Title : Micro(nano)plastics in marine medaka: Entry pathways and cardiotoxicity with triphenyltin

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Affiliation of Author(s):山东大学海洋学院

Title of Paper:Micro(nano)plastics in marine medaka: Entry pathways and cardiotoxicity with triphenyltin

Teaching and Research Group:山东大学海洋学院

Journal:Environmental Pollution

Place of Publication:荷兰

Key Words:Micro(nano)plastics；Triphenyltin；Marine medaka；Entry pathway；Cardiotoxicity

Abstract:The simultaneous presence of micro(nano)plastics (MNPs) and pollutants represents a prevalent environmental challenge that necessitates understanding their combined impact on toxicity. This study examined the distribution of 5 μm (PS-MP5) and 50 nm (PS-NP50) polystyrene plastic particles during the early developmental stages of marine medaka (Oryzias melastigma) and assessed their combined toxicity with triphenyltin (TPT). Results showed that 2 mg/L PS-MP5 and PS-NP50 could adhere to the embryo surface. PS-NP50 can passively enter the larvae and accumulate predominantly in the intestine and head, while PS-MP5 cannot. Nonetheless, both types can be actively ingested by the larvae and distributed in the intestine. 2 mg/L PS-MNPs enhance the acute toxicity of TPT. Interestingly, high concentrations of PS-NP50 (20 mg/L) diminish the acute toxicity of TPT due to their sedimentation properties and interactions with TPT. 200 μg/L PS-MNPs and 200 ng/L TPT affect complement and coagulation cascade pathways and cardiac development of medaka larvae. PS-MNPs exacerbate TPT-induced cardiotoxicity, with PS-NP50 exhibiting stronger effects than PS-MP5, which may be related to the higher adsorption capacity of NPs to TPT and their ability to enter the embryos before hatching. This study elucidates the distribution of MNPs during the early developmental stages of marine medaka and their effects on TPT toxicity, offering a theoretical foundation for the ecological risk assessment of MNPs.

All the Authors:Ren-Yan Du,Ruo-Lan Jia,Jin-Xin Wang,Cheng-Zhuang Chen,Ping Li,Ling-Ming Kong

First Author:Ling Liu

Indexed by:原始研究论文

Correspondence Author:Zhi-Hua Li

Document Code:123079

First-Level Discipline:Environmental Science and Engineering

Document Type:​实验研究论文

Volume:342

ISSN No.:0269-7491

Translation or Not:no

Date of Publication:2024-02-01