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    刘磊

    • 教授 博士生导师 硕士生导师
    • 性别:男
    • 毕业院校:匹兹堡大学
    • 学历:博士研究生毕业
    • 学位:博士
    • 在职信息:在职
    • 所在单位:化学与化工学院
    • 入职时间: 2012-06-04
    • 办公地点:中心校区老数学楼113

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    个人简介

    刘磊,男,1981年11月生,教授、博士生导师,学院副院长

    入选国家优青、泰山学者特聘专家、教育部新世纪优秀人才、山东省杰青、山东大学齐鲁青年学者


    学术任职:任 中国化学会有机化学学科委员会委员(2022-)、 Chin. Chem. Lett.编委(2021-)、《有机化学》青年编委(2019-)


    研究方向:仿生不对称氧化、复杂分子不对称合成、抗菌金属药物化学生物学 


    邮箱:leiliu@sdu.edu.cn

    地址:山东省济南市历城区山大南路27号山东大学老数学楼113

    课题组英文主页:http://leiliugroup.com


    课题组长期招聘有机合成、金属有机化学、化学生物学、药物化学、理论计算化学专业的博士后

    招聘启示见:https://www.chem.sdu.edu.cn/info/1285/17324.htm 


    简历

    2012.06-        山东大学    教授、博士生导师

    2011.03-2012.04   哈佛大学    博士后  导师:Yoshito Kishi 教授

    2006.08-2011.03   匹兹堡大学  博士    导师:Paul Floreancig 教授

    2003.09-2006.06   兰州大学    硕士    导师:王锐 院士

    1999.09-2003.06   兰州大学    本科    



    主要研究方向

    不对称氧化是创造高氧化态手性物质最直接的手段。传统研究多局限于烯烃、硫化物、酮和醇这四类底物参与的五类反应探索新底物类型和新反应模式是不对称氧化领域面临的挑战性难题。课题组的研究方向是仿生开发高效、高选择性的不对称催化氧化新体系,发展新型不对称氧化反应并探索其合成和生物学应用。


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    课题组聚焦不对称氧化新反应的发展,瞄准氧化反应的化学和对映选择性调控关键科学问题,根据底物与金属配位能力的不同,利用仿生学原理,开发了锰、铁和钛三类大位阻手性丰产金属催化剂,对一系列难与金属催化剂形成有效相互作用的底物开展不对称氧化研究,并取得如下创新性成果:

    是实现了sp3碳氢键的不对称氧化。针对缺少与催化剂作用位点的底物,模仿细胞色素P450的“氧回弹”催化机制和选择性调控模式,构建具有潜在弱相互作用位点的大位阻手性锰催化剂,建立其与底物和氧化中间体的有效相互作用模型,实现了醚、有机叠氮、氮杂环和炔烃四类底物中sp3碳氢键的不对称氧化;

    是实现了胺的不对称脱氢。针对易毒化催化剂的底物,模仿甲烷单加氧酶MMO催化中心的结构,构建了两类大位阻手性双核铁催化剂,通过变换金属中心的桥连方式,调控催化剂手性空穴尺寸,有效地避免了底物与金属中心的配位作用,解决了催化剂效率低和选择性差的难题,实现了二级胺的不对称脱氢;

    是实现了氮原子和芳香杂环化合物的不对称氧化。针对氧化反应途径多样的特点,使用路易斯酸性强的钛为催化剂金属中心,改变氧化剂的活化模式,提高金属氧化活性物种的亲电性,调控了反应的化学选择性,实现了氮原子和吲哚类芳香杂环的不对称氧化。


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    主要奖励和荣誉

    Asian Core Program (ACP) Lectureship Award(to Korea,2023) 

    泰山学者特聘专家(2023)

    山东省优秀研究生导师(2023)

    山东省自然科学二等奖(第一位 2022)

    山东省青年科技奖(2022)

    山东大学优秀教师(2022)

    山东省青创人才引育计划(2021)

    国家基金委优秀青年基金(结题优秀)(2017

    霍英东青年教师基金(2016

    Thieme Chemistry Journal Award (2016)

    山东省“杰出青年基金”(2014)

    教育部“新世纪优秀人才”2013

    山东大学齐鲁青年学者2012

    国家优秀自费留学生奖学金(中国驻纽约总领事馆)(2010

    中国科学院奖学金2005


    主要科研成果

    山东大学独立研究工作

    2024

    80. Catalytic Enantioselective Hydroxylation of Tertiary Propargylic C(sp3)-H Bonds in Acyclic Systems. Cao, M.#; Wang, H.#; Hou, F.; Zhu, Y.; Liu, Q.; Tung, C.-H.; Liu, L.*  under revision.


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    79. Catalytic Asymmetric Access to Structurally Diverse N-Alkoxy Amines via A Kinetic Resolution Strategy. Cao, M.#; Wang, Z.#; Hou, F.#; Liu, X.; Sun, S.; Wang, X.; Liu, L.* JACS Au. 10.1021/jacsau.4c00174link


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    78. Enzymatic and Chemo-catalytic Redox Deracemization: Recent Progress. Wan, Q.*; Wang, Z.; Sun, H.; Song, D.; Wang, X.*; Liu, L.* ChemCatChem. 2024, doi.org/10.1002/cctc.202301757. link

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    2023

    77. Late-Stage Chemo- and Enantioselective Oxidation of Indoles to C3-Monosubstituted Oxindoles. Li, S.; Liu, X.*; Tung, C.-H.; Liu, L.* J. Am. Chem. Soc. 2023, 145, 27120. link    

     

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    76. Catalytic Asymmetric Oxidation of Amines to Hydroxylamines. Wang, G.; Chen, T.; Jia, K.; Ma, W.; Tung, C.-H.; Liu, L.* J. Am. Chem. Soc. 2023145, 22276. link  (Highlighted by Org. Process Res. Dev. 202327,  link)


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    2022

    75. Hydride Abstraction Initiated Catalytic Stereoselective Intermolecular Bond-Forming Processes. Liu, L.* Acc. Chem. Res. 202255, 3537. link

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    74. Site- and Enantioselective Manganese-Catalyzed Benzylic C-H Azidation of Indolines. Cao, M.; Wang, H.; Ma, Y.; Tung, C.-H.; Liu, L.* J. Am. Chem. Soc. 2022144,  15383link  (Highlighted by Org. Process Res. Dev. 202226link)

           

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    73. Practical and Selective Bio-inspired Iron-catalyzed Oxidation of Si-H Bonds to Diversely Functionalized Organosilanols. Li, S.; Li, H.; Tung, C.-H.; Liu, L.* ACS. Catal. 2022, 12, 9143. link       

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    72. Copper-Catalyzed [3+2+1] Cycloaddition of Akenes with Benzoquinones and Dicarbonyl Compounds via Tandem Oxidative Dicarbofunctionalization/Cyclization Sequence. Du, T.; Li, S.; He, Y.; Long, H.; Liu, X.*; Li, H.-B.*; Liu, L.* Chin. J. Chem. 202240,  1681. (invited contribution to the special issue of "Emerging Investigators in 2022"link     

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    71. Methane Monooxygenase Mimic Asymmetric Oxidant: Self-Assembling μ-Hydroxo, Carboxylate-Bridged Diiron(III) Catalyzed Enantioselective Dehydrogenation. Guan, H.; Tung, C.-H.; Liu, L.* J. Am. Chem. Soc. 2022144,  5976. link


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    70. Kinetic Resolution of Cyclic Benzylic Azides Enabled by Site- and Enantioselective C(sp3)-H Oxidation. Ye, P.; Feng, A.; Wang, L.; Cao, M.; Zhu, R.; Liu, L.*  Nat. Commun. 202213, 1621. link Highlighted by Synform2022, A110. link

     

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    69. Design, Synthesis and Biological Evaluation of Novel 1,3,4,9-Tetrahydropyrano[3,4-b] indoles as Potential Treatment of Triple Negative Breast Cancer by Treating PI3K/AKT/mTOR pathway. Qin, J.; Sun, X.; Ma, Y.; Cheng, Y.; Ma, Q.; Jing, W.; Qu, S.*; Liu, L.* Bioorg. Med. Chem. 202233, 116594. link

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    68. Enantioselective Transfer Hydrogenation of Oxocarbenium Ions Enables Asymmetric Access to α-Substituted 1,3-Dihydroisobenzofurans. Zhou, L.; Jia, K.; Liu, X.*; Liu, L.* Synthesis 2022, 421. link 

    2021

    67. Enantioselective Construction of Single and Vicinal All-Carbon Quaternary Stereocenters through Ion Pair Catalyzed 1,6-Conjugate Addition. Zhu, Y.; Wang, H.; Wang, G.; Wang, Z.; Liu, Z.*; Liu, L.* Org. Lett. 202123, 7248link   

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    66. Construction of Vicinal Quaternary Carbon Stereocenters Through Diastereo- and Enantioselective Oxidative 1,6-Conjugate Addition. Liu, X.; Zhao, C.; Zhu, R.; Liu, L.* Angew. Chem. Int. Ed. 202160, 18499. link


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    65. NaOtBu-catalyzed hydrophosphonylation of δ-CN-δ-aryl-disubstituted para-quinone methides with phosphine oxides. Wang, D.; Kan, L.; Ma, Y.*; Liu, L.* Chin. J. Org. Chem. 202141, 3192. link


    64. Kinetic resolution of indolines by asymmetric hydroxylamine formation. Wang, G.; Lu, R.; He, C.; Liu, L.* Nat. Commun. 2021, 122512. link


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    63. Synthesis of diarylmethanes bearing CF3- and CN-substituted all-carbon quaternary centers and diarylmalononitriles via cyanation of δ-disubstituted para-quinone methides. Pan, X.; Cao, M.; Li, S.; Wang, H.*; Liu, X.*; Liu, L.* Eur. J. Org. Chem. 20211643. link 

    62. Redox deracemization of alpha-substituted 1,3-dihydroisobenzofurans. Chen, X.; Zhao, R.; Liu, Z.; Sun, S.; Ma, Y.; Liu, Q.*; Sun, X.*; Liu, L.* Chin. Chem. Lett. 202132, 2305. link

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    61. Rational design and synthesis of 6-aryl-6H-benzo[c] chromenes as non-steroidal progesterone receptor antagonists for the use against cancers. Qin, J.; Qu, S.; Cheng, Y.; Pan, G.; Jing, W.; Liu, X.; Sun, X.*; Liu, L.* Bioorg. Med. Chem. 202132, 116003. link

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    60. Oxidative Kinetic Resolution of Cyclic Benzylic Ethers. Sun, S.; Ma, Y.; Liu, Z.; Liu, L.* Angew. Chem. Int. Ed. 202160, 176. link


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    59. Nickel(II)-Catalyzed Asymmetric Alkylation of Acyclic Oxocarbenium Ions with Carboxylic Acid Derivatives. Ye, P.; Liu, X.; Wang, G.; Liu, L.* Chin. Chem. Lett. 202132, 1237. link

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    2020

    58. Site- and Enantio-differentiating C(sp3)–H Oxidation Enables Asymmetric Access to Structurally and Stereochemically Diverse Saturated Cyclic Ethers. Sun, S.; Yang, Y.; Zhao, R.; Zhang, D.*; Liu, L.* J. Am. Chem. Soc. 2020, 142, 19346. link (Highlight by Synfacts)


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    57. Redox Deracemization of Diarylmethyl Alkynes. Ma, Y.; Liu, X.; Mao, Y.; Huang, J.; Ma, S.*; Liu, L.* Org. Chem. Front. 20207, 2526. link

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    56. Synthesis of Unsymmetric Triarylmethanes Bearing CF3-Substituted All-Carbon Quaternary Stereocenters: 1,6-Arylation of delta-Trifluoromethyl Substituted para-Quinone Methides. Ma, Y.; Pang, J.; Pan, X.; Ma, S.*; Liu, X.*; Liu, L.* Synlett 202031, 1619. link

    55. Catalytic Enantioselective Alkylation of 2-Alkoxyl-tetrahydrofurans. Liu, X.; Sun, S.; Wang, G.; Bai, Z.; Pang, J.*;  Liu, L.* Org. Chem. Front. 2020, 7, 2202. link

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    54. Redox Deracemization of Tertiary Stereocenters Adjacent to An Electron-withdrawing Group. Mao, Y.; Wang, Z.; Wang, G.; Zhao, R.; Kan, L.; Pan, X.; Liu, L.* ACS Catal. 2020, 10, 7785. link 

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    53. Catalytic Asymmetric Synthesis of β,γ-Alkynyl α-Amino Esters via Chemo- and Enantioselective Transfer Hydrogenation. Zhang, L.; Liu, A.; Liu, H.; Wan, R.*; Sun, S.*; Liu, L.Chin. J. Org. Chem. 202040, 2904. link

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    52. Aerobic Redox Deracemization of α-Aryl Glycine Esters. Chen, X.; Yan, L.; Zhang, L.; Zhao, C.; Feng, G.; Chen, L.; Sun, S.*; Liu, Q.*; Liu, L.* Tetrahedron Lett. 2020, 61, 152107. link

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    51. Synthesis of Sterically Hindered α-Aminonitriles through 1,6-Aza-Conjugate Addition of Anilines to δ-Cyano Substituted para-Quinone Methides. Wang, L.; Wang, N.; Qi, Y.; Sun, S.; Liu, X.*; Li, W.*; Liu, L.*Chin. J. Org. Chem. 202040, 3934. link (“庆祝《有机化学》创刊四十周年专辑”约稿).

    50. δ-Cyano substituted para-quinone methides enables access to unsymmetric tri- and tetraarylmethanes containing all-carbon quaternary stereocenters. Qi, Y.; Zhang, F.; Wang, L.; Feng, A.; Zhu, R.; Sun, S.*; Li, W.*;  Liu, L.* Org. Biomol. Chem. 2020183522. link 


    49. Redox Deracemization of β,γ-Alkynyl α-Amino Esters. Zhang, L.; Zhu, R.; Feng, A.; Zhao, C.; Chen, L.; Feng, G.; Liu, L.* Chem. Sci. 2020, 11, 4444. link 

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    48. Cross-dehydrogenative coupling enables enantioselective access to CF3-substituted all-carbon quaternary stereocenters. Pan, X.; Wang, Z.; Kan, L.; Mao, Y.; Zhu, Y.; Liu, L.* Chem. Sci. 2020, 11, 2414. link

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    47. Synthesis of chiral triarylmethanes bearing all-carbon qyaternary stereocenters: catalytic asymmetric oxidative cross-coupling of 2,2-diarylacetonitriles and (hetero)arenes. Wang, Z.; Zhu, Y.; Pan, X.; Wang, G.; Liu, L.* Angew. Chem. Int. Ed. 2020, 59, 3053. link

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    2019

    46. Cross-dehydrogenative coupling of 3,6-dihydro-2H-pyrans with 1,3-dicarbonyls and aryl moieties. Feng, G.; Sun, C.; Xin, X.; Wan, R.*, Liu, L.* Tetrahedron Lett201960, 1547. link 

    45. Oxidative C–H alkylation of naphthoquinones with simple alkenes. Cao, L.; Long, H.; Guan, H.; Bi, Y.; Bi, G.; Huang, H.* Liu, L.* Tetrahedron Lett. 201960, 1268. link 

    44. Oxidative C–H alkynylation of 3,6-dihydro-2H-pyrans. Zhao, R.; Feng, G.; Xin, X.; Guan, H.; Hua, J.; Wan, R.*; Li, W.*; Liu, L.* Chin. Chem. Lett. 2019, 30, 1432. link 

    43. Cross-dehydrogenative coupling of secondary benzylic ethers with indoles and pyrroles. Cao, M.; Mao, Y.; Huang, J.; Ma, Y.*; Liu, L.* Tetrahedron Lett201960, 1075link

    42. Direct oxidative C(sp3)–H cyanation of secondary benzylic ethers. Wang, Z.; Mao, Y.; Guan, H.; Cao, M.; Hua, J.; Feng, L.*; Liu, L.Chin. Chem. Lett. 2019, 30, 1241. link

    41. Bimolecular oxidative C-H alkynylation of α-substituted Isochromans. Mao, Y.; Cao, M.; Pan, X.; Huang, J.; Li, J.; Xu, L.; Liu, L.Org. Chem. Front. 6, 2028. link


    40. Iron-catalyzed aerobic dehydrogenative kinetic resolution of cyclic secondary amines. Lu, R.; Cao, L.; Guan, H.; Liu, L.J. Am. Chem. Soc. 2019, 141, 6318. link 

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    39. Catalytic enantioselective cross-dehydrogenative coupling of 3,6-dihydro-2H-pyrans with aldehydes. Xin, X.; Pan, X.; Meng, Z.; Liu, X.;  Liu, L.* Org. Chem. Front. 2019, 6, 1448. link

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    38. Catalytic enantioselective oxidative coupling of saturated ethers with carboxylic acid derivatives. Wang, G.; Xin, X.; Wang, Z.; Lu, G.; Ma, Y.; Liu, L.* Nature Commun. 10.1038/s41467-019-08473-x. link (Featured in Nature Communications Editors' Highlights Webpage)

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    2018

    37. Three-component oxyarylation of alkenes enables access to C3-substituted dihydrobenzofurans. Feng, G.; Sun, S.; Liu, G.; Long, H.; Liu, L.* Org. Lett. 201820, 7522. link (Top 20 most downloaded article for Nov 2018)

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    36. Metal-free three-component oxyalkynylation of alkenes. Li, Y.; Lu, R.; Sun, S.; Liu, L.Org. Lett. 201820, 6836. link cited in Org. Chem. Highlights. link 

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    35. Catalytic asymmetric cross-dehydrogenative coupling of 2H-chromenes and aldehydes. Pan, X.; Liu, X.; Sun, S.; Meng, Z.; Liu, L.Chin. J. Chem. 201836, 1187. link (Dedicated to Professor Xiyan Lu on the occasion of his 90th birthday)

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    34. Iron(II)-catalyzed site-selective functionalization of unactivated C-H bonds guided by alkoxyl radical. Guan, H.; Sun, S.; Mao, Y.; Chen, L.; Lu, R.; Huang, J.; Liu, L.* Angew. Chem. Int. Ed. 2018, 57, 11413. link

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    33. Copper-catalyzed oxidative cross-dehydrogenative coupling of 2H-chromenes and terminal alkynes. Yang, F.; Li, Y.; Floreancig, P. E.*; Li, X.*; Liu, L.Org. Biomol. Chem. 201816, 5144. link

    32. 饱和开链醚的氧化碳氢炔基化研究. Guan, H.; Chen, L.; Liu, L.Acta Chimica Sinica 201876, 440(invited contribution)

    31. Redox deracemization of 1,3,4,9-tetrahydropyrano[3,4-b]indoles. Lu, R.; Li, Y.; Zhao, J.; Li, J.; Wang, S.; Liu, L.* Chem. Commun. 201854, 4445. link 

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    30. Direct Oxidative C-H Alkynylation of N-Carbamoyl Tetrahydroisoquinolines and Dihydroisoquinolines. Chen, L.; Sun, C.; Feng, G.; Cao, M.; Zhao, S.; Yan, J.; Wan, R.*; Liu, L.* Org. Biomol. Chem. 2018, 16, 2792. link

    29.  A novel tetrahydroisoquinoline (THIQ) analogue induces mitochondria-dependent Apoptosis. Sun, X.; Liu, M.; Gao, L.; Mao, Y.; Zhao, D.; Zhang, J.; Liu, L.Eur. J. Med. Chem. 2018150, 719. link

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    28. Efficient Access to Chiral Benzo[c]chromenes via Asymmetric Transfer Hydrogenation of Ketals. Li, Y.; Wan, M.; Sun, S.; Fu, Z.; Huang, H.; Liu, L.Org. Chem. Front. 2018, 5, 1280. link

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    2017

    27. Oxidative C-H functionalization of N-carbamoyl 1,2-Dihydroquinolines. Liu, Z.; Chen, L.; Li, J.; Liu, K.; Zhao, J.; Xu, M.; Feng, L.; Wan, R.; Li, W.; Liu, L.* Org. Biomol. Chem. 2017, 15, 7600. link

    26. Regio- and Diastereoselective Cross-Dehydrogenative Coupling of Tetrahydropyridines with 1,3-Dicarbonyl Compounds. Long, H.; Wang, G.; Lu, R.; Xu, M.; Zhang, K.; Qi, S.; He, Y.; Bu, Y.; Liu, L.* Org. Lett. 201719, 2146. link

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    25. Organocatalytic Redox Deracemization of Cyclic Benzylic Ethers Enabled by An "Acetal Pool" Strategy. Wan, M.; Shu, S.; Li, Y.; Liu, L.* Angew. Chem. Int. Ed. 2017, 56, 5116. link (Highlight by Synfacts)

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    2016

    24. Wang, G.; Mao, Y.; Liu, L.Diastereoselectively Complementary C-H Functionalization Enables Access to Structurally and Stereochemically Diverse 2,6-Substituted Piperidines. Org. Lett. 2016,18, 6476. link

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    23. Wang, G.; Sun, S.; Mao, Y.; Xie, Z.; Liu, L.* Chromium (II) Catalyzed Enantioselective Arylation of Ketones. Beilstein. J. Org. Chem. 2016, 12, 2771. link (Invited by Professor Tehshik P Yoon for Thematic Series "Strategies in Asymmetric Synthesis")

    22. Sun, Y.; Wang, G.; Chen, J.; Liu, C.; Cai, M.; Zhu, R.*; Huang, H.*; Li, W.*; Liu, L.A Practical Oxidative C-H Functionalization of N-Carbamoyl Tetrahydro-beta-Carbolines with Diverse Potassium Trifluoroborates. Org. Biomol. Chem. 201614, 9431. link

    21. Xie, Z.; Zan, X.; Sun, S.; Pan, X.; Liu, L.* Organocatalytic Enantioselective Cross-Dehydrogenative Coupling of N-Carbamoyl Cyclic Amines with Aldehydes. Org. Lett. 201618, 3944. link

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    20. Xie, Z.; Liu, X.; Liu, L.* Copper-Catalyzed Aerobic Enantioselective Cross-Dehydrogenative Coupling of N-Aryl Glycine Esters with Terminal Alkynes. Org. Lett. 2016, 18, 2982. link (Highlight by Synfacts)

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    19. Sun, S.; Liu, L.* Catalytic Enantioselective Alkynylation of Tetrahydroisoquinoline-Based N-Acyl Hemiaminals. Synthesis 201648, 2627. link (Invited for specific topic "Asymmetric Synthesis" by Erick Carreira)

    18. Xie, Z.; Jia, J.; Liu, X.; Liu, L.* Copper(II) Triflate-Catalyzed Aerobic Oxidative C-H Functionalization of Glycine Derivatives with Olefins and Organoboranes. Adv. Synth. Catal. 2016358, 919. link 

    17. Liu, G.; Qian, J.; Hua, J.; Cai, F.; Li, X.; Liu, L.* An Economical Synthesis of Substituted Quinoline-2-Carboxylates through the Potassium Persulfate-Mediated Cross-Dehydrogenative Coupling of N-Aryl Glycine Derivatives with Olefins. Org. Biomol. Chem. 201614, 1147. link


    2015

    16. Chen.J.; Wan, M.; Hua, J.; Sun, Y.; Lv, Z.; Li, W.*; Liu, L.* TBHP/TFA Mediated Oxidative Cross-Dehydrogenative Coupling of N-Heterocycles with Aldehydes. Org. Biomol. Chem. 201513, 11561. link (Highlight by Synfacts)

    15. Wan, M.; Lou,H.; Liu, L.* C1-Benzyl and benzoyl isoquinoline synthesis throughdirect oxidative cross-dehydrogenative coupling with methyl arenes. Chem. Commun. 201551, 13953. link (Highlight by Synfacts)  

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    14. Sun, S.; Mao,Y.; Lou, H.; Liu, L.* Copper(II)/amine synergisticallycatalyzed enantioselective alkylation of cyclic N-acyl hemiaminals withaldehydes. Chem. Commun. 201551, 10691. link

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    13. Liu, X.; Sun,S.; Meng, Z.; Lou, H.; Liu, L.* Organocatalytic asymmetricC-H vinylation and arylation of N-acyl tetrahydroisoquinolines. Org. Lett. 201517, 2396. link (Top 20 most downloaded article for May2015)

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    12. Li, F.; Meng,Z.; Hua, J.; Li, W.; Lou, H.; Liu, L.* Indium-catalyzedoxidative cross-dehydrogenative coupling of chromenes with 1,3-dicarbonyls andaryl rings. Org. Biomol. Chem201513, 5710. link

    11. Sun, S.; Li,C.; Floreancig, P. E.; Lou, H.; Liu, L.* Highly enantioselectivecatalytic cross-dehydrogenative coupling of N-carbamoyl tetrahydro isoquino-lines and terminal alkynes. Org. Lett. 201517, 1684. link (Highlight by Synfacts)

    11.png


    10. Liu, X.;Meng, Z.; Li, C.; Lou, H.; Liu, L.* OrganocatalyticEnantioselective Oxidative C-H Alkenylation and Arylation of N-CarbamoylTetrahydropyridines and Tetrahydro-β-Carbolines. Angew. Chem. Int. Ed. 201554,6012. link (Highlight by Synfacts, cited in Org. Chem. Highlights) link

    10.png

    2014年

    9. Chen, W.;Xie, Z.; Zheng, H.; Lou, H.*; Liu, L.* Structurally Diverseα-Substituted Benzopyran Synthesis through A Practical Metal-Free C(sp3)-HFunctionalization. Org. Lett. 201416, 5988. link

    8. Sun, S.; Yang,J.; Li, F.; Lv, Z.; Li, W.*; Lou, H.*; Liu, L.* Seven- and Eight-MemberedHeterocyclic Biaryl Synthesis through A Metal-Free Oxidative Coupling Reaction.Tetrahedron Lett. 201455, 6899. link


    7. Wan, M.; Meng,Z.; Lou, H.; Liu, L.* Practical and Highly Selective C-H Functionalizationof Structurally Diverse Ethers. Angew. Chem. Int. Ed. 201453,13845. link (Selected as “hot paper” by Angew Chem)

    7.png

    6. Yang, J.; Sun, S.; Zeng, Z.; Zheng, H.; Lou, H.; Liu, L.* An economic and Environmentally Friendly Oxidative Biaryl Coupling Promoted byActivated MnO2Org. Biomol. Chem. 201412,7774. link

    5. Pan, X. H.;Hu, Q. W.; Chen, W. F.; Liu, X. G.; Sun, B.; Huang, Z. L.; Zeng, Z. Y.; Wang,L. G.; Zhao, D.; Ji, M.; Liu, L.*; Lou, H.* Copper(II) CatalyzedCross-Dehydrogenative Coupling of Cyclic Benzylic Ethers with Simple Carbonyl Compoundsby Na2S2O8Tetrahedron 201470,3447. link

    4. Chen, W. F.;Zheng, H. B.; Pan, X. H.; Xie, Z. Y.; Zan, X.; Sun, B.; Liu, L.*;Lou, H.* A Metal-Free Cross-Dehydrogenative Coupling of N-Carbamoyl Tetrahydroispquinolineby Sodium Persulfate. Tetrahedron Lett. 201455, 2879. link


    3. Xie, Z. Y.; Liu, L.*; Chen, W. F.; Zheng, H. B.; Xu, Q. Q.; Yuan, H. Q.; Lou, H.* PracticalMetal-Free C(sp3)-H Functionalization: Construction of Structurally Diverse a-SubstitutedN-Benzyl and N-Allyl Carbamates. Angew. Chem. Int. Ed. 201453,3904. link (Highlight by Chinese J Org Chem)

    3.jpg

    2. Meng, Z. L.; Sun, S. T.; Yuan, H. Q.; Lou, H. X.*; Liu, L.Catalytic Enantioselective Oxidative Cross-Coupling of Benzylic Ethers withAldehydes. Angew. Chem. Int. Ed. 201453, 543. link (selectedas “Hot Paper” by AngewChem/Highlightby Synfact2014341)

    2.jpg


    2013

    1. Liu, X. G.; Sun, B.; Xie, Z. Y.; Qin, X. J.; Liu, L.*; Lou, H. X.* Manganese dioxide-Methanesulfonic Acid Promoted Direct DehydrogenativeAlkylation of sp3 C–H Bonds Adjacent to A Heteroatom. J. Org. Chem. 201378, 3104. link


    哈佛大学博士后研究工作(2011-2012)

    13. Liu, L.;Henderson, J. A.; Yamamoto, A.; Brémond, P.; Kishi, Y. Synthesis of alcoholsfrom m-Fluorophenylsulfones and Dialkylboranes: Application to theC14-C35 Building Block of E7389. Org. Lett. 201214,2262. 


    匹兹堡大学攻读博士期间工作(2006-2011)
    12. Liu,L.; Floreancig, P. E. Stereoselective Synthesis of Tertiary Ethersthrough Geometrical Control of Highly Substituted Oxocarbenium Ions. Angew. Chem. Int. Ed. 201049, 5894. (Highlighted in SynFacts2010, 1152 and Synstory 2010, A101)

    11. Liu, L.; Floreancig, P. E. Structurally and Stereochemically Diverse TetrahydropyranSynthesis through Oxidative Carbon–Hydrogen Bond Activation. Angew. Chem. Int. Ed. 201049, 3069. (Selected as “Hot Paper” in Angew.Chem. Int. Ed.)

    10. Liu, L.; Floreancig, P. E. Stereoselective Heterocycles Synthesis through OxidativeCarbon–Hydrogen Bond Activation. Curr. Opin. Drug. Discov. Devel. 2010,13, 733.

    9. Liu, L.;Floreancig, P. E. DDQ-Catalyzed Reactions Employing MnO2 as A StoichiometricOxidant. Org. Lett. 201012, 4686.

    8. Liu, L.;Floreancig, P. E. Cyclization Reactions through DDQ-Mediated Vinyl OxazolidinoneOxidation. Org. Lett. 200911, 3152. (Highlightedin SynFacts 2009, 998)

    7. Tu, W.; Liu,L.; Floreancig, P. E. Diastereoselective Tetrahydropyrone Synthesis throughTransition-Metal-Free Oxidative Carbon–Hydrogen Bond Activation. Angew. Chem. Int. Ed. 200847, 4184.


    兰州大学攻读硕士期间工作(2003-2006)

    6. Liu, L.;Wang, R.; Kang, Y.-F.; Cai, H.-Q.; Chen, C. Highly Enantioselective Addition of Phenylacetylene to Ketones Catalyzed by Bis(hydroxycamphorsulfonamide)-copper(II) Complex. Synlett. 20068, 1245.

    5. Liu, L.;Wang, R.; Kang, Y.-F.; Chen, C.; Xu, Z.-Q.; Zhou, Y.-F.; Ni, M.; Cai, H.-Q.;Gong, M.-Z. Highly Enantioselective Phenylacetylene Addition to Aromatic KetonesCatalyzed by Cinchona Alkaloid-Aluminum Complexes. J. Org. Chem. 2005,70, 1084.

    4. Liu, L.;Kang, Y.-F.; Wang, R.; Zhou, Y.-F.; Chen, C.; Ni, M.; Gong, M.-Z. EnantioselectiveAlkynylation of Aromatic Ketones Promoted by (S)-Phenylalanine-derived β-Amino Alcohol. Tetrahedron: Asymmetry 200415, 3757.

    3. Kang, Y.-F.; Liu,L.; Wang, R.; Zhou, Y.-F.; Yan, W.-J. Enantioselective Alkynylation ofAromatic Ketones Catalyzed by New Chiral Oxazolidine Ligands. Adv. Synth.Catal. 2005347, 243.

    2. Kang, Y.-F.; Liu,L.; Wang, R.; Yan, W.-J.; Zhou, Y.-F. The Use of Bifunctional CatalystSystems in the Asymmetric Addition of Alkynylzinc to Aldehydes. Tetrahedron:Asymmetry 200415, 3155.

    1. Kang, Y.-F.; Liu,L.; Wang, R.; Ni, M.; Han, Z.-J. Enantioselective Addition of Diethylzincto Aromatic Aldehydes Catalyzed by New Chiral Oxazolidine Ligand. Synth.Commun. 200535, 1819.