Title : Biotransport and toxic effects of micro- and nanoplastics in fish model and their potential risk to humans: A review

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Affiliation of Author(s):山东大学海洋学院

Title of Paper:Biotransport and toxic effects of micro- and nanoplastics in fish model and their potential risk to humans: A review

Teaching and Research Group:山东大学海洋学院

Journal:Aquatic Toxicology

Place of Publication:荷兰

Key Words:Micro- and nanoplastics (MPs/NPs)；Transport；Toxic effects；Influencing factors；Human health

Abstract:The growing body of scientific evidence suggests that micro- and nanoplastics (MPs/NPs) pose a significant threat to aquatic ecosystems and human health. These particles can enter organisms through ingestion, inhalation, dermal contact, and trophic transfer. Exposure can directly affect multiple organs and systems (respiratory, digestive, neurological, reproductive, urinary, cardiovascular) and activate extensive intracellular signaling, inducing cytotoxicity involving mechanisms such as membrane disruption, extracellular polymer degradation, reactive oxygen species (ROS) production, DNA damage, cellular pore blockage, lysosomal instability, and mitochondrial depolarization. This review focuses on current research examining the in vivo and in vitro toxic effects of MPs/NPs on aquatic organisms, particularly fish, in relation to particulate toxicity aspects (such as particle transport mechanisms and structural modifications). Meanwhile, from the perspectives of the food chain and environmental factors, it emphasizes the comprehensive threats of MPs/NPs to human health in terms of both direct and indirect toxicity. Additionally, future research needs and strategies are discussed to aid in mitigating the potential risks of particulate plastics as carriers of toxic trace elements to human health.

All the Authors:Yuqing Ma,Cunlong Wang,Fengshang Duan,Jianxue Feng,Haiyang Yin,Le Sun,Zhihan Cao,Jinho Jung,Ping Li 

First Author:Yanan Xu,Ling Liu

Indexed by:综述论文

Correspondence Author:Zhi-Hua Li

Document Code:107215

Document Type:期刊论文

Volume:279

ISSN No.:0166-445X

Translation or Not:no

Date of Publication:2025-02-01