Institution:山东大学海洋学院

Title of Paper:Micro(nano)plastics in marine medaka: Entry pathways and cardiotoxicity with triphenyltin

Teaching and Research Group:山东大学海洋学院

Journal:Environmental Pollution

Place of Publication:荷兰

Key Words:Micro(nano)plastics；Triphenyltin；Marine medaka；Entry pathway；Cardiotoxicity

Summary:The simultaneous presence of micro(nano)plastics (MNPs) and pollutants represents a prevalent environmental challenge that necessitates understanding their combined impact on toxicity. This study examined the distribution of 5 μm (PS-MP5) and 50 nm (PS-NP50) polystyrene plastic particles during the early developmental stages of marine medaka (Oryzias melastigma) and assessed their combined toxicity with triphenyltin (TPT). Results showed that 2 mg/L PS-MP5 and PS-NP50 could adhere to the embryo surface. PS-NP50 can passively enter the larvae and accumulate predominantly in the intestine and head, while PS-MP5 cannot. Nonetheless, both types can be actively ingested by the larvae and distributed in the intestine. 2 mg/L PS-MNPs enhance the acute toxicity of TPT. Interestingly, high concentrations of PS-NP50 (20 mg/L) diminish the acute toxicity of TPT due to their sedimentation properties and interactions with TPT. 200 μg/L PS-MNPs and 200 ng/L TPT affect complement and coagulation cascade pathways and cardiac development of medaka larvae. PS-MNPs exacerbate TPT-induced cardiotoxicity, with PS-NP50 exhibiting stronger effects than PS-MP5, which may be related to the higher adsorption capacity of NPs to TPT and their ability to enter the embryos before hatching. This study elucidates the distribution of MNPs during the early developmental stages of marine medaka and their effects on TPT toxicity, offering a theoretical foundation for the ecological risk assessment of MNPs.

First Author:Ling Liu

Correspondence Author:Zhi-Hua Li

All the Authors:Ling-Ming Kong,Ping Li,Cheng-Zhuang Chen,Jin-Xin Wang,Ruo-Lan Jia,Ren-Yan Du

Document Code:123079

Document Type:期刊论文

Volume:342

ISSN:0269-7491

Translation or Not:No

Date of Publication:2024-02

Release Time:2025-04-09