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    刘磊

    • 教授 博士生导师 硕士生导师
    • 性别:男
    • 毕业院校:匹兹堡大学
    • 学历:博士研究生毕业
    • 学位:博士
    • 在职信息:在职
    • 所在单位:化学与化工学院
    • 入职时间: 2012-06-04
    • 办公地点:中心校区老数学楼113

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    个人简介

    刘磊,男,1981年11月生,教授、博士生导师

    入选国家优青、教育部新世纪优秀人才、山东省杰青、山东大学齐鲁青年学者


    研究方向:课题组长期从事有机合成和药物化学研究,主要研究兴趣为基于氧化的不对称催化与合成、活性天然产物的全合成、药物化学。


    联系电话:0531-88363010

    邮箱:leiliu@sdu.edu.cn

    地址:山东省济南市历城区山大南路27号山东大学老数学楼113

    课题组主页:http://leiliugroup.com


    课题组长期招聘有机化学、药物化学和理论计算化学专业的博士后


    学习及工作经历】

    教育经历:

    2006.08-2011.03  匹兹堡大学  有机化学              博士   导师:Paul Floreancig教授

    2003.09-2006.06  兰州大学    生物化学与分子生物学  硕士   导师:王锐 院士

    1999.09-2003.06  兰州大学    生物科学(基地班)    学士   导师:王锐 院士


    工作经历:

    2012.06-至今     山东大学    教授、博士生导师

    2011.03-2012.04  哈佛大学    博士后  导师:Yoshito Kishi 教授


    【主讲课程】

    《有机化学》(本科生)



    【研究领域和兴趣】

    (1)不对称催化与合成:不对称催化氧化

    (2)活性天然产物的全合成及构效关系研究

    (3)药物化学:具有生物活性的小分子试剂的设计和发现研究


    【科研项目】

    在研项目

    国家自然科学基金面上项目   2020-2023   负责人

    深圳市面上项目             2020-2023   负责人


    结题项目

    国家优秀青年基金           2018-2020   负责人

    霍英东青年教师基金         2016-2020   负责人

    国家自然科学基金面上项目   2015-2018   负责人

    广西师大国重室开放基金     2016-2018   负责人

    山东省“杰出青年基金”     2015-2017   负责人

    深圳市科技计划项目         2015-2017   负责人

    山东大学交叉学科培育基金   2015-2017   负责人

    教育部“新世纪优秀人才”   2014-2016   负责人

    “齐鲁青年学者”启动经费   2012-2016   负责人

    国家自然科学基金青年项目   2013-2015   负责人

    山东省优秀中青年科学家科研奖励基金  2013-2015   负责人


    人才计划和获奖情况

    国家基金委优秀青年基金(2017)

    霍英东教育基金奖励(2016)

    Thieme Chemistry Journal Award (2016)

    山东省自然科学基金“杰出青年基金”(2014)

    教育部“新世纪优秀人才”(2013

    “齐鲁青年学者”(2012

    国家优秀自费留学生奖学金(中国驻纽约总领事馆)(2010)

    中国科学院奖学金(2005



    【主要论著】

    山东大学独立研究工作

    2021年

    64. Kinetic resolution of indolines by asymmetric hydroxylamine formation. Wang, G.; Lu, R.; He, C.; Liu, L.* Nat. Commun. 2021, 1210.1038/s41467-021-22658-3.

    63. Synthesis of diarylmethanes bearing CF3- and CN-substituted all-carbon quaternary centers and diarylmalononitriles via cyanation of δ-disubstituted para-quinone methides. Pan, X.; Cao, M.; Li, S.; Wang, H.*; Liu, X.*; Liu, L.* Eur. J. Org. Chem. 20211643.  

    62. Redox deracemization of alpha-substituted 1,3-dihydroisobenzofurans. Chen, X.; Zhao, R.; Liu, Z.; Sun, S.; Ma, Y.; Liu, Q.*; Sun, X.*; Liu, L.* Chin. Chem. Lett. 202132, 10.1016/j.cclet.2021.02.012.

    61. Rational design and synthesis of 6-aryl-6H-benzo[c] chromenes as non-steroidal progesterone receptor antagonists for the use against cancers. Qin, J.; Qu, S.; Cheng, Y.; Pan, G.; Jing, W.; Liu, X.; Sun, X.*; Liu, L.* Bioorg. Med. Chem. 202132, 116003.

    60. Oxidative Kinetic Resolution of Cyclic Benzylic Ethers. Sun, S.; Ma, Y.; Liu, Z.; Liu, L.* Angew. Chem. Int. Ed. 202160, 176. 

     

    2020年

    59. Site- and Enantio-differentiating C(sp3)–H Oxidation Enables Asymmetric Access to Structurally and Stereochemically Diverse Saturated Cyclic Ethers. Sun, S.; Yang, Y.; Zhao, R.; Zhang, D.*; Liu, L.* J. Am. Chem. Soc. 2020, 142, 19346.

    58. Nickel(II)-Catalyzed Asymmetric Alkylation of Acyclic Oxocarbenium Ions with Carboxylic Acid Derivatives. Ye, P.; Liu, X.; Wang, G.; Liu, L.* Chin. Chem. Lett. 2021, 32, 1237.

    57. Redox Deracemization of Diarylmethyl Alkynes. Ma, Y.; Liu, X.; Mao, Y.; Huang, J.; Ma, S.*; Liu, L.* Org. Chem. Front20207, 10.1039/D0QO00811G.

    56. Synthesis of Unsymmetric Triarylmethanes Bearing CF3-Substituted All-Carbon Quaternary Stereocenters: 1,6-Arylation of delta-Trifluoromethyl Substituted para-Quinone Methides. Ma, Y.; Pang, J.; Pan, X.; Ma, S.*; Liu, X.*; Liu, L.* Synlett 2020, 10.1055/s-0040-1706408.

    55. Catalytic Asymmetric Alkylation of 2-Alkoxyl-tetrahydrofurans. Liu, X.; Sun, S.; Wang, G.; Bai, Z.; Pang, J.*;  Liu, L.* Org. Chem. Front. 2020, 7, 10.1039/d0qo00104j. 

    54. Redox Deracemization of Tertiary Stereocenters Adjacent to An Electron-withdrawing Group. Mao, Y.; Wang, Z.; Wang, G.; Zhao, R.; Kan, L.; Pan, X.; Liu, L.* ACS Catal. 2020, 10, 7785.  

    53. Catalytic Asymmetric Synthesis of β,γ-Alkynyl α-Amino Esters via Chemo- and Enantioselective Transfer Hydrogenation. Zhang, L.; Liu, A.; Liu, H.; Wan, R.*; Sun, S.*; Liu, L.Chin. J. Org. Chem. 202040, 10.6023/cjoc202005037.

    52. Aerobic Redox Deracemization of α-Aryl Glycine Esters. Chen, X.; Yan, L.; Zhang, L.; Zhao, C.; Feng, G.; Chen, L.; Sun, S.*; Liu, Q.*; Liu, L.* Tetrahedron Lett. 2020, 61, 152107.

    51. Synthesis of Sterically Hindered α-Aminonitriles through 1,6-Aza-Conjugate Addition of Anilines to δ-Cyano Substituted para-Quinone Methides. Wang, L.; Wang, N.; Qi, Y.; Sun, S.; Liu, X.*; Li, W.*; Liu, L.*Chin. J. Org. Chem. 202040, 10.6023/cjoc202004027. (“庆祝《有机化学》创刊四十周年专辑”约稿).

    50. δ-Cyano substituted para-quinone methides enables access to unsymmetric tri- and tetraarylmethanes containing all-carbon quaternary stereocenters. Qi, Y.; Zhang, F.; Wang, L.; Feng, A.; Zhu, R.; Sun, S.*; Li, W.*;  Liu, L.* Org. Biomol. Chem. 2020183522.  

    49. Redox Deracemization of β,γ-Alkynyl α-Amino Esters. Zhang, L.; Zhu, R.; Feng, A.; Zhao, C.; Chen, L.; Feng, G.; Liu, L.* Chem. Sci. 2020, 11, 4444.  

    48. Cross-dehydrogenative coupling enables enantioselective access to CF3-substituted all-carbon quaternary stereocenters. Pan, X.; Wang, Z.; Kan, L.; Mao, Y.; Zhu, Y.; Liu, L.* Chem. Sci. 2020, 11, 2414.  

    47. Synthesis of chiral triarylmethanes bearing all-carbon qyaternary stereocenters: catalytic asymmetric oxidative cross-coupling of 2,2-diarylacetonitriles and (hetero)arenes. Wang, Z.; Zhu, Y.; Pan, X.; Wang, G.; Liu, L.* Angew. Chem. Int. Ed. 2020, 59, 3053.


    2019年

    46. Cross-dehydrogenative coupling of 3,6-dihydro-2H-pyrans with 1,3-dicarbonyls and aryl moieties. Feng, G.; Sun, C.; Xin, X.; Wan, R.*, Liu, L.* Tetrahedron Lett201960, 1547.  

    45. Oxidative C–H alkylation of naphthoquinones with simple alkenes. Cao, L.; Long, H.; Guan, H.; Bi, Y.; Bi, G.; Huang, H.* Liu, L.* Tetrahedron Lett. 201960, 1268.

    44. Oxidative C–H alkynylation of 3,6-dihydro-2H-pyrans. Zhao, R.; Feng, G.; Xin, X.; Guan, H.; Hua, J.; Wan, R.*; Li, W.*; Liu, L.* Chin. Chem. Lett. 2019, 30, 1432.

    43. Cross-dehydrogenative coupling of secondary benzylic ethers with indoles and pyrroles. Cao, M.; Mao, Y.; Huang, J.; Ma, Y.*; Liu, L.* Tetrahedron Lett201960, 1075.

    42. Direct oxidative C(sp3)–H cyanation of secondary benzylic ethers. Wang, Z.; Mao, Y.; Guan, H.; Cao, M.; Hua, J.; Feng, L.*; Liu, L.Chin. Chem. Lett. 2019, 30, 1241.

    41. Bimolecular oxidative C-H alkynylation of α-substituted Isochromans. Mao, Y.; Cao, M.; Pan, X.; Huang, J.; Li, J.; Xu, L.; Liu, L.Org. Chem. Front. 6, 2028.

    40. Iron-catalyzed aerobic dehydrogenative kinetic resolution of cyclic secondary amines. Lu, R.; Cao, L.; Guan, H.; Liu, L.* J. Am. Chem. Soc. 2019, 141, 6318.  

    39. Catalytic enantioselective cross-dehydrogenative coupling of 3,6-dihydro-2H-pyrans with aldehydes. Xin, X.; Pan, X.; Meng, Z.; Liu, X.;  Liu, L.* Org. Chem. Front. 2019, 6, 1448. 

    38. Catalytic enantioselective oxidative coupling of saturated ethers with carboxylic acid derivatives. Wang, G.; Xin, X.; Wang, Z.; Lu, G.; Ma, Y.; Liu, L.* Nature Commun. 10.1038/s41467-019-08473-x. (Featured in Nature Communications Editors' Highlights Webpage)


    2018年

    37. Three-component oxyarylation of alkenes enables access to C3-substituted dihydrobenzofurans. Feng, G.; Sun, S.; Liu, G.; Long, H.; Liu, L.* Org. Lett. 201820, 7522. (Top 20 most downloaded article for Nov 2018)

    36. Metal-free three-component oxyalkynylation of alkenes. Li, Y.; Lu, R.; Sun, S.; Liu, L.Org. Lett. 201820, 6836.

    35. Catalytic asymmetric cross-dehydrogenative coupling of 2H-chromenes and aldehydes. Pan, X.; Liu, X.; Sun, S.; Meng, Z.; Liu, L.Chin. J. Chem. 201836, 1187. (Dedicated to Professor Xiyan Lu on the occasion of his 90th birthday)

    34. Iron(II)-catalyzed site-selective functionalization of unactivated C-H bonds guided by alkoxyl radical. Guan, H.; Sun, S.; Mao, Y.; Chen, L.; Lu, R.; Huang, J.; Liu, L.* Angew. Chem. Int. Ed. 2018, 57, 11413.

    33. Copper-catalyzed oxidative cross-dehydrogenative coupling of 2H-chromenes and terminal alkynes. Yang, F.; Li, Y.; Floreancig, P. E.*; Li, X.*; Liu, L.Org. Biomol. Chem. 201816, 5144.

    32. 饱和开链醚的氧化碳氢炔基化研究. Guan, H.; Chen, L.; Liu, L.Acta Chimica Sinica 201876, 440(invited contribution)

    31. Redox deracemization of 1,3,4,9-tetrahydropyrano[3,4-b]indoles. Lu, R.; Li, Y.; Zhao, J.; Li, J.; Wang, S.; Liu, L.* Chem. Commun. 2018, 54, 4445.

    30. Direct Oxidative C-H Alkynylation of N-Carbamoyl Tetrahydroisoquinolines and Dihydroisoquinolines. Chen, L.; Sun, C.; Feng, G.; Cao, M.; Zhao, S.; Yan, J.; Wan, R.*; Liu, L.* Org. Biomol. Chem. 2018, 16, 2792.

    29.  A novel tetrahydroisoquinoline (THIQ) analogue induces mitochondria-dependent Apoptosis. Sun, X.; Liu, M.; Gao, L.; Mao, Y.; Zhao, D.; Zhang, J.; Liu, L.Eur. J. Med. Chem. 2018150, 719.

    28. Efficient Access to Chiral Benzo[c]chromenes via Asymmetric Transfer Hydrogenation of Ketals. Li, Y.; Wan, M.; Sun, S.; Fu, Z.; Huang, H.; Liu, L.Org. Chem. Front. 2018, 5, 1280.


    2017年

    27. Oxidative C-H functionalization of N-carbamoyl 1,2-Dihydroquinolines. Liu, Z.; Chen, L.; Li, J.; Liu, K.; Zhao, J.; Xu, M.; Feng, L.; Wan, R.; Li, W.; Liu, L.* Org. Biomol. Chem. 2017, 15, 7600.

    26. Regio- and Diastereoselective Cross-Dehydrogenative Coupling of Tetrahydropyridines with 1,3-Dicarbonyl Compounds. Long, H.; Wang, G.; Lu, R.; Xu, M.; Zhang, K.; Qi, S.; He, Y.; Bu, Y.; Liu, L.* Org. Lett. 201719, 2146.

    25. Organocatalytic Redox Deracemization of Cyclic Benzylic Ethers Enabled by An "Acetal Pool" Strategy. Wan, M.; Shu, S.; Li, Y.; Liu, L.* Angew. Chem. Int. Ed. 2017, 56, 5116.


    2016年

    24. Wang, G.; Mao, Y.; Liu, L.Diastereoselectively Complementary C-H Functionalization Enables Access to Structurally and Stereochemically Diverse 2,6-Substituted Piperidines. Org. Lett. 2016,18, 6476.

    23. Wang, G.; Sun, S.; Mao, Y.; Xie, Z.; Liu, L.* Chromium (II) Catalyzed Enantioselective Arylation of Ketones. Beilstein. J. Org. Chem. 2016, 12, 2771. (Invited by Professor Tehshik P Yoon for Thematic Series "Strategies in Asymmetric Synthesis")

    22. Sun, Y.; Wang, G.; Chen, J.; Liu, C.; Cai, M.; Zhu, R.*; Huang, H.*; Li, W.*; Liu, L.A Practical Oxidative C-H Functionalization of N-Carbamoyl Tetrahydro-beta-Carbolines with Diverse Potassium Trifluoroborates. Org. Biomol. Chem. 201614, 9431.

    21. Xie, Z.; Zan, X.; Sun, S.; Pan, X.; Liu, L.* Organocatalytic Enantioselective Cross-Dehydrogenative Coupling of N-Carbamoyl Cyclic Amines with Aldehydes. Org. Lett. 201618, 3944.  

    20. Xie, Z.; Liu, X.; Liu, L.* Copper-Catalyzed Aerobic Enantioselective Cross-Dehydrogenative Coupling of N-Aryl Glycine Esters with Terminal Alkynes. Org. Lett. 2016, 18, 2982. (Highlight by Synfacts)

    19. Sun, S.; Liu, L.* Catalytic Enantioselective Alkynylation of Tetrahydroisoquinoline-Based N-Acyl Hemiaminals. Synthesis 201648, 2627 (Invited for specific topic "Asymmetric Synthesis" by Erick Carreira)

    18. Xie, Z.; Jia, J.; Liu, X.; Liu, L.* Copper(II) Triflate-Catalyzed Aerobic Oxidative C-H Functionalization of Glycine Derivatives with Olefins and Organoboranes. Adv. Synth. Catal. 2016358, 919.  

    17. Liu, G.; Qian, J.; Hua, J.; Cai, F.; Li, X.; Liu, L.* An Economical Synthesis of Substituted Quinoline-2-Carboxylates through the Potassium Persulfate-Mediated Cross-Dehydrogenative Coupling of N-Aryl Glycine Derivatives with Olefins. Org. Biomol. Chem. 201614, 1147.


    2015年

    16. Chen.J.; Wan, M.; Hua, J.; Sun, Y.; Lv, Z.; Li, W.*; Liu, L.* TBHP/TFA Mediated Oxidative Cross-Dehydrogenative Coupling of N-Heterocycles with Aldehydes. Org. Biomol. Chem. 201513, 11561. (Highlight by Synfacts)

    15. Wan, M.; Lou,H.; Liu, L.* C1-Benzyl and benzoyl isoquinoline synthesis throughdirect oxidative cross-dehydrogenative coupling with methyl arenes. Chem. Commun. 201551, 13953. (Highlight by Synfacts)  

    14. Sun, S.; Mao,Y.; Lou, H.; Liu, L.* Copper(II)/amine synergisticallycatalyzed enantioselective alkylation of cyclic N-acyl hemiaminals withaldehydes. Chem. Commun. 201551, 10691.

    13. Liu, X.; Sun,S.; Meng, Z.; Lou, H.; Liu, L.* Organocatalytic asymmetricC-H vinylation and arylation of N-acyl tetrahydroisoquinolines. Org. Lett. 201517, 2396. (Top 20 most downloaded article for May2015)

    12. Li, F.; Meng,Z.; Hua, J.; Li, W.; Lou, H.; Liu, L.* Indium-catalyzedoxidative cross-dehydrogenative coupling of chromenes with 1,3-dicarbonyls andaryl rings. Org. Biomol. Chem201513, 5710.

    11. Sun, S.; Li,C.; Floreancig, P. E.; Lou, H.; Liu, L.* Highly enantioselectivecatalytic cross-dehydrogenative coupling of N-carbamoyl tetrahydro isoquino-lines and terminal alkynes. Org. Lett. 201517, 1684.(Highlight by Synfacts)

    10. Liu, X.;Meng, Z.; Li, C.; Lou, H.; Liu, L.* OrganocatalyticEnantioselective Oxidative C-H Alkenylation and Arylation of N-CarbamoylTetrahydropyridines and Tetrahydro-β-Carbolines. Angew. Chem. Int. Ed. 201554,6012. (Highlight by Synfacts)


    2014年

    9. Chen, W.;Xie, Z.; Zheng, H.; Lou, H.*; Liu, L.* Structurally Diverseα-Substituted Benzopyran Synthesis through A Practical Metal-Free C(sp3)-HFunctionalization. Org. Lett. 201416, 5988.

    8. Sun, S.; Yang,J.; Li, F.; Lv, Z.; Li, W.*; Lou, H.*; Liu, L.* Seven- and Eight-MemberedHeterocyclic Biaryl Synthesis through A Metal-Free Oxidative Coupling Reaction.Tetrahedron Lett. 201455, 6899.

    7. Wan, M.; Meng,Z.; Lou, H.; Liu, L.* Practical and Highly Selective C-H Functionalizationof Structurally Diverse Ethers. Angew. Chem. Int. Ed. 201453,13845. (Selected as “hot paper” by Angew Chem)

    6. Yang, J.; Sun, S.; Zeng, Z.; Zheng, H.; Lou, H.; Liu, L.* Aneconomic and Environmentally Friendly Oxidative Biaryl Coupling Promoted byActivated MnO2Org. Biomol. Chem. 201412,7774.

    5. Pan, X. H.;Hu, Q. W.; Chen, W. F.; Liu, X. G.; Sun, B.; Huang, Z. L.; Zeng, Z. Y.; Wang,L. G.; Zhao, D.; Ji, M.; Liu, L.*; Lou, H.* Copper(II) CatalyzedCross-Dehydrogenative Coupling of Cyclic Benzylic Ethers with Simple Carbonyl Compoundsby Na2S2O8Tetrahedron 201470,3447.

    4. Chen, W. F.;Zheng, H. B.; Pan, X. H.; Xie, Z. Y.; Zan, X.; Sun, B.; Liu, L.*;Lou, H.* A Metal-Free Cross-Dehydrogenative Coupling of N-Carbamoyl Tetrahydroispquinolineby Sodium Persulfate. Tetrahedron Lett. 201455, 2879.

    3. Xie, Z. Y.; Liu,L.*; Chen, W. F.; Zheng, H. B.; Xu, Q. Q.; Yuan, H. Q.; Lou, H.* PracticalMetal-Free C(sp3)-H Functionalization: Construction of Structurally Diverse a-SubstitutedN-Benzyl and N-Allyl Carbamates. Angew. Chem. Int. Ed. 201453,3904. (Highlight by Chinese J Org Chem)

    2. Meng, Z. L.; Sun, S. T.; Yuan, H. Q.; Lou, H. X.*; Liu, L.Catalytic Enantioselective Oxidative Cross-Coupling of Benzylic Ethers withAldehydes. Angew. Chem. Int. Ed. 201453, 543. (selectedas “Hot Paper” by AngewChem/Highlightby Synfact2014341)


    2013年

    1. Liu, X. G.; Sun, B.; Xie, Z. Y.; Qin, X. J.; Liu, L.*; Lou, H. X.* Manganese dioxide-Methanesulfonic Acid Promoted Direct DehydrogenativeAlkylation of sp3 C–H Bonds Adjacent to A Heteroatom. J. Org. Chem. 201378, 3104.


    哈佛大学博士后研究工作(2011-2012)

    13. Liu, L.;Henderson, J. A.; Yamamoto, A.; Brémond, P.; Kishi, Y. Synthesis of alcoholsfrom m-Fluorophenylsulfones and Dialkylboranes: Application to theC14-C35 Building Block of E7389. Org. Lett. 201214,2262. 


    匹兹堡大学攻读博士期间工作2006-2011
    12. Liu,L.; Floreancig, P. E. Stereoselective Synthesis of Tertiary Ethersthrough Geometrical Control of Highly Substituted Oxocarbenium Ions. Angew. Chem. Int. Ed. 201049, 5894. (Highlighted in SynFacts2010, 1152 and Synstory 2010, A101)

    11. Liu, L.; Floreancig, P. E. Structurally and Stereochemically Diverse TetrahydropyranSynthesis through Oxidative Carbon–Hydrogen Bond Activation. Angew. Chem. Int. Ed. 201049, 3069. (Selected as “Hot Paper” in Angew.Chem. Int. Ed.)

    10. Liu, L.; Floreancig, P. E. Stereoselective Heterocycles Synthesis through OxidativeCarbon–Hydrogen Bond Activation. Curr. Opin. Drug. Discov. Devel. 2010,13, 733.

    9. Liu, L.;Floreancig, P. E. DDQ-Catalyzed Reactions Employing MnO2 as A StoichiometricOxidant. Org. Lett. 201012, 4686.

    8. Liu, L.;Floreancig, P. E. Cyclization Reactions through DDQ-Mediated Vinyl OxazolidinoneOxidation. Org. Lett. 200911, 3152. (Highlightedin SynFacts 2009, 998)

    7. Tu, W.; Liu,L.; Floreancig, P. E. Diastereoselective Tetrahydropyrone Synthesis throughTransition-Metal-Free Oxidative Carbon–Hydrogen Bond Activation. Angew. Chem. Int. Ed. 200847, 4184.


    兰州大学攻读硕士期间工作(2003-2006

    6. Liu, L.;Wang, R.; Kang, Y.-F.; Cai, H.-Q.; Chen, C. Highly Enantioselective Addition of Phenylacetylene to Ketones Catalyzed by Bis(hydroxycamphorsulfonamide)-copper(II) Complex. Synlett. 20068, 1245.

    5. Liu, L.;Wang, R.; Kang, Y.-F.; Chen, C.; Xu, Z.-Q.; Zhou, Y.-F.; Ni, M.; Cai, H.-Q.;Gong, M.-Z. Highly Enantioselective Phenylacetylene Addition to Aromatic KetonesCatalyzed by Cinchona Alkaloid-Aluminum Complexes. J. Org. Chem. 2005,70, 1084.

    4. Liu, L.;Kang, Y.-F.; Wang, R.; Zhou, Y.-F.; Chen, C.; Ni, M.; Gong, M.-Z. EnantioselectiveAlkynylation of Aromatic Ketones Promoted by (S)-Phenylalanine-derived β-Amino Alcohol. Tetrahedron: Asymmetry 200415, 3757.

    3. Kang, Y.-F.; Liu,L.; Wang, R.; Zhou, Y.-F.; Yan, W.-J. Enantioselective Alkynylation ofAromatic Ketones Catalyzed by New Chiral Oxazolidine Ligands. Adv. Synth.Catal. 2005347, 243.

    2. Kang, Y.-F.; Liu,L.; Wang, R.; Yan, W.-J.; Zhou, Y.-F. The Use of Bifunctional CatalystSystems in the Asymmetric Addition of Alkynylzinc to Aldehydes. Tetrahedron:Asymmetry 200415, 3155.

    1. Kang, Y.-F.; Liu,L.; Wang, R.; Ni, M.; Han, Z.-J. Enantioselective Addition of Diethylzincto Aromatic Aldehydes Catalyzed by New Chiral Oxazolidine Ligand. Synth.Commun. 200535, 1819.


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