，并取得如下创新性成果：
一是实现了sp3碳氢键的不对称氧化。针对缺少与催化剂作用位点的底物，模仿细胞色素P450的“氧回弹”催化机制和选择性调控模式，构建具有潜在弱相互作用位点的大位阻手性锰催化剂，建立其与底物和氧化中间体的有效相互作用模型，实现了醚、有机叠氮、氮杂环和炔烃四类底物中sp3碳氢键的不对称氧化；
二是实现了胺的不对称脱氢。针对易毒化催化剂的底物，模仿甲烷单加氧酶MMO催化中心的结构，构建了两类大位阻手性双核铁催化剂，通过变换金属中心的桥连方式，调控催化剂手性空穴尺寸，有效地避免了底物与金属中心的配位作用，解决了催化剂效率低和选择性差的难题，实现了二级胺的不对称脱氢；
三是实现了氮原子和芳香杂环化合物的不对称氧化。针对氧化反应途径多样的特点，使用路易斯酸性强的钛为催化剂金属中心，改变氧化剂的活化模式，提高金属氧化活性物种的亲电性，调控了反应的化学选择性，实现了氮原子和吲哚类芳香杂环的不对称氧化。
主要奖励和荣誉
Asian Core Program (ACP) Lectureship Award（to Korea，2023）
泰山学者特聘专家（2023）
山东省优秀研究生导师（2023）
山东省自然科学二等奖（第一位 2022）
山东省青年科技奖（2022）
山东大学优秀教师（2022）
山东省青创人才引育计划（2021）
国家基金委优秀青年基金（结题优秀）（2017）
霍英东青年教师基金（2016）
Thieme Chemistry Journal Award (2016)
山东省“杰出青年基金”(2014)
教育部“新世纪优秀人才”（2013）
山东大学齐鲁青年学者（2012）
国家优秀自费留学生奖学金（中国驻纽约总领事馆）（2010）
中国科学院奖学金（2005）
主要科研成果
山东大学独立研究工作
2024年
80. Catalytic Enantioselective Hydroxylation of Tertiary Propargylic C(sp3)-H Bonds in Acyclic Systems. Cao, M.#; Wang, H.#; Hou, F.; Zhu, Y.; Liu, Q.; Tung, C.-H.; Liu, L.* under revision.
79. Catalytic Asymmetric Access to Structurally Diverse N-Alkoxy Amines via A Kinetic Resolution Strategy. Cao, M.#; Wang, Z.#; Hou, F.#; Liu, X.; Sun, S.; Wang, X.; Liu, L.* JACS Au. under revision.
78. Enzymatic and Chemo-catalytic Redox Deracemization: Recent Progress. Wan, Q.*; Wang, Z.; Sun, H.; Song, D.; Wang, X.*; Liu, L.* ChemCatChem. 2024, doi.org/10.1002/cctc.202301757. link
2023年
77. Late-Stage Chemo- and Enantioselective Oxidation of Indoles to C3-Monosubstituted Oxindoles. Li, S.; Liu, X.*; Tung, C.-H.; Liu, L.* J. Am. Chem. Soc. 2023, 145, 27120. link
76. Catalytic Asymmetric Oxidation of Amines to Hydroxylamines. Wang, G.; Chen, T.; Jia, K.; Ma, W.; Tung, C.-H.; Liu, L.* J. Am. Chem. Soc. 2023, 145, 22276. link (Highlighted by Org. Process Res. Dev. 2023, 27, link)
2022年
75. Hydride Abstraction Initiated Catalytic Stereoselective Intermolecular Bond-Forming Processes. Liu, L.* Acc. Chem. Res. 2022, 55, 3537. link
74. Site- and Enantioselective Manganese-Catalyzed Benzylic C-H Azidation of Indolines. Cao, M.; Wang, H.; Ma, Y.; Tung, C.-H.; Liu, L.* J. Am. Chem. Soc. 2022, 144, 15383. link (Highlighted by Org. Process Res. Dev. 2022, 26, link)
73. Practical and Selective Bio-inspired Iron-catalyzed Oxidation of Si-H Bonds to Diversely Functionalized Organosilanols. Li, S.; Li, H.; Tung, C.-H.; Liu, L.* ACS. Catal. 2022, 12, 9143. link
72. Copper-Catalyzed [3+2+1] Cycloaddition of Akenes with Benzoquinones and Dicarbonyl Compounds via Tandem Oxidative Dicarbofunctionalization/Cyclization Sequence. Du, T.; Li, S.; He, Y.; Long, H.; Liu, X.*; Li, H.-B.*; Liu, L.* Chin. J. Chem. 2022, 40, 1681. (invited contribution to the special issue of "Emerging Investigators in 2022") link
71. Methane Monooxygenase Mimic Asymmetric Oxidant: Self-Assembling μ-Hydroxo, Carboxylate-Bridged Diiron(III) Catalyzed Enantioselective Dehydrogenation. Guan, H.; Tung, C.-H.; Liu, L.* J. Am. Chem. Soc. 2022, 144, 5976. link
70. Kinetic Resolution of Cyclic Benzylic Azides Enabled by Site- and Enantioselective C(sp3)-H Oxidation. Ye, P.; Feng, A.; Wang, L.; Cao, M.; Zhu, R.; Liu, L.* Nat. Commun. 2022, 13, 1621. link Highlighted by Synform, 2022, A110. link
69. Design, Synthesis and Biological Evaluation of Novel 1,3,4,9-Tetrahydropyrano[3,4-b] indoles as Potential Treatment of Triple Negative Breast Cancer by Treating PI3K/AKT/mTOR pathway. Qin, J.; Sun, X.; Ma, Y.; Cheng, Y.; Ma, Q.; Jing, W.; Qu, S.*; Liu, L.* Bioorg. Med. Chem. 2022, 33, 116594. link
68. Enantioselective Transfer Hydrogenation of Oxocarbenium Ions Enables Asymmetric Access to α-Substituted 1,3-Dihydroisobenzofurans. Zhou, L.; Jia, K.; Liu, X.*; Liu, L.* Synthesis 2022, 421. link
2021年
67. Enantioselective Construction of Single and Vicinal All-Carbon Quaternary Stereocenters through Ion Pair Catalyzed 1,6-Conjugate Addition. Zhu, Y.; Wang, H.; Wang, G.; Wang, Z.; Liu, Z.*; Liu, L.* Org. Lett. 2021, 23, 7248. link
66. Construction of Vicinal Quaternary Carbon Stereocenters Through Diastereo- and Enantioselective Oxidative 1,6-Conjugate Addition. Liu, X.; Zhao, C.; Zhu, R.; Liu, L.* Angew. Chem. Int. Ed. 2021, 60, 18499. link
65. NaOtBu-catalyzed hydrophosphonylation of δ-CN-δ-aryl-disubstituted para-quinone methides with phosphine oxides. Wang, D.; Kan, L.; Ma, Y.*; Liu, L.* Chin. J. Org. Chem. 2021, 41, 3192. link
64. Kinetic resolution of indolines by asymmetric hydroxylamine formation. Wang, G.; Lu, R.; He, C.; Liu, L.* Nat. Commun. 2021, 12, 2512. link
63. Synthesis of diarylmethanes bearing CF3- and CN-substituted all-carbon quaternary centers and diarylmalononitriles via cyanation of δ-disubstituted para-quinone methides. Pan, X.; Cao, M.; Li, S.; Wang, H.*; Liu, X.*; Liu, L.* Eur. J. Org. Chem. 2021, 1643. link
62. Redox deracemization of alpha-substituted 1,3-dihydroisobenzofurans. Chen, X.; Zhao, R.; Liu, Z.; Sun, S.; Ma, Y.; Liu, Q.*; Sun, X.*; Liu, L.* Chin. Chem. Lett. 2021, 32, 2305. link
61. Rational design and synthesis of 6-aryl-6H-benzo[c] chromenes as non-steroidal progesterone receptor antagonists for the use against cancers. Qin, J.; Qu, S.; Cheng, Y.; Pan, G.; Jing, W.; Liu, X.; Sun, X.*; Liu, L.* Bioorg. Med. Chem. 2021, 32, 116003. link
60. Oxidative Kinetic Resolution of Cyclic Benzylic Ethers. Sun, S.; Ma, Y.; Liu, Z.; Liu, L.* Angew. Chem. Int. Ed. 2021, 60, 176. link
59. Nickel(II)-Catalyzed Asymmetric Alkylation of Acyclic Oxocarbenium Ions with Carboxylic Acid Derivatives. Ye, P.; Liu, X.; Wang, G.; Liu, L.* Chin. Chem. Lett. 2021, 32, 1237. link
2020年
58. Site- and Enantio-differentiating C(sp3)–H Oxidation Enables Asymmetric Access to Structurally and Stereochemically Diverse Saturated Cyclic Ethers. Sun, S.; Yang, Y.; Zhao, R.; Zhang, D.*; Liu, L.* J. Am. Chem. Soc. 2020, 142, 19346. link (Highlight by Synfacts)
57. Redox Deracemization of Diarylmethyl Alkynes. Ma, Y.; Liu, X.; Mao, Y.; Huang, J.; Ma, S.*; Liu, L.* Org. Chem. Front. 2020, 7, 2526. link
56. Synthesis of Unsymmetric Triarylmethanes Bearing CF3-Substituted All-Carbon Quaternary Stereocenters: 1,6-Arylation of delta-Trifluoromethyl Substituted para-Quinone Methides. Ma, Y.; Pang, J.; Pan, X.; Ma, S.*; Liu, X.*; Liu, L.* Synlett 2020, 31, 1619. link
55. Catalytic Enantioselective Alkylation of 2-Alkoxyl-tetrahydrofurans. Liu, X.; Sun, S.; Wang, G.; Bai, Z.; Pang, J.*; Liu, L.* Org. Chem. Front. 2020, 7, 2202. link
54. Redox Deracemization of Tertiary Stereocenters Adjacent to An Electron-withdrawing Group. Mao, Y.; Wang, Z.; Wang, G.; Zhao, R.; Kan, L.; Pan, X.; Liu, L.* ACS Catal. 2020, 10, 7785. link
53. Catalytic Asymmetric Synthesis of β,γ-Alkynyl α-Amino Esters via Chemo- and Enantioselective Transfer Hydrogenation. Zhang, L.; Liu, A.; Liu, H.; Wan, R.*; Sun, S.*; Liu, L.* Chin. J. Org. Chem. 2020, 40, 2904. link
52. Aerobic Redox Deracemization of α-Aryl Glycine Esters. Chen, X.; Yan, L.; Zhang, L.; Zhao, C.; Feng, G.; Chen, L.; Sun, S.*; Liu, Q.*; Liu, L.* Tetrahedron Lett. 2020, 61, 152107. link
51. Synthesis of Sterically Hindered α-Aminonitriles through 1,6-Aza-Conjugate Addition of Anilines to δ-Cyano Substituted para-Quinone Methides. Wang, L.; Wang, N.; Qi, Y.; Sun, S.; Liu, X.*; Li, W.*; Liu, L.*Chin. J. Org. Chem. 2020, 40, 3934. link (“庆祝《有机化学》创刊四十周年专辑”约稿）.
50. δ-Cyano substituted para-quinone methides enables access to unsymmetric tri- and tetraarylmethanes containing all-carbon quaternary stereocenters. Qi, Y.; Zhang, F.; Wang, L.; Feng, A.; Zhu, R.; Sun, S.*; Li, W.*; Liu, L.* Org. Biomol. Chem. 2020, 18, 3522. link
49. Redox Deracemization of β,γ-Alkynyl α-Amino Esters. Zhang, L.; Zhu, R.; Feng, A.; Zhao, C.; Chen, L.; Feng, G.; Liu, L.* Chem. Sci. 2020, 11, 4444. link
48. Cross-dehydrogenative coupling enables enantioselective access to CF3-substituted all-carbon quaternary stereocenters. Pan, X.; Wang, Z.; Kan, L.; Mao, Y.; Zhu, Y.; Liu, L.* Chem. Sci. 2020, 11, 2414. link
47. Synthesis of chiral triarylmethanes bearing all-carbon qyaternary stereocenters: catalytic asymmetric oxidative cross-coupling of 2,2-diarylacetonitriles and (hetero)arenes. Wang, Z.; Zhu, Y.; Pan, X.; Wang, G.; Liu, L.* Angew. Chem. Int. Ed. 2020, 59, 3053. link
2019年
46. Cross-dehydrogenative coupling of 3,6-dihydro-2H-pyrans with 1,3-dicarbonyls and aryl moieties. Feng, G.; Sun, C.; Xin, X.; Wan, R.*, Liu, L.* Tetrahedron Lett. 2019, 60, 1547. link
45. Oxidative C–H alkylation of naphthoquinones with simple alkenes. Cao, L.; Long, H.; Guan, H.; Bi, Y.; Bi, G.; Huang, H.* Liu, L.* Tetrahedron Lett. 2019, 60, 1268. link
44. Oxidative C–H alkynylation of 3,6-dihydro-2H-pyrans. Zhao, R.; Feng, G.; Xin, X.; Guan, H.; Hua, J.; Wan, R.*; Li, W.*; Liu, L.* Chin. Chem. Lett. 2019, 30, 1432. link
43. Cross-dehydrogenative coupling of secondary benzylic ethers with indoles and pyrroles. Cao, M.; Mao, Y.; Huang, J.; Ma, Y.*; Liu, L.* Tetrahedron Lett. 2019, 60, 1075. link
42. Direct oxidative C(sp3)–H cyanation of secondary benzylic ethers. Wang, Z.; Mao, Y.; Guan, H.; Cao, M.; Hua, J.; Feng, L.*; Liu, L.* Chin. Chem. Lett. 2019, 30, 1241. link
41. Bimolecular oxidative C-H alkynylation of α-substituted Isochromans. Mao, Y.; Cao, M.; Pan, X.; Huang, J.; Li, J.; Xu, L.; Liu, L.* Org. Chem. Front. 6, 2028. link
40. Iron-catalyzed aerobic dehydrogenative kinetic resolution of cyclic secondary amines. Lu, R.; Cao, L.; Guan, H.; Liu, L.* J. Am. Chem. Soc. 2019, 141, 6318. link
39. Catalytic enantioselective cross-dehydrogenative coupling of 3,6-dihydro-2H-pyrans with aldehydes. Xin, X.; Pan, X.; Meng, Z.; Liu, X.; Liu, L.* Org. Chem. Front. 2019, 6, 1448. link
38. Catalytic enantioselective oxidative coupling of saturated ethers with carboxylic acid derivatives. Wang, G.; Xin, X.; Wang, Z.; Lu, G.; Ma, Y.; Liu, L.* Nature Commun. 10.1038/s41467-019-08473-x. link (Featured in Nature Communications Editors' Highlights Webpage)
2018年
37. Three-component oxyarylation of alkenes enables access to C3-substituted dihydrobenzofurans. Feng, G.; Sun, S.; Liu, G.; Long, H.; Liu, L.* Org. Lett. 2018. 20, 7522. link (Top 20 most downloaded article for Nov 2018)
36. Metal-free three-component oxyalkynylation of alkenes. Li, Y.; Lu, R.; Sun, S.; Liu, L.* Org. Lett. 2018. 20, 6836. link cited in Org. Chem. Highlights. link
35. Catalytic asymmetric cross-dehydrogenative coupling of 2H-chromenes and aldehydes. Pan, X.; Liu, X.; Sun, S.; Meng, Z.; Liu, L.* Chin. J. Chem. 2018, 36, 1187. link (Dedicated to Professor Xiyan Lu on the occasion of his 90th birthday)
34. Iron(II)-catalyzed site-selective functionalization of unactivated C-H bonds guided by alkoxyl radical. Guan, H.; Sun, S.; Mao, Y.; Chen, L.; Lu, R.; Huang, J.; Liu, L.* Angew. Chem. Int. Ed. 2018, 57, 11413. link
33. Copper-catalyzed oxidative cross-dehydrogenative coupling of 2H-chromenes and terminal alkynes. Yang, F.; Li, Y.; Floreancig, P. E.*; Li, X.*; Liu, L.* Org. Biomol. Chem. 2018, 16, 5144. link
32. 饱和开链醚的氧化碳氢炔基化研究. Guan, H.; Chen, L.; Liu, L.* Acta Chimica Sinica 2018, 76, 440. (invited contribution)
31. Redox deracemization of 1,3,4,9-tetrahydropyrano[3,4-b]indoles. Lu, R.; Li, Y.; Zhao, J.; Li, J.; Wang, S.; Liu, L.* Chem. Commun. 2018, 54, 4445. link
30. Direct Oxidative C-H Alkynylation of N-Carbamoyl Tetrahydroisoquinolines and Dihydroisoquinolines. Chen, L.; Sun, C.; Feng, G.; Cao, M.; Zhao, S.; Yan, J.; Wan, R.*; Liu, L.* Org. Biomol. Chem. 2018, 16, 2792. link
29. A novel tetrahydroisoquinoline (THIQ) analogue induces mitochondria-dependent Apoptosis. Sun, X.; Liu, M.; Gao, L.; Mao, Y.; Zhao, D.; Zhang, J.; Liu, L.* Eur. J. Med. Chem. 2018, 150, 719. link
28. Efficient Access to Chiral Benzo[c]chromenes via Asymmetric Transfer Hydrogenation of Ketals. Li, Y.; Wan, M.; Sun, S.; Fu, Z.; Huang, H.; Liu, L.* Org. Chem. Front. 2018, 5, 1280. link
2017年
27. Oxidative C-H functionalization of N-carbamoyl 1,2-Dihydroquinolines. Liu, Z.; Chen, L.; Li, J.; Liu, K.; Zhao, J.; Xu, M.; Feng, L.; Wan, R.; Li, W.; Liu, L.* Org. Biomol. Chem. 2017, 15, 7600. link
26. Regio- and Diastereoselective Cross-Dehydrogenative Coupling of Tetrahydropyridines with 1,3-Dicarbonyl Compounds. Long, H.; Wang, G.; Lu, R.; Xu, M.; Zhang, K.; Qi, S.; He, Y.; Bu, Y.; Liu, L.* Org. Lett. 2017, 19, 2146. link
25. Organocatalytic Redox Deracemization of Cyclic Benzylic Ethers Enabled by An "Acetal Pool" Strategy. Wan, M.; Shu, S.; Li, Y.; Liu, L.* Angew. Chem. Int. Ed. 2017, 56, 5116. link (Highlight by Synfacts)
2016年
24. Wang, G.; Mao, Y.; Liu, L.* Diastereoselectively Complementary C-H Functionalization Enables Access to Structurally and Stereochemically Diverse 2,6-Substituted Piperidines. Org. Lett. 2016,18, 6476. link
23. Wang, G.; Sun, S.; Mao, Y.; Xie, Z.; Liu, L.* Chromium (II) Catalyzed Enantioselective Arylation of Ketones. Beilstein. J. Org. Chem. 2016, 12, 2771. link (Invited by Professor Tehshik P Yoon for Thematic Series "Strategies in Asymmetric Synthesis")
22. Sun, Y.; Wang, G.; Chen, J.; Liu, C.; Cai, M.; Zhu, R.*; Huang, H.*; Li, W.*; Liu, L.* A Practical Oxidative C-H Functionalization of N-Carbamoyl Tetrahydro-beta-Carbolines with Diverse Potassium Trifluoroborates. Org. Biomol. Chem. 2016, 14, 9431. link
21. Xie, Z.; Zan, X.; Sun, S.; Pan, X.; Liu, L.* Organocatalytic Enantioselective Cross-Dehydrogenative Coupling of N-Carbamoyl Cyclic Amines with Aldehydes. Org. Lett. 2016, 18, 3944. link
20. Xie, Z.; Liu, X.; Liu, L.* Copper-Catalyzed Aerobic Enantioselective Cross-Dehydrogenative Coupling of N-Aryl Glycine Esters with Terminal Alkynes. Org. Lett. 2016, 18, 2982. link (Highlight by Synfacts)
19. Sun, S.; Liu, L.* Catalytic Enantioselective Alkynylation of Tetrahydroisoquinoline-Based N-Acyl Hemiaminals. Synthesis 2016, 48, 2627. link (Invited for specific topic "Asymmetric Synthesis" by Erick Carreira)
18. Xie, Z.; Jia, J.; Liu, X.; Liu, L.* Copper(II) Triflate-Catalyzed Aerobic Oxidative C-H Functionalization of Glycine Derivatives with Olefins and Organoboranes. Adv. Synth. Catal. 2016, 358, 919. link
17. Liu, G.; Qian, J.; Hua, J.; Cai, F.; Li, X.; Liu, L.* An Economical Synthesis of Substituted Quinoline-2-Carboxylates through the Potassium Persulfate-Mediated Cross-Dehydrogenative Coupling of N-Aryl Glycine Derivatives with Olefins. Org. Biomol. Chem. 2016, 14, 1147. link
2015年
16. Chen.J.; Wan, M.; Hua, J.; Sun, Y.; Lv, Z.; Li, W.*; Liu, L.* TBHP/TFA Mediated Oxidative Cross-Dehydrogenative Coupling of N-Heterocycles with Aldehydes. Org. Biomol. Chem. 2015, 13, 11561. link (Highlight by Synfacts)
15. Wan, M.; Lou,H.; Liu, L.* C1-Benzyl and benzoyl isoquinoline synthesis throughdirect oxidative cross-dehydrogenative coupling with methyl arenes. Chem. Commun. 2015, 51, 13953. link (Highlight by Synfacts)
14. Sun, S.; Mao,Y.; Lou, H.; Liu, L.* Copper(II)/amine synergisticallycatalyzed enantioselective alkylation of cyclic N-acyl hemiaminals withaldehydes. Chem. Commun. 2015, 51, 10691. link
13. Liu, X.; Sun,S.; Meng, Z.; Lou, H.; Liu, L.* Organocatalytic asymmetricC-H vinylation and arylation of N-acyl tetrahydroisoquinolines. Org. Lett. 2015, 17, 2396. link (Top 20 most downloaded article for May2015)
12. Li, F.; Meng,Z.; Hua, J.; Li, W.; Lou, H.; Liu, L.* Indium-catalyzedoxidative cross-dehydrogenative coupling of chromenes with 1,3-dicarbonyls andaryl rings. Org. Biomol. Chem. 2015, 13, 5710. link
11. Sun, S.; Li,C.; Floreancig, P. E.; Lou, H.; Liu, L.* Highly enantioselectivecatalytic cross-dehydrogenative coupling of N-carbamoyl tetrahydro isoquino-lines and terminal alkynes. Org. Lett. 2015, 17, 1684. link (Highlight by Synfacts)
10. Liu, X.;Meng, Z.; Li, C.; Lou, H.; Liu, L.* OrganocatalyticEnantioselective Oxidative C-H Alkenylation and Arylation of N-CarbamoylTetrahydropyridines and Tetrahydro-β-Carbolines. Angew. Chem. Int. Ed. 2015, 54,6012. link (Highlight by Synfacts, cited in Org. Chem. Highlights) link
2014年
9. Chen, W.;Xie, Z.; Zheng, H.; Lou, H.*; Liu, L.* Structurally Diverseα-Substituted Benzopyran Synthesis through A Practical Metal-Free C(sp3)-HFunctionalization. Org. Lett. 2014, 16, 5988. link
8. Sun, S.; Yang,J.; Li, F.; Lv, Z.; Li, W.*; Lou, H.*; Liu, L.* Seven- and Eight-MemberedHeterocyclic Biaryl Synthesis through A Metal-Free Oxidative Coupling Reaction.Tetrahedron Lett. 2014, 55, 6899. link
7. Wan, M.; Meng,Z.; Lou, H.; Liu, L.* Practical and Highly Selective C-H Functionalizationof Structurally Diverse Ethers. Angew. Chem. Int. Ed. 2014, 53,13845. link (Selected as “hot paper” by Angew Chem)
6. Yang, J.; Sun, S.; Zeng, Z.; Zheng, H.; Lou, H.; Liu, L.* An economic and Environmentally Friendly Oxidative Biaryl Coupling Promoted byActivated MnO2. Org. Biomol. Chem. 2014, 12,7774. link
5. Pan, X. H.;Hu, Q. W.; Chen, W. F.; Liu, X. G.; Sun, B.; Huang, Z. L.; Zeng, Z. Y.; Wang,L. G.; Zhao, D.; Ji, M.; Liu, L.*; Lou, H.* Copper(II) CatalyzedCross-Dehydrogenative Coupling of Cyclic Benzylic Ethers with Simple Carbonyl Compoundsby Na2S2O8. Tetrahedron 2014, 70,3447. link
4. Chen, W. F.;Zheng, H. B.; Pan, X. H.; Xie, Z. Y.; Zan, X.; Sun, B.; Liu, L.*;Lou, H.* A Metal-Free Cross-Dehydrogenative Coupling of N-Carbamoyl Tetrahydroispquinolineby Sodium Persulfate. Tetrahedron Lett. 2014, 55, 2879. link
3. Xie, Z. Y.; Liu, L.*; Chen, W. F.; Zheng, H. B.; Xu, Q. Q.; Yuan, H. Q.; Lou, H.* PracticalMetal-Free C(sp3)-H Functionalization: Construction of Structurally Diverse a-SubstitutedN-Benzyl and N-Allyl Carbamates. Angew. Chem. Int. Ed. 2014, 53,3904. link (Highlight by Chinese J Org Chem)
2. Meng, Z. L.; Sun, S. T.; Yuan, H. Q.; Lou, H. X.*; Liu, L.* Catalytic Enantioselective Oxidative Cross-Coupling of Benzylic Ethers withAldehydes. Angew. Chem. Int. Ed. 2014, 53, 543. link (selectedas “Hot Paper” by AngewChem/Highlightby Synfact, 2014, 341)
2013年
1. Liu, X. G.; Sun, B.; Xie, Z. Y.; Qin, X. J.; Liu, L.*; Lou, H. X.* Manganese dioxide-Methanesulfonic Acid Promoted Direct DehydrogenativeAlkylation of sp3 C–H Bonds Adjacent to A Heteroatom. J. Org. Chem. 2013, 78, 3104. link
哈佛大学博士后研究工作（2011-2012）
13. Liu, L.;Henderson, J. A.; Yamamoto, A.; Brémond, P.; Kishi, Y. Synthesis of alcoholsfrom m-Fluorophenylsulfones and Dialkylboranes: Application to theC14-C35 Building Block of E7389. Org. Lett. 2012, 14,2262.
匹兹堡大学攻读博士期间工作（2006-2011）
12. Liu,L.; Floreancig, P. E. Stereoselective Synthesis of Tertiary Ethersthrough Geometrical Control of Highly Substituted Oxocarbenium Ions. Angew. Chem. Int. Ed. 2010, 49, 5894. (Highlighted in SynFacts2010, 1152 and Synstory 2010, A101)
11. Liu, L.; Floreancig, P. E. Structurally and Stereochemically Diverse TetrahydropyranSynthesis through Oxidative Carbon–Hydrogen Bond Activation. Angew. Chem. Int. Ed. 2010, 49, 3069. (Selected as “Hot Paper” in Angew.Chem. Int. Ed.)
10. Liu, L.; Floreancig, P. E. Stereoselective Heterocycles Synthesis through OxidativeCarbon–Hydrogen Bond Activation. Curr. Opin. Drug. Discov. Devel. 2010,13, 733.
9. Liu, L.;Floreancig, P. E. DDQ-Catalyzed Reactions Employing MnO2 as A StoichiometricOxidant. Org. Lett. 2010, 12, 4686.
8. Liu, L.;Floreancig, P. E. Cyclization Reactions through DDQ-Mediated Vinyl OxazolidinoneOxidation. Org. Lett. 2009, 11, 3152. (Highlightedin SynFacts 2009, 998)
7. Tu, W.; Liu,L.; Floreancig, P. E. Diastereoselective Tetrahydropyrone Synthesis throughTransition-Metal-Free Oxidative Carbon–Hydrogen Bond Activation. Angew. Chem. Int. Ed. 2008, 47, 4184.
兰州大学攻读硕士期间工作（2003-2006）
6. Liu, L.;Wang, R.; Kang, Y.-F.; Cai, H.-Q.; Chen, C. Highly Enantioselective Addition of Phenylacetylene to Ketones Catalyzed by Bis(hydroxycamphorsulfonamide)-copper(II) Complex. Synlett. 2006, 8, 1245.
5. Liu, L.;Wang, R.; Kang, Y.-F.; Chen, C.; Xu, Z.-Q.; Zhou, Y.-F.; Ni, M.; Cai, H.-Q.;Gong, M.-Z. Highly Enantioselective Phenylacetylene Addition to Aromatic KetonesCatalyzed by Cinchona Alkaloid-Aluminum Complexes. J. Org. Chem. 2005,70, 1084.
4. Liu, L.;Kang, Y.-F.; Wang, R.; Zhou, Y.-F.; Chen, C.; Ni, M.; Gong, M.-Z. EnantioselectiveAlkynylation of Aromatic Ketones Promoted by (S)-Phenylalanine-derived β-Amino Alcohol. Tetrahedron: Asymmetry 2004, 15, 3757.
3. Kang, Y.-F.; Liu,L.; Wang, R.; Zhou, Y.-F.; Yan, W.-J. Enantioselective Alkynylation ofAromatic Ketones Catalyzed by New Chiral Oxazolidine Ligands. Adv. Synth.Catal. 2005, 347, 243.
2. Kang, Y.-F.; Liu,L.; Wang, R.; Yan, W.-J.; Zhou, Y.-F. The Use of Bifunctional CatalystSystems in the Asymmetric Addition of Alkynylzinc to Aldehydes. Tetrahedron:Asymmetry 2004, 15, 3155.
1. Kang, Y.-F.; Liu,L.; Wang, R.; Ni, M.; Han, Z.-J. Enantioselective Addition of Diethylzincto Aromatic Aldehydes Catalyzed by New Chiral Oxazolidine Ligand. Synth.Commun. 2005, 35, 1819.
