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Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus.

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Affiliation of Author(s):药学院

Journal:Eur J Med Chem.

All the Authors:zhanpeng,kangdongwei

First Author:liuxinyong

Indexed by:Unit Twenty Basic Research

Document Code:CFFB149AE82C4483A48A71BBF654924A

Translation or Not:no

Date of Publication:2018-05-10

Pre One:First discovery of a potential carbonate prodrug of NNRTI drug candidate RDEA427 with submicromolar inhibitory activity against HIV-1 K103N/Y181C double mutant strain.

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