location: Current position: Home >> Scientific Research >> Paper Publications

Identification of Dihydrofuro[3,4-d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties

Hits:

Affiliation of Author(s):药学院

Journal:《Journal of Medicinal Chemistry》

All the Authors:liuxinyong,zhanpeng

First Author:kangdongwei

Document Code:89D3DEE965214D80B7A854DD5F32EE56

Volume:62

Issue:3

Page Number:1484

Translation or Not:no

Date of Publication:2019-02-14

Pre One:Targeting the hydrophobic channel of NNIBP: discovery of novel 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs with high potency against wild-type and K103N mutant virus

Next One:Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles